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Which Patients First? Setting Priorities for Antiretroviral Therapy Where Resources Are Limited

Identifieur interne : 000A96 ( Pmc/Corpus ); précédent : 000A95; suivant : 000A97

Which Patients First? Setting Priorities for Antiretroviral Therapy Where Resources Are Limited

Auteurs : Laura J. Mcgough ; Steven J. Reynolds ; Thomas C. Quinn ; Jonathan M. Zenilman

Source :

RBID : PMC:1449336

Abstract

The availability of limited funds from international agencies for the purchase of antiretroviral (ARV) treatment in developing countries presents challenges, especially in prioritizing who should receive therapy. Public input and the protection of human rights are crucial in making treatment programs equitable and accountable. By examining historical precedents of resource allocation, we aim to provoke and inform debate about current ARV programs.

Through a critical review of the published literature, we evaluate 4 precedents for key lessons: the discovery of insulin for diabetes in 1922, the release of penicillin for civilian use in 1943, the development of chronic hemodialysis programs in 1961, and current allocation of liver transplants. We then describe current rationing mechanisms for ARVs.


Url:
DOI: 10.2105/AJPH.2004.052738
PubMed: 15983271
PubMed Central: 1449336

Links to Exploration step

PMC:1449336

Le document en format XML

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<nlm:aff id="aff1">At the time this article was written, all authors were with the Department of Infectious Diseases, Johns Hopkins University, Baltimore, Md. Laura J. McGough is also with the Department of the History of Medicine, Johns Hopkins University. Steven J. Reynolds and Thomas C. Quinn are also with the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.</nlm:aff>
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<p>The availability of limited funds from international agencies for the purchase of antiretroviral (ARV) treatment in developing countries presents challenges, especially in prioritizing who should receive therapy. Public input and the protection of human rights are crucial in making treatment programs equitable and accountable. By examining historical precedents of resource allocation, we aim to provoke and inform debate about current ARV programs.</p>
<p>Through a critical review of the published literature, we evaluate 4 precedents for key lessons: the discovery of insulin for diabetes in 1922, the release of penicillin for civilian use in 1943, the development of chronic hemodialysis programs in 1961, and current allocation of liver transplants. We then describe current rationing mechanisms for ARVs.</p>
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<aff id="aff1">At the time this article was written, all authors were with the Department of Infectious Diseases, Johns Hopkins University, Baltimore, Md. Laura J. McGough is also with the Department of the History of Medicine, Johns Hopkins University. Steven J. Reynolds and Thomas C. Quinn are also with the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.</aff>
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<italic>Requests for reprints should be sent to Jonathan M. Zenilman, MD, Infectious Diseases Division, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, B-3 North, Baltimore, MD 21224 (e-mail:
<email>jzenilma@jhmi.edu</email>
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<copyright-statement>© American Journal of Public Health 2005</copyright-statement>
<copyright-year>2005</copyright-year>
<abstract>
<p>The availability of limited funds from international agencies for the purchase of antiretroviral (ARV) treatment in developing countries presents challenges, especially in prioritizing who should receive therapy. Public input and the protection of human rights are crucial in making treatment programs equitable and accountable. By examining historical precedents of resource allocation, we aim to provoke and inform debate about current ARV programs.</p>
<p>Through a critical review of the published literature, we evaluate 4 precedents for key lessons: the discovery of insulin for diabetes in 1922, the release of penicillin for civilian use in 1943, the development of chronic hemodialysis programs in 1961, and current allocation of liver transplants. We then describe current rationing mechanisms for ARVs.</p>
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<p>Peer Reviewed</p>
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<bold>Contributors</bold>
…L. J. McGough conceived the study and led the research and writing. S. J. Reynolds and T. C. Quinn offered technical advice and analysis. J. M. Zenilman supervised the entire process of analysis and article preparation. All authors helped to conceptualize ideas, interpret findings, and revise drafts of the article.</p>
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