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<title xml:lang="en">Cumulative Effects of HIV Illness and Caring for Children Orphaned by AIDS on Anxiety Symptoms Among Adults Caring for Children in HIV-Endemic South Africa</title>
<author>
<name sortKey="Kuo, Caroline" sort="Kuo, Caroline" uniqKey="Kuo C" first="Caroline" last="Kuo">Caroline Kuo</name>
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<name sortKey="Cluver, Lucie" sort="Cluver, Lucie" uniqKey="Cluver L" first="Lucie" last="Cluver">Lucie Cluver</name>
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<author>
<name sortKey="Casale, Marisa" sort="Casale, Marisa" uniqKey="Casale M" first="Marisa" last="Casale">Marisa Casale</name>
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<affiliation>
<nlm:aff id="aff5"></nlm:aff>
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<author>
<name sortKey="Lane, Tyler" sort="Lane, Tyler" uniqKey="Lane T" first="Tyler" last="Lane">Tyler Lane</name>
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<idno type="pmid">24901465</idno>
<idno type="pmc">4046216</idno>
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<idno type="doi">10.1089/apc.2013.0225</idno>
<date when="2014">2014</date>
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<title xml:lang="en" level="a" type="main">Cumulative Effects of HIV Illness and Caring for Children Orphaned by AIDS on Anxiety Symptoms Among Adults Caring for Children in HIV-Endemic South Africa</title>
<author>
<name sortKey="Kuo, Caroline" sort="Kuo, Caroline" uniqKey="Kuo C" first="Caroline" last="Kuo">Caroline Kuo</name>
<affiliation>
<nlm:aff id="aff1"></nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff2"></nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Cluver, Lucie" sort="Cluver, Lucie" uniqKey="Cluver L" first="Lucie" last="Cluver">Lucie Cluver</name>
<affiliation>
<nlm:aff id="aff2"></nlm:aff>
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<affiliation>
<nlm:aff id="aff3"></nlm:aff>
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<affiliation>
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<author>
<name sortKey="Casale, Marisa" sort="Casale, Marisa" uniqKey="Casale M" first="Marisa" last="Casale">Marisa Casale</name>
<affiliation>
<nlm:aff id="aff4"></nlm:aff>
</affiliation>
<affiliation>
<nlm:aff id="aff5"></nlm:aff>
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</author>
<author>
<name sortKey="Lane, Tyler" sort="Lane, Tyler" uniqKey="Lane T" first="Tyler" last="Lane">Tyler Lane</name>
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<nlm:aff id="aff3"></nlm:aff>
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<affiliation>
<nlm:aff id="aff4"></nlm:aff>
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<series>
<title level="j">AIDS Patient Care and STDs</title>
<idno type="ISSN">1087-2914</idno>
<idno type="eISSN">1557-7449</idno>
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<date when="2014">2014</date>
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<title>Abstract</title>
<p>Adults caring for children in HIV-endemic communities are at risk for poor psychological outcomes. However, we still have a limited understanding of how various HIV impacts—including caregiver's own HIV illness, responsibilities of caring for a child orphaned by AIDS, or both—affect psychological outcomes among caregivers. Furthermore, few studies have explored the relationship between stigma, HIV, and psychological outcomes among caregivers of children in HIV-endemic communities. A cross-sectional survey conducted from 2009 to 2010 assessed anxiety among 2477 caregivers of children in HIV-endemic South Africa. Chi-square tested differences in anxiety among caregivers living with HIV, caregivers of a child orphaned by AIDS, and caregivers affected with both conditions. Multivariate logistic regressions identified whether the relationship between HIV impacts and anxiety remained after controlling for socio-demographic co-factors. Mediation analysis tested the relationship between stigma, HIV, and anxiety. The odds of meeting threshold criteria for clinically relevant anxiety symptoms were two and a half times greater among caregivers living with HIV compared to nonaffected caregivers. The odds of meeting threshold criteria for clinically relevant anxiety symptoms were greatest among caregivers living with HIV and caring for a child orphaned by AIDS. Exposure to AIDS-related stigma partially mediated the relationship between HIV and anxiety. Interventions are needed to address caregiver psychological health, particularly among caregivers affected with both conditions of living with HIV and caring for a child orphaned by AIDS.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">AIDS Patient Care STDS</journal-id>
<journal-id journal-id-type="iso-abbrev">AIDS Patient Care STDS</journal-id>
<journal-id journal-id-type="publisher-id">apc</journal-id>
<journal-title-group>
<journal-title>AIDS Patient Care and STDs</journal-title>
</journal-title-group>
<issn pub-type="ppub">1087-2914</issn>
<issn pub-type="epub">1557-7449</issn>
<publisher>
<publisher-name>Mary Ann Liebert, Inc.</publisher-name>
<publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">24901465</article-id>
<article-id pub-id-type="pmc">4046216</article-id>
<article-id pub-id-type="publisher-id">10.1089/apc.2013.0225</article-id>
<article-id pub-id-type="doi">10.1089/apc.2013.0225</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Behavioral and Psychosocial Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Cumulative Effects of HIV Illness and Caring for Children Orphaned by AIDS on Anxiety Symptoms Among Adults Caring for Children in HIV-Endemic South Africa</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Kuo</surname>
<given-names>Caroline</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff1">
<sup>1,</sup>
</xref>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Cluver</surname>
<given-names>Lucie</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="aff2">
<sup>2,</sup>
</xref>
<xref ref-type="aff" rid="aff3">
<sup>3,</sup>
</xref>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Casale</surname>
<given-names>Marisa</given-names>
</name>
<xref ref-type="aff" rid="aff4">
<sup>4,</sup>
</xref>
<xref ref-type="aff" rid="aff5">
<sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Lane</surname>
<given-names>Tyler</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3,</sup>
</xref>
<xref ref-type="aff" rid="aff4">
<sup>4</sup>
</xref>
</contrib>
<aff id="aff1">
<label>
<sup>1</sup>
</label>
Department of Behavioral and Social Sciences and Center for Alcohol and Addiction Studies,
<institution>Brown University School of Public Health</institution>
, Providence, Rhode Island.</aff>
<aff id="aff2">
<label>
<sup>2</sup>
</label>
Department of Psychiatry and Mental Health,
<institution>University of Cape Town</institution>
, Cape Town,
<country>South Africa</country>
.</aff>
<aff id="aff3">
<label>
<sup>3</sup>
</label>
Department of Social Policy and Intervention,
<institution>University of Oxford</institution>
, Oxford,
<country>United Kingdom</country>
.</aff>
<aff id="aff4">
<label>
<sup>4</sup>
</label>
Health Economics and HIV/AIDS Research Division,
<institution>University of KwaZulu-Natal</institution>
,
<country>South Africa</country>
.</aff>
<aff id="aff5">
<label>
<sup>5</sup>
</label>
Department of Psychology,
<institution>University of Cape Town</institution>
, Cape Town,
<country>South Africa</country>
.</aff>
</contrib-group>
<author-notes>
<corresp>
<addr-line>Address correspondence to:</addr-line>
<addr-line>
<italic>Dr. Caroline Kuo</italic>
</addr-line>
<addr-line>
<italic>Department of Behavioral and Social Sciences</italic>
</addr-line>
<institution>
<italic>Brown University School of Public Health</italic>
</institution>
<addr-line>
<italic>Box G-S121-Floor 4</italic>
</addr-line>
<addr-line>
<italic>Providence, RI 02903</italic>
</addr-line>
<italic>E-mail:</italic>
<email xlink:href="mailto:caroline_kuo@brown.edu">caroline_kuo@brown.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<day>01</day>
<month>6</month>
<year>2014</year>
<pmc-comment>string-date: June 2014</pmc-comment>
</pub-date>
<volume>28</volume>
<issue>6</issue>
<fpage>318</fpage>
<lpage>326</lpage>
<permissions>
<copyright-statement>Copyright 2014, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="apc.2013.0225.pdf"></self-uri>
<abstract>
<title>Abstract</title>
<p>Adults caring for children in HIV-endemic communities are at risk for poor psychological outcomes. However, we still have a limited understanding of how various HIV impacts—including caregiver's own HIV illness, responsibilities of caring for a child orphaned by AIDS, or both—affect psychological outcomes among caregivers. Furthermore, few studies have explored the relationship between stigma, HIV, and psychological outcomes among caregivers of children in HIV-endemic communities. A cross-sectional survey conducted from 2009 to 2010 assessed anxiety among 2477 caregivers of children in HIV-endemic South Africa. Chi-square tested differences in anxiety among caregivers living with HIV, caregivers of a child orphaned by AIDS, and caregivers affected with both conditions. Multivariate logistic regressions identified whether the relationship between HIV impacts and anxiety remained after controlling for socio-demographic co-factors. Mediation analysis tested the relationship between stigma, HIV, and anxiety. The odds of meeting threshold criteria for clinically relevant anxiety symptoms were two and a half times greater among caregivers living with HIV compared to nonaffected caregivers. The odds of meeting threshold criteria for clinically relevant anxiety symptoms were greatest among caregivers living with HIV and caring for a child orphaned by AIDS. Exposure to AIDS-related stigma partially mediated the relationship between HIV and anxiety. Interventions are needed to address caregiver psychological health, particularly among caregivers affected with both conditions of living with HIV and caring for a child orphaned by AIDS.</p>
</abstract>
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</front>
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