Le SIDA en Afrique subsaharienne (serveur d'exploration)

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HIV-1 Prevention for HIV-1 Serodiscordant Couples

Identifieur interne : 001A13 ( Pmc/Corpus ); précédent : 001A12; suivant : 001A14

HIV-1 Prevention for HIV-1 Serodiscordant Couples

Auteurs : Kathryn Curran ; Jared M. Baeten ; Thomas J. Coates ; Ann Kurth ; Nelly R. Mugo ; Connie Celum

Source :

RBID : PMC:3570050

Abstract

A substantial proportion of HIV-1-infected individuals in sub-Saharan Africa are in stable relationships with HIV-1-uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother to child transmission for HIV-1- infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.


Url:
DOI: 10.1007/s11904-012-0114-z
PubMed: 22415473
PubMed Central: 3570050

Links to Exploration step

PMC:3570050

Le document en format XML

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<p id="P1">A substantial proportion of HIV-1-infected individuals in sub-Saharan Africa are in stable relationships with HIV-1-uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother to child transmission for HIV-1- infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.</p>
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<journal-id journal-id-type="nlm-ta">Curr HIV/AIDS Rep</journal-id>
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<journal-title>Current HIV/AIDS reports</journal-title>
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<surname>Curran</surname>
<given-names>Kathryn</given-names>
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<degrees>MHS</degrees>
<aff id="A1">Department of Epidemiology, University of Washington, Seattle USA International Clinical Research Center, Department of Global Health University of Washington, Box 359927 325 Ninth Avenue; Seattle, WA 98104 T: 206-520-3811; F: 206-520-3831
<email>kgcurran@uw.edu</email>
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<name>
<surname>Baeten</surname>
<given-names>Jared M.</given-names>
</name>
<degrees>MD PhD</degrees>
<aff id="A2">Departments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, USA International Clinical Research Center, Department of Global Health University of Washington, Box 359927 325 Ninth Avenue; Seattle, WA 98104 T: 206-520-3808; F: 206-520-3831
<email>jbaeten@uw.edu</email>
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<name>
<surname>Coates</surname>
<given-names>Thomas J.</given-names>
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<degrees>PhD</degrees>
<aff id="A3">Division of Infectious Diseases and Program in Global Health, David Geffen School of Medicine, University of California, Los Angeles, USA 9911 West Pico Blvd., Suite 955; Los Angeles, CA 90035-2703 T: 310-557-3044; F: 310-557-3679
<email>tcoates@mednet.ucla.edu</email>
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<name>
<surname>Kurth</surname>
<given-names>Ann</given-names>
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<degrees>CNM PhD</degrees>
<aff id="A4">New York University College of Nursing, New York, USA 1006 726 Broadway; New York, NY 10003 T: 212-998-5316; F: 212-995-3143
<email>akurth@nyu.edu</email>
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<surname>Mugo</surname>
<given-names>Nelly R.</given-names>
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<degrees>MBChB MMed MPH</degrees>
<aff id="A5">Department of Obstetrics and Gynecology, Kenyatta National Hospital/University of Nairobi, Nairobi, Kenya University of Nairobi Institute of Tropical and Infectious Diseases (UNITID) Kenyatta National Hospital, Ngong Rd, P.O. Box 19865-00202, Nairobi, Kenya T: 254-20-27376
<email>rwamba@csrtkenya.org</email>
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<name>
<surname>Celum</surname>
<given-names>Connie</given-names>
</name>
<degrees>MD MPH</degrees>
<aff id="A6">Departments of Global Health, Medicine, and Epidemiology, University of Washington, Seattle, USA International Clinical Research Center, Department of Global Health University of Washington, Box 359927 325 Ninth Avenue; Seattle, WA 98104 T: 206 520-382; F: 206-520-3831
<email>ccelum@uw.edu</email>
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<month>2</month>
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<month>6</month>
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<pub-date pub-type="pmc-release">
<day>01</day>
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<volume>9</volume>
<issue>2</issue>
<fpage>160</fpage>
<lpage>170</lpage>
<abstract>
<p id="P1">A substantial proportion of HIV-1-infected individuals in sub-Saharan Africa are in stable relationships with HIV-1-uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother to child transmission for HIV-1- infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.</p>
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<funding-source country="United States">National Institute of Nursing Research : NINR</funding-source>
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<funding-source country="United States">National Institute of Mental Health : NIMH</funding-source>
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