HIV and Aging: State of Knowledge and Areas of Critical Need for Research
Identifieur interne : 001906 ( Pmc/Corpus ); précédent : 001905; suivant : 001907HIV and Aging: State of Knowledge and Areas of Critical Need for Research
Auteurs :Source :
- Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2012.
Abstract
HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to anti-retroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to > 70 years of age. Biologic, medical, individual social and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups’ findings and recommendations are summarized in this report. Key overarching themes identified by the group included: multi-morbidity, poly-pharmacy and the need to emphasize maintenance of function; the complexity of assessing HIV vs. treatment effects vs. aging vs. concurrent disease; the inter-related mechanisms of immune senescence, inflammation and hypercoagulability; the utility of multi-variable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures and multi-morbidity, as well as facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.
Url:
DOI: 10.1097/QAI.0b013e31825a3668
PubMed: 22688010
PubMed Central: 3413877
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PMC:3413877Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to anti-retroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to > 70 years of age. Biologic, medical, individual social and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups’ findings and recommendations are summarized in this report. Key overarching themes identified by the group included: multi-morbidity, poly-pharmacy and the need to emphasize maintenance of function; the complexity of assessing HIV vs. treatment effects vs. aging vs. concurrent disease; the inter-related mechanisms of immune senescence, inflammation and hypercoagulability; the utility of multi-variable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures and multi-morbidity, as well as facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.</p>
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<journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id>
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<title-group><article-title>HIV and Aging: State of Knowledge and Areas of Critical Need for Research</article-title>
<subtitle>A report to the NIH Office of AIDS Research by the HIV and Aging Working Group</subtitle>
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<contrib-group><contrib contrib-type="author"><collab>OAR Working Group on HIV and Aging</collab>
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<xref rid="FN2" ref-type="author-notes">*</xref>
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<author-notes><fn id="FN2"><label>*</label>
<p>See below for all members and affiliations</p>
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<corresp id="FN1">Corresponding Author: Kevin P. High, MD, MS, Professor of Medicine and Translational Science, Wake Forest School of Medicine, Address: 100 Medical Center Blvd., Winston-Salem, NC 27157-1042, Phone: 336-716-4584, Fax: 336-716-3825, <email>khigh@wakehealth.edu</email>
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<pub-date pub-type="nihms-submitted"><day>18</day>
<month>6</month>
<year>2012</year>
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<pub-date pub-type="ppub"><day>1</day>
<month>7</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>7</month>
<year>2013</year>
</pub-date>
<volume>60</volume>
<issue>Suppl 1</issue>
<fpage>S1</fpage>
<lpage>18</lpage>
<abstract><p id="P1">HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection, and response to anti-retroviral therapy all vary by age. In those living with HIV, current effective treatment has increased the median life expectancy to > 70 years of age. Biologic, medical, individual social and societal issues change as one ages with HIV infection, but there has been only a small amount of research in this field. Therefore, the Office of AIDS Research of the National Institutes of Health commissioned a working group to develop an outline of the current state of knowledge and areas of critical need for research in HIV and Aging; the working groups’ findings and recommendations are summarized in this report. Key overarching themes identified by the group included: multi-morbidity, poly-pharmacy and the need to emphasize maintenance of function; the complexity of assessing HIV vs. treatment effects vs. aging vs. concurrent disease; the inter-related mechanisms of immune senescence, inflammation and hypercoagulability; the utility of multi-variable indices for predicting outcomes; a need to emphasize human studies to account for complexity; and a required focus on issues of community support, caregivers and systems infrastructure. Critical resources are needed to enact this research agenda and include expanded review panel expertise in aging, functional measures and multi-morbidity, as well as facilitated use and continued funding to allow long-term follow-up of cohorts aging with HIV.</p>
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<kwd-group><kwd>Aging</kwd>
<kwd>HIV/AIDS</kwd>
<kwd>Co-morbidity</kwd>
<kwd>Research Priorities</kwd>
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<funding-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source>
<award-id>P30 AG021332 || AG</award-id>
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