Low birth weight and macrosomia in Tigray, Northern Ethiopia: who are the mothers at risk?
Identifieur interne : 000671 ( Pmc/Corpus ); précédent : 000670; suivant : 000672Low birth weight and macrosomia in Tigray, Northern Ethiopia: who are the mothers at risk?
Auteurs : Hayelom Gebrekirstos Mengesha ; Alem Desta Wuneh ; Berhe Weldearegawi ; Divya L. SelvakumarSource :
- BMC Pediatrics [ 1471-2431 ] ; 2017.
Abstract
Infant birth weight, which is classified into low birth weight, normal birth weight and macrosomia, is associated with short and long-term health consequences, such as neonatal mortality and chronic disease in life. Macrosomia and low birth weight are double burden problems in developing counties, such as Ethiopia, but the paucity of evidence has made it difficult to assess the extent of this situation. As a result there has been inconsistency in the reported prevalence of low birth weight and macrosomia in Ethiopia. This study aimed to determine the incidence and predictors of low birth weight and macrosomia in Tigray, Northern Ethiopia.
We conducted a cross-sectional survey among a cohort of 1152 neonates delivered in Tigray Region at randomly selected hospitals between April and July 2014. We used the birth weight category described previously as an outcome variable. Data were collected using structured questionnaire by midwives. We entered and analyzed data using STATA™ Version 11.0. Data were described using a frequency, percentage, relative risk ratio, and 95% confidence interval. Multinomial logistic regression was conducted to identify independent predictors of low birth weight and macrosomia.
In this study, we found a 10.5% and 6.68% incidence of low birth weight and macrosomia, respectively. Seventy (57.8%) of all low birth weight neonates were term births. The predictors for low birth weight were: early marriage (<18 year) (RRR: 0.59, CI: 0.35–0.97); rural residence (RRR: 0.53, CI: 0.32–0.9); prematurity (RRR: 15.4, CI: 9.18–25.9); no antenatal follow-up (RRR: 6.78, CI: 2.39–19.25); and female sex (RRR: 1.77, CI: 1.13–2.77). Predictors for macrosomia were: female gender (RRR: 0.58, CI: 0.35–0.9); high body mass index (RRR: 5.0, CI: 1.56–16); post-maturity (RRR: 2.23, CI: 1.06–4.6); and no maternal complication (RRR: 0.46, CI: 0.27–0.8).
In this study, we found gestational age and gender of the neonate to be common risk factors for both low birth weight and macrosomia. Strengthening antenatal follow up, prevention of pre and post maturity, controlling body mass index, and improving socioeconomic status of mothers are recommendations to prevent the double burden (low birth weight and macrosomia) and associated short and long-term consequences.
Url:
DOI: 10.1186/s12887-017-0901-1
PubMed: 28606178
PubMed Central: 5469141
Links to Exploration step
PMC:5469141Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Low birth weight and macrosomia in Tigray, Northern Ethiopia: who are the mothers at risk?</title><author><name sortKey="Mengesha, Hayelom Gebrekirstos" sort="Mengesha, Hayelom Gebrekirstos" uniqKey="Mengesha H" first="Hayelom Gebrekirstos" last="Mengesha">Hayelom Gebrekirstos Mengesha</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1783 9494</institution-id><institution-id institution-id-type="GRID">grid.472243.4</institution-id><institution>College of Medicine and Health Sciences,</institution><institution>Adigrat University,</institution></institution-wrap>Adigrat, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Wuneh, Alem Desta" sort="Wuneh, Alem Desta" uniqKey="Wuneh A" first="Alem Desta" last="Wuneh">Alem Desta Wuneh</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>School of Public Health,</institution><institution>Mekelle University,</institution></institution-wrap>Mekelle, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Weldearegawi, Berhe" sort="Weldearegawi, Berhe" uniqKey="Weldearegawi B" first="Berhe" last="Weldearegawi">Berhe Weldearegawi</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>School of Public Health,</institution><institution>Mekelle University,</institution></institution-wrap>Mekelle, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Selvakumar, Divya L" sort="Selvakumar, Divya L" uniqKey="Selvakumar D" first="Divya L." last="Selvakumar">Divya L. Selvakumar</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8935 936X</institution-id><institution-id institution-id-type="GRID">grid.421826.b</institution-id><institution></institution><institution>School of Public Health, Montgomery College,</institution></institution-wrap>Rockville, MD USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28606178</idno><idno type="pmc">5469141</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469141</idno><idno type="RBID">PMC:5469141</idno><idno type="doi">10.1186/s12887-017-0901-1</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000671</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000671</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Low birth weight and macrosomia in Tigray, Northern Ethiopia: who are the mothers at risk?</title><author><name sortKey="Mengesha, Hayelom Gebrekirstos" sort="Mengesha, Hayelom Gebrekirstos" uniqKey="Mengesha H" first="Hayelom Gebrekirstos" last="Mengesha">Hayelom Gebrekirstos Mengesha</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1783 9494</institution-id><institution-id institution-id-type="GRID">grid.472243.4</institution-id><institution>College of Medicine and Health Sciences,</institution><institution>Adigrat University,</institution></institution-wrap>Adigrat, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Wuneh, Alem Desta" sort="Wuneh, Alem Desta" uniqKey="Wuneh A" first="Alem Desta" last="Wuneh">Alem Desta Wuneh</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>School of Public Health,</institution><institution>Mekelle University,</institution></institution-wrap>Mekelle, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Weldearegawi, Berhe" sort="Weldearegawi, Berhe" uniqKey="Weldearegawi B" first="Berhe" last="Weldearegawi">Berhe Weldearegawi</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>School of Public Health,</institution><institution>Mekelle University,</institution></institution-wrap>Mekelle, Ethiopia</nlm:aff></affiliation></author><author><name sortKey="Selvakumar, Divya L" sort="Selvakumar, Divya L" uniqKey="Selvakumar D" first="Divya L." last="Selvakumar">Divya L. Selvakumar</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8935 936X</institution-id><institution-id institution-id-type="GRID">grid.421826.b</institution-id><institution></institution><institution>School of Public Health, Montgomery College,</institution></institution-wrap>Rockville, MD USA</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Pediatrics</title><idno type="eISSN">1471-2431</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Infant birth weight, which is classified into low birth weight, normal birth weight and macrosomia, is associated with short and long-term health consequences, such as neonatal mortality and chronic disease in life. Macrosomia and low birth weight are double burden problems in developing counties, such as Ethiopia, but the paucity of evidence has made it difficult to assess the extent of this situation. As a result there has been inconsistency in the reported prevalence of low birth weight and macrosomia in Ethiopia. This study aimed to determine the incidence and predictors of low birth weight and macrosomia in Tigray, Northern Ethiopia.</p></sec><sec><title>Method</title><p>We conducted a cross-sectional survey among a cohort of 1152 neonates delivered in Tigray Region at randomly selected hospitals between April and July 2014. We used the birth weight category described previously as an outcome variable. Data were collected using structured questionnaire by midwives. We entered and analyzed data using STATA™ Version 11.0. Data were described using a frequency, percentage, relative risk ratio, and 95% confidence interval. Multinomial logistic regression was conducted to identify independent predictors of low birth weight and macrosomia.</p></sec><sec><title>Result</title><p>In this study, we found a 10.5% and 6.68% incidence of low birth weight and macrosomia, respectively. Seventy (57.8%) of all low birth weight neonates were term births. The predictors for low birth weight were: early marriage (<18 year) (RRR: 0.59, CI: 0.35–0.97); rural residence (RRR: 0.53, CI: 0.32–0.9); prematurity (RRR: 15.4, CI: 9.18–25.9); no antenatal follow-up (RRR: 6.78, CI: 2.39–19.25); and female sex (RRR: 1.77, CI: 1.13–2.77). Predictors for macrosomia were: female gender (RRR: 0.58, CI: 0.35–0.9); high body mass index (RRR: 5.0, CI: 1.56–16); post-maturity (RRR: 2.23, CI: 1.06–4.6); and no maternal complication (RRR: 0.46, CI: 0.27–0.8).</p></sec><sec><title>Conclusion</title><p>In this study, we found gestational age and gender of the neonate to be common risk factors for both low birth weight and macrosomia. Strengthening antenatal follow up, prevention of pre and post maturity, controlling body mass index, and improving socioeconomic status of mothers are recommendations to prevent the double burden (low birth weight and macrosomia) and associated short and long-term consequences.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Badshah, S" uniqKey="Badshah S">S Badshah</name></author><author><name sortKey="Mason, L" uniqKey="Mason L">L Mason</name></author><author><name sortKey="Mckelvie, K" uniqKey="Mckelvie K">K McKelvie</name></author><author><name sortKey="Payne, R" uniqKey="Payne R">R Payne</name></author><author><name sortKey="Lisboa, Pj" uniqKey="Lisboa P">PJ Lisboa</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Berard, J" uniqKey="Berard J">J Berard</name></author><author><name sortKey="Dufour, P" uniqKey="Dufour P">P Dufour</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Pediatr</journal-id><journal-id journal-id-type="iso-abbrev">BMC Pediatr</journal-id><journal-title-group><journal-title>BMC Pediatrics</journal-title></journal-title-group><issn pub-type="epub">1471-2431</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28606178</article-id><article-id pub-id-type="pmc">5469141</article-id><article-id pub-id-type="publisher-id">901</article-id><article-id pub-id-type="doi">10.1186/s12887-017-0901-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Low birth weight and macrosomia in Tigray, Northern Ethiopia: who are the mothers at risk?</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Mengesha</surname><given-names>Hayelom Gebrekirstos</given-names></name><address><email>hayetgeb@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Wuneh</surname><given-names>Alem Desta</given-names></name><address><email>alemdw@gmail.com</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Weldearegawi</surname><given-names>Berhe</given-names></name><address><email>berheph@gmail.com</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Selvakumar</surname><given-names>Divya L.</given-names></name><address><email>divyals123@gmail.com</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1783 9494</institution-id><institution-id institution-id-type="GRID">grid.472243.4</institution-id><institution>College of Medicine and Health Sciences,</institution><institution>Adigrat University,</institution></institution-wrap>Adigrat, Ethiopia</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 1539 8988</institution-id><institution-id institution-id-type="GRID">grid.30820.39</institution-id><institution>School of Public Health,</institution><institution>Mekelle University,</institution></institution-wrap>Mekelle, Ethiopia</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 8935 936X</institution-id><institution-id institution-id-type="GRID">grid.421826.b</institution-id><institution></institution><institution>School of Public Health, Montgomery College,</institution></institution-wrap>Rockville, MD USA</aff></contrib-group><pub-date pub-type="epub"><day>12</day><month>6</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>6</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>17</volume><elocation-id>144</elocation-id><history><date date-type="received"><day>17</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>5</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s). 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Infant birth weight, which is classified into low birth weight, normal birth weight and macrosomia, is associated with short and long-term health consequences, such as neonatal mortality and chronic disease in life. Macrosomia and low birth weight are double burden problems in developing counties, such as Ethiopia, but the paucity of evidence has made it difficult to assess the extent of this situation. As a result there has been inconsistency in the reported prevalence of low birth weight and macrosomia in Ethiopia. This study aimed to determine the incidence and predictors of low birth weight and macrosomia in Tigray, Northern Ethiopia.</p></sec><sec><title>Method</title><p>We conducted a cross-sectional survey among a cohort of 1152 neonates delivered in Tigray Region at randomly selected hospitals between April and July 2014. We used the birth weight category described previously as an outcome variable. Data were collected using structured questionnaire by midwives. We entered and analyzed data using STATA™ Version 11.0. Data were described using a frequency, percentage, relative risk ratio, and 95% confidence interval. Multinomial logistic regression was conducted to identify independent predictors of low birth weight and macrosomia.</p></sec><sec><title>Result</title><p>In this study, we found a 10.5% and 6.68% incidence of low birth weight and macrosomia, respectively. Seventy (57.8%) of all low birth weight neonates were term births. The predictors for low birth weight were: early marriage (<18 year) (RRR: 0.59, CI: 0.35–0.97); rural residence (RRR: 0.53, CI: 0.32–0.9); prematurity (RRR: 15.4, CI: 9.18–25.9); no antenatal follow-up (RRR: 6.78, CI: 2.39–19.25); and female sex (RRR: 1.77, CI: 1.13–2.77). Predictors for macrosomia were: female gender (RRR: 0.58, CI: 0.35–0.9); high body mass index (RRR: 5.0, CI: 1.56–16); post-maturity (RRR: 2.23, CI: 1.06–4.6); and no maternal complication (RRR: 0.46, CI: 0.27–0.8).</p></sec><sec><title>Conclusion</title><p>In this study, we found gestational age and gender of the neonate to be common risk factors for both low birth weight and macrosomia. Strengthening antenatal follow up, prevention of pre and post maturity, controlling body mass index, and improving socioeconomic status of mothers are recommendations to prevent the double burden (low birth weight and macrosomia) and associated short and long-term consequences.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Low birth weight</kwd><kwd>Macrosomia</kwd><kwd>Multinomial regression</kwd><kwd>Northern Ethiopia</kwd><kwd>Tigray</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Background</title><p>Birth weight is an important indicator in the prediction of short- and long-term health outcomes [<xref ref-type="bibr" rid="CR1">1</xref>]. Based on birth weight, the World Health Organization (WHO) classifies infants as Low Birth Weight(LBW) (<2500 g), Normal birth weight (2500–4000), and Macrosomia (≥4000 g) [<xref ref-type="bibr" rid="CR2">2</xref>, <xref ref-type="bibr" rid="CR3">3</xref>]. Evidence shows that pregnancies with macrosomic infants are associated with increased risk of complications for both the neonates and their mothers [<xref ref-type="bibr" rid="CR4">4</xref>–<xref ref-type="bibr" rid="CR6">6</xref>]. Macrosomia is associated with increased risk of perinatal asphyxia, death, and shoulder dystocia. Similarly, mothers with macrosomic pregnancies are at an increased risk of caesarean section, prolonged labor, abnormal hemorrhage, perineal trauma and adverse perinatal outcomes [<xref ref-type="bibr" rid="CR4">4</xref>–<xref ref-type="bibr" rid="CR6">6</xref>]. The incidence of fetal macrosomia significantly varies across different geographic regions, with frequency ranging from 0.5% to 15% in 23 developing countries in Africa, Asia, and Latin America [<xref ref-type="bibr" rid="CR6">6</xref>]. In developing countries the prevalence of LBW is estimated to be 19%, in comparison to between 5% and 7% in developed countries, [<xref ref-type="bibr" rid="CR7">7</xref>]. In sub-Saharan Africa, the rate of LBW has been reported between 12 and 17% [<xref ref-type="bibr" rid="CR8">8</xref>–<xref ref-type="bibr" rid="CR10">10</xref>].</p><p>Studies also showed macrosomia to be associated with long-term consequences including obesity, diabetes, and heart disease [<xref ref-type="bibr" rid="CR11">11</xref>–<xref ref-type="bibr" rid="CR15">15</xref>]. LBW is a significant determinant of infant and childhood morbidity, particularly of neuro-development impairments, such as mental retardation and learning disabilities. It is also closely associated with fetal and neonatal mortality and morbidity, inhibited growth, cognitive delays, and chronic diseases later in life [<xref ref-type="bibr" rid="CR16">16</xref>]. Hence, both macrosomia and LBW are associated with long-term consequences, which may lead to economic and social burdens unless efforts are undertaken to modify/address the major risk factors.</p><p>Several maternal characteristics, such as prior history of diabetes, prolonged gestation, multiparty, older maternal age, short height, high body mass index, and significant weight gain during pregnancy are associated with an increased risk of macrosomia [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR17">17</xref>–<xref ref-type="bibr" rid="CR19">19</xref>]. Due to a rapid increase in the prevalence of overweight and obese conditions of the reproductive age population, macrosomia and its complications are rapidly increasing in developing countries [<xref ref-type="bibr" rid="CR6">6</xref>]. However, in Ethiopia, there is no evidence on the levels of macrosomia and complications resulting from it.</p><p>There is evidence that the risk factors for LBW, such as high risk pregnancy, extremes of age at time of pregnancy, anemia, pregnancy-induced hypertension, and poor nutritional status, are widely reported in Sub-Saharan Africa including Ethiopia [<xref ref-type="bibr" rid="CR8">8</xref>–<xref ref-type="bibr" rid="CR10">10</xref>, <xref ref-type="bibr" rid="CR20">20</xref>, <xref ref-type="bibr" rid="CR21">21</xref>]. Though there is not sufficient evidence regarding the magnitude of LBW, some studies in Ethiopia have reported that the incidence may be as high as one LBW in every 10 live births [<xref ref-type="bibr" rid="CR9">9</xref>, <xref ref-type="bibr" rid="CR22">22</xref>].</p><p>Findings from recent studies in Ethiopia have shown that despite the decline in infant and child mortality, neonatal mortality remains unacceptably high [<xref ref-type="bibr" rid="CR22">22</xref>, <xref ref-type="bibr" rid="CR23">23</xref>]. Despite the significant improvement in health and health related indicators over the last decade, Ethiopia still bears one of the highest burdens of maternal mortality [<xref ref-type="bibr" rid="CR23">23</xref>, <xref ref-type="bibr" rid="CR24">24</xref>]. Of note, a recent study in eastern Ethiopia reported that one in every five pregnant women were malnourished [<xref ref-type="bibr" rid="CR25">25</xref>]. It is also well established that LBW is the significant contributor for neonatal and infant deaths [<xref ref-type="bibr" rid="CR26">26</xref>]. It is in this context, that the imperative to investigate the levels and underlying risk factors of both LBW and macrosomia arises in order to inform future policy and interventions to reduce maternal and neonatal morbidity and mortality.</p><p>The present study aims to measure the levels of LBW and macrosomia among women in Tigray region. In addition, the study identifies maternal and obstetric characteristics associated with the risk of LBW, and macrosomia in this setting in an effort to identify potentially modifiable factors in order to mitigate their short and long-term consequences.</p></sec><sec id="Sec2"><title>Method</title><sec id="Sec3"><title>Study design</title><p>This study is a part of a large prospective observational study undertaken in one of the nine administrative regions of Ethiopia to investigate pregnancy outcome and neonatal survival. The current study is a cross-sectional survey of 1162 neonates-maternal dyads delivered in select hospitals between April and July 2014 in Tigray, Ethiopia. Details of sample size calculation and sampling procedure have been published previously [<xref ref-type="bibr" rid="CR27">27</xref>].</p></sec><sec id="Sec4"><title>Study setting and population</title><p>This study was conducted in seven randomly selected public hospitals in Tigray region, northern Ethiopia. Tigray Region is one of the 11 administrative states in Ethiopia with a total population of 5,055,999 (49.2% male and 50.8% female). The Ethiopian health system is structured into a three-tier system with the primary care level comprised of health posts, health centers and primary hospitals, the secondary care level including general hospitals, and the tertiary care level of specialized hospitals. In Tigray region there are 15 public general hospitals, 1 specialized referral hospital and 20 primary hospitals, 204 health centers and 712 health posts. All general hospitals and specialized referral hospital provide comprehensive maternal and newborn services, emergency and elective caesarean sections. This study was conducted in the specialized referral hospital, and six general hospitals which were randomly selected from the 16 hospitals of the region by lottery method [<xref ref-type="bibr" rid="CR28">28</xref>].</p></sec><sec id="Sec5"><title>Data collection and quality assurance</title><p>Data were collected using a pre-tested structured questionnaire on 5% of the sample size to improve clarity and modify the data collection instruments and a checklist adapted from the WHO standard verbal neonatal autopsy questionnaires [<xref ref-type="bibr" rid="CR29">29</xref>]. The questionnaire was initially developed in English and translated to local language (i.e., Tigrigna). Two degree-prepared midwives, who were fluent Tigrigna speakers, were recruited for data collection. The data collectors interviewed all mothers who had live births at the selected hospitals. This interview was done within the first 6-h after delivery. In addition, clinical information, including maternal complications, birth weight, gestational age and any relevant medical diagnosis, was extracted through assessment of the neonate and mother. Prospective data collected including sociodemographic, neonatal, maternal, and health service-related characteristics.</p></sec><sec id="Sec6"><title>Inclusion and exclusion criteria</title><p>Women, who experienced live births in the study hospitals from April –July, 2014 were included in the study. Mothers who were unable to speak and mothers with psychiatric illnesses were excluded from the study.</p></sec><sec id="Sec7"><title>Assessment and definition of variables</title><p>Considering previous evidence and the nature of our study, which includes both clinical and sociodemographic characteristics, the independent variables were broadly categorized as distal, intermediate, and proximal. Distal variables included socioeconomic and demographic factors such as: reported income [low (<500 ETB), medium (500–2000 ETB) and rich (>2000ETB)]; residence [urban and rural]; age at first marriage [below age of 18, 18 years and above]. Intermediate factors related to maternal, neonatal, and health services included: maternal factors, such as body mass index (BMI) [underweight (BMI less than 18.5), normal (BMI 18.5–24.99), overweight (BMI >25.0)]; fertility (number of live children) [primiparae, 2–4 and multiparty (≥5)]; antenatal follow up is defined as care or supervision given to a pregnant, parturient, peurperal woman so as to enable her to pass through the dangers of pregnancy with least possible risk. It was categorized into [“yes” if the mother had at least one antenatal follow up; “no” if the mother never had antenatal follow up]; neonatal factors such as birth weight [measured using a standard beam balance within one hour of delivery], gender [female/male], gestational age [measured by using last menstrual period and/or ultrasound and categorized as preterm (<259 days), term (259–293 days) and post- term birth (≥294 days]</p><p>Diagnosed medical disease was assessed using “yes” if the mother had a medical diagnosis (i.e., HIV/AIDS, hypertension, or diabetes mellitus), either during the delivery or before delivery and “no” if the mother did not have such a diagnosis.</p><p>Proximal variables included maternal complication (i.e., obstetric hemorrhage, puerperal sepsis and pyrexia, prolonged labour, (pre)eclampsia, malpresentation or malposition, premature rupture of membranes, cord prolapse, obstructed labour, cephalo-pelvic disproportion, emergency caesarean section, and retained placenta). Categorized as “yes” or “no”.</p></sec><sec id="Sec8"><title>Data analysis and management</title><p>The distribution of maternal and neonatal characteristics by type of pregnancy outcome was summarized using frequency distribution, with prevalence of LBW and macrosomia were also reported. Categorical data was described using frequency and percentage. Birth weight was analyzed by categorizing into three outcome variables - LBW, normal birth weight (base) and macrosomia, which were considered as nominal variables.</p><p>To identify the predictors of LBW and macrosomia, we used multinomial logistic regression. A bivariable multinomial logistic regression was performed using the crude risk ratio of regression, and variables with likelihood ratio test <italic>P</italic>-values of less than 0.05 were retained in the multiple regression models. Multivariable multinomial logistic regression was used to estimate the relative risk ratio (RRR) and corresponding 95% confidence interval (CI) of the association between birth weight and predictors at <italic>P</italic> < 0.05. Interaction between predictor variables was tested at a significance level <italic>P</italic> < 0.05 by including an interaction term in the multivariate model. Potential predictors were categorized into three hierarchies: 1) proximal factors 2) intermediate factors (such as maternal, neonatal and health service factors) and 3) distal factors (such as sociodemographic and economic variables). Data was entered, cleaned, and analyzed using STATA™ version 11.0 statistical packages.</p></sec></sec><sec id="Sec9"><title>Result</title><sec id="Sec10"><title>Sociodemographic characteristics of participants</title><p>Responses were obtained from all participants (<italic>n</italic> = 1162); however, ten (0.96%) observations were excluded from the analysis due to incompleteness. The mean current age of mothers was 26.6 ± 5.4. Nearly half 55(45%) of the mothers of LBW babies were married before age 18, while almost two-third 50(64.8%) of mothers of macrosomic babies married at the age of 18 or above.</p><p>The study revealed the highest number [25(20.7%)] of LBW neonates and of macrosomia neonates [16(20.6%)] were delivered in Ayder (referral) and Suhl (Zonal) hospitals, respectively. Maternal residence indicated 755(65.5%) resided in the urban settings and the remaining numbers resided in the rural areas. Of these, the highest proportion of 62 mothers (51.2%) of LBW neonates were delivered by rural mothers, while 54 mothers (70.1%) of macrosomic neonates were from urban mothers (Table <xref rid="Tab1" ref-type="table">1</xref>). Bivariable analysis using multinomial regression showed urban residence was associated with LBW (RRR: 0.46, CI: 0.3–0.67) but not associated with macrosomia (RRR: 1.1, CI: 0.68–1.89). Mothers who married first at ≥18 years old were at less risk to deliver LBW (RRR: 0.5, CI: 0.35–0.75) but maternal age was not associated with macrosomia (RRR: 0.79, CI: 0.48–1.29).<table-wrap id="Tab1"><label>Table 1</label><caption><p>Association of selected socio-demographic characteristics with low birth weight and macrosomia on neonates born in Tigray, Northern Ethiopia, April–July, 2014 (<italic>n</italic> = 1152)</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Characteristics</th><th colspan="2">Total live births</th><th>LBW</th><th>Macrosomia</th><th>LBW & Macrosomia</th></tr><tr><th>Freq.</th><th>Percent</th><th>Freq (RRR, 95% CI)</th><th>Freq (RRR, 95% CI)</th><th><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="6">Hospital</td></tr><tr><td> Ayder Referral</td><td>139</td><td>12.1</td><td>25</td><td>12</td><td></td></tr><tr><td> Adwa Hospital</td><td>198</td><td>17.2</td><td>19</td><td>11</td><td></td></tr><tr><td> Lemlem Karl</td><td>147</td><td>12.8</td><td>15</td><td>8</td><td></td></tr><tr><td> Suhl Hospital</td><td>143</td><td>12.4</td><td>23</td><td>16</td><td></td></tr><tr><td> Kahsay Abera</td><td>102</td><td>8.8</td><td>7</td><td>8</td><td></td></tr><tr><td> Kidist Mariam</td><td>213</td><td>18.5</td><td>21</td><td>12</td><td></td></tr><tr><td> Adigrat</td><td>210</td><td>18.2</td><td>11</td><td>10</td><td></td></tr><tr><td colspan="6">Residence</td></tr><tr><td> Rural</td><td>397</td><td>34.5</td><td>62(ref)</td><td>23(ref)</td><td></td></tr><tr><td> Urban</td><td>755</td><td>65.5</td><td>59(0.46, 0.3–0.67)</td><td>54(1.1, 0.68–1.89)</td><td><0.001,0.61</td></tr><tr><td colspan="6">Educational status</td></tr><tr><td> Unable to read</td><td>275</td><td>23.9</td><td>50(ref)</td><td>15(ref)</td><td></td></tr><tr><td> Primary</td><td>338</td><td>29.3</td><td>23(0.33, 0.2–0.56)</td><td>24(1.15, 0.59–2.25)</td><td><0.001,0.67</td></tr><tr><td> Secondary</td><td>361</td><td>31.3</td><td>31(0.42, 0.26–0.7)</td><td>22(1, 0.5–1.97)</td><td><0.001,0.99</td></tr><tr><td> Tertiary</td><td>178</td><td>15.5</td><td>17(0.49, 0.27–0.9)</td><td>16(1.54, 0.74–3.22)</td><td>0.019, 0.25</td></tr><tr><td colspan="6">Income<sup>a</sup></td></tr><tr><td> Poor</td><td>327</td><td>32.2</td><td>40(ref)</td><td>20(ref)</td><td>ref</td></tr><tr><td> Medium</td><td>316</td><td>31.1</td><td>33(0.83, 0.5–1.36)</td><td>20(1.01, 0.53–1.93)</td><td>0.47,0.31</td></tr><tr><td> Rich</td><td>373</td><td>36.7</td><td>36(0.78, 0.5–1.25)</td><td>29(1.25, 0.69–2.27)</td><td>0.96,0.45</td></tr><tr><td colspan="6">Age at marriage</td></tr><tr><td> < 18</td><td>368</td><td>31.9</td><td>55(ref)</td><td>27(ref)</td><td></td></tr><tr><td> ≥ 18</td><td>784</td><td>68.1</td><td>66(0.5, 0.35–0.75)</td><td>50(0.79, 0.48–1.29)</td><td>0.001,0.35</td></tr></tbody></table><table-wrap-foot><p><italic>RRR</italic> Relative Risk Ratio, <italic>CI</italic> Confidence Interval, <italic>Ref</italic> Reference</p><p><sup>a</sup>Rich ≥ 1500, Ethiopian birr (ETB), Medium:600–1500 ETB, Poor: <600 ETB</p></table-wrap-foot></table-wrap></p></sec><sec id="Sec11"><title>Prevalence of low birth weight, and macrosmonia</title><p>One in every 10 live births (10.5%) was underweight (121/1152), and 6.7% (77/1152) were macrosomic, while the remainder (954/1152) were within the normal range of birth weight. Considerable LBW babies [40% (49/121)] were pre-term births <bold>(</bold>Table <xref rid="Tab2" ref-type="table">2</xref>).<table-wrap id="Tab2"><label>Table 2</label><caption><p>Association of select maternal and neonatal characteristics with low birth weight and macrosomia on neonates born in Tigray Region, Northern Ethiopia (<italic>n</italic> = 1152)</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Characteristics</th><th>Total live births</th><th></th><th>LBW</th><th>Macrosomia</th><th>LBW, Macrosomia</th></tr><tr><th>Freq.</th><th>Percent</th><th>Freq.(RRR,95% CI)</th><th>Freq(RRR,95% CI)</th><th><italic>P</italic>-value</th></tr></thead><tbody><tr><td colspan="6">Birth weight</td></tr><tr><td> Low birth weight</td><td>121</td><td>10.5</td><td></td><td></td><td></td></tr><tr><td> Normal</td><td>954</td><td>82.8</td><td></td><td></td><td></td></tr><tr><td> Macrosomia</td><td>77</td><td>6.7</td><td></td><td></td><td></td></tr><tr><td colspan="6">Current age</td></tr><tr><td> < 20 year</td><td>95</td><td>8.2</td><td>9(ref)</td><td>6(ref)</td><td>ref</td></tr><tr><td> 20–24 year</td><td>328</td><td>28.5</td><td>32(1.0, 0.47–2.24)</td><td>20(0.96, 0.37–2.5)</td><td>0.94,0.94</td></tr><tr><td> 25–35 year</td><td>590</td><td>57.2</td><td>65(1.2, 0.57–2.48)</td><td>40(1.1, 0.45–2.67)</td><td>0.64,0.83</td></tr><tr><td> ≥ 35 year</td><td>139</td><td>12.1</td><td>15(1.17, 0.49–2.8)</td><td>11(1.3, 0.46–3.65)</td><td>0.71,0.62</td></tr><tr><td colspan="6">Number of children</td></tr><tr><td> Primiparae</td><td>610</td><td>53.0</td><td>60(ref)</td><td>36(ref)</td><td>ref</td></tr><tr><td> 2–4 children</td><td>424</td><td>36.8</td><td>39(0.94, 0.61–1.9)</td><td>32(1.29, 0.78–2.1)</td><td>0.80,0.30</td></tr><tr><td> Multiple(≥5)</td><td>118</td><td>10.2</td><td>22(2.16, 1.26–3.7)</td><td>9(1.47, 0.68–3.17)</td><td>0.005,0.31</td></tr><tr><td colspan="6">Birth interval</td></tr><tr><td> Not applicable</td><td>537</td><td>46.6</td><td>52(ref)</td><td>29(ref)</td><td>ref</td></tr><tr><td> < Two years</td><td>127</td><td>11.0</td><td>10(0.8, 0.39–1.64)</td><td>9(1.31, 0.60–2.84)</td><td>0.56,0.49</td></tr><tr><td> > Two years</td><td>488</td><td>42.4</td><td>59(1.32, 0.9–1.97)</td><td>39(1.57, 0.95–2.6)</td><td>0.16,0.07</td></tr><tr><td colspan="6">Disease</td></tr><tr><td> Yes</td><td>100</td><td>8.7</td><td>9(ref)</td><td>5(ref)</td><td>ref</td></tr><tr><td> No</td><td>1052</td><td>91.3</td><td>112(1.23, 0.6–2.5)</td><td>72(1.42, 0.56–3.6)</td><td>0.56,0.45</td></tr><tr><td colspan="6">Maternal complications</td></tr><tr><td> Yes</td><td>221</td><td>19.2</td><td>34(ref)</td><td>23(ref)</td><td>ref</td></tr><tr><td> No</td><td>930</td><td>80.8</td><td>86(0.52, 0.34–0.8)</td><td>54(0.48, 0.29–0.8)</td><td>0.003,0.006</td></tr><tr><td colspan="6">Sex</td></tr><tr><td> Male</td><td>610</td><td>52.9</td><td>54(ref)</td><td>50(ref)</td><td>ref</td></tr><tr><td> Female</td><td>542</td><td>47.1</td><td>67(1.4, 0.95–2.04)</td><td>27(0.6, 0.37–0.99)</td><td>0.082,0.046</td></tr><tr><td colspan="6">Body mass index</td></tr><tr><td> Underweight</td><td>119</td><td>10.6</td><td>14(ref)</td><td>4(ref)</td><td>ref</td></tr><tr><td> Normal</td><td>907</td><td>80.8</td><td>94(0.9, 0.49–1.63)</td><td>58(1.9, 0.68–5.45)</td><td>0.72,0.20</td></tr><tr><td> Overweight</td><td>96</td><td>8.6</td><td>12(1.25, 0.54–2.8)</td><td>15(5.48, 1.7–17.2)</td><td>0.59,0.004</td></tr><tr><td colspan="6">Gestational age</td></tr><tr><td> Preterm</td><td>93</td><td>8.1</td><td>49(13.6,8.5–22)</td><td>1(0.3, 0.23–2.21)</td><td><0.001,0.12</td></tr><tr><td> Term</td><td>990</td><td>85.9</td><td>71(ref)</td><td>66(ref)</td><td></td></tr><tr><td> Post term</td><td>69</td><td>6.0</td><td>1(0.2, 0.02–1.51)</td><td>10(2.22, 1.1–4.56)</td><td>0.23,0.03</td></tr><tr><td colspan="6">Mode of delivery</td></tr><tr><td> Vaginal</td><td>846</td><td>73.5</td><td>90(ref)</td><td>44(ref)</td><td></td></tr><tr><td> Cesarean section</td><td>241</td><td>20.9</td><td>27(1.15, 0.72–1.8)</td><td>29(2.5,1.54–4.16)</td><td>0.54,<0.001</td></tr><tr><td> Instrumental</td><td>65</td><td>5.6</td><td>4(0.55, 0.2–1.56)</td><td>4(1.13, 0.4–3.27)</td><td>0.26,0.81</td></tr><tr><td colspan="6">Antenatal follow up</td></tr><tr><td> Yes</td><td>1131</td><td>98.2</td><td>113(ref)</td><td>76(ref)</td><td></td></tr><tr><td> No</td><td>21</td><td>1.8</td><td>8(5.55, 2.2–13.88)</td><td>1(1.03, 0.13–8.05)</td><td><0.001,0.975</td></tr></tbody></table><table-wrap-foot><p><italic>RRR</italic> relative risk ratio, <italic>CI</italic> confidence interval, <italic>LBW</italic> low birth weight, <italic>Freq</italic>.: Frequency</p></table-wrap-foot></table-wrap></p><sec id="Sec12"><title>Maternal and neonatal characteristics</title><p>Regarding maternal complication, 19.2% of the mothers had complications, of which 15% related to macrosomic births and 10.4% to LBW deliveries. With regard to mode of delivery, 241(20.92%) babies were delivered by Caesarean section and, of these, 29(12%) were macrosomic neonates and 27(11.2%) preterm. Neonates showed a 1:1.12 male to female ratio. Nearly 60% (71) of LBW babies were at term <bold>(</bold>Table <xref rid="Tab2" ref-type="table">2</xref><bold>).</bold></p><p>On bivariable analysis, using multinomial regression, multiparty (≥5) was associated with LBW but not with macrosomia (RR: 2.16, CI: 1.26–3.7). Four in ten LBW births (40%) was preterm, which was associated with LBW (RRR: 2.1, CI: 1.24–3.8) and post-term birth was significantly associated with macrosomia (RRR: 2.48, CI: 1.2–5.12) (Table <xref rid="Tab2" ref-type="table">2</xref>).</p></sec><sec id="Sec13"><title>Multivariate analysis</title><p>In the multivariable regression, having no antenatal follow-up, early marriage, preterm birth, rural residence, and female gender of neonate were significant predictors of LBW, while high body mass index of mothers, post-term birth, having a male neonate, and maternal complications were associated with macrosomia (Table <xref rid="Tab3" ref-type="table">3</xref>).<table-wrap id="Tab3"><label>Table 3</label><caption><p>Multivariate analysis using hierarchical regression on predictors of low birth weight and macrosomia on neonates born in Tigray Region, Northern Ethiopia, April–July, 2014 (<italic>n</italic> = 1152)</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="3">Predictors</th><th>Model 1:</th><th></th><th>Model 2:</th><th></th><th>Model 3:</th><th></th></tr><tr><th>Proximal</th><th>Factors</th><th>Intermediate</th><th>Factors</th><th>Distal</th><th>Factors</th></tr><tr><th>RRR, 95% CI LBW</th><th>RRR, CI 95% macrosomia</th><th>RRR, 95% CI LBW</th><th>RRR, 95% CI macrosomia</th><th>RRR, 95% CI LBW</th><th>RRR, 95% CI macrosomia</th></tr></thead><tbody><tr><td colspan="7">Body mass index</td></tr><tr><td> Normal</td><td></td><td></td><td>ref</td><td>ref</td><td>ref</td><td>ref</td></tr><tr><td> Underweight</td><td></td><td></td><td>1.0(0.5–1.99)</td><td>1.93(0.68–5.5)</td><td>1.01(0.50–2.03)</td><td>1.9(0.67–5.48)</td></tr><tr><td> Overweight</td><td></td><td></td><td>1.73(0.67–4.5)</td><td>5.2(1.6–16.5)</td><td>1.9(0.73–5.05)</td><td>5(1.56–16)</td></tr><tr><td colspan="7">Gestational age</td></tr><tr><td> Term</td><td></td><td></td><td>ref</td><td>ref</td><td>ref</td><td>ref</td></tr><tr><td> Preterm</td><td></td><td></td><td>15.5(9.32–25.7)</td><td>0.2(0.03–2.0)</td><td>15.4(9.18–25.9)</td><td>0.26(0.35–2.0)</td></tr><tr><td> Post term</td><td></td><td></td><td>0.21(0.02–1.59)</td><td>2.26(1.08–4.7)</td><td>0.2(0.027–1.52)</td><td>2.23(1.06–4.6)</td></tr><tr><td>Antenatal(Yes ref)</td><td></td><td></td><td>6.9(2.49–19.5)</td><td>0.8(0.11–7.26)</td><td>6.78(2.39–19.2)</td><td>0.9(0.11–7.76)</td></tr><tr><td>Female sex(male ref)</td><td></td><td></td><td>1.7(1.1–2.68)</td><td>0.58(0.35–0.9)</td><td>1.77(1.13–2.77)</td><td>0.58(0.35–0.9)</td></tr><tr><td>Complication(yes ref)</td><td char="(" align="char">0.52(0.34–0.8)</td><td char="(" align="char">0.48(0.29–0.81)</td><td>0.74(0.44–1.23)</td><td>0.47(0.27–0.8)</td><td>0.74(0.44–1.24)</td><td>0.46(0.27–0.8)</td></tr><tr><td colspan="7">Parity</td></tr><tr><td> Priampre</td><td></td><td></td><td>ref</td><td>ref</td><td>ref</td><td>ref</td></tr><tr><td> Two</td><td></td><td></td><td>0.83(0.51–1.36)</td><td>1.19(0.71–2.0)</td><td>0.83(0.5–1.38)</td><td>1.21(0.72–2.0)</td></tr><tr><td> Multiparity (≥3)</td><td></td><td></td><td>1.65(0.86–3.18)</td><td>1.39(0.61–3.1)</td><td>1.27(0.62–2.61)</td><td>1.67(0.7–3.9)</td></tr><tr><td colspan="7">Age at marriage</td></tr><tr><td>≥18 (“<18” ref)</td><td></td><td></td><td></td><td></td><td>0.59(0.35–0.97)</td><td>0.71(0.4–1.23)</td></tr><tr><td>Residence(“Rural” ref)</td><td></td><td></td><td></td><td></td><td>0.53(0.32–0.9)</td><td>1.08(0.6–1.96)</td></tr><tr><td colspan="7">Education</td></tr><tr><td> Unable to read & write</td><td></td><td></td><td></td><td></td><td>ref</td><td>ref</td></tr><tr><td> Primary</td><td></td><td></td><td></td><td></td><td>0.53(0.27–1.01)</td><td>1.31(0.2–2.7)</td></tr><tr><td> Secondary</td><td></td><td></td><td></td><td></td><td>0.99(0.5–1.98)</td><td>1.39(0.6–3.2)</td></tr><tr><td> Tertiary</td><td></td><td></td><td></td><td></td><td>1.2(0.52–2.7)</td><td>1.85(0.74–4.6)</td></tr></tbody></table><table-wrap-foot><p>*<italic>ref</italic> reference, <italic>RRR</italic> Relative Risk Ratio, <italic>CI</italic> Confidence Interval, <italic>LBW</italic> Low Birth Weight</p></table-wrap-foot></table-wrap></p><p>Mothers classified as high BMI were 5 times more likely to be to deliver macrosomic neonates than mothers in the normal BMI category (RRR: 5.0, CI: 1.56–16)). Regarding gestational age, the risk of macrosomia was twice as high in post-term neonates compared to term babies (RRR: 2.23, CI: 1.06–4.6)) and risk of LBW was fifteen times higher in pre-term neonates than in term neonates (ARR: 15.4, CI: 9.18–25.9). Female neonate were found 42% less at risk of becoming macrosomic than their counterpart male neonates (RRR: 0.58, CI: 0.35–0.9), but 1.77 times (RRR: 1.77, CI: 1.13–2.77) more likely to experience low birth weight than their male counterparts. Similarly, mothers who had no complication around birth had a 54% lower risk of delivering macrosomia (RRR: 0.46, CI: 0.27–0.8) than these mothers who had complications. Delivery complications were not significantly associated with LBW (RRR: 0.74, CI: 0.44–1.24). Concerning antenatal follow-up, with relative to normal birth weight neonates mothers who never had antenatal follow-up were 6.78 times at increased risk of delivering LBW neonates compared to those who attended antenatal care (RRR:6.78,CI:2.39–19.25).</p><p>From the sociodemographic characteristics, mothers who resided in the urban area were at 47% lower risk of delivering LBW neonates than their rural counterparts (ARR: 0.53, CI: 0.32–0.9).</p><p>From the intermediate factors, first marriage was significantly associated with LBW for mothers who married after 18 years and above. Specifically, they were 41% less likely to deliver LBW neonate than mothers married before the age of 18 (RRR:0.59,CI:0.35–0.97), but marital age was not significantly associated with macrosomic birth (RRR:0.71,CI:0.4–1.23) (Table <xref rid="Tab3" ref-type="table">3</xref><bold>).</bold></p></sec></sec></sec><sec id="Sec14"><title>Discussion</title><p>In this study, we determined the incidence of LBW and macrosomia. We also identified the independent predictors of LBW and macrosomia on the same model.</p><p>Accordingly, we found the incidence of macrosomia to be 6.7%. The rate of macrosomia is within the worldwide and range of African studies [<xref ref-type="bibr" rid="CR6">6</xref>]. This rate is higher than a prevalence from Democratic Republic Congo, Kenya, Niger, and Angola, but it is less than the rate from Algeria, Uganda, Nigeria, and most Asian countries [<xref ref-type="bibr" rid="CR6">6</xref>]. This difference could be due to the nature of macrosomia trends, as it is expected to increase incrementally with the development of a country [<xref ref-type="bibr" rid="CR6">6</xref>]. It is lower than the long-term Iranian cohort study and Nigerian retrospective study [<xref ref-type="bibr" rid="CR11">11</xref>, <xref ref-type="bibr" rid="CR30">30</xref>]. In contrast to these studies, our study was conducted for a short period of time and was hospital-based, which may underestimate the incidence rate and may not indicate the true prevalence.</p><p>The incidence of LBW found was 10.5% which is higher than the reported rates in developed countries and lower than the rate of some sub-Saharan African studies [<xref ref-type="bibr" rid="CR7">7</xref>, <xref ref-type="bibr" rid="CR31">31</xref>]. It is also lower than studies from northwest Ethiopia, Kenya and Zimbabwe [<xref ref-type="bibr" rid="CR8">8</xref>–<xref ref-type="bibr" rid="CR10">10</xref>]. The reason for this discrepancy may be the time this study is conducted and recent interventions in the prevention of LBW may have strengthen and contributed towards reduction in the incidence of LBW. Further this study was conducted in hospitals, which may indicate mothers with better socioeconomic status [<xref ref-type="bibr" rid="CR16">16</xref>] and subsequently would underestimate the incidence rate. However, this rate is higher than the national retrospective household survey, which estimated 8.1% prevalence in the region, but in this national survey only 10.1% of mothers responded about birth weight [<xref ref-type="bibr" rid="CR22">22</xref>].</p><sec id="Sec15"><title>Predictors for macrosomia and LBW</title><p>Gestational age was one of the independent predictors of macrosomia and LBW. Post-maturity was significantly associated with macrosomia, which is similar to previous findings [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR17">17</xref>]. This may be attributable to the period of post-maturity that there could lead to excessive fetal weight gain. Further, other potential causes may include maternal weight gain, diabetes, and other chronic disease [<xref ref-type="bibr" rid="CR32">32</xref>, <xref ref-type="bibr" rid="CR33">33</xref>]. Prematurity is significantly associated with LBW and this finding is supported by previous findings from Kenya, Oman and Iran [<xref ref-type="bibr" rid="CR10">10</xref>, <xref ref-type="bibr" rid="CR20">20</xref>, <xref ref-type="bibr" rid="CR34">34</xref>]. Similar to our study, in which we found (RRR: 15.4, CI: 9.18–25.9), the Iranian study also found a very strong association (OR: 42.82, 95% CI: 21.93–83.57). This showed that prematurity and LBW are strongly associated. Although it did not have a statistically significant association, we found over half 58% of LBW neonates were term births, indicating intrauterine growth retardation. It is evident that preterm births are exposed to LBW due to inadequate weight gain during pregnancy because of early delivery but intrauterine growth retardation demands further investigations.</p><p>Male neonates are also associated with increased risk of being macrosomic, which aligns with a previous meta-analysis conducted in 23 countries and a study in China [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR18">18</xref>]. There may be biological reasons which could expose male neonates to excessive weight gain during pregnancy. Conversely, female birth is associated with being a LBW, which aligns with recent studies conducted in the African context [<xref ref-type="bibr" rid="CR8">8</xref>–<xref ref-type="bibr" rid="CR10">10</xref>].</p><p>Maternal complications were associated with macrosomia. This finding is supported with previous study for macrosomia [<xref ref-type="bibr" rid="CR6">6</xref>, <xref ref-type="bibr" rid="CR17">17</xref>]. In our study, hemorrhage, pregnancy-induced hypertension, and obstructed labor were the major maternal complications which may be associated with macrosomia. High BMI of mothers was significantly associated with delivering macrosomic neonates, which concurs with previous studies which showed the association of obesity and high BMI with macrosomic birth [<xref ref-type="bibr" rid="CR3">3</xref>, <xref ref-type="bibr" rid="CR18">18</xref>, <xref ref-type="bibr" rid="CR19">19</xref>]. As Ethiopia is a developing country, we are beginning to be affected by the double burden of diseases with emerging chronic disease like obesity (high BMI) [<xref ref-type="bibr" rid="CR35">35</xref>], hence a parallel increase in macrosomia is expected.</p><p>Rural residence and early marriage were also associated with delivering LBW babies, which is a similar finding to previous studies [<xref ref-type="bibr" rid="CR21">21</xref>, <xref ref-type="bibr" rid="CR31">31</xref>, <xref ref-type="bibr" rid="CR34">34</xref>, <xref ref-type="bibr" rid="CR36">36</xref>–<xref ref-type="bibr" rid="CR38">38</xref>]. Rural mothers and those who were married young are at increased risk of delivering LBW often due to low risk awareness and are poor utilization of health services [<xref ref-type="bibr" rid="CR23">23</xref>]. These gaps may expose these mothers to low quality of antenatal follow-up and related services. Further, these women may lack adequate nutrition due to their rural residence, in which most mothers in our study were farmers [<xref ref-type="bibr" rid="CR39">39</xref>]. These factors could potentiate the incidence of LBW. In addition mothers who married early have immature body systems in which the body could not withstand the pregnancy and these situations expose the mothers to complications [<xref ref-type="bibr" rid="CR40">40</xref>]. Large epidemiological studies also found increased risk for LBW with extreme of ages of mother [<xref ref-type="bibr" rid="CR20">20</xref>, <xref ref-type="bibr" rid="CR21">21</xref>].</p><p>Having no antenatal follow up is significant predictors of LBW, which mirrors prior findings [<xref ref-type="bibr" rid="CR8">8</xref>, <xref ref-type="bibr" rid="CR36">36</xref>, <xref ref-type="bibr" rid="CR38">38</xref>]. We had a few (1.8%) mothers who never had antenatal follow-up in our study and this widens the confidence interval. It is evident that mothers who never had antenatal follow up would be affected by delays in early detection and management of complications as well as not receiving supplements which could helpful to prevent prematurity and/or intrauterine growth retardation.</p><p>The strength of this data is that it is a prospective study. In addition, our study covers the entire range of hospitals in the study region so that it will be generalizable to all Ethiopian hospitals. This study concurrently considered both LBW and macrosomia and identified the common factors, such as gestational age and gender. It is favorable to tackle both of these problems at the same time.</p><p>The limitations of this study are that did not specifically study mothers with diabetes, or term births yielding low birth weight neonates, nor fully consider maternal complications owing to nature of our study. Further, this study was also conducted cross-sectionally and only in hospitals, whereby, in the study region, only 27% of mothers deliver in hospitals or another health care facility [<xref ref-type="bibr" rid="CR28">28</xref>]. Consequently, this may underestimate and/or overestimate the rates.</p></sec></sec><sec id="Sec16"><title>Conclusion</title><p>Our study revealed that mothers with early marriage, delivery of premature neonates, lacking antenatal follow-up, bearing female neonates, and/or who had pregnancy related complications are at higher risk to deliver low birth weight neonates. In addition, mothers who delivered male neonates, had pregnancy related complications, post-maturity, and high BMI are at risk of delivering macrosomic neonates. Therefore, strengthening antenatal follow-up, improving socioeconomic status and lifestyle, promoting early detection and management of complications, enhancing early detection of prematurity and post-maturity are recommended to prevent or mitigate both low birth weight and macrosomia and their long term consequences. We also recommend longitudinal studies on the long-term consequences of low birth weight and macrosomia throughout Ethiopia.</p></sec></body><back><glossary><title>Abbreviations</title><def-list><def-item><term>AIDS</term><def><p>Acquired immune deficiency syndrome</p></def></def-item><def-item><term>BMI</term><def><p>Body mass index</p></def></def-item><def-item><term>ETB</term><def><p>Ethiopian birr</p></def></def-item><def-item><term>HIV</term><def><p>Human immunodeficiency virus</p></def></def-item><def-item><term>LBW</term><def><p>Low birth weight</p></def></def-item><def-item><term>RRR</term><def><p>Relative risk ratio</p></def></def-item><def-item><term>WHO</term><def><p>World Health Organization</p></def></def-item></def-list></glossary><ack><p>We are indebted to colleagues and friends for their constructive comments and suggestions that were essential input to this manuscript. We would like to gratitude Prof.Pammla Petrucka for her kind help during write up of this manuscript.</p><sec id="FPar1"><title>Funding</title><p>We have not received any funding for the research, authorship and publication of this manuscript.</p></sec><sec id="FPar2"><title>Availability of data and materials</title><p>The data sets used during the current study are available from the corresponding author on reasonable request.</p></sec><sec id="FPar3"><title>Authors’ contributions</title><p>HG: carried out the conception of the research, design, statistical analysis and writing the draft manuscript of the research. AD: carried out the statistical analysis, design and revising the draft manuscript. DS: conducted the proofreading, Analysis and editing tasks of the final manuscript version. BW: carried out the statistical analysis, design and revising the draft manuscript. All authors approved the final version of the manuscript.</p></sec><sec id="FPar4"><title>Competing interests</title><p>The authors declare that they have no competing interests.</p></sec><sec id="FPar5"><title>Consent for publication</title><p>Not applicable</p></sec><sec id="FPar6"><title>Ethics approval and consent to participate</title><p>Ethical clearance was obtained from Mekelle University, College of Health Sciences Ethical Review Board. A permission letter was also sought and obtained from Tigray Regional Health Bureau. Written informed consent from each participating mother was obtained. 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