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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Global Burden of Liver Disease: The Major Impact of China</title><author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><affiliation><nlm:aff id="A1">Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), School of Medicine, Zhejiang University, Hangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Fan, Jian Gao" sort="Fan, Jian Gao" uniqKey="Fan J" first="Jian-Gao" last="Fan">Jian-Gao Fan</name><affiliation><nlm:aff id="A3">Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation><nlm:aff id="A1">Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Bin" sort="Gao, Bin" uniqKey="Gao B" first="Bin" last="Gao">Bin Gao</name><affiliation><nlm:aff id="A4">Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Hong Yang" sort="Wang, Hong Yang" uniqKey="Wang H" first="Hong-Yang" last="Wang">Hong-Yang Wang</name><affiliation><nlm:aff id="A5">National Centre of Liver Cancer; Eastern Hepatobiliary Surgery Hospital, Shanghai, China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25164003</idno><idno type="pmc">4867229</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867229</idno><idno type="RBID">PMC:4867229</idno><idno type="doi">10.1002/hep.27406</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001C44</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Global Burden of Liver Disease: The Major Impact of China</title><author><name sortKey="Wang, Fu Sheng" sort="Wang, Fu Sheng" uniqKey="Wang F" first="Fu-Sheng" last="Wang">Fu-Sheng Wang</name><affiliation><nlm:aff id="A1">Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), School of Medicine, Zhejiang University, Hangzhou, China</nlm:aff></affiliation></author><author><name sortKey="Fan, Jian Gao" sort="Fan, Jian Gao" uniqKey="Fan J" first="Jian-Gao" last="Fan">Jian-Gao Fan</name><affiliation><nlm:aff id="A3">Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation><nlm:aff id="A1">Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China</nlm:aff></affiliation></author><author><name sortKey="Gao, Bin" sort="Gao, Bin" uniqKey="Gao B" first="Bin" last="Gao">Bin Gao</name><affiliation><nlm:aff id="A4">Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff></affiliation></author><author><name sortKey="Wang, Hong Yang" sort="Wang, Hong Yang" uniqKey="Wang H" first="Hong-Yang" last="Wang">Hong-Yang Wang</name><affiliation><nlm:aff id="A5">National Centre of Liver Cancer; Eastern Hepatobiliary Surgery Hospital, Shanghai, China</nlm:aff></affiliation></author></analytic><series><title level="j">Hepatology (Baltimore, Md.)</title><idno type="ISSN">0270-9139</idno><idno type="eISSN">1527-3350</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Liver disease is a major cause of illness and death worldwide. In China alone, liver diseases, primarily viral hepatitis (predominantly hepatitis B virus, HBV), nonalcoholic fatty liver disease and alcoholic liver disease affect approximately 300 million people. The establishment of the Expanded Program on Immunization in 1992 has resulted in a substantial decline in the number of newly HBV-infected patients; however, the number of patients with alcoholic and nonalcoholic fatty liver diseases is rising at an alarming rate. Liver cancer, one of the most deadly cancers, is the second most common cancer in China. Approximately 383,000 people die from liver cancer every year in China, which accounts for 51% of the deaths from liver cancer worldwide. Over the past 10 years, China has made some significant efforts to shed its “leader in liver diseases” title by investing large amounts of money in funding research, vaccines and drug development for liver diseases, and by recruiting many Western-trained hepatologists and scientists. Over the last two decades, hepatologists and scientists in China have made significant improvements in liver disease prevention, diagnosis, management and therapy. They have been very active in liver disease research, as shown by the dramatic increase in the number of publications in <italic>Hepatology</italic>. Nevertheless, many challenges remain that must be tackled collaboratively. In this review, we discuss the epidemiology and characteristics of liver diseases and liver-related research in China.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8302946</journal-id><journal-id journal-id-type="pubmed-jr-id">4093</journal-id><journal-id journal-id-type="nlm-ta">Hepatology</journal-id><journal-id journal-id-type="iso-abbrev">Hepatology</journal-id><journal-title-group><journal-title>Hepatology (Baltimore, Md.)</journal-title></journal-title-group><issn pub-type="ppub">0270-9139</issn><issn pub-type="epub">1527-3350</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25164003</article-id><article-id pub-id-type="pmc">4867229</article-id><article-id pub-id-type="doi">10.1002/hep.27406</article-id><article-id pub-id-type="manuscript">NIHMS625784</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Global Burden of Liver Disease: The Major Impact of China</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Fu-Sheng</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Fan</surname><given-names>Jian-Gao</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Zheng</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Bin</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Hong-Yang</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib></contrib-group><aff id="A1"><label>1</label>Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China</aff><aff id="A2"><label>2</label>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases (CCID), School of Medicine, Zhejiang University, Hangzhou, China</aff><aff id="A3"><label>3</label>Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China</aff><aff id="A4"><label>4</label>Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA</aff><aff id="A5"><label>5</label>National Centre of Liver Cancer; Eastern Hepatobiliary Surgery Hospital, Shanghai, China</aff><author-notes><corresp id="cor1">Corresponding authors: Fu-Sheng Wang, M.D., Ph.D., Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China (<email>fswang302@163.com</email>); Hong-Yang Wang, MD., National Centre of Liver Cancer; Eastern Hepatobiliary Surgery Hospital, Shanghai, China (<email>hywangk@vip.sina.com</email>)</corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">Dr. Fu-Sheng Wang and Dr. Jian-Gao Fan contributed equally to this work and share the co-first authorship.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>5</month><year>2016</year></pub-date><volume>60</volume><issue>6</issue><fpage>2099</fpage><lpage>2108</lpage><pmc-comment>elocation-id from pubmed: 10.1002/hep.27406</pmc-comment>
<abstract><p id="P2">Liver disease is a major cause of illness and death worldwide. In China alone, liver diseases, primarily viral hepatitis (predominantly hepatitis B virus, HBV), nonalcoholic fatty liver disease and alcoholic liver disease affect approximately 300 million people. The establishment of the Expanded Program on Immunization in 1992 has resulted in a substantial decline in the number of newly HBV-infected patients; however, the number of patients with alcoholic and nonalcoholic fatty liver diseases is rising at an alarming rate. Liver cancer, one of the most deadly cancers, is the second most common cancer in China. Approximately 383,000 people die from liver cancer every year in China, which accounts for 51% of the deaths from liver cancer worldwide. Over the past 10 years, China has made some significant efforts to shed its “leader in liver diseases” title by investing large amounts of money in funding research, vaccines and drug development for liver diseases, and by recruiting many Western-trained hepatologists and scientists. Over the last two decades, hepatologists and scientists in China have made significant improvements in liver disease prevention, diagnosis, management and therapy. They have been very active in liver disease research, as shown by the dramatic increase in the number of publications in <italic>Hepatology</italic>. Nevertheless, many challenges remain that must be tackled collaboratively. In this review, we discuss the epidemiology and characteristics of liver diseases and liver-related research in China.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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