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<title xml:lang="en">Formative Investigation of Acceptability of Typhoid Vaccine during a Typhoid Fever Outbreak in Neno District, Malawi</title>
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<name sortKey="Blum, Lauren S" sort="Blum, Lauren S" uniqKey="Blum L" first="Lauren S." last="Blum">Lauren S. Blum</name>
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<name sortKey="Dentz, Holly" sort="Dentz, Holly" uniqKey="Dentz H" first="Holly" last="Dentz">Holly Dentz</name>
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<name sortKey="Chingoli, Felix" sort="Chingoli, Felix" uniqKey="Chingoli F" first="Felix" last="Chingoli">Felix Chingoli</name>
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<name sortKey="Chilima, Benson" sort="Chilima, Benson" uniqKey="Chilima B" first="Benson" last="Chilima">Benson Chilima</name>
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<name sortKey="Warne, Thomas" sort="Warne, Thomas" uniqKey="Warne T" first="Thomas" last="Warne">Thomas Warne</name>
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<name sortKey="Lee, Carla" sort="Lee, Carla" uniqKey="Lee C" first="Carla" last="Lee">Carla Lee</name>
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<name sortKey="Hyde, Terri" sort="Hyde, Terri" uniqKey="Hyde T" first="Terri" last="Hyde">Terri Hyde</name>
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<name sortKey="Gindler, Jacqueline" sort="Gindler, Jacqueline" uniqKey="Gindler J" first="Jacqueline" last="Gindler">Jacqueline Gindler</name>
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<name sortKey="Sejvar, James" sort="Sejvar, James" uniqKey="Sejvar J" first="James" last="Sejvar">James Sejvar</name>
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<name sortKey="Mintz, Eric D" sort="Mintz, Eric D" uniqKey="Mintz E" first="Eric D." last="Mintz">Eric D. Mintz</name>
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<idno type="pmid">25002303</idno>
<idno type="pmc">4183395</idno>
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<idno type="RBID">PMC:4183395</idno>
<idno type="doi">10.4269/ajtmh.14-0067</idno>
<date when="2014">2014</date>
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<title xml:lang="en" level="a" type="main">Formative Investigation of Acceptability of Typhoid Vaccine during a Typhoid Fever Outbreak in Neno District, Malawi</title>
<author>
<name sortKey="Blum, Lauren S" sort="Blum, Lauren S" uniqKey="Blum L" first="Lauren S." last="Blum">Lauren S. Blum</name>
</author>
<author>
<name sortKey="Dentz, Holly" sort="Dentz, Holly" uniqKey="Dentz H" first="Holly" last="Dentz">Holly Dentz</name>
</author>
<author>
<name sortKey="Chingoli, Felix" sort="Chingoli, Felix" uniqKey="Chingoli F" first="Felix" last="Chingoli">Felix Chingoli</name>
</author>
<author>
<name sortKey="Chilima, Benson" sort="Chilima, Benson" uniqKey="Chilima B" first="Benson" last="Chilima">Benson Chilima</name>
</author>
<author>
<name sortKey="Warne, Thomas" sort="Warne, Thomas" uniqKey="Warne T" first="Thomas" last="Warne">Thomas Warne</name>
</author>
<author>
<name sortKey="Lee, Carla" sort="Lee, Carla" uniqKey="Lee C" first="Carla" last="Lee">Carla Lee</name>
</author>
<author>
<name sortKey="Hyde, Terri" sort="Hyde, Terri" uniqKey="Hyde T" first="Terri" last="Hyde">Terri Hyde</name>
</author>
<author>
<name sortKey="Gindler, Jacqueline" sort="Gindler, Jacqueline" uniqKey="Gindler J" first="Jacqueline" last="Gindler">Jacqueline Gindler</name>
</author>
<author>
<name sortKey="Sejvar, James" sort="Sejvar, James" uniqKey="Sejvar J" first="James" last="Sejvar">James Sejvar</name>
</author>
<author>
<name sortKey="Mintz, Eric D" sort="Mintz, Eric D" uniqKey="Mintz E" first="Eric D." last="Mintz">Eric D. Mintz</name>
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<title level="j">The American Journal of Tropical Medicine and Hygiene</title>
<idno type="ISSN">0002-9637</idno>
<idno type="eISSN">1476-1645</idno>
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<date when="2014">2014</date>
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<div type="abstract" xml:lang="en">
<p>Typhoid fever affects an estimated 22 million people annually and causes 216,000 deaths worldwide. We conducted an investigation in August and September 2010 to examine the acceptability of typhoid vaccine in Neno District, Malawi where a typhoid outbreak was ongoing. We used qualitative methods, including freelisting exercises, key informant and in-depth interviews, and group discussions. Respondents associated illness with exposure to “bad wind,” and transmission was believed to be airborne. Typhoid was considered extremely dangerous because of its rapid spread, the debilitating conditions it produced, the number of related fatalities, and the perception that it was highly contagious. Respondents were skeptical about the effectiveness of water, sanitation, and hygiene (WaSH) interventions. The perceived severity of typhoid and fear of exposure, uncertainty about the effectiveness of WaSH measures, and widespread belief in the efficacy of vaccines in preventing disease resulted in an overwhelming interest in receiving typhoid vaccine during an outbreak.</p>
</div>
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<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<journal-meta>
<journal-id journal-id-type="nlm-ta">Am J Trop Med Hyg</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Trop. Med. Hyg</journal-id>
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<journal-title>The American Journal of Tropical Medicine and Hygiene</journal-title>
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<issn pub-type="ppub">0002-9637</issn>
<issn pub-type="epub">1476-1645</issn>
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<publisher-name>The American Society of Tropical Medicine and Hygiene</publisher-name>
</publisher>
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<article-id pub-id-type="pmid">25002303</article-id>
<article-id pub-id-type="pmc">4183395</article-id>
<article-id pub-id-type="doi">10.4269/ajtmh.14-0067</article-id>
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<subject>Articles</subject>
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<title-group>
<article-title>Formative Investigation of Acceptability of Typhoid Vaccine during a Typhoid Fever Outbreak in Neno District, Malawi</article-title>
<alt-title alt-title-type="left-running-head">BLUM AND OTHERS</alt-title>
<alt-title alt-title-type="right-running-head">TYPHOID VACCINE ACCEPTABILITY IN MALAWI</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Blum</surname>
<given-names>Lauren S.</given-names>
</name>
<xref ref-type="corresp" rid="COR1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Dentz</surname>
<given-names>Holly</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chingoli</surname>
<given-names>Felix</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chilima</surname>
<given-names>Benson</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Warne</surname>
<given-names>Thomas</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lee</surname>
<given-names>Carla</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hyde</surname>
<given-names>Terri</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gindler</surname>
<given-names>Jacqueline</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Sejvar</surname>
<given-names>James</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Mintz</surname>
<given-names>Eric D.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="AFF1">Waterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, (NCEZID), CDC, Atlanta, Georgia; Strengthening Immunization Systems Branch, Global Immunization Division, Center for Global Health (CGH), CDC, Atlanta, Georgia; Neno District Health Office, Neno, Malawi; Community Health Services Unit, MOH, Lilongwe, Malawi; Global AIDS Program Malawi, Division of Global HIV AIDS, CGH, CDC, Lilongwe, Malawi; Office of the Director, Division of High Consequence Pathogens and Pathology, NCEZID, CDC, Atlanta, Georgia</aff>
<author-notes>
<corresp id="COR1">*Address correspondence to Lauren S. Blum, 2130 Dakar Place, Dulles, VA 20189. E-mail:
<email>laurensblum@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<day>01</day>
<month>10</month>
<year>2014</year>
</pub-date>
<volume>91</volume>
<issue>4</issue>
<fpage>729</fpage>
<lpage>737</lpage>
<history>
<date date-type="received">
<day>31</day>
<month>1</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>02</day>
<month>5</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>©The American Society of Tropical Medicine and Hygiene</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract>
<p>Typhoid fever affects an estimated 22 million people annually and causes 216,000 deaths worldwide. We conducted an investigation in August and September 2010 to examine the acceptability of typhoid vaccine in Neno District, Malawi where a typhoid outbreak was ongoing. We used qualitative methods, including freelisting exercises, key informant and in-depth interviews, and group discussions. Respondents associated illness with exposure to “bad wind,” and transmission was believed to be airborne. Typhoid was considered extremely dangerous because of its rapid spread, the debilitating conditions it produced, the number of related fatalities, and the perception that it was highly contagious. Respondents were skeptical about the effectiveness of water, sanitation, and hygiene (WaSH) interventions. The perceived severity of typhoid and fear of exposure, uncertainty about the effectiveness of WaSH measures, and widespread belief in the efficacy of vaccines in preventing disease resulted in an overwhelming interest in receiving typhoid vaccine during an outbreak.</p>
</abstract>
</article-meta>
<notes notes-type="disclaimer">
<p>Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.</p>
</notes>
</front>
</pmc>
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