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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References</title><author><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Blaser, Nello" sort="Blaser, Nello" uniqKey="Blaser N" first="Nello" last="Blaser">Nello Blaser</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name><affiliation><nlm:aff id="A2">School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Wessa, Patrick" sort="Wessa, Patrick" uniqKey="Wessa P" first="Patrick" last="Wessa">Patrick Wessa</name><affiliation><nlm:aff id="A3">Leuven Institute for Research on Information Systems, KU Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Eley, Brian" sort="Eley, Brian" uniqKey="Eley B" first="Brian" last="Eley">Brian Eley</name><affiliation><nlm:aff id="A4">Red Cross War Memorial Children’s Hospital, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Moultrie, Harry" sort="Moultrie, Harry" uniqKey="Moultrie H" first="Harry" last="Moultrie">Harry Moultrie</name><affiliation><nlm:aff id="A5">Wits Reproductive Health and HIV Institute (Harriet Shezi Children’s Clinic, Chris Hani Baragwanath Hospital, Soweto) University of Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Rabie, Helena" sort="Rabie, Helena" uniqKey="Rabie H" first="Helena" last="Rabie">Helena Rabie</name><affiliation><nlm:aff id="A6">Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa</nlm:aff></affiliation></author><author><name sortKey="Technau, Karl" sort="Technau, Karl" uniqKey="Technau K" first="Karl" last="Technau">Karl Technau</name><affiliation><nlm:aff id="A7">Empilweni Services and Research Unit (Rahima Moosa Mother and Child Hospital, Johannesburg) and University of Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ndirangu, James" sort="Ndirangu, James" uniqKey="Ndirangu J" first="James" last="Ndirangu">James Ndirangu</name><affiliation><nlm:aff id="A8">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation></author><author><name sortKey="Garone, Daniela" sort="Garone, Daniela" uniqKey="Garone D" first="Daniela" last="Garone">Daniela Garone</name><affiliation><nlm:aff id="A9">Médecins Sans Frontières (MSF) South Africa, Khayelitsha, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Giddy, Janet" sort="Giddy, Janet" uniqKey="Giddy J" first="Janet" last="Giddy">Janet Giddy</name><affiliation><nlm:aff id="A10">Sinikithemba Clinic, McCord Hospital, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Grimwood, Ashraf" sort="Grimwood, Ashraf" uniqKey="Grimwood A" first="Ashraf" last="Grimwood">Ashraf Grimwood</name><affiliation><nlm:aff id="A11">Kheth’Impilo, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Gsponer, Thomas" sort="Gsponer, Thomas" uniqKey="Gsponer T" first="Thomas" last="Gsponer">Thomas Gsponer</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Egger, Matthias" sort="Egger, Matthias" uniqKey="Egger M" first="Matthias" last="Egger">Matthias Egger</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A2">School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26192393</idno><idno type="pmc">4570854</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570854</idno><idno type="RBID">PMC:4570854</idno><idno type="doi">10.1097/INF.0000000000000801</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">001D22</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References</title><author><name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Blaser, Nello" sort="Blaser, Nello" uniqKey="Blaser N" first="Nello" last="Blaser">Nello Blaser</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Davies, Mary Ann" sort="Davies, Mary Ann" uniqKey="Davies M" first="Mary-Ann" last="Davies">Mary-Ann Davies</name><affiliation><nlm:aff id="A2">School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Wessa, Patrick" sort="Wessa, Patrick" uniqKey="Wessa P" first="Patrick" last="Wessa">Patrick Wessa</name><affiliation><nlm:aff id="A3">Leuven Institute for Research on Information Systems, KU Leuven, Belgium</nlm:aff></affiliation></author><author><name sortKey="Eley, Brian" sort="Eley, Brian" uniqKey="Eley B" first="Brian" last="Eley">Brian Eley</name><affiliation><nlm:aff id="A4">Red Cross War Memorial Children’s Hospital, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Moultrie, Harry" sort="Moultrie, Harry" uniqKey="Moultrie H" first="Harry" last="Moultrie">Harry Moultrie</name><affiliation><nlm:aff id="A5">Wits Reproductive Health and HIV Institute (Harriet Shezi Children’s Clinic, Chris Hani Baragwanath Hospital, Soweto) University of Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Rabie, Helena" sort="Rabie, Helena" uniqKey="Rabie H" first="Helena" last="Rabie">Helena Rabie</name><affiliation><nlm:aff id="A6">Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa</nlm:aff></affiliation></author><author><name sortKey="Technau, Karl" sort="Technau, Karl" uniqKey="Technau K" first="Karl" last="Technau">Karl Technau</name><affiliation><nlm:aff id="A7">Empilweni Services and Research Unit (Rahima Moosa Mother and Child Hospital, Johannesburg) and University of Witwatersrand, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Ndirangu, James" sort="Ndirangu, James" uniqKey="Ndirangu J" first="James" last="Ndirangu">James Ndirangu</name><affiliation><nlm:aff id="A8">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</nlm:aff></affiliation></author><author><name sortKey="Garone, Daniela" sort="Garone, Daniela" uniqKey="Garone D" first="Daniela" last="Garone">Daniela Garone</name><affiliation><nlm:aff id="A9">Médecins Sans Frontières (MSF) South Africa, Khayelitsha, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Giddy, Janet" sort="Giddy, Janet" uniqKey="Giddy J" first="Janet" last="Giddy">Janet Giddy</name><affiliation><nlm:aff id="A10">Sinikithemba Clinic, McCord Hospital, Johannesburg, South Africa</nlm:aff></affiliation></author><author><name sortKey="Grimwood, Ashraf" sort="Grimwood, Ashraf" uniqKey="Grimwood A" first="Ashraf" last="Grimwood">Ashraf Grimwood</name><affiliation><nlm:aff id="A11">Kheth’Impilo, Cape Town, South Africa</nlm:aff></affiliation></author><author><name sortKey="Gsponer, Thomas" sort="Gsponer, Thomas" uniqKey="Gsponer T" first="Thomas" last="Gsponer">Thomas Gsponer</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation></author><author><name sortKey="Egger, Matthias" sort="Egger, Matthias" uniqKey="Egger M" first="Matthias" last="Egger">Matthias Egger</name><affiliation><nlm:aff id="A1">Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</nlm:aff></affiliation><affiliation><nlm:aff id="A2">School of Public Health and Family Medicine, University of Cape Town, South Africa</nlm:aff></affiliation></author></analytic><series><title level="j">The Pediatric infectious disease journal</title><idno type="ISSN">0891-3668</idno><idno type="eISSN">1532-0987</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">Combination antiretroviral therapy (ART) suppresses viral replication in HIV-infected children. The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age z scores (WAZ) and height-for-age z scores (HAZ).</p></sec><sec id="S2"><title>Methods</title><p id="P3">Children aged <11 years at ART initiation with continuously undetectable viral loads (<400 copies/ml) treated at seven South African ART programs with routine viral load monitoring were included. We used multilevel models to define trajectories of WAZ and HAZ up to 3 years and developed a web application to monitor trajectories in individual children.</p></sec><sec id="S3"><title>Results</title><p id="P4">A total of 4,876 children were followed for 7,407 person-years. Analyses were stratified by baseline z-scores and age, which were the most important predictors of growth response. The youngest children showed the most pronounced increase in weight and height initially but catch-up growth stagnated after 1–2 years. Three years after starting ART, WAZ ranged from −2.2 (95% Prediction interval −5.6 to 0.8) in children with baseline age >5 years and z-score <−3 to 0.0 (−2.7 to 2.4) in children with baseline age <2 years and WAZ >−1. For HAZ the corresponding range was −2.3 (−4.9 to 0.3) in children with baseline age>5 years and z-score <−3 to 0.3 (−3.1 to 3.4) in children with baseline age 2–5 years and HAZ >−1.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">We have developed an online tool to calculate reference trajectories in fully suppressed children. The web application could help to define ‘optimal’ growth response and identify children with treatment failure.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8701858</journal-id><journal-id journal-id-type="pubmed-jr-id">6404</journal-id><journal-id journal-id-type="nlm-ta">Pediatr Infect Dis J</journal-id><journal-id journal-id-type="iso-abbrev">Pediatr. Infect. Dis. J.</journal-id><journal-title-group><journal-title>The Pediatric infectious disease journal</journal-title></journal-title-group><issn pub-type="ppub">0891-3668</issn><issn pub-type="epub">1532-0987</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26192393</article-id><article-id pub-id-type="pmc">4570854</article-id><article-id pub-id-type="doi">10.1097/INF.0000000000000801</article-id><article-id pub-id-type="manuscript">NIHMS699813</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Growth in Virologically Suppressed HIV Positive Children on Antiretroviral Therapy: Individual and Population-Level References</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Keiser</surname><given-names>Olivia</given-names></name><degrees>PhD</degrees><xref ref-type="author-notes" rid="FN1">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Blaser</surname><given-names>Nello</given-names></name><degrees>MSc</degrees><xref ref-type="author-notes" rid="FN1">*</xref><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>Mary-Ann</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Wessa</surname><given-names>Patrick</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Eley</surname><given-names>Brian</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Moultrie</surname><given-names>Harry</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Rabie</surname><given-names>Helena</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Technau</surname><given-names>Karl</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Ndirangu</surname><given-names>James</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Garone</surname><given-names>Daniela</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>Giddy</surname><given-names>Janet</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Grimwood</surname><given-names>Ashraf</given-names></name><degrees>MBChBMPH</degrees><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Gsponer</surname><given-names>Thomas</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Egger</surname><given-names>Matthias</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><collab>for IeDEA Southern Africa</collab></contrib></contrib-group><aff id="A1"><label>1</label>Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland</aff><aff id="A2"><label>2</label>School of Public Health and Family Medicine, University of Cape Town, South Africa</aff><aff id="A3"><label>3</label>Leuven Institute for Research on Information Systems, KU Leuven, Belgium</aff><aff id="A4"><label>4</label>Red Cross War Memorial Children’s Hospital, Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa</aff><aff id="A5"><label>5</label>Wits Reproductive Health and HIV Institute (Harriet Shezi Children’s Clinic, Chris Hani Baragwanath Hospital, Soweto) University of Witwatersrand, Johannesburg, South Africa</aff><aff id="A6"><label>6</label>Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa</aff><aff id="A7"><label>7</label>Empilweni Services and Research Unit (Rahima Moosa Mother and Child Hospital, Johannesburg) and University of Witwatersrand, Johannesburg, South Africa</aff><aff id="A8"><label>8</label>Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa</aff><aff id="A9"><label>9</label>Médecins Sans Frontières (MSF) South Africa, Khayelitsha, Cape Town, South Africa</aff><aff id="A10"><label>10</label>Sinikithemba Clinic, McCord Hospital, Johannesburg, South Africa</aff><aff id="A11"><label>11</label>Kheth’Impilo, Cape Town, South Africa</aff><author-notes><corresp id="cor1"><bold>Correspondence to:</bold> Olivia Keiser, PhD, Institute of Social & Preventive Medicine, University of Bern, CH-3012 Bern, Switzerland, Tel. +41 31 631 35 15, <email>okeiser@ispm.unibe.ch</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">equal contribution</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2016</year></pub-date><volume>34</volume><issue>10</issue><fpage>e254</fpage><lpage>e259</lpage><pmc-comment>elocation-id from pubmed: 10.1097/INF.0000000000000801</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P2">Combination antiretroviral therapy (ART) suppresses viral replication in HIV-infected children. The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age z scores (WAZ) and height-for-age z scores (HAZ).</p></sec><sec id="S2"><title>Methods</title><p id="P3">Children aged <11 years at ART initiation with continuously undetectable viral loads (<400 copies/ml) treated at seven South African ART programs with routine viral load monitoring were included. We used multilevel models to define trajectories of WAZ and HAZ up to 3 years and developed a web application to monitor trajectories in individual children.</p></sec><sec id="S3"><title>Results</title><p id="P4">A total of 4,876 children were followed for 7,407 person-years. Analyses were stratified by baseline z-scores and age, which were the most important predictors of growth response. The youngest children showed the most pronounced increase in weight and height initially but catch-up growth stagnated after 1–2 years. Three years after starting ART, WAZ ranged from −2.2 (95% Prediction interval −5.6 to 0.8) in children with baseline age >5 years and z-score <−3 to 0.0 (−2.7 to 2.4) in children with baseline age <2 years and WAZ >−1. For HAZ the corresponding range was −2.3 (−4.9 to 0.3) in children with baseline age>5 years and z-score <−3 to 0.3 (−3.1 to 3.4) in children with baseline age 2–5 years and HAZ >−1.</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">We have developed an online tool to calculate reference trajectories in fully suppressed children. The web application could help to define ‘optimal’ growth response and identify children with treatment failure.</p></sec></abstract><kwd-group><kwd>HIV</kwd><kwd>antiretroviral therapy</kwd><kwd>growth</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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