HIV Drug Resistance Surveillance Among Jamaican Men Who Have Sex with Men Should Be Prioritized for Reducing HIV Transmission
Identifieur interne : 000020 ( Pmc/Corpus ); précédent : 000019; suivant : 000021HIV Drug Resistance Surveillance Among Jamaican Men Who Have Sex with Men Should Be Prioritized for Reducing HIV Transmission
Auteurs : Aneisha M. Collins-Fairclough ; Ann M. Dennis ; Julie A. E. Nelson ; Sharon S. Weir ; J. Peter FigueroaSource :
- AIDS Research and Human Retroviruses [ 0889-2229 ] ; 2015.
Abstract
The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (
Url:
DOI: 10.1089/aid.2015.0040
PubMed: 26133540
PubMed Central: 4533094
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HIV Drug Resistance Surveillance Among Jamaican Men Who Have Sex with Men Should Be Prioritized for Reducing HIV Transmission</title><author><name sortKey="Collins Fairclough, Aneisha M" sort="Collins Fairclough, Aneisha M" uniqKey="Collins Fairclough A" first="Aneisha M." last="Collins-Fairclough">Aneisha M. Collins-Fairclough</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dennis, Ann M" sort="Dennis, Ann M" uniqKey="Dennis A" first="Ann M." last="Dennis">Ann M. Dennis</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Nelson, Julie A E" sort="Nelson, Julie A E" uniqKey="Nelson J" first="Julie A. E." last="Nelson">Julie A. E. Nelson</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Weir, Sharon S" sort="Weir, Sharon S" uniqKey="Weir S" first="Sharon S." last="Weir">Sharon S. Weir</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Figueroa, J Peter" sort="Figueroa, J Peter" uniqKey="Figueroa J" first="J. Peter" last="Figueroa">J. Peter Figueroa</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26133540</idno><idno type="pmc">4533094</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533094</idno><idno type="RBID">PMC:4533094</idno><idno type="doi">10.1089/aid.2015.0040</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000020</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HIV Drug Resistance Surveillance Among Jamaican Men Who Have Sex with Men Should Be Prioritized for Reducing HIV Transmission</title><author><name sortKey="Collins Fairclough, Aneisha M" sort="Collins Fairclough, Aneisha M" uniqKey="Collins Fairclough A" first="Aneisha M." last="Collins-Fairclough">Aneisha M. Collins-Fairclough</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Dennis, Ann M" sort="Dennis, Ann M" uniqKey="Dennis A" first="Ann M." last="Dennis">Ann M. Dennis</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Nelson, Julie A E" sort="Nelson, Julie A E" uniqKey="Nelson J" first="Julie A. E." last="Nelson">Julie A. E. Nelson</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Weir, Sharon S" sort="Weir, Sharon S" uniqKey="Weir S" first="Sharon S." last="Weir">Sharon S. Weir</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Figueroa, J Peter" sort="Figueroa, J Peter" uniqKey="Figueroa J" first="J. Peter" last="Figueroa">J. Peter Figueroa</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author></analytic><series><title level="j">AIDS Research and Human Retroviruses</title><idno type="ISSN">0889-2229</idno><idno type="eISSN">1931-8405</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (<italic>pol</italic>) genes from 65 MSM were sequenced and used to predict drug resistance mutations. An HIV drug resistance prevalence of 28% (minimum 13%) was observed among this cohort, with the most frequent mutations conferring resistance to efavirenz, nevirapine, and lamivudine. Phylogenetic analysis of the sequences revealed 10 times the number of linked HIV infections among this cohort than respondent reporting. HIV treatment and prevention efforts in Jamaica could benefit significantly from Pol genotyping of the HIV strains infecting socially vulnerable MSM prior to initiating antiretroviral therapy (ART), as this would guide suppressive ART and unearth HIV transmission clusters to enable more effective delivery of treatment and prevention programs.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS Res Hum Retroviruses</journal-id><journal-id journal-id-type="iso-abbrev">AIDS Res. Hum. Retroviruses</journal-id><journal-id journal-id-type="publisher-id">aid</journal-id><journal-title-group><journal-title>AIDS Research and Human Retroviruses</journal-title></journal-title-group><issn pub-type="ppub">0889-2229</issn><issn pub-type="epub">1931-8405</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26133540</article-id><article-id pub-id-type="pmc">4533094</article-id><article-id pub-id-type="publisher-id">10.1089/aid.2015.0040</article-id><article-id pub-id-type="doi">10.1089/aid.2015.0040</article-id><article-categories><subj-group subj-group-type="heading"><subject>Sequence Notes</subject></subj-group></article-categories><title-group><article-title>HIV Drug Resistance Surveillance Among Jamaican Men Who Have Sex with Men Should Be Prioritized for Reducing HIV Transmission</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Collins-Fairclough</surname><given-names>Aneisha M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dennis</surname><given-names>Ann M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nelson</surname><given-names>Julie A.E.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weir</surname><given-names>Sharon S.</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Figueroa</surname><given-names>J. Peter</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Biology Division, School of Natural and Applied Sciences, Faculty of Science and Sport,<institution>University of Technology</institution>, Kingston,<country>Jamaica</country>.</aff><aff id="aff2"><label><sup>2</sup></label>Division of Infectious Diseases, School of Medicine,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill, North Carolina.</aff><aff id="aff3"><label><sup>3</sup></label>University of North Carolina Center for AIDS Research and Department of Microbiology and Immunology, School of Medicine,<institution>University of North Carolina at Chapel Hill</institution>, Chapel Hill, North Carolina.</aff><aff id="aff4"><label><sup>4</sup></label>Department of Epidemiology,<institution>University of North Carolina</institution>, Chapel Hill, North Carolina.</aff><aff id="aff5"><label><sup>5</sup></label>Department of Community Health and Psychiatry,<institution>University of the West Indies</institution>, Mona, Kingston,<country>Jamaica</country>.</aff></contrib-group><author-notes><corresp><addr-line>Address correspondence to:</addr-line><addr-line><italic>Aneisha M. Collins-Fairclough</italic></addr-line><addr-line><italic>Biology Division</italic></addr-line><addr-line><italic>School of Natural and Applied Sciences</italic></addr-line><addr-line><italic>Faculty of Science and Sport</italic></addr-line><institution><italic>University of Technology</italic></institution><addr-line><italic>237 Old Hope Road</italic></addr-line><addr-line><italic>Kingston 6</italic></addr-line><country>Jamaica</country><break></break><italic>E-mail:</italic><email xlink:href="mailto:aneishacollins@gmail.com">aneishacollins@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><day>01</day><month>8</month><year>2015</year><pmc-comment>string-date: August 2015</pmc-comment>
</pub-date><volume>31</volume><issue>8</issue><fpage>841</fpage><lpage>844</lpage><permissions><copyright-statement>Copyright 2015, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2015</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="aid.2015.0040.pdf"></self-uri><abstract><title>Abstract</title><p>The prevalence of human immunodeficiency virus type 1 (HIV-1) is highest among men who have sex with men (MSM) in Jamaica but no genotypic data are available on the virus strains that are responsible for the epidemic among this key population. HIV-1 polymerase (<italic>pol</italic>) genes from 65 MSM were sequenced and used to predict drug resistance mutations. An HIV drug resistance prevalence of 28% (minimum 13%) was observed among this cohort, with the most frequent mutations conferring resistance to efavirenz, nevirapine, and lamivudine. Phylogenetic analysis of the sequences revealed 10 times the number of linked HIV infections among this cohort than respondent reporting. HIV treatment and prevention efforts in Jamaica could benefit significantly from Pol genotyping of the HIV strains infecting socially vulnerable MSM prior to initiating antiretroviral therapy (ART), as this would guide suppressive ART and unearth HIV transmission clusters to enable more effective delivery of treatment and prevention programs.</p></abstract><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><ref-count count="15"></ref-count><page-count count="4"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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