Future of Phylogeny in HIV Prevention
Identifieur interne : 001917 ( Pmc/Corpus ); précédent : 001916; suivant : 001918Future of Phylogeny in HIV Prevention
Auteurs : Bluma G. Brenner ; Mark A. WainbergSource :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2013.
Abstract
The success of the HPTN 052 trial has led to revisions in HIV-1 treatment guidelines. Antiretroviral therapy (ART) may reduce the risk of HIV-1 transmissions at the population-level. The design of successful Treatment as Prevention interventions will be predicated on a comprehensive understanding of the spatial, temporal, and biological dynamics of heterosexual (HET), men having sex with men (MSM), and intravenous drug user (IDU) epidemics. Viral phylogenetics can capture the underlying structure of transmission networks based on the genetic interrelatedness of viral sequences and cluster networks that could not be otherwise identified. This article describes the phylogenetic expansion of the Montreal MSM epidemic over the last decade. High rates of co-clustering of primary infections are associated with one infection leading to 13 onward transmissions. Phylogeny substantiates the role of primary and recent stage infection in transmission dynamics, underlying the importance of timely diagnosis and immediate ART initiation to avert transmission cascades.
Url:
DOI: 10.1097/QAI.0b013e3182986f96
PubMed: 23764643
PubMed Central: 3689150
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Future of Phylogeny in HIV Prevention</title><author><name sortKey="Brenner, Bluma G" sort="Brenner, Bluma G" uniqKey="Brenner B" first="Bluma G." last="Brenner">Bluma G. Brenner</name></author><author><name sortKey="Wainberg, Mark A" sort="Wainberg, Mark A" uniqKey="Wainberg M" first="Mark A." last="Wainberg">Mark A. Wainberg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23764643</idno><idno type="pmc">3689150</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689150</idno><idno type="RBID">PMC:3689150</idno><idno type="doi">10.1097/QAI.0b013e3182986f96</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001917</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Future of Phylogeny in HIV Prevention</title><author><name sortKey="Brenner, Bluma G" sort="Brenner, Bluma G" uniqKey="Brenner B" first="Bluma G." last="Brenner">Bluma G. Brenner</name></author><author><name sortKey="Wainberg, Mark A" sort="Wainberg, Mark A" uniqKey="Wainberg M" first="Mark A." last="Wainberg">Mark A. Wainberg</name></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The success of the HPTN 052 trial has led to revisions in HIV-1 treatment guidelines. Antiretroviral therapy (ART) may reduce the risk of HIV-1 transmissions at the population-level. The design of successful Treatment as Prevention interventions will be predicated on a comprehensive understanding of the spatial, temporal, and biological dynamics of heterosexual (HET), men having sex with men (MSM), and intravenous drug user (IDU) epidemics. Viral phylogenetics can capture the underlying structure of transmission networks based on the genetic interrelatedness of viral sequences and cluster networks that could not be otherwise identified. This article describes the phylogenetic expansion of the Montreal MSM epidemic over the last decade. High rates of co-clustering of primary infections are associated with one infection leading to 13 onward transmissions. Phylogeny substantiates the role of primary and recent stage infection in transmission dynamics, underlying the importance of timely diagnosis and immediate ART initiation to avert transmission cascades.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100892005</journal-id><journal-id journal-id-type="pubmed-jr-id">21821</journal-id><journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id><journal-id journal-id-type="iso-abbrev">J. Acquir. Immune Defic. Syndr.</journal-id><journal-title-group><journal-title>Journal of acquired immune deficiency syndromes (1999)</journal-title></journal-title-group><issn pub-type="ppub">1525-4135</issn><issn pub-type="epub">1944-7884</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23764643</article-id><article-id pub-id-type="pmc">3689150</article-id><article-id pub-id-type="doi">10.1097/QAI.0b013e3182986f96</article-id><article-id pub-id-type="manuscript">NIHMS485407</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Future of Phylogeny in HIV Prevention</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brenner</surname><given-names>Bluma G.</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Wainberg</surname><given-names>Mark A.</given-names></name><degrees>PhD</degrees></contrib><aff id="A1">Lady Davis Research Institute and the McGill AIDS Centre, Montreal, Canada</aff></contrib-group><author-notes><corresp id="CR1"><bold>Corresponding author:</bold> Dr. Mark Wainberg, Lady Davis Institute, 3755 Cote Ste. Catherine Road, Montreal, Quebec, Canada, H3T 1E2. Tel: 514-340-8260, Fax: 514-340-7537, <email>mark.wainberg@mcgill.ca</email>.</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>31</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2014</year></pub-date><volume>63</volume><issue>0 2</issue><fpage>S248</fpage><lpage>S254</lpage><abstract><p id="P1">The success of the HPTN 052 trial has led to revisions in HIV-1 treatment guidelines. Antiretroviral therapy (ART) may reduce the risk of HIV-1 transmissions at the population-level. The design of successful Treatment as Prevention interventions will be predicated on a comprehensive understanding of the spatial, temporal, and biological dynamics of heterosexual (HET), men having sex with men (MSM), and intravenous drug user (IDU) epidemics. Viral phylogenetics can capture the underlying structure of transmission networks based on the genetic interrelatedness of viral sequences and cluster networks that could not be otherwise identified. This article describes the phylogenetic expansion of the Montreal MSM epidemic over the last decade. High rates of co-clustering of primary infections are associated with one infection leading to 13 onward transmissions. Phylogeny substantiates the role of primary and recent stage infection in transmission dynamics, underlying the importance of timely diagnosis and immediate ART initiation to avert transmission cascades.</p></abstract><kwd-group><kwd>HIV transmission</kwd><kwd>Phylogenetics</kwd><kwd>Treatment as Prevention</kwd><kwd>Primary infection</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source><award-id>R01 AI078752 || AI</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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