Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD
Identifieur interne : 000293 ( Pmc/Corpus ); précédent : 000292; suivant : 000294Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD
Auteurs : Su Jin Jeong ; Claire Italiano ; Romanee Chaiwarith ; Oon Tek Ng ; Sasheela Vanar ; Awachana Jiamsakul ; Vonthanak Saphonn ; Kinh Van Nguyen ; Sasisopin Kiertiburanakul ; Man Po Lee ; Tuti Parwati Merati ; Thuy Thanh Pham ; Evy Yunihastuti ; Rossana Ditangco ; Nagalingeswaran Kumarasamy ; Fujie Zhang ; Wingwai Wong ; Benedict L. H. Sim ; Sanjay Pujari ; Pacharee Kantipong ; Praphan Phanuphak ; Winai Ratanasuwan ; Shinichi Oka ; Mahiran Mustafa ; Nicolas Durier ; Jun Yong ChoiSource :
- AIDS Research and Human Retroviruses [ 0889-2229 ] ; 2016.
Abstract
Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003–2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31–40, 41–50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31–1.88; OR = 2.01, 95% CI 1.58–2.56; and OR = 1.69, 95% CI 1.23–2.31, respectively; all
Url:
DOI: 10.1089/aid.2015.0058
PubMed: 26414065
PubMed Central: 4779961
Links to Exploration step
PMC:4779961Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD</title><author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Italiano, Claire" sort="Italiano, Claire" uniqKey="Italiano C" first="Claire" last="Italiano">Claire Italiano</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Chaiwarith, Romanee" sort="Chaiwarith, Romanee" uniqKey="Chaiwarith R" first="Romanee" last="Chaiwarith">Romanee Chaiwarith</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ng, Oon Tek" sort="Ng, Oon Tek" uniqKey="Ng O" first="Oon Tek" last="Ng">Oon Tek Ng</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Vanar, Sasheela" sort="Vanar, Sasheela" uniqKey="Vanar S" first="Sasheela" last="Vanar">Sasheela Vanar</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Jiamsakul, Awachana" sort="Jiamsakul, Awachana" uniqKey="Jiamsakul A" first="Awachana" last="Jiamsakul">Awachana Jiamsakul</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Nguyen, Kinh Van" sort="Nguyen, Kinh Van" uniqKey="Nguyen K" first="Kinh Van" last="Nguyen">Kinh Van Nguyen</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Kiertiburanakul, Sasisopin" sort="Kiertiburanakul, Sasisopin" uniqKey="Kiertiburanakul S" first="Sasisopin" last="Kiertiburanakul">Sasisopin Kiertiburanakul</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Lee, Man Po" sort="Lee, Man Po" uniqKey="Lee M" first="Man Po" last="Lee">Man Po Lee</name><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author><author><name sortKey="Merati, Tuti Parwati" sort="Merati, Tuti Parwati" uniqKey="Merati T" first="Tuti Parwati" last="Merati">Tuti Parwati Merati</name><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation></author><author><name sortKey="Pham, Thuy Thanh" sort="Pham, Thuy Thanh" uniqKey="Pham T" first="Thuy Thanh" last="Pham">Thuy Thanh Pham</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Yunihastuti, Evy" sort="Yunihastuti, Evy" uniqKey="Yunihastuti E" first="Evy" last="Yunihastuti">Evy Yunihastuti</name><affiliation><nlm:aff id="aff12"></nlm:aff></affiliation></author><author><name sortKey="Ditangco, Rossana" sort="Ditangco, Rossana" uniqKey="Ditangco R" first="Rossana" last="Ditangco">Rossana Ditangco</name><affiliation><nlm:aff id="aff13"></nlm:aff></affiliation></author><author><name sortKey="Kumarasamy, Nagalingeswaran" sort="Kumarasamy, Nagalingeswaran" uniqKey="Kumarasamy N" first="Nagalingeswaran" last="Kumarasamy">Nagalingeswaran Kumarasamy</name><affiliation><nlm:aff id="aff14"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Fujie" sort="Zhang, Fujie" uniqKey="Zhang F" first="Fujie" last="Zhang">Fujie Zhang</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Wong, Wingwai" sort="Wong, Wingwai" uniqKey="Wong W" first="Wingwai" last="Wong">Wingwai Wong</name><affiliation><nlm:aff id="aff16"></nlm:aff></affiliation></author><author><name sortKey="Sim, Benedict L H" sort="Sim, Benedict L H" uniqKey="Sim B" first="Benedict L. H." last="Sim">Benedict L. H. Sim</name><affiliation><nlm:aff id="aff17"></nlm:aff></affiliation></author><author><name sortKey="Pujari, Sanjay" sort="Pujari, Sanjay" uniqKey="Pujari S" first="Sanjay" last="Pujari">Sanjay Pujari</name><affiliation><nlm:aff id="aff18"></nlm:aff></affiliation></author><author><name sortKey="Kantipong, Pacharee" sort="Kantipong, Pacharee" uniqKey="Kantipong P" first="Pacharee" last="Kantipong">Pacharee Kantipong</name><affiliation><nlm:aff id="aff19"></nlm:aff></affiliation></author><author><name sortKey="Phanuphak, Praphan" sort="Phanuphak, Praphan" uniqKey="Phanuphak P" first="Praphan" last="Phanuphak">Praphan Phanuphak</name><affiliation><nlm:aff id="aff20"></nlm:aff></affiliation></author><author><name sortKey="Ratanasuwan, Winai" sort="Ratanasuwan, Winai" uniqKey="Ratanasuwan W" first="Winai" last="Ratanasuwan">Winai Ratanasuwan</name><affiliation><nlm:aff id="aff21"></nlm:aff></affiliation></author><author><name sortKey="Oka, Shinichi" sort="Oka, Shinichi" uniqKey="Oka S" first="Shinichi" last="Oka">Shinichi Oka</name><affiliation><nlm:aff id="aff22"></nlm:aff></affiliation></author><author><name sortKey="Mustafa, Mahiran" sort="Mustafa, Mahiran" uniqKey="Mustafa M" first="Mahiran" last="Mustafa">Mahiran Mustafa</name><affiliation><nlm:aff id="aff23"></nlm:aff></affiliation></author><author><name sortKey="Durier, Nicolas" sort="Durier, Nicolas" uniqKey="Durier N" first="Nicolas" last="Durier">Nicolas Durier</name><affiliation><nlm:aff id="aff24"></nlm:aff></affiliation></author><author><name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26414065</idno><idno type="pmc">4779961</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779961</idno><idno type="RBID">PMC:4779961</idno><idno type="doi">10.1089/aid.2015.0058</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000293</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000293</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD</title><author><name sortKey="Jeong, Su Jin" sort="Jeong, Su Jin" uniqKey="Jeong S" first="Su Jin" last="Jeong">Su Jin Jeong</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Italiano, Claire" sort="Italiano, Claire" uniqKey="Italiano C" first="Claire" last="Italiano">Claire Italiano</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Chaiwarith, Romanee" sort="Chaiwarith, Romanee" uniqKey="Chaiwarith R" first="Romanee" last="Chaiwarith">Romanee Chaiwarith</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ng, Oon Tek" sort="Ng, Oon Tek" uniqKey="Ng O" first="Oon Tek" last="Ng">Oon Tek Ng</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Vanar, Sasheela" sort="Vanar, Sasheela" uniqKey="Vanar S" first="Sasheela" last="Vanar">Sasheela Vanar</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Jiamsakul, Awachana" sort="Jiamsakul, Awachana" uniqKey="Jiamsakul A" first="Awachana" last="Jiamsakul">Awachana Jiamsakul</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Saphonn, Vonthanak" sort="Saphonn, Vonthanak" uniqKey="Saphonn V" first="Vonthanak" last="Saphonn">Vonthanak Saphonn</name><affiliation><nlm:aff id="aff6"></nlm:aff></affiliation></author><author><name sortKey="Nguyen, Kinh Van" sort="Nguyen, Kinh Van" uniqKey="Nguyen K" first="Kinh Van" last="Nguyen">Kinh Van Nguyen</name><affiliation><nlm:aff id="aff7"></nlm:aff></affiliation></author><author><name sortKey="Kiertiburanakul, Sasisopin" sort="Kiertiburanakul, Sasisopin" uniqKey="Kiertiburanakul S" first="Sasisopin" last="Kiertiburanakul">Sasisopin Kiertiburanakul</name><affiliation><nlm:aff id="aff8"></nlm:aff></affiliation></author><author><name sortKey="Lee, Man Po" sort="Lee, Man Po" uniqKey="Lee M" first="Man Po" last="Lee">Man Po Lee</name><affiliation><nlm:aff id="aff9"></nlm:aff></affiliation></author><author><name sortKey="Merati, Tuti Parwati" sort="Merati, Tuti Parwati" uniqKey="Merati T" first="Tuti Parwati" last="Merati">Tuti Parwati Merati</name><affiliation><nlm:aff id="aff10"></nlm:aff></affiliation></author><author><name sortKey="Pham, Thuy Thanh" sort="Pham, Thuy Thanh" uniqKey="Pham T" first="Thuy Thanh" last="Pham">Thuy Thanh Pham</name><affiliation><nlm:aff id="aff11"></nlm:aff></affiliation></author><author><name sortKey="Yunihastuti, Evy" sort="Yunihastuti, Evy" uniqKey="Yunihastuti E" first="Evy" last="Yunihastuti">Evy Yunihastuti</name><affiliation><nlm:aff id="aff12"></nlm:aff></affiliation></author><author><name sortKey="Ditangco, Rossana" sort="Ditangco, Rossana" uniqKey="Ditangco R" first="Rossana" last="Ditangco">Rossana Ditangco</name><affiliation><nlm:aff id="aff13"></nlm:aff></affiliation></author><author><name sortKey="Kumarasamy, Nagalingeswaran" sort="Kumarasamy, Nagalingeswaran" uniqKey="Kumarasamy N" first="Nagalingeswaran" last="Kumarasamy">Nagalingeswaran Kumarasamy</name><affiliation><nlm:aff id="aff14"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Fujie" sort="Zhang, Fujie" uniqKey="Zhang F" first="Fujie" last="Zhang">Fujie Zhang</name><affiliation><nlm:aff id="aff15"></nlm:aff></affiliation></author><author><name sortKey="Wong, Wingwai" sort="Wong, Wingwai" uniqKey="Wong W" first="Wingwai" last="Wong">Wingwai Wong</name><affiliation><nlm:aff id="aff16"></nlm:aff></affiliation></author><author><name sortKey="Sim, Benedict L H" sort="Sim, Benedict L H" uniqKey="Sim B" first="Benedict L. H." last="Sim">Benedict L. H. Sim</name><affiliation><nlm:aff id="aff17"></nlm:aff></affiliation></author><author><name sortKey="Pujari, Sanjay" sort="Pujari, Sanjay" uniqKey="Pujari S" first="Sanjay" last="Pujari">Sanjay Pujari</name><affiliation><nlm:aff id="aff18"></nlm:aff></affiliation></author><author><name sortKey="Kantipong, Pacharee" sort="Kantipong, Pacharee" uniqKey="Kantipong P" first="Pacharee" last="Kantipong">Pacharee Kantipong</name><affiliation><nlm:aff id="aff19"></nlm:aff></affiliation></author><author><name sortKey="Phanuphak, Praphan" sort="Phanuphak, Praphan" uniqKey="Phanuphak P" first="Praphan" last="Phanuphak">Praphan Phanuphak</name><affiliation><nlm:aff id="aff20"></nlm:aff></affiliation></author><author><name sortKey="Ratanasuwan, Winai" sort="Ratanasuwan, Winai" uniqKey="Ratanasuwan W" first="Winai" last="Ratanasuwan">Winai Ratanasuwan</name><affiliation><nlm:aff id="aff21"></nlm:aff></affiliation></author><author><name sortKey="Oka, Shinichi" sort="Oka, Shinichi" uniqKey="Oka S" first="Shinichi" last="Oka">Shinichi Oka</name><affiliation><nlm:aff id="aff22"></nlm:aff></affiliation></author><author><name sortKey="Mustafa, Mahiran" sort="Mustafa, Mahiran" uniqKey="Mustafa M" first="Mahiran" last="Mustafa">Mahiran Mustafa</name><affiliation><nlm:aff id="aff23"></nlm:aff></affiliation></author><author><name sortKey="Durier, Nicolas" sort="Durier, Nicolas" uniqKey="Durier N" first="Nicolas" last="Durier">Nicolas Durier</name><affiliation><nlm:aff id="aff24"></nlm:aff></affiliation></author><author><name sortKey="Choi, Jun Yong" sort="Choi, Jun Yong" uniqKey="Choi J" first="Jun Yong" last="Choi">Jun Yong Choi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">AIDS Research and Human Retroviruses</title><idno type="ISSN">0889-2229</idno><idno type="eISSN">1931-8405</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003–2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31–40, 41–50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31–1.88; OR = 2.01, 95% CI 1.58–2.56; and OR = 1.69, 95% CI 1.23–2.31, respectively; all <italic>p</italic> ≤ 0.001]. Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42–3.27, <italic>p</italic> < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35–0.58, <italic>p</italic> < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36–0.53, <italic>p</italic> < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS Res Hum Retroviruses</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Res. Hum. Retroviruses</journal-id><journal-id journal-id-type="publisher-id">aid</journal-id><journal-title-group><journal-title>AIDS Research and Human Retroviruses</journal-title></journal-title-group><issn pub-type="ppub">0889-2229</issn><issn pub-type="epub">1931-8405</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26414065</article-id><article-id pub-id-type="pmc">4779961</article-id><article-id pub-id-type="publisher-id">10.1089/aid.2015.0058</article-id><article-id pub-id-type="doi">10.1089/aid.2015.0058</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis</subject></subj-group></article-categories><title-group><article-title>Late Presentation into Care of HIV Disease and Its Associated Factors in Asia: Results of TAHOD</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Jeong</surname><given-names>Su Jin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Italiano</surname><given-names>Claire</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chaiwarith</surname><given-names>Romanee</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ng</surname><given-names>Oon Tek</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vanar</surname><given-names>Sasheela</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Jiamsakul</surname><given-names>Awachana</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Saphonn</surname><given-names>Vonthanak</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nguyen</surname><given-names>Kinh Van</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kiertiburanakul</surname><given-names>Sasisopin</given-names></name><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Man Po</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref></contrib><contrib contrib-type="author"><name><surname>Merati</surname><given-names>Tuti Parwati</given-names></name><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pham</surname><given-names>Thuy Thanh</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yunihastuti</surname><given-names>Evy</given-names></name><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ditangco</surname><given-names>Rossana</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kumarasamy</surname><given-names>Nagalingeswaran</given-names></name><xref ref-type="aff" rid="aff14"><sup>14</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Fujie</given-names></name><xref ref-type="aff" rid="aff15"><sup>15</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Wingwai</given-names></name><xref ref-type="aff" rid="aff16"><sup>16</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sim</surname><given-names>Benedict L.H.</given-names></name><xref ref-type="aff" rid="aff17"><sup>17</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pujari</surname><given-names>Sanjay</given-names></name><xref ref-type="aff" rid="aff18"><sup>18</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kantipong</surname><given-names>Pacharee</given-names></name><xref ref-type="aff" rid="aff19"><sup>19</sup></xref></contrib><contrib contrib-type="author"><name><surname>Phanuphak</surname><given-names>Praphan</given-names></name><xref ref-type="aff" rid="aff20"><sup>20</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ratanasuwan</surname><given-names>Winai</given-names></name><xref ref-type="aff" rid="aff21"><sup>21</sup></xref></contrib><contrib contrib-type="author"><name><surname>Oka</surname><given-names>Shinichi</given-names></name><xref ref-type="aff" rid="aff22"><sup>22</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mustafa</surname><given-names>Mahiran</given-names></name><xref ref-type="aff" rid="aff23"><sup>23</sup></xref></contrib><contrib contrib-type="author"><name><surname>Durier</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="aff24"><sup>24</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Choi</surname><given-names>Jun Yong</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Department of Internal Medicine and AIDS Research Institute,<institution>Yonsei University College of Medicine</institution>, Seoul, Korea.</aff><aff id="aff2"><label><sup>2</sup></label><institution>University of Malaya Medical Centre</institution>, Kuala Lumpur,<country>Malaysia</country>.</aff><aff id="aff3"><label><sup>3</sup></label>Research Institute for Health Sciences,<institution>Chiang Mai University</institution>, Chiang Mai,<country>Thailand</country>.</aff><aff id="aff4"><label><sup>4</sup></label>Department of Infectious Diseases,<institution>Tan Tock Seng Hospital</institution>, Singapore,<country>Singapore</country>.</aff><aff id="aff5"><label><sup>5</sup></label><institution>The Kirby Institute</institution>, UNSW Australia, Sydney,<country>Australia</country>.</aff><aff id="aff6"><label><sup>6</sup></label>National Center for HIV/AIDS, Dermatology & STDs, and<institution>University of Health Sciences</institution>, Phnom Penh,<country>Cambodia</country>.</aff><aff id="aff7"><label><sup>7</sup></label><institution>National Hospital for Tropical Diseases</institution>, Hanoi,<country>Vietnam</country>.</aff><aff id="aff8"><label><sup>8</sup></label>Faculty of Medicine Ramathibodi Hospital,<institution>Mahidol University</institution>, Bangkok,<country>Thailand</country>.</aff><aff id="aff9"><label><sup>9</sup></label><institution>Queen Elizabeth Hospital</institution>, Hong Kong,<country>China</country>.</aff><aff id="aff10"><label><sup>10</sup></label><institution>Faculty of Medicine Udayana University and Sanglah Hospital</institution>, Bali,<country>Indonesia</country>.</aff><aff id="aff11"><label><sup>11</sup></label><institution>Bach Mai Hospital</institution>, Hanoi,<country>Vietnam</country>.</aff><aff id="aff12"><label><sup>12</sup></label>Working Group on AIDS Faculty of Medicine,<institution>University of Indonesia/Cipto Mangunkusumo Hospital</institution>, Jakarta,<country>Indonesia</country>.</aff><aff id="aff13"><label><sup>13</sup></label><institution>Research Institute for Tropical Medicine</institution>, Manila,<country>Philippines</country>.</aff><aff id="aff14"><label><sup>14</sup></label>YRGCARE Medical Centre,<institution>VHS</institution>, Chennai,<country>India</country>.</aff><aff id="aff15"><label><sup>15</sup></label>Beijing Ditan Hospital,<institution>Capital Medical University</institution>, Beijing,<country>China</country>.</aff><aff id="aff16"><label><sup>16</sup></label><institution>Taipei Veterans General Hospital</institution>, Taipei,<country>Taiwan</country>.</aff><aff id="aff17"><label><sup>17</sup></label><institution>Hospital Sungai Buloh</institution>, Sungai Buloh,<country>Malaysia</country>.</aff><aff id="aff18"><label><sup>18</sup></label><institution>Institute of Infectious Diseases</institution>, Pune,<country>India</country>.</aff><aff id="aff19"><label><sup>19</sup></label><institution>Chiangrai Prachanukroh Hospital</institution>, Chiang Rai,<country>Thailand</country>.</aff><aff id="aff20"><label><sup>20</sup></label><institution>HIV-NAT/Thai Red Cross AIDS Research Centre</institution>, Bangkok,<country>Thailand</country>.</aff><aff id="aff21"><label><sup>21</sup></label>Faculty of Medicine, Siriraj Hospital,<institution>Mahidol University</institution>, Bangkok,<country>Thailand</country>.</aff><aff id="aff22"><label><sup>22</sup></label><institution>National Center for Global Health and Medicine</institution>, Tokyo,<country>Japan</country>.</aff><aff id="aff23"><label><sup>23</sup></label><institution>Hospital Raja Perempuan Zainab II</institution>, Kota Bharu,<country>Malaysia</country>.</aff><aff id="aff24"><label><sup>24</sup></label><institution>TREAT Asia, amfAR–The Foundation for AIDS Research</institution>, Bangkok,<country>Thailand</country>.</aff></contrib-group><author-notes><corresp><addr-line>Address correspondence to:</addr-line><addr-line><italic>Jun Yong Choi</italic></addr-line><addr-line><italic>Department of Internal Medicine</italic></addr-line><institution><italic>Yonsei University College of Medicine</italic></institution><addr-line><italic>50 Yonsei-ro, Seodaemun-gu</italic></addr-line><addr-line><italic>Seoul, 120-752</italic></addr-line><addr-line><italic>Korea</italic></addr-line><italic>E-mail:</italic><email xlink:href="mailto:seran@yuhs.ac">seran@yuhs.ac</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>3</month><year>2016</year><pmc-comment>string-date: March 2016</pmc-comment>
</pub-date><volume>32</volume><issue>3</issue><fpage>255</fpage><lpage>261</lpage><permissions><copyright-statement>Copyright 2016, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2016</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="aid.2015.0058.pdf"></self-uri><abstract><title>Abstract</title><p>Many HIV-infected individuals do not enter health care until late in the infection course. Despite encouraging earlier testing, this situation has continued for several years. We investigated the prevalence of late presenters and factors associated with late presentation among HIV-infected patients in an Asian regional cohort. This cohort study included HIV-infected patients with their first positive HIV test during 2003–2012 and CD4 count and clinical status data within 3 months of that test. Factors associated with late presentation into care (CD4 count <200 cells/μl or an AIDS-defining event within ±3 months of first positive HIV test) were analyzed in a random effects logistic regression model. Among 3,744 patients, 2,681 (72%) were late presenters. In the multivariable model, older patients were more likely to be late presenters than younger (≤30 years) patients [31–40, 41–50, and ≥51 years: odds ratio (OR) = 1.57, 95% confidence interval (CI) 1.31–1.88; OR = 2.01, 95% CI 1.58–2.56; and OR = 1.69, 95% CI 1.23–2.31, respectively; all <italic>p</italic> ≤ 0.001]. Injecting drug users (IDU) were more likely (OR = 2.15, 95% CI 1.42–3.27, <italic>p</italic> < 0.001) and those with homosexual HIV exposure were less likely (OR = 0.45, 95% CI 0.35–0.58, <italic>p</italic> < 0.001) to be late presenters compared to those with heterosexual HIV exposure. Females were less likely to be late presenters (OR = 0.44, 95% CI 0.36–0.53, <italic>p</italic> < 0.001). The year of first positive HIV test was not associated with late presentation. Efforts to reduce the patients who first seek HIV care at the late stage are needed. The identified risk factors associated with late presentation should be utilized in formulating targeted public health intervention to improve earlier entry into HIV care.</p></abstract><counts><fig-count count="2"></fig-count><table-count count="2"></table-count><ref-count count="35"></ref-count><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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