SidaSubSaharaV1, Pmc, Corpus, bibRecord, 001D17

Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi

Identifieur interne : 001D17 ( Pmc/Corpus ); précédent : 001D16; suivant : 001D18

Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi

Auteurs : Taha E. Taha ; Sufia S. Dadabhai ; M. Hafizur Rahman ; Jin Sun ; Johnstone Kumwenda ; Newton I. Kumwenda

Source :

The Pediatric Infectious Disease Journal [ 0891-3668 ] ; 2012.

RBID : PMC:3329585

Abstract

Background

We analyzed birth outcomes among infants of treatment-naïve, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi.

Methods

Data from six prospective studies at one research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA<37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from earlier studies (1989-94) and later studies (2000-07) are presented separately.

Results

The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% CI) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67 (0.48-0.95)) and PT birth (AOR 0.70 (0.51-0.95)) and later birth year was associated with lower odds of PT birth (AOR 0.35 (0.19-0.70)).

Conclusions

BW and GA remained stable within each time period. This analysis provides important baseline information for monitoring HIV treatment effects on birth outcomes. Modifiable factors affecting BW and GA should continue to be explored.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329585

DOI: 10.1097/INF.0b013e31824d9bd9
PubMed: 22327871
PubMed Central: 3329585

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PMC:3329585

Le document en format XML

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<author><name sortKey="Taha, Taha E" sort="Taha, Taha E" uniqKey="Taha T" first="Taha E." last="Taha">Taha E. Taha</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dadabhai, Sufia S" sort="Dadabhai, Sufia S" uniqKey="Dadabhai S" first="Sufia S." last="Dadabhai">Sufia S. Dadabhai</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Rahman, M Hafizur" sort="Rahman, M Hafizur" uniqKey="Rahman M" first="M. Hafizur" last="Rahman">M. Hafizur Rahman</name>
<affiliation><nlm:aff id="A2">Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
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<author><name sortKey="Sun, Jin" sort="Sun, Jin" uniqKey="Sun J" first="Jin" last="Sun">Jin Sun</name>
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<author><name sortKey="Kumwenda, Johnstone" sort="Kumwenda, Johnstone" uniqKey="Kumwenda J" first="Johnstone" last="Kumwenda">Johnstone Kumwenda</name>
<affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
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<author><name sortKey="Kumwenda, Newton I" sort="Kumwenda, Newton I" uniqKey="Kumwenda N" first="Newton I." last="Kumwenda">Newton I. Kumwenda</name>
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<author><name sortKey="Taha, Taha E" sort="Taha, Taha E" uniqKey="Taha T" first="Taha E." last="Taha">Taha E. Taha</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
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<author><name sortKey="Dadabhai, Sufia S" sort="Dadabhai, Sufia S" uniqKey="Dadabhai S" first="Sufia S." last="Dadabhai">Sufia S. Dadabhai</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rahman, M Hafizur" sort="Rahman, M Hafizur" uniqKey="Rahman M" first="M. Hafizur" last="Rahman">M. Hafizur Rahman</name>
<affiliation><nlm:aff id="A2">Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sun, Jin" sort="Sun, Jin" uniqKey="Sun J" first="Jin" last="Sun">Jin Sun</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumwenda, Johnstone" sort="Kumwenda, Johnstone" uniqKey="Kumwenda J" first="Johnstone" last="Kumwenda">Johnstone Kumwenda</name>
<affiliation><nlm:aff id="A3">Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kumwenda, Newton I" sort="Kumwenda, Newton I" uniqKey="Kumwenda N" first="Newton I." last="Kumwenda">Newton I. Kumwenda</name>
<affiliation><nlm:aff id="A1">Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</nlm:aff>
</affiliation>
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<series><title level="j">The Pediatric Infectious Disease Journal</title>
<idno type="ISSN">0891-3668</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">We analyzed birth outcomes among infants of treatment-naïve, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data from six prospective studies at one research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA<37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from earlier studies (1989-94) and later studies (2000-07) are presented separately.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% CI) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67 (0.48-0.95)) and PT birth (AOR 0.70 (0.51-0.95)) and later birth year was associated with lower odds of PT birth (AOR 0.35 (0.19-0.70)).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">BW and GA remained stable within each time period. This analysis provides important baseline information for monitoring HIV treatment effects on birth outcomes. Modifiable factors affecting BW and GA should continue to be explored.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">8701858</journal-id>
<journal-id journal-id-type="pubmed-jr-id">6404</journal-id>
<journal-id journal-id-type="nlm-ta">Pediatr Infect Dis J</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr. Infect. Dis. J.</journal-id>
<journal-title-group><journal-title>The Pediatric Infectious Disease Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">0891-3668</issn>
<issn pub-type="epub">1532-0987</issn>
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<article-meta><article-id pub-id-type="pmid">22327871</article-id>
<article-id pub-id-type="pmc">3329585</article-id>
<article-id pub-id-type="doi">10.1097/INF.0b013e31824d9bd9</article-id>
<article-id pub-id-type="manuscript">NIHMS361114</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Taha</surname>
<given-names>Taha E.</given-names>
</name>
<degrees>MBBS, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dadabhai</surname>
<given-names>Sufia S.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rahman</surname>
<given-names>M. Hafizur</given-names>
</name>
<degrees>DrPH</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sun</surname>
<given-names>Jin</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumwenda</surname>
<given-names>Johnstone</given-names>
</name>
<degrees>FRCP</degrees>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kumwenda</surname>
<given-names>Newton I.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</aff>
<aff id="A2"><label>2</label>
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA</aff>
<aff id="A3"><label>3</label>
Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi</aff>
<author-notes><corresp id="FN1">Corresponding author: Dr. Taha E. Taha, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Room E7138, Baltimore, MD 21205, USA, Ph 410 614 5255, Fax 443 287 5188, <email>ttaha@jhsph.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>20</day>
<month>3</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>31</volume>
<issue>5</issue>
<fpage>481</fpage>
<lpage>486</lpage>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">We analyzed birth outcomes among infants of treatment-naïve, HIV-infected women from a series of mother-to-child transmission of HIV studies in Blantyre, Malawi.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Data from six prospective studies at one research site were analyzed. Mean birth weight (BW) and gestational age (GA), and frequency of low birth weight (LBW; <2500 g) and preterm (PT) birth (GA<37 weeks) were estimated. We assessed risk factors for LBW and PT birth using mixed-effects logistic regression. Adjusted odds ratios (AOR) and 95% confidence intervals (CI) from earlier studies (1989-94) and later studies (2000-07) are presented separately.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The analysis included 8874 HIV-exposed infants. Mean BW and GA ranged from 2793 to 3079 g, and 37.8 to 39.0 weeks. Greater maternal age was consistently (during both the early and late periods) associated with lower odds of LBW and PT birth; AOR (95% CI) for both outcomes in the early and late periods, respectively, were 0.98 (0.96-1.00) and 0.97 (0.95-0.99). Female infant gender was consistently associated with higher odds of PT birth during both periods and with higher odds of LBW during the later period. During the early period, higher maternal education was associated with lower odds of LBW (AOR 0.67 (0.48-0.95)) and PT birth (AOR 0.70 (0.51-0.95)) and later birth year was associated with lower odds of PT birth (AOR 0.35 (0.19-0.70)).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">BW and GA remained stable within each time period. This analysis provides important baseline information for monitoring HIV treatment effects on birth outcomes. Modifiable factors affecting BW and GA should continue to be explored.</p>
</sec>
</abstract>
<kwd-group><kwd>antiretroviral therapy</kwd>
<kwd>pregnancy outcomes</kwd>
<kwd>HIV</kwd>
<kwd>Malawi</kwd>
<kwd>trends</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>U01 AI048005-05 || AI</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>U01 AI048005-01 || AI</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
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Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi

Trends in Birth Weight and Gestational Age for Infants Born to HIV-infected, Antiretroviral Treatment-Naïve Women in Malawi

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