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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women</title><author><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A." last="Slyker">Jennifer A. Slyker</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Casper, Corey" sort="Casper, Corey" uniqKey="Casper C" first="Corey" last="Casper">Corey Casper</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Medicine, Division of Allergy and Infectious Diseases</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Tapia, Kenneth" sort="Tapia, Kenneth" uniqKey="Tapia K" first="Kenneth" last="Tapia">Kenneth Tapia</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Richardson, Barbra" sort="Richardson, Barbra" uniqKey="Richardson B" first="Barbra" last="Richardson">Barbra Richardson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bunts, Lisa" sort="Bunts, Lisa" uniqKey="Bunts L" first="Lisa" last="Bunts">Lisa Bunts</name><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Huang, Meei Li" sort="Huang, Meei Li" uniqKey="Huang M" first="Meei-Li" last="Huang">Meei-Li Huang</name><affiliation><nlm:aff id="af8"><addr-line>Division of Laboratory Medicine</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation></author><author><name sortKey="Maleche Obimbo, Elizabeth" sort="Maleche Obimbo, Elizabeth" uniqKey="Maleche Obimbo E" first="Elizabeth" last="Maleche-Obimbo">Elizabeth Maleche-Obimbo</name><affiliation><nlm:aff id="af6"><addr-line>Department of Pediatrics and Child Health, School of Medicine</addr-line>,<institution>University of Nairobi</institution></nlm:aff></affiliation></author><author><name sortKey="Nduati, Ruth" sort="Nduati, Ruth" uniqKey="Nduati R" first="Ruth" last="Nduati">Ruth Nduati</name><affiliation><nlm:aff id="af6"><addr-line>Department of Pediatrics and Child Health, School of Medicine</addr-line>,<institution>University of Nairobi</institution></nlm:aff></affiliation></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Medicine, Division of Allergy and Infectious Diseases</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23493724</idno><idno type="pmc">3654744</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654744</idno><idno type="RBID">PMC:3654744</idno><idno type="doi">10.1093/infdis/jit093</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001698</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001698</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women</title><author><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A." last="Slyker">Jennifer A. Slyker</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation></author><author><name sortKey="Casper, Corey" sort="Casper, Corey" uniqKey="Casper C" first="Corey" last="Casper">Corey Casper</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Medicine, Division of Allergy and Infectious Diseases</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Tapia, Kenneth" sort="Tapia, Kenneth" uniqKey="Tapia K" first="Kenneth" last="Tapia">Kenneth Tapia</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Richardson, Barbra" sort="Richardson, Barbra" uniqKey="Richardson B" first="Barbra" last="Richardson">Barbra Richardson</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af5"><addr-line>Department of Biostatistics</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bunts, Lisa" sort="Bunts, Lisa" uniqKey="Bunts L" first="Lisa" last="Bunts">Lisa Bunts</name><affiliation><nlm:aff id="af4"><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></nlm:aff></affiliation></author><author><name sortKey="Huang, Meei Li" sort="Huang, Meei Li" uniqKey="Huang M" first="Meei-Li" last="Huang">Meei-Li Huang</name><affiliation><nlm:aff id="af8"><addr-line>Division of Laboratory Medicine</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation></author><author><name sortKey="Maleche Obimbo, Elizabeth" sort="Maleche Obimbo, Elizabeth" uniqKey="Maleche Obimbo E" first="Elizabeth" last="Maleche-Obimbo">Elizabeth Maleche-Obimbo</name><affiliation><nlm:aff id="af6"><addr-line>Department of Pediatrics and Child Health, School of Medicine</addr-line>,<institution>University of Nairobi</institution></nlm:aff></affiliation></author><author><name sortKey="Nduati, Ruth" sort="Nduati, Ruth" uniqKey="Nduati R" first="Ruth" last="Nduati">Ruth Nduati</name><affiliation><nlm:aff id="af6"><addr-line>Department of Pediatrics and Child Health, School of Medicine</addr-line>,<institution>University of Nairobi</institution></nlm:aff></affiliation></author><author><name sortKey="John Stewart, Grace" sort="John Stewart, Grace" uniqKey="John Stewart G" first="Grace" last="John-Stewart">Grace John-Stewart</name><affiliation><nlm:aff id="af1"><addr-line>Department of Global Health</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af2"><addr-line>Department of Epidemiology</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="af3"><addr-line>Department of Medicine, Division of Allergy and Infectious Diseases</addr-line>,<institution>University of Washington</institution></nlm:aff></affiliation><affiliation><nlm:aff id="af7"><addr-line>Department of Pediatrics</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic></bold> Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)–associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy.</p><p><bold><italic>Methods.</italic></bold> To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA–negative infants. Monthly clinical examinations were performed by pediatricians.</p><p><bold><italic>Results.</italic></bold> The probability of EBV infection by 1 year of age was .78 (95% CI, .67–.88) in HIV-infected and .49 (95% CI, .35–.65) in HIV-uninfected infants (<italic>P</italic> < .0001). At 2 years, probability of EBV infection was .96 (95% CI, .89–.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log<sub>10</sub> copies/mL; <italic>P</italic> < .0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants.</p><p><bold><italic>Conclusions.</italic></bold> EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id><journal-id journal-id-type="publisher-id">jid</journal-id><journal-id journal-id-type="hwp">jinfdis</journal-id><journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">0022-1899</issn><issn pub-type="epub">1537-6613</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23493724</article-id><article-id pub-id-type="pmc">3654744</article-id><article-id pub-id-type="doi">10.1093/infdis/jit093</article-id><article-id pub-id-type="publisher-id">jit093</article-id><article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject><subj-group subj-group-type="heading"><subject>HIV/AIDS</subject></subj-group></subj-group><series-title>Editor's choice</series-title></article-categories><title-group><article-title>Clinical and Virologic Manifestations of Primary Epstein-Barr Virus (EBV) Infection in Kenyan Infants Born to HIV-Infected Women</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Slyker</surname><given-names>Jennifer A.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Casper</surname><given-names>Corey</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Tapia</surname><given-names>Kenneth</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Richardson</surname><given-names>Barbra</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af4">4</xref><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Bunts</surname><given-names>Lisa</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Meei-Li</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Maleche-Obimbo</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Nduati</surname><given-names>Ruth</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>John-Stewart</surname><given-names>Grace</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref><xref ref-type="aff" rid="af3">3</xref><xref ref-type="aff" rid="af7">7</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Global Health</addr-line></aff><aff id="af2"><label>2</label><addr-line>Department of Epidemiology</addr-line></aff><aff id="af3"><label>3</label><addr-line>Department of Medicine, Division of Allergy and Infectious Diseases</addr-line>,<institution>University of Washington</institution></aff><aff id="af4"><label>4</label><addr-line>Divisions of Vaccine and Infectious Disease, Public Health Sciences, and Clinical Research</addr-line>,<institution>Fred Hutchinson Cancer Research Center</institution></aff><aff id="af5"><label>5</label><addr-line>Department of Biostatistics</addr-line></aff><aff id="af6"><label>6</label><addr-line>Department of Pediatrics and Child Health, School of Medicine</addr-line>,<institution>University of Nairobi</institution></aff><aff id="af7"><label>7</label><addr-line>Department of Pediatrics</addr-line></aff><aff id="af8"><label>8</label><addr-line>Division of Laboratory Medicine</addr-line>,<institution>University of Washington</institution></aff><author-notes><fn fn-type="con"><p>Presented in part: 19th Conference on Retroviruses and Opportunistic Infections, Seattle, Washington, March 2012. Abstract S-180.</p></fn><corresp>Correspondence: Jennifer Slyker, PhD, Harborview Medical Center, 325 9th Ave, Box 359931, Seattle, WA 98104 USA (<email>jslyker@u.washington.edu</email>).</corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>6</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>14</day><month>3</month><year>2013</year></pub-date><volume>207</volume><issue>12</issue><fpage>1798</fpage><lpage>1806</lpage><history><date date-type="received"><day>8</day><month>10</month><year>2012</year></date><date date-type="accepted"><day>21</day><month>12</month><year>2012</year></date></history><permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: <email>journals.permissions@oup.com</email>.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="jit093.pdf"></self-uri><abstract><p><bold><italic>Background.</italic></bold> Human immunodeficiency virus (HIV) infection is a risk factor for Epstein-Barr virus (EBV)–associated lymphomas. Characterizing primary infection may elucidate risk factors for malignancy.</p><p><bold><italic>Methods.</italic></bold> To describe clinical and virologic manifestations of primary EBV infection among infants born to HIV-infected women, specimens were utilized from a cohort study conducted in Nairobi, Kenya. HIV and EBV viral loads were measured serially in plasma. EBV serology was performed on EBV DNA–negative infants. Monthly clinical examinations were performed by pediatricians.</p><p><bold><italic>Results.</italic></bold> The probability of EBV infection by 1 year of age was .78 (95% CI, .67–.88) in HIV-infected and .49 (95% CI, .35–.65) in HIV-uninfected infants (<italic>P</italic> < .0001). At 2 years, probability of EBV infection was .96 (95% CI, .89–.99) in HIV-infected infants. Peak EBV loads were higher in HIV-infected versus HIV-uninfected infants (median 2.6 vs 2.1 log<sub>10</sub> copies/mL; <italic>P</italic> < .0001). The majority of HIV-infected infants had detectable EBV DNA for >3 months (79%). Primary EBV infection was associated with cough, fever, otitis media, pneumonia, hepatomegaly, splenomegaly, and hospitalization in HIV-infected infants; conjunctivitis and rhinorrhea in HIV-uninfected infants.</p><p><bold><italic>Conclusions.</italic></bold> EBV infection occurs early in infants born to HIV-infected women. HIV infection was associated with more frequent and higher quantity EBV DNA detection.</p></abstract><kwd-group><kwd>EBV</kwd><kwd>primary infection</kwd><kwd>HIV</kwd><kwd>pediatric</kwd><kwd>herpesviruses</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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