SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001D45

Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme

Identifieur interne : 001D45 ( Pmc/Corpus ); précédent : 001D44; suivant : 001D46

Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme

Auteurs : Ralf Weigel ; Janne Estill ; Matthias Egger ; Anthony Harries ; Simon Makombe ; Hannock Tweya ; Andreas Jahn ; Olivia Keiser

Source :

AIDS (London, England) [ 0269-9370 ] ; 2012.

RBID : PMC:3811026

Abstract

Objectives

To analyse mortality, loss to follow-up (LTFU) and retention on antiretroviral treatment (ART) in the first year of ART across all age-groups in the Malawi national ART programme.

Design

Cohort study including all patients who started ART in Malawi’s public sector clinics between 2004 and 2007.

Methods

ART registers were photographed, information entered into a database and merged with data from clinics with electronic records. Rates per 100 patient-years and cumulative incidence of retention were calculated. Subhazard ratios (sHR) of outcomes adjusted for patient and clinic level characteristics were calculated in multivariate analysis, applying competing risk models.

Results

A total of 117,945 patients contributed 85,246 person-years: 1.0% were infants <2 years, 7.4 % children 2–14, 7.5% young people 15–24, and 84.2% adults 25 years and above. Sixty percent of patients were female: women outnumbered men from age 14 to 35 years. Mortality and LTFU were higher in men from age 20 years. Infants and young people had the highest rates per 100 person-years for mortality (23.0 and 19.4) and LTFU (24.7 and 19.3), and the highest adjusted relative risks compared to age group 25–34 years: sHRs were 1.37 (95%CI 1.17–1.60) and 1.17 (95%CI 1.10–1.25) for death and 1.37 (95%CI 1.18–1.59) and 1.27 (95%CI 1.19–1.35) for LTFU, respectively.

Conclusion

In this country-wide study patients aged 0–1 and 15–24 years had the highest risk of death and LTFU, and from age 20 and older men were at higher risk than women. Interventions to improve outcomes in these patient groups are required.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811026

DOI: 10.1097/QAD.0b013e32834ed814
PubMed: 22095194
PubMed Central: 3811026

Links to Exploration step

PMC:3811026

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme</title>
<author><name sortKey="Weigel, Ralf" sort="Weigel, Ralf" uniqKey="Weigel R" first="Ralf" last="Weigel">Ralf Weigel</name>
<affiliation><nlm:aff id="A1">Liverpool School of Tropical Medicine, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Lighthouse Trust at Kamuzu Central Hospital, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Estill, Janne" sort="Estill, Janne" uniqKey="Estill J" first="Janne" last="Estill">Janne Estill</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Egger, Matthias" sort="Egger, Matthias" uniqKey="Egger M" first="Matthias" last="Egger">Matthias Egger</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harries, Anthony" sort="Harries, Anthony" uniqKey="Harries A" first="Anthony" last="Harries">Anthony Harries</name>
<affiliation><nlm:aff id="A4">International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Makombe, Simon" sort="Makombe, Simon" uniqKey="Makombe S" first="Simon" last="Makombe">Simon Makombe</name>
<affiliation><nlm:aff id="A6">Department of HIV and AIDS, Ministry of Health, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tweya, Hannock" sort="Tweya, Hannock" uniqKey="Tweya H" first="Hannock" last="Tweya">Hannock Tweya</name>
<affiliation><nlm:aff id="A2">Lighthouse Trust at Kamuzu Central Hospital, Lilongwe, Malawi</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jahn, Andreas" sort="Jahn, Andreas" uniqKey="Jahn A" first="Andreas" last="Jahn">Andreas Jahn</name>
<affiliation><nlm:aff id="A6">Department of HIV and AIDS, Ministry of Health, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22095194</idno>
<idno type="pmc">3811026</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811026</idno>
<idno type="RBID">PMC:3811026</idno>
<idno type="doi">10.1097/QAD.0b013e32834ed814</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001D45</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D45</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme</title>
<author><name sortKey="Weigel, Ralf" sort="Weigel, Ralf" uniqKey="Weigel R" first="Ralf" last="Weigel">Ralf Weigel</name>
<affiliation><nlm:aff id="A1">Liverpool School of Tropical Medicine, UK</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Lighthouse Trust at Kamuzu Central Hospital, Lilongwe, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Estill, Janne" sort="Estill, Janne" uniqKey="Estill J" first="Janne" last="Estill">Janne Estill</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Egger, Matthias" sort="Egger, Matthias" uniqKey="Egger M" first="Matthias" last="Egger">Matthias Egger</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harries, Anthony" sort="Harries, Anthony" uniqKey="Harries A" first="Anthony" last="Harries">Anthony Harries</name>
<affiliation><nlm:aff id="A4">International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A5">London School of Hygiene and Tropical Medicine, London, UK</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Makombe, Simon" sort="Makombe, Simon" uniqKey="Makombe S" first="Simon" last="Makombe">Simon Makombe</name>
<affiliation><nlm:aff id="A6">Department of HIV and AIDS, Ministry of Health, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tweya, Hannock" sort="Tweya, Hannock" uniqKey="Tweya H" first="Hannock" last="Tweya">Hannock Tweya</name>
<affiliation><nlm:aff id="A2">Lighthouse Trust at Kamuzu Central Hospital, Lilongwe, Malawi</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">International Union Against Tuberculosis and Lung Disease, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jahn, Andreas" sort="Jahn, Andreas" uniqKey="Jahn A" first="Andreas" last="Jahn">Andreas Jahn</name>
<affiliation><nlm:aff id="A6">Department of HIV and AIDS, Ministry of Health, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name>
<affiliation><nlm:aff id="A3">International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">AIDS (London, England)</title>
<idno type="ISSN">0269-9370</idno>
<idno type="eISSN">1473-5571</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">To analyse mortality, loss to follow-up (LTFU) and retention on antiretroviral treatment (ART) in the first year of ART across all age-groups in the Malawi national ART programme.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Cohort study including all patients who started ART in Malawi’s public sector clinics between 2004 and 2007.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">ART registers were photographed, information entered into a database and merged with data from clinics with electronic records. Rates per 100 patient-years and cumulative incidence of retention were calculated. Subhazard ratios (sHR) of outcomes adjusted for patient and clinic level characteristics were calculated in multivariate analysis, applying competing risk models.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">A total of 117,945 patients contributed 85,246 person-years: 1.0% were infants <2 years, 7.4 % children 2–14, 7.5% young people 15–24, and 84.2% adults 25 years and above. Sixty percent of patients were female: women outnumbered men from age 14 to 35 years. Mortality and LTFU were higher in men from age 20 years. Infants and young people had the highest rates per 100 person-years for mortality (23.0 and 19.4) and LTFU (24.7 and 19.3), and the highest adjusted relative risks compared to age group 25–34 years: sHRs were 1.37 (95%CI 1.17–1.60) and 1.17 (95%CI 1.10–1.25) for death and 1.37 (95%CI 1.18–1.59) and 1.27 (95%CI 1.19–1.35) for LTFU, respectively.</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">In this country-wide study patients aged 0–1 and 15–24 years had the highest risk of death and LTFU, and from age 20 and older men were at higher risk than women. Interventions to improve outcomes in these patient groups are required.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8710219</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1493</journal-id>
<journal-id journal-id-type="nlm-ta">AIDS</journal-id>
<journal-id journal-id-type="iso-abbrev">AIDS</journal-id>
<journal-title-group><journal-title>AIDS (London, England)</journal-title>
</journal-title-group>
<issn pub-type="ppub">0269-9370</issn>
<issn pub-type="epub">1473-5571</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22095194</article-id>
<article-id pub-id-type="pmc">3811026</article-id>
<article-id pub-id-type="doi">10.1097/QAD.0b013e32834ed814</article-id>
<article-id pub-id-type="manuscript">NIHMS493978</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Weigel</surname>
<given-names>Ralf</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Estill</surname>
<given-names>Janne</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Egger</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harries</surname>
<given-names>Anthony</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Makombe</surname>
<given-names>Simon</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tweya</surname>
<given-names>Hannock</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jahn</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keiser</surname>
<given-names>Olivia</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Liverpool School of Tropical Medicine, UK</aff>
<aff id="A2"><label>2</label>
Lighthouse Trust at Kamuzu Central Hospital, Lilongwe, Malawi</aff>
<aff id="A3"><label>3</label>
International epidemiological Databases to Evaluate AIDS (IeDEA) Southern Africa Collaboration; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland</aff>
<aff id="A4"><label>4</label>
International Union Against Tuberculosis and Lung Disease, Paris, France</aff>
<aff id="A5"><label>5</label>
London School of Hygiene and Tropical Medicine, London, UK</aff>
<aff id="A6"><label>6</label>
Department of HIV and AIDS, Ministry of Health, Malawi</aff>
<author-notes><corresp id="FN1">Correspondence to: Janne Estill, Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, CH-3012 Bern, Switzerland. Tel.: +41 31 631 35 15; Fax: +41 31 631 35 20; <email>jestill@ispm.unibe.ch</email>
</corresp>
<fn id="FN2" fn-type="equal"><label>*</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>10</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><day>28</day>
<month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>29</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>26</volume>
<issue>3</issue>
<elocation-id>10.1097/QAD.0b013e32834ed814</elocation-id>
<abstract><sec id="S1"><title>Objectives</title>
<p id="P1">To analyse mortality, loss to follow-up (LTFU) and retention on antiretroviral treatment (ART) in the first year of ART across all age-groups in the Malawi national ART programme.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">Cohort study including all patients who started ART in Malawi’s public sector clinics between 2004 and 2007.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">ART registers were photographed, information entered into a database and merged with data from clinics with electronic records. Rates per 100 patient-years and cumulative incidence of retention were calculated. Subhazard ratios (sHR) of outcomes adjusted for patient and clinic level characteristics were calculated in multivariate analysis, applying competing risk models.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">A total of 117,945 patients contributed 85,246 person-years: 1.0% were infants <2 years, 7.4 % children 2–14, 7.5% young people 15–24, and 84.2% adults 25 years and above. Sixty percent of patients were female: women outnumbered men from age 14 to 35 years. Mortality and LTFU were higher in men from age 20 years. Infants and young people had the highest rates per 100 person-years for mortality (23.0 and 19.4) and LTFU (24.7 and 19.3), and the highest adjusted relative risks compared to age group 25–34 years: sHRs were 1.37 (95%CI 1.17–1.60) and 1.17 (95%CI 1.10–1.25) for death and 1.37 (95%CI 1.18–1.59) and 1.27 (95%CI 1.19–1.35) for LTFU, respectively.</p>
</sec>
<sec id="S5"><title>Conclusion</title>
<p id="P5">In this country-wide study patients aged 0–1 and 15–24 years had the highest risk of death and LTFU, and from age 20 and older men were at higher risk than women. Interventions to improve outcomes in these patient groups are required.</p>
</sec>
</abstract>
<kwd-group><kwd>Antiretroviral therapy</kwd>
<kwd>Malawi</kwd>
<kwd>mortality</kwd>
<kwd>loss to follow-up</kwd>
<kwd>retention on ART</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>U01 AI069924 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D45 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001D45 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:3811026
   |texte=   Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:22095194" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaSubSaharaV1

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme

Mortality and loss to follow-up in the first year of ART: Malawi National ART Programme

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki