Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women
Identifieur interne : 001B91 ( Pmc/Corpus ); précédent : 001B90; suivant : 001B92Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women
Auteurs : Frank Tanser ; Kyle G. Jones ; Johannes Viljoen ; Fc Path Sa Viro ; John Imrie ; Erofili Grapsa ; Marie-Louise NewellSource :
- Sexually transmitted diseases [ 0148-5717 ] ; 2013.
Abstract
This study aimed to provide a population-based estimate of human papillomavirus (HPV) seropositivity for women in a rural African context and to evaluate the impact of HPV serostatus on subsequent acquisition of HIVoutside a clinical setting.
A random sample of women participating in a longitudinal, population-based HIV survey combined with a case-control study.
Blood samples of women participating in a single round of population-based HIV surveillance (N = 1049) in a rural South African population were used to measure vaccine-preventable HPV seropositivity (types 6, 11, 16, and 18) in the general population in 2010. Using results from the repeat HIV surveys, a case-control analysis was then performed comparing HPV sero-status in samples taken from HIV sero-converting women (prior to infection with HIV) against samples from HIV-uninfected, sexually-active controls matched 1:1 according to 5-year age band (377:377). Unconditional multivariable logistic regression with multiple imputations was used to control for sociodemographic and behavioral variables associated with HIV acquisition.
Human papillomavirus seropositivity in the population-based sample of women was 20.8% (95% confidence interval [CI], 18.3–23.4), and HIV prevalence was 27.6% (95% CI, 24.9–30.4). In the case-control analysis, allowing for variables known to be associated with HIV incidence, HPV seropositivity was associated with nearly 2.5 times the odds of subsequent acquisition of HIV (adjusted odds ratio, 2.33 [95% CI, 1.61–3.39];
These results suggest that HPV vaccination before or soon after sexual debut could lower HIV infection risk. Randomized trials that quantify the impact of HPV vaccination in girls on the risk of acquiring HIV are urgently required.
Url:
DOI: 10.1097/OLQ.0b013e3182918578
PubMed: 23965780
PubMed Central: 4239474
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PMC:4239474Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women</title><author><name sortKey="Tanser, Frank" sort="Tanser, Frank" uniqKey="Tanser F" first="Frank" last="Tanser">Frank Tanser</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Jones, Kyle G" sort="Jones, Kyle G" uniqKey="Jones K" first="Kyle G." last="Jones">Kyle G. Jones</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Viljoen, Johannes" sort="Viljoen, Johannes" uniqKey="Viljoen J" first="Johannes" last="Viljoen">Johannes Viljoen</name></author><author><name sortKey="Path Sa Viro, Fc" sort="Path Sa Viro, Fc" uniqKey="Path Sa Viro F" first="Fc" last="Path Sa Viro">Fc Path Sa Viro</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Imrie, John" sort="Imrie, John" uniqKey="Imrie J" first="John" last="Imrie">John Imrie</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Sexual Health and HIV Research, Faculty of Population Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Grapsa, Erofili" sort="Grapsa, Erofili" uniqKey="Grapsa E" first="Erofili" last="Grapsa">Erofili Grapsa</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Sexual Health and HIV Research, Faculty of Population Health Sciences, University College London, London, UK</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23965780</idno><idno type="pmc">4239474</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239474</idno><idno type="RBID">PMC:4239474</idno><idno type="doi">10.1097/OLQ.0b013e3182918578</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001B91</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001B91</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women</title><author><name sortKey="Tanser, Frank" sort="Tanser, Frank" uniqKey="Tanser F" first="Frank" last="Tanser">Frank Tanser</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Jones, Kyle G" sort="Jones, Kyle G" uniqKey="Jones K" first="Kyle G." last="Jones">Kyle G. Jones</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Viljoen, Johannes" sort="Viljoen, Johannes" uniqKey="Viljoen J" first="Johannes" last="Viljoen">Johannes Viljoen</name></author><author><name sortKey="Path Sa Viro, Fc" sort="Path Sa Viro, Fc" uniqKey="Path Sa Viro F" first="Fc" last="Path Sa Viro">Fc Path Sa Viro</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Imrie, John" sort="Imrie, John" uniqKey="Imrie J" first="John" last="Imrie">John Imrie</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Sexual Health and HIV Research, Faculty of Population Health Sciences, University College London, London, UK</nlm:aff></affiliation></author><author><name sortKey="Grapsa, Erofili" sort="Grapsa, Erofili" uniqKey="Grapsa E" first="Erofili" last="Grapsa">Erofili Grapsa</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation></author><author><name sortKey="Newell, Marie Louise" sort="Newell, Marie Louise" uniqKey="Newell M" first="Marie-Louise" last="Newell">Marie-Louise Newell</name><affiliation><nlm:aff id="A1">Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Centre for Sexual Health and HIV Research, Faculty of Population Health Sciences, University College London, London, UK</nlm:aff></affiliation></author></analytic><series><title level="j">Sexually transmitted diseases</title><idno type="ISSN">0148-5717</idno><idno type="eISSN">1537-4521</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">This study aimed to provide a population-based estimate of human papillomavirus (HPV) seropositivity for women in a rural African context and to evaluate the impact of HPV serostatus on subsequent acquisition of HIVoutside a clinical setting.</p></sec><sec id="S2"><title>Design</title><p id="P2">A random sample of women participating in a longitudinal, population-based HIV survey combined with a case-control study.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Blood samples of women participating in a single round of population-based HIV surveillance (N = 1049) in a rural South African population were used to measure vaccine-preventable HPV seropositivity (types 6, 11, 16, and 18) in the general population in 2010. Using results from the repeat HIV surveys, a case-control analysis was then performed comparing HPV sero-status in samples taken from HIV sero-converting women (prior to infection with HIV) against samples from HIV-uninfected, sexually-active controls matched 1:1 according to 5-year age band (377:377). Unconditional multivariable logistic regression with multiple imputations was used to control for sociodemographic and behavioral variables associated with HIV acquisition.</p></sec><sec id="S4"><title>Results</title><p id="P4">Human papillomavirus seropositivity in the population-based sample of women was 20.8% (95% confidence interval [CI], 18.3–23.4), and HIV prevalence was 27.6% (95% CI, 24.9–30.4). In the case-control analysis, allowing for variables known to be associated with HIV incidence, HPV seropositivity was associated with nearly 2.5 times the odds of subsequent acquisition of HIV (adjusted odds ratio, 2.33 [95% CI, 1.61–3.39]; <italic>P</italic> < 0.001).</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">These results suggest that HPV vaccination before or soon after sexual debut could lower HIV infection risk. Randomized trials that quantify the impact of HPV vaccination in girls on the risk of acquiring HIV are urgently required.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7705941</journal-id><journal-id journal-id-type="pubmed-jr-id">7382</journal-id><journal-id journal-id-type="nlm-ta">Sex Transm Dis</journal-id><journal-id journal-id-type="iso-abbrev">Sex Transm Dis</journal-id><journal-title-group><journal-title>Sexually transmitted diseases</journal-title></journal-title-group><issn pub-type="ppub">0148-5717</issn><issn pub-type="epub">1537-4521</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23965780</article-id><article-id pub-id-type="pmc">4239474</article-id><article-id pub-id-type="doi">10.1097/OLQ.0b013e3182918578</article-id><article-id pub-id-type="manuscript">NIHMS642393</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Human Papillomavirus Seropositivity and Subsequent Risk of HIV Acquisition in Rural South African Women</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tanser</surname><given-names>Frank</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>Kyle G.</given-names></name><degrees>MSc</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Viljoen</surname><given-names>Johannes</given-names></name></contrib><contrib contrib-type="author"><name><surname>Path(SA)Viro</surname><given-names>FC</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Imrie</surname><given-names>John</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Grapsa</surname><given-names>Erofili</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Newell</surname><given-names>Marie-Louise</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">*</xref><xref ref-type="aff" rid="A2">†</xref></contrib></contrib-group><aff id="A1"><label>*</label>Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa</aff><aff id="A2"><label>†</label>Centre for Sexual Health and HIV Research, Faculty of Population Health Sciences, University College London, London, UK</aff><aff id="A3"><label>‡</label>MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK</aff><author-notes><corresp id="FN1">Correspondence: Frank Tanser, PhD, Africa Centre for Health and Population Studies, University of KwaZulu-Natal, PO Box 198, Mtubatuba, 3935, South Africa. <email>tanserf@africacentre.ac.za</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>14</day><month>11</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>11</month><year>2014</year></pub-date><volume>40</volume><issue>7</issue><fpage>601</fpage><lpage>606</lpage><pmc-comment>elocation-id from pubmed: 10.1097/OLQ.0b013e3182918578</pmc-comment>
<permissions><copyright-statement>Copyright © 2013 American Sexually Transmitted Diseases Association All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><sec id="S1"><title>Objective</title><p id="P1">This study aimed to provide a population-based estimate of human papillomavirus (HPV) seropositivity for women in a rural African context and to evaluate the impact of HPV serostatus on subsequent acquisition of HIVoutside a clinical setting.</p></sec><sec id="S2"><title>Design</title><p id="P2">A random sample of women participating in a longitudinal, population-based HIV survey combined with a case-control study.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Blood samples of women participating in a single round of population-based HIV surveillance (N = 1049) in a rural South African population were used to measure vaccine-preventable HPV seropositivity (types 6, 11, 16, and 18) in the general population in 2010. Using results from the repeat HIV surveys, a case-control analysis was then performed comparing HPV sero-status in samples taken from HIV sero-converting women (prior to infection with HIV) against samples from HIV-uninfected, sexually-active controls matched 1:1 according to 5-year age band (377:377). Unconditional multivariable logistic regression with multiple imputations was used to control for sociodemographic and behavioral variables associated with HIV acquisition.</p></sec><sec id="S4"><title>Results</title><p id="P4">Human papillomavirus seropositivity in the population-based sample of women was 20.8% (95% confidence interval [CI], 18.3–23.4), and HIV prevalence was 27.6% (95% CI, 24.9–30.4). In the case-control analysis, allowing for variables known to be associated with HIV incidence, HPV seropositivity was associated with nearly 2.5 times the odds of subsequent acquisition of HIV (adjusted odds ratio, 2.33 [95% CI, 1.61–3.39]; <italic>P</italic> < 0.001).</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">These results suggest that HPV vaccination before or soon after sexual debut could lower HIV infection risk. Randomized trials that quantify the impact of HPV vaccination in girls on the risk of acquiring HIV are urgently required.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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