SidaSubSaharaV1, Pmc, Corpus, bibRecord, 000F65

Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia

Identifieur interne : 000F65 ( Pmc/Corpus ); précédent : 000F64; suivant : 000F66

Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia

Auteurs : Groesbeck P. Parham ; Vikrant V. Sahasrabuddhe ; Mulindi H. Mwanahamuntu ; Bryan E. Shepherd ; Michael L. Hicks ; Elizabeth M. Stringer ; Sten H. Vermund

Source :

Gynecologic oncology [ 0090-8258 ] ; 2006.

RBID : PMC:2748907

Abstract

Objectives

HIV-infected women living in resource-constrained nations like Zambia are now accessing antiretroviral therapy and thus may live long enough for HPV-induced cervical cancer to manifest and progress. We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia.

Methods

We screened 150 consecutive, non-pregnant HIV-infected women accessing HIV/AIDS care services in Lusaka, Zambia. We collected cervical specimens for cytological analysis by liquid-based monolayer cytology (ThinPrep Pap Test®) and HPV typing using the Roche Linear Array® PCR assay.

Results

The median age of study participants was 36 years (range 23-49 years) and their median CD4+ count was 165/μL (range 7-942). The prevalence of SIL on cytology was 76% (114/150), of which 23.3% (35/150) women had low-grade SIL, 32.6% (49/150) had high-grade SIL, and 20% (30/150) had lesions suspicious for squamous cell carcinoma (SCC). High-risk HPV types were present in 85.3% (128/150) women. On univariate analyses, age of the participant, CD4+ cell count, and presence of any high-risk HPV type were significantly associated with the presence of severely abnormal cytological lesions (i.e., high-grade SIL and lesions suspicious for SCC). Multivariable logistic regression modeling suggested the presence of any high-risk HPV type as an independent predictor of severely abnormal cytology (adjusted OR: 12.4, 95% CI 2.62-58.1, p=0.02).

Conclusions

The high prevalence of abnormal squamous cytology in our study is one of the highest reported in any population worldwide. Screening of HIV-infected women in resource-constrained settings like Zambia should be implemented to prevent development of HPV-induced SCC.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748907

DOI: 10.1016/j.ygyno.2006.06.015
PubMed: 16875716
PubMed Central: 2748907

Links to Exploration step

PMC:2748907

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia</title>
<author><name sortKey="Parham, Groesbeck P" sort="Parham, Groesbeck P" uniqKey="Parham G" first="Groesbeck P." last="Parham">Groesbeck P. Parham</name>
<affiliation><nlm:aff id="A1">School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sahasrabuddhe, Vikrant V" sort="Sahasrabuddhe, Vikrant V" uniqKey="Sahasrabuddhe V" first="Vikrant V." last="Sahasrabuddhe">Vikrant V. Sahasrabuddhe</name>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mwanahamuntu, Mulindi H" sort="Mwanahamuntu, Mulindi H" uniqKey="Mwanahamuntu M" first="Mulindi H." last="Mwanahamuntu">Mulindi H. Mwanahamuntu</name>
<affiliation><nlm:aff id="A4">University Teaching Hospital, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shepherd, Bryan E" sort="Shepherd, Bryan E" uniqKey="Shepherd B" first="Bryan E." last="Shepherd">Bryan E. Shepherd</name>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hicks, Michael L" sort="Hicks, Michael L" uniqKey="Hicks M" first="Michael L." last="Hicks">Michael L. Hicks</name>
<affiliation><nlm:aff id="A5">Pontiac Cancer Institute, Pontiac, Michigan, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stringer, Elizabeth M" sort="Stringer, Elizabeth M" uniqKey="Stringer E" first="Elizabeth M." last="Stringer">Elizabeth M. Stringer</name>
<affiliation><nlm:aff id="A1">School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vermund, Sten H" sort="Vermund, Sten H" uniqKey="Vermund S" first="Sten H." last="Vermund">Sten H. Vermund</name>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">16875716</idno>
<idno type="pmc">2748907</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748907</idno>
<idno type="RBID">PMC:2748907</idno>
<idno type="doi">10.1016/j.ygyno.2006.06.015</idno>
<date when="2006">2006</date>
<idno type="wicri:Area/Pmc/Corpus">000F65</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F65</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia</title>
<author><name sortKey="Parham, Groesbeck P" sort="Parham, Groesbeck P" uniqKey="Parham G" first="Groesbeck P." last="Parham">Groesbeck P. Parham</name>
<affiliation><nlm:aff id="A1">School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sahasrabuddhe, Vikrant V" sort="Sahasrabuddhe, Vikrant V" uniqKey="Sahasrabuddhe V" first="Vikrant V." last="Sahasrabuddhe">Vikrant V. Sahasrabuddhe</name>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mwanahamuntu, Mulindi H" sort="Mwanahamuntu, Mulindi H" uniqKey="Mwanahamuntu M" first="Mulindi H." last="Mwanahamuntu">Mulindi H. Mwanahamuntu</name>
<affiliation><nlm:aff id="A4">University Teaching Hospital, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shepherd, Bryan E" sort="Shepherd, Bryan E" uniqKey="Shepherd B" first="Bryan E." last="Shepherd">Bryan E. Shepherd</name>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hicks, Michael L" sort="Hicks, Michael L" uniqKey="Hicks M" first="Michael L." last="Hicks">Michael L. Hicks</name>
<affiliation><nlm:aff id="A5">Pontiac Cancer Institute, Pontiac, Michigan, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stringer, Elizabeth M" sort="Stringer, Elizabeth M" uniqKey="Stringer E" first="Elizabeth M." last="Stringer">Elizabeth M. Stringer</name>
<affiliation><nlm:aff id="A1">School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vermund, Sten H" sort="Vermund, Sten H" uniqKey="Vermund S" first="Sten H." last="Vermund">Sten H. Vermund</name>
<affiliation><nlm:aff id="A2">Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">School of Medicine, Vanderbilt University, Nashville, TN, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Gynecologic oncology</title>
<idno type="ISSN">0090-8258</idno>
<idno type="eISSN">1095-6859</idno>
<imprint><date when="2006">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P2">HIV-infected women living in resource-constrained nations like Zambia are now accessing antiretroviral therapy and thus may live long enough for HPV-induced cervical cancer to manifest and progress. We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We screened 150 consecutive, non-pregnant HIV-infected women accessing HIV/AIDS care services in Lusaka, Zambia. We collected cervical specimens for cytological analysis by liquid-based monolayer cytology (ThinPrep Pap Test®) and HPV typing using the Roche Linear Array® PCR assay.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">The median age of study participants was 36 years (range 23-49 years) and their median CD4+ count was 165/μL (range 7-942). The prevalence of SIL on cytology was 76% (114/150), of which 23.3% (35/150) women had low-grade SIL, 32.6% (49/150) had high-grade SIL, and 20% (30/150) had lesions suspicious for squamous cell carcinoma (SCC). High-risk HPV types were present in 85.3% (128/150) women. On univariate analyses, age of the participant, CD4+ cell count, and presence of any high-risk HPV type were significantly associated with the presence of severely abnormal cytological lesions (i.e., high-grade SIL and lesions suspicious for SCC). Multivariable logistic regression modeling suggested the presence of any high-risk HPV type as an independent predictor of severely abnormal cytology (adjusted OR: 12.4, 95% CI 2.62-58.1, <italic>p</italic>
=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">The high prevalence of abnormal squamous cytology in our study is one of the highest reported in any population worldwide. Screening of HIV-infected women in resource-constrained settings like Zambia should be implemented to prevent development of HPV-induced SCC.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">0365304</journal-id>
<journal-id journal-id-type="pubmed-jr-id">3932</journal-id>
<journal-id journal-id-type="nlm-ta">Gynecol Oncol</journal-id>
<journal-title>Gynecologic oncology</journal-title>
<issn pub-type="ppub">0090-8258</issn>
<issn pub-type="epub">1095-6859</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">16875716</article-id>
<article-id pub-id-type="pmc">2748907</article-id>
<article-id pub-id-type="doi">10.1016/j.ygyno.2006.06.015</article-id>
<article-id pub-id-type="manuscript">NIHMS132957</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Parham</surname>
<given-names>Groesbeck P.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sahasrabuddhe</surname>
<given-names>Vikrant V.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mwanahamuntu</surname>
<given-names>Mulindi H.</given-names>
</name>
<xref ref-type="aff" rid="A4">d</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shepherd</surname>
<given-names>Bryan E.</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hicks</surname>
<given-names>Michael L.</given-names>
</name>
<xref ref-type="aff" rid="A5">e</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stringer</surname>
<given-names>Elizabeth M.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vermund</surname>
<given-names>Sten H.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA</aff>
<aff id="A2"><label>b</label>
Center for Infectious Disease Research in Zambia, Lusaka, Zambia, USA</aff>
<aff id="A3"><label>c</label>
School of Medicine, Vanderbilt University, Nashville, TN, USA</aff>
<aff id="A4"><label>d</label>
University Teaching Hospital, Lusaka, Zambia, USA</aff>
<aff id="A5"><label>e</label>
Pontiac Cancer Institute, Pontiac, Michigan, USA</aff>
<author-notes><fn fn-type="corresp" id="FN1"><label>*</label>
<p id="P1">Corresponding author. Department of Medicine, Div. of Infectious Diseases-Center for AIDS Research, Center for Infectious Disease Research in Zambia, University of Alabama at Birmingham, Community Care Building, 908-20th Street South, Birmingham, AL 35294, USA. Fax: +1 205 975 6448. <italic>E-mail address:</italic>
 <email>gparham@uabmc.edu</email>
 (G.P. Parham).</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>21</day>
<month>7</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>7</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2006</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>22</day>
<month>9</month>
<year>2009</year>
</pub-date>
<volume>103</volume>
<issue>3</issue>
<fpage>1017</fpage>
<lpage>1022</lpage>
<permissions><copyright-statement>© 2006 Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2006</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Objectives</title>
<p id="P2">HIV-infected women living in resource-constrained nations like Zambia are now accessing antiretroviral therapy and thus may live long enough for HPV-induced cervical cancer to manifest and progress. We evaluated the prevalence and predictors of cervical squamous intraepithelial lesions (SIL) among HIV-infected women in Zambia.</p>
</sec>
<sec sec-type="methods" id="S2"><title>Methods</title>
<p id="P3">We screened 150 consecutive, non-pregnant HIV-infected women accessing HIV/AIDS care services in Lusaka, Zambia. We collected cervical specimens for cytological analysis by liquid-based monolayer cytology (ThinPrep Pap Test®) and HPV typing using the Roche Linear Array® PCR assay.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P4">The median age of study participants was 36 years (range 23-49 years) and their median CD4+ count was 165/μL (range 7-942). The prevalence of SIL on cytology was 76% (114/150), of which 23.3% (35/150) women had low-grade SIL, 32.6% (49/150) had high-grade SIL, and 20% (30/150) had lesions suspicious for squamous cell carcinoma (SCC). High-risk HPV types were present in 85.3% (128/150) women. On univariate analyses, age of the participant, CD4+ cell count, and presence of any high-risk HPV type were significantly associated with the presence of severely abnormal cytological lesions (i.e., high-grade SIL and lesions suspicious for SCC). Multivariable logistic regression modeling suggested the presence of any high-risk HPV type as an independent predictor of severely abnormal cytology (adjusted OR: 12.4, 95% CI 2.62-58.1, <italic>p</italic>
=0.02).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P5">The high prevalence of abnormal squamous cytology in our study is one of the highest reported in any population worldwide. Screening of HIV-infected women in resource-constrained settings like Zambia should be implemented to prevent development of HPV-induced SCC.</p>
</sec>
</abstract>
<kwd-group><kwd>HIV</kwd>
<kwd>Cervical Cancer</kwd>
<kwd>Screening</kwd>
<kwd>Cytology</kwd>
<kwd>Zambia</kwd>
</kwd-group>
<contract-num rid="TW1">D43 TW001035-08</contract-num>
<contract-sponsor id="TW1">Fogarty International Center : FIC</contract-sponsor>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F65 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000F65 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:2748907
   |texte=   Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:16875716" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SidaSubSaharaV1

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia

Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki