Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Elevations in mortality due to weaning persist into the second year of life among uninfected children born to HIV-infected mothers</title><author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name><affiliation><nlm:aff id="A1">Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name><affiliation><nlm:aff id="A2">Lusaka District Health Management Team, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Semrau, Katherine" sort="Semrau, Katherine" uniqKey="Semrau K" first="Katherine" last="Semrau">Katherine Semrau</name><affiliation><nlm:aff id="A3">Center for International Health & Development, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Kasonde, Prisca" sort="Kasonde, Prisca" uniqKey="Kasonde P" first="Prisca" last="Kasonde">Prisca Kasonde</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Mwiya, Mwiya" sort="Mwiya, Mwiya" uniqKey="Mwiya M" first="Mwiya" last="Mwiya">Mwiya Mwiya</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Hu, Chih Chi" sort="Hu, Chih Chi" uniqKey="Hu C" first="Chih-Chi" last="Hu">Chih-Chi Hu</name><affiliation><nlm:aff id="A5">Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Tsai, Wei Yann" sort="Tsai, Wei Yann" uniqKey="Tsai W" first="Wei-Yann" last="Tsai">Wei-Yann Tsai</name><affiliation><nlm:aff id="A5">Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M." last="Thea">Donald M. Thea</name><affiliation><nlm:aff id="A3">Center for International Health & Development, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Aldrovandi, Grace M" sort="Aldrovandi, Grace M" uniqKey="Aldrovandi G" first="Grace M." last="Aldrovandi">Grace M. Aldrovandi</name><affiliation><nlm:aff id="A6">Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20047479</idno><idno type="pmc">2805776</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805776</idno><idno type="RBID">PMC:2805776</idno><idno type="doi">10.1086/649886</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001107</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001107</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Elevations in mortality due to weaning persist into the second year of life among uninfected children born to HIV-infected mothers</title><author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name><affiliation><nlm:aff id="A1">Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name><affiliation><nlm:aff id="A2">Lusaka District Health Management Team, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Semrau, Katherine" sort="Semrau, Katherine" uniqKey="Semrau K" first="Katherine" last="Semrau">Katherine Semrau</name><affiliation><nlm:aff id="A3">Center for International Health & Development, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Kasonde, Prisca" sort="Kasonde, Prisca" uniqKey="Kasonde P" first="Prisca" last="Kasonde">Prisca Kasonde</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Mwiya, Mwiya" sort="Mwiya, Mwiya" uniqKey="Mwiya M" first="Mwiya" last="Mwiya">Mwiya Mwiya</name><affiliation><nlm:aff id="A4">University Teaching Hospital, University of Zambia, Lusaka, Zambia</nlm:aff></affiliation></author><author><name sortKey="Hu, Chih Chi" sort="Hu, Chih Chi" uniqKey="Hu C" first="Chih-Chi" last="Hu">Chih-Chi Hu</name><affiliation><nlm:aff id="A5">Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Tsai, Wei Yann" sort="Tsai, Wei Yann" uniqKey="Tsai W" first="Wei-Yann" last="Tsai">Wei-Yann Tsai</name><affiliation><nlm:aff id="A5">Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M." last="Thea">Donald M. Thea</name><affiliation><nlm:aff id="A3">Center for International Health & Development, Boston University School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Aldrovandi, Grace M" sort="Aldrovandi, Grace M" uniqKey="Aldrovandi G" first="Grace M." last="Aldrovandi">Grace M. Aldrovandi</name><affiliation><nlm:aff id="A6">Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA</nlm:aff></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Early weaning has been recommended to reduce postnatal HIV transmission. We evaluated the safety of stopping breastfeeding at different ages for mortality of uninfected children born to HIV-infected mothers.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">During a trial of early weaning, 958 HIV-infected mothers and their infants were recruited and followed from birth to 24 months in Lusaka, Zambia. Half of the cohort was randomized to wean abruptly at 4 months and the other half to continue breastfeeding. We examined associations between uninfected child mortality and actual breastfeeding duration investigating possible confounding and effect modification.</p></sec><sec id="S3"><title>Results</title><p id="P3">The mortality rate among 749 uninfected children was 9.4% by 12 months and 13.6% by 24 months. Weaning during the interval encouraged by the protocol (4-5 months) was associated with a 2.03-fold increased risk of mortality (95% CI: 1.13 - 3.65), weaning 6-11 months a 3.54-fold increase (95% CI: 1.68 - 7.46) and 12-18 months a 4.22-fold increase (95% CI: 1.59 - 11.24). Significant effect modification was detected such that risks associated with weaning were stronger among infants born to mothers with higher CD4 counts (>350 cells/mL).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Shortening the normal duration of breastfeeding for uninfected children born to HIV-infected mothers living in low resource settings is associated with significant increases mortality extending into the second year of life. Intensive nutritional and counseling interventions reduce, but do not eliminate, this excess mortality.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9203213</journal-id><journal-id journal-id-type="pubmed-jr-id">1135</journal-id><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id><journal-title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</journal-title><issn pub-type="ppub">1058-4838</issn><issn pub-type="epub">1537-6591</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20047479</article-id><article-id pub-id-type="pmc">2805776</article-id><article-id pub-id-type="doi">10.1086/649886</article-id><article-id pub-id-type="manuscript">NIHMS158833</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Elevations in mortality due to weaning persist into the second year of life among uninfected children born to HIV-infected mothers</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kuhn</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sinkala</surname><given-names>Moses</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Semrau</surname><given-names>Katherine</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kankasa</surname><given-names>Chipepo</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kasonde</surname><given-names>Prisca</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Mwiya</surname><given-names>Mwiya</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Chih-Chi</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Tsai</surname><given-names>Wei-Yann</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Thea</surname><given-names>Donald M.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aldrovandi</surname><given-names>Grace M.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib></contrib-group><aff id="A1"><label>1</label>Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY</aff><aff id="A2"><label>2</label>Lusaka District Health Management Team, Lusaka, Zambia</aff><aff id="A3"><label>3</label>Center for International Health & Development, Boston University School of Public Health, Boston, MA</aff><aff id="A4"><label>4</label>University Teaching Hospital, University of Zambia, Lusaka, Zambia</aff><aff id="A5"><label>5</label>Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY</aff><aff id="A6"><label>6</label>Department of Pediatrics, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA</aff><author-notes><corresp id="CR1"><underline>Address for correspondence</underline>: Dr. Louise Kuhn, Sergievsky Center, Columbia University, 630 W 168<sup>th</sup> Street, New York, NY 10032. Tel 212-305-2398. Fax: 212-305-2426. <email>lk24@columbia.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>24</day><month>11</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>2</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>2</month><year>2011</year></pub-date><volume>50</volume><issue>3</issue><fpage>437</fpage><lpage>444</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Early weaning has been recommended to reduce postnatal HIV transmission. We evaluated the safety of stopping breastfeeding at different ages for mortality of uninfected children born to HIV-infected mothers.</p></sec><sec sec-type="methods" id="S2"><title>Methods</title><p id="P2">During a trial of early weaning, 958 HIV-infected mothers and their infants were recruited and followed from birth to 24 months in Lusaka, Zambia. Half of the cohort was randomized to wean abruptly at 4 months and the other half to continue breastfeeding. We examined associations between uninfected child mortality and actual breastfeeding duration investigating possible confounding and effect modification.</p></sec><sec id="S3"><title>Results</title><p id="P3">The mortality rate among 749 uninfected children was 9.4% by 12 months and 13.6% by 24 months. Weaning during the interval encouraged by the protocol (4-5 months) was associated with a 2.03-fold increased risk of mortality (95% CI: 1.13 - 3.65), weaning 6-11 months a 3.54-fold increase (95% CI: 1.68 - 7.46) and 12-18 months a 4.22-fold increase (95% CI: 1.59 - 11.24). Significant effect modification was detected such that risks associated with weaning were stronger among infants born to mothers with higher CD4 counts (>350 cells/mL).</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">Shortening the normal duration of breastfeeding for uninfected children born to HIV-infected mothers living in low resource settings is associated with significant increases mortality extending into the second year of life. Intensive nutritional and counseling interventions reduce, but do not eliminate, this excess mortality.</p></sec></abstract><contract-num rid="HD1">R01 HD057617-01
||HD</contract-num><contract-num rid="HD1">R01 HD040777-08
||HD</contract-num><contract-sponsor id="HD1">National Institute of Child Health & Human Development : NICHD</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0011070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0011070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.32. |  |