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Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?

Identifieur interne : 001B08 ( Pmc/Corpus ); précédent : 001B07; suivant : 001B09

Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?

Auteurs : Deborah Jones ; Ryan Cook ; Andrew Spence ; Stephen M. Weiss ; Ndashi Chitalu

Source :

Journal of the International Association of Providers of AIDS Care [ 2325-9574 ] ; 2014.

RBID : PMC:4721649

Abstract

Background

Adherence to antiretroviral therapy (ART) is essential to optimize HIV treatment outcomes. Among individuals on ART, targeted peer support has been found to support adherence. This study of Zambian heterosexual couples living with HIV examined whether partners would exert a positive influence on each other's adherence, and compared adherence between couples in which either one or both members were on ART.

Methods

Couples (n = 446 participants), in which either or both member were on ART were assessed at baseline, 6 and 12 months.

Results

Most participants (64%, n = 263) were on ART; overall, uptake of ART increased to 74% at 12 months. At baseline, 76% reported near perfect adherence; at 6 and 12 months, 66% and 70% were adherent, respectively. A regression analysis indicated that the decline in adherence did not differ between those couples in which one or both partners were on ART [F (2, 624) = 0.37, p = .692]. Pairwise comparison indicated that adherence primarily decreased between baseline and 6 months (t = 2.72, p = .007), and was stable 6 to 12 months.

Conclusions

This study of couples in Zambia found adherence was not enhanced by having a partner on ART, and that adherence declined over time. Partners on ART may not necessarily provide support for adherence to each other. Partners may represent an untapped resource for optimizing adherence; results highlight the need for provider guidance and structured adherence interventions targeting partner adherence support.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721649

DOI: 10.1177/2325957414553843
PubMed: 25294856
PubMed Central: 4721649

Links to Exploration step

PMC:4721649

Le document en format XML

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<author><name sortKey="Jones, Deborah" sort="Jones, Deborah" uniqKey="Jones D" first="Deborah" last="Jones">Deborah Jones</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Ryan" sort="Cook, Ryan" uniqKey="Cook R" first="Ryan" last="Cook">Ryan Cook</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Spence, Andrew" sort="Spence, Andrew" uniqKey="Spence A" first="Andrew" last="Spence">Andrew Spence</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiss, Stephen M" sort="Weiss, Stephen M" uniqKey="Weiss S" first="Stephen M." last="Weiss">Stephen M. Weiss</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chitalu, Ndashi" sort="Chitalu, Ndashi" uniqKey="Chitalu N" first="Ndashi" last="Chitalu">Ndashi Chitalu</name>
<affiliation><nlm:aff id="A2">University of Zambia School of Medicine, Department of Paediatrics, Lusaka, Zambia</nlm:aff>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?</title>
<author><name sortKey="Jones, Deborah" sort="Jones, Deborah" uniqKey="Jones D" first="Deborah" last="Jones">Deborah Jones</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cook, Ryan" sort="Cook, Ryan" uniqKey="Cook R" first="Ryan" last="Cook">Ryan Cook</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
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</author>
<author><name sortKey="Spence, Andrew" sort="Spence, Andrew" uniqKey="Spence A" first="Andrew" last="Spence">Andrew Spence</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weiss, Stephen M" sort="Weiss, Stephen M" uniqKey="Weiss S" first="Stephen M." last="Weiss">Stephen M. Weiss</name>
<affiliation><nlm:aff id="A1">University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chitalu, Ndashi" sort="Chitalu, Ndashi" uniqKey="Chitalu N" first="Ndashi" last="Chitalu">Ndashi Chitalu</name>
<affiliation><nlm:aff id="A2">University of Zambia School of Medicine, Department of Paediatrics, Lusaka, Zambia</nlm:aff>
</affiliation>
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</analytic>
<series><title level="j">Journal of the International Association of Providers of AIDS Care</title>
<idno type="ISSN">2325-9574</idno>
<idno type="eISSN">2325-9582</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Adherence to antiretroviral therapy (ART) is essential to optimize HIV treatment outcomes. Among individuals on ART, targeted peer support has been found to support adherence. This study of Zambian heterosexual couples living with HIV examined whether partners would exert a positive influence on each other's adherence, and compared adherence between couples in which either one or both members were on ART.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Couples (n = 446 participants), in which either or both member were on ART were assessed at baseline, 6 and 12 months.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Most participants (64%, n = 263) were on ART; overall, uptake of ART increased to 74% at 12 months. At baseline, 76% reported near perfect adherence; at 6 and 12 months, 66% and 70% were adherent, respectively. A regression analysis indicated that the decline in adherence did not differ between those couples in which one or both partners were on ART [F (2, 624) = 0.37, <italic>p</italic>
 = .692]. Pairwise comparison indicated that adherence primarily decreased between baseline and 6 months (t = 2.72, <italic>p</italic>
 = .007), and was stable 6 to 12 months.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">This study of couples in Zambia found adherence was not enhanced by having a partner on ART, and that adherence declined over time. Partners on ART may not necessarily provide support for adherence to each other. Partners may represent an untapped resource for optimizing adherence; results highlight the need for provider guidance and structured adherence interventions targeting partner adherence support.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">101603896</journal-id>
<journal-id journal-id-type="pubmed-jr-id">41074</journal-id>
<journal-id journal-id-type="nlm-ta">J Int Assoc Provid AIDS Care</journal-id>
<journal-id journal-id-type="iso-abbrev">J Int Assoc Provid AIDS Care</journal-id>
<journal-title-group><journal-title>Journal of the International Association of Providers of AIDS Care</journal-title>
</journal-title-group>
<issn pub-type="ppub">2325-9574</issn>
<issn pub-type="epub">2325-9582</issn>
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<article-meta><article-id pub-id-type="pmid">25294856</article-id>
<article-id pub-id-type="pmc">4721649</article-id>
<article-id pub-id-type="doi">10.1177/2325957414553843</article-id>
<article-id pub-id-type="manuscript">NIHMS752075</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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</article-categories>
<title-group><article-title>Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Deborah</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cook</surname>
<given-names>Ryan</given-names>
</name>
<degrees>BA</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spence</surname>
<given-names>Andrew</given-names>
</name>
<degrees>BS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiss</surname>
<given-names>Stephen M.</given-names>
</name>
<degrees>PhD, MPH</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chitalu</surname>
<given-names>Ndashi</given-names>
</name>
<degrees>MD, MPH</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral, Miami, FL, USA</aff>
<aff id="A2"><label>2</label>
University of Zambia School of Medicine, Department of Paediatrics, Lusaka, Zambia</aff>
<author-notes><corresp id="FN1">Corresponding Author: Deborah Jones, Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 1400 NW 10th Ave, Miami, FL 33141, USA. <email>djones@med.miami.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>18</day>
<month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><season>Nov-Dec</season>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>21</day>
<month>1</month>
<year>2016</year>
</pub-date>
<volume>13</volume>
<issue>6</issue>
<fpage>497</fpage>
<lpage>500</lpage>
<pmc-comment>elocation-id from pubmed: 10.1177/2325957414553843</pmc-comment>
      <permissions><license license-type="permissions-link"><license-p>Reprints and permission: <ext-link ext-link-type="uri" xlink:href="http://sagepub.com/journalsPermissions.nav">sagepub.com/journalsPermissions.nav</ext-link>
</license-p>
</license>
</permissions>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Adherence to antiretroviral therapy (ART) is essential to optimize HIV treatment outcomes. Among individuals on ART, targeted peer support has been found to support adherence. This study of Zambian heterosexual couples living with HIV examined whether partners would exert a positive influence on each other's adherence, and compared adherence between couples in which either one or both members were on ART.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Couples (n = 446 participants), in which either or both member were on ART were assessed at baseline, 6 and 12 months.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Most participants (64%, n = 263) were on ART; overall, uptake of ART increased to 74% at 12 months. At baseline, 76% reported near perfect adherence; at 6 and 12 months, 66% and 70% were adherent, respectively. A regression analysis indicated that the decline in adherence did not differ between those couples in which one or both partners were on ART [F (2, 624) = 0.37, <italic>p</italic>
 = .692]. Pairwise comparison indicated that adherence primarily decreased between baseline and 6 months (t = 2.72, <italic>p</italic>
 = .007), and was stable 6 to 12 months.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">This study of couples in Zambia found adherence was not enhanced by having a partner on ART, and that adherence declined over time. Partners on ART may not necessarily provide support for adherence to each other. Partners may represent an untapped resource for optimizing adherence; results highlight the need for provider guidance and structured adherence interventions targeting partner adherence support.</p>
</sec>
</abstract>
<kwd-group><kwd>HIV</kwd>
<kwd>Zambia</kwd>
<kwd>adherence</kwd>
<kwd>ART</kwd>
<kwd>couples</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?

Antiretroviral Therapy in Zambia: Do Partners on ART Enhance Adherence?

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki