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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Suboptimal antiretroviral therapy adherence among HIV-infected adults in Guangzhou, China</title><author><name sortKey="Muessig, Kathryn E" sort="Muessig, Kathryn E" uniqKey="Muessig K" first="Kathryn E." last="Muessig">Kathryn E. Muessig</name><affiliation><nlm:aff id="A1">Department of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, Megan M" sort="Mclaughlin, Megan M" uniqKey="Mclaughlin M" first="Megan M." last="Mclaughlin">Megan M. Mclaughlin</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Nie, Jing Min" sort="Nie, Jing Min" uniqKey="Nie J" first="Jing Min" last="Nie">Jing Min Nie</name><affiliation><nlm:aff id="A3">Department of Infectious Disease, Number Eight Municipal Hospital, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Weiping" sort="Cai, Weiping" uniqKey="Cai W" first="Weiping" last="Cai">Weiping Cai</name><affiliation><nlm:aff id="A3">Department of Infectious Disease, Number Eight Municipal Hospital, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Zheng, Heping" sort="Zheng, Heping" uniqKey="Zheng H" first="Heping" last="Zheng">Heping Zheng</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Yang, Ligang" sort="Yang, Ligang" uniqKey="Yang L" first="Ligang" last="Yang">Ligang Yang</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Tucker, Joseph D" sort="Tucker, Joseph D" uniqKey="Tucker J" first="Joseph D." last="Tucker">Joseph D. Tucker</name><affiliation><nlm:aff id="A1">Department of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24666239</idno><idno type="pmc">4024070</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024070</idno><idno type="RBID">PMC:4024070</idno><idno type="doi">10.1080/09540121.2014.897912</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001E08</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001E08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Suboptimal antiretroviral therapy adherence among HIV-infected adults in Guangzhou, China</title><author><name sortKey="Muessig, Kathryn E" sort="Muessig, Kathryn E" uniqKey="Muessig K" first="Kathryn E." last="Muessig">Kathryn E. Muessig</name><affiliation><nlm:aff id="A1">Department of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Mclaughlin, Megan M" sort="Mclaughlin, Megan M" uniqKey="Mclaughlin M" first="Megan M." last="Mclaughlin">Megan M. Mclaughlin</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Nie, Jing Min" sort="Nie, Jing Min" uniqKey="Nie J" first="Jing Min" last="Nie">Jing Min Nie</name><affiliation><nlm:aff id="A3">Department of Infectious Disease, Number Eight Municipal Hospital, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Cai, Weiping" sort="Cai, Weiping" uniqKey="Cai W" first="Weiping" last="Cai">Weiping Cai</name><affiliation><nlm:aff id="A3">Department of Infectious Disease, Number Eight Municipal Hospital, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Zheng, Heping" sort="Zheng, Heping" uniqKey="Zheng H" first="Heping" last="Zheng">Heping Zheng</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Yang, Ligang" sort="Yang, Ligang" uniqKey="Yang L" first="Ligang" last="Yang">Ligang Yang</name><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Tucker, Joseph D" sort="Tucker, Joseph D" uniqKey="Tucker J" first="Joseph D." last="Tucker">Joseph D. Tucker</name><affiliation><nlm:aff id="A1">Department of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</nlm:aff></affiliation></author></analytic><series><title level="j">AIDS care</title><idno type="ISSN">0954-0121</idno><idno type="eISSN">1360-0451</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Despite China“s free antiretroviral treatment (ART) program, there are high rates of treatment failure, large sociodemographic disparities in care outcomes and emerging medication resistance. Understanding patient medication adherence behaviors and challenges could inform adherence interventions to maximize the individual and prevention benefits of ART. This study assessed recent non-adherence and treatment interruption among 813 HIV-infected adult outpatients in Guangzhou, China. Participants completed a behavioral survey, underwent chart review, and were tested for syphilis, gonorrhea, and chlamydia. Factors associated with suboptimal adherence were identified using univariate and multivariate logistic regression. Among 721 HIV-infected adults receiving ART, 18.9% reported recent non-adherence (any missed ART in the past 4 weeks) and 6.8% reported treatment interruption (four or more weeks of missed ART in the past year). Lower education, living alone, alcohol use and being on ART one to three years were associated with recent non-adherence. Male gender, lower education and being on ART one to three years were associated with treatment interruption. ART medication adherence interventions are needed in China that include individualized, long-term adherence plans sensitive to patients“ educational and economic situations. These interventions should also consider possible gender disparities in treatment outcomes and address the use of alcohol during ART. Successful ART medication adherence interventions in China can inform other international settings that face similar adherence challenges and disparities.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8915313</journal-id><journal-id journal-id-type="pubmed-jr-id">1056</journal-id><journal-id journal-id-type="nlm-ta">AIDS Care</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Care</journal-id><journal-title-group><journal-title>AIDS care</journal-title></journal-title-group><issn pub-type="ppub">0954-0121</issn><issn pub-type="epub">1360-0451</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24666239</article-id><article-id pub-id-type="pmc">4024070</article-id><article-id pub-id-type="doi">10.1080/09540121.2014.897912</article-id><article-id pub-id-type="manuscript">NIHMS573197</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Suboptimal antiretroviral therapy adherence among HIV-infected adults in Guangzhou, China</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Muessig</surname><given-names>Kathryn E.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>McLaughlin</surname><given-names>Megan M.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Nie</surname><given-names>Jing Min</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Weiping</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Heping</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Ligang</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Tucker</surname><given-names>Joseph D.</given-names></name><degrees>MD, MA</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, USA</aff><aff id="A2"><label>2</label>UNC Project-China, Guangdong Provincial STD Control Center, Guangzhou, China</aff><aff id="A3"><label>3</label>Department of Infectious Disease, Number Eight Municipal Hospital, Guangzhou, China</aff><aff id="A4"><label>4</label>Guangdong Provincial STD Control Center, Guangzhou, China</aff><author-notes><corresp id="CR1"><bold>Correspondence to:</bold> Weiping Cai, MD, Department of Medicine, Number Eight People“s Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China. <email>caiwp@163.net</email>; <email>caiwp@vip.tom.com</email>; Kathryn E. Muessig, PhD, Department of Health Behavior, University of North Carolina Gillings School of Global Public Health, CB#7440, Chapel Hill, NC. <email>kmuessig@med.unc.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>26</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>8</month><year>2015</year></pub-date><volume>26</volume><issue>8</issue><fpage>988</fpage><lpage>995</lpage><pmc-comment>elocation-id from pubmed: 10.1080/09540121.2014.897912</pmc-comment>
<abstract><p id="P1">Despite China“s free antiretroviral treatment (ART) program, there are high rates of treatment failure, large sociodemographic disparities in care outcomes and emerging medication resistance. Understanding patient medication adherence behaviors and challenges could inform adherence interventions to maximize the individual and prevention benefits of ART. This study assessed recent non-adherence and treatment interruption among 813 HIV-infected adult outpatients in Guangzhou, China. Participants completed a behavioral survey, underwent chart review, and were tested for syphilis, gonorrhea, and chlamydia. Factors associated with suboptimal adherence were identified using univariate and multivariate logistic regression. Among 721 HIV-infected adults receiving ART, 18.9% reported recent non-adherence (any missed ART in the past 4 weeks) and 6.8% reported treatment interruption (four or more weeks of missed ART in the past year). Lower education, living alone, alcohol use and being on ART one to three years were associated with recent non-adherence. Male gender, lower education and being on ART one to three years were associated with treatment interruption. ART medication adherence interventions are needed in China that include individualized, long-term adherence plans sensitive to patients“ educational and economic situations. These interventions should also consider possible gender disparities in treatment outcomes and address the use of alcohol during ART. Successful ART medication adherence interventions in China can inform other international settings that face similar adherence challenges and disparities.</p></abstract><kwd-group><kwd>antiretroviral therapy</kwd><kwd>ART</kwd><kwd>ARV</kwd><kwd>adherence</kwd><kwd>alcohol</kwd><kwd>China</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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