Characterization of treatment failure in HIV positive patients in the Colombian Caribbean region
Identifieur interne : 002F45 ( Pmc/Checkpoint ); précédent : 002F44; suivant : 002F46Characterization of treatment failure in HIV positive patients in the Colombian Caribbean region
Auteurs : Juan Manuel De La Hoz [Colombie] ; Laura Bola O [Colombie] ; Oriana Cárdenas [Colombie] ; Robertulio González [Colombie] ; José Sabbag [Colombie] ; Lucy Palacio [Colombie] ; Luz Marina Alonso [Colombie] ; Homero San-Juan-Vergara [Colombie] ; Guillermo Cervantes-Acosta [Colombie]Source :
- Colombia Médica : CM [ 0120-8322 ] ; ????.
Abstract
Treatment failure (TF) in patients receiving antiretroviral therapy against human immunodeficiency virus (HIV) is always a concern.
To examine the correlates associated with TF in patients living in the Colombian Caribbean city of Barranquilla, an aspect that was poorly studied in this region.
Treatment failure was evaluated in a cross-sectional study from virological, immunological and clinical standpoints.
It was established that 29.5% of patients under highly active antiretroviral therapy (ART) could be considered in TF. Among those, virological failure was most frequent (20.9%), followed by immunological- (14.0%) and clinical failure (4.7%). In patients showing lack of adherence to the treatment, the likelihood of suffering from TF and virogical failure were respectively increased by 6.67-fold and 12.19-fold, compared with patients showing good adherence. Although there was no statistically significant association, TF tended to be more frequent in young adults, in patients with low income and, low level of education. When ART regimens were compared, there was no apparent difference in TF between regimens based on non-nucleoside reverse transcriptase inhibitors and those based on protease inhibitors. This is very important in the context of recent ART strategies, such as early-initiated ART, aimed at achieving long-term infection control.
Is confirmed the importance of treatment adherence to avoid TF and further highlights the importance of educating HIV-infected patients in all parts of the world, especially those individuals with a lower socio-economic status.
Url:
PubMed: 25767304
PubMed Central: 4350381
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of treatment failure in HIV positive patients in the Colombian Caribbean region</title><author><name sortKey="De La Hoz, Juan Manuel" sort="De La Hoz, Juan Manuel" uniqKey="De La Hoz J" first="Juan Manuel" last="De La Hoz">Juan Manuel De La Hoz</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bola O, Laura" sort="Bola O, Laura" uniqKey="Bola O L" first="Laura" last="Bola O">Laura Bola O</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardenas, Oriana" sort="Cardenas, Oriana" uniqKey="Cardenas O" first="Oriana" last="Cárdenas">Oriana Cárdenas</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Robertulio" sort="Gonzalez, Robertulio" uniqKey="Gonzalez R" first="Robertulio" last="González">Robertulio González</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sabbag, Jose" sort="Sabbag, Jose" uniqKey="Sabbag J" first="José" last="Sabbag">José Sabbag</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palacio, Lucy" sort="Palacio, Lucy" uniqKey="Palacio L" first="Lucy" last="Palacio">Lucy Palacio</name><affiliation wicri:level="1"><nlm:aff id="aff2"> IPS QUIMIOSALUD. Barranquilla,<country>Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alonso, Luz Marina" sort="Alonso, Luz Marina" uniqKey="Alonso L" first="Luz Marina" last="Alonso">Luz Marina Alonso</name><affiliation wicri:level="1"><nlm:aff id="aff3"> Departamento de Salud Pública, Universidad del Norte, Barranquilla,<country>Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="San Juan Vergara, Homero" sort="San Juan Vergara, Homero" uniqKey="San Juan Vergara H" first="Homero" last="San-Juan-Vergara">Homero San-Juan-Vergara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cervantes Acosta, Guillermo" sort="Cervantes Acosta, Guillermo" uniqKey="Cervantes Acosta G" first="Guillermo" last="Cervantes-Acosta">Guillermo Cervantes-Acosta</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25767304</idno><idno type="pmc">4350381</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350381</idno><idno type="RBID">PMC:4350381</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">002325</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002325</idno><idno type="wicri:Area/Pmc/Curation">002324</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002324</idno><idno type="wicri:Area/Pmc/Checkpoint">002F45</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002F45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of treatment failure in HIV positive patients in the Colombian Caribbean region</title><author><name sortKey="De La Hoz, Juan Manuel" sort="De La Hoz, Juan Manuel" uniqKey="De La Hoz J" first="Juan Manuel" last="De La Hoz">Juan Manuel De La Hoz</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bola O, Laura" sort="Bola O, Laura" uniqKey="Bola O L" first="Laura" last="Bola O">Laura Bola O</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cardenas, Oriana" sort="Cardenas, Oriana" uniqKey="Cardenas O" first="Oriana" last="Cárdenas">Oriana Cárdenas</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gonzalez, Robertulio" sort="Gonzalez, Robertulio" uniqKey="Gonzalez R" first="Robertulio" last="González">Robertulio González</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sabbag, Jose" sort="Sabbag, Jose" uniqKey="Sabbag J" first="José" last="Sabbag">José Sabbag</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Palacio, Lucy" sort="Palacio, Lucy" uniqKey="Palacio L" first="Lucy" last="Palacio">Lucy Palacio</name><affiliation wicri:level="1"><nlm:aff id="aff2"> IPS QUIMIOSALUD. Barranquilla,<country>Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alonso, Luz Marina" sort="Alonso, Luz Marina" uniqKey="Alonso L" first="Luz Marina" last="Alonso">Luz Marina Alonso</name><affiliation wicri:level="1"><nlm:aff id="aff3"> Departamento de Salud Pública, Universidad del Norte, Barranquilla,<country>Colombia</country></nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="San Juan Vergara, Homero" sort="San Juan Vergara, Homero" uniqKey="San Juan Vergara H" first="Homero" last="San-Juan-Vergara">Homero San-Juan-Vergara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cervantes Acosta, Guillermo" sort="Cervantes Acosta, Guillermo" uniqKey="Cervantes Acosta G" first="Guillermo" last="Cervantes-Acosta">Guillermo Cervantes-Acosta</name><affiliation wicri:level="1"><nlm:aff id="aff1">Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Colombia Médica : CM</title><idno type="ISSN">0120-8322</idno><idno type="eISSN">1657-9534</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Treatment failure (TF) in patients receiving antiretroviral therapy against human immunodeficiency virus (HIV) is always a concern. </p></sec><sec><title>Objective:</title><p>To examine the correlates associated with TF in patients living in the Colombian Caribbean city of Barranquilla, an aspect that was poorly studied in this region.</p></sec><sec><title>Methods:</title><p>Treatment failure was evaluated in a cross-sectional study from virological, immunological and clinical standpoints.</p></sec><sec><title>Results:</title><p> It was established that 29.5% of patients under highly active antiretroviral therapy (ART) could be considered in TF. Among those, virological failure was most frequent (20.9%), followed by immunological- (14.0%) and clinical failure (4.7%). In patients showing lack of adherence to the treatment, the likelihood of suffering from TF and virogical failure were respectively increased by 6.67-fold and 12.19-fold, compared with patients showing good adherence. Although there was no statistically significant association, TF tended to be more frequent in young adults, in patients with low income and, low level of education. When ART regimens were compared, there was no apparent difference in TF between regimens based on non-nucleoside reverse transcriptase inhibitors and those based on protease inhibitors. This is very important in the context of recent ART strategies, such as early-initiated ART, aimed at achieving long-term infection control. </p></sec><sec><title>Conclusions:</title><p> Is confirmed the importance of treatment adherence to avoid TF and further highlights the importance of educating HIV-infected patients in all parts of the world, especially those individuals with a lower socio-economic status. </p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Matthews, Tj" uniqKey="Matthews T">TJ Matthews</name></author><author><name sortKey="Langlois, Aj" uniqKey="Langlois A">AJ Langlois</name></author><author><name sortKey="Robey, Wg" uniqKey="Robey W">WG Robey</name></author><author><name sortKey="Chang, Nt" uniqKey="Chang N">NT Chang</name></author><author><name sortKey="Gallo, R" uniqKey="Gallo R">R Gallo</name></author><author><name sortKey="Fischinger, Pj" uniqKey="Fischinger P">PJ 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Colomb Med (Cali)</journal-id><journal-id journal-id-type="iso-abbrev">Colomb. Med</journal-id><journal-title-group><journal-title>Colombia Médica : CM</journal-title></journal-title-group><issn pub-type="ppub">0120-8322</issn><issn pub-type="epub">1657-9534</issn><publisher><publisher-name>Universidad del Valle</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25767304</article-id><article-id pub-id-type="pmc">4350381</article-id><article-id pub-id-type="publisher-id">1566</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Characterization of treatment failure in HIV positive patients in the Colombian Caribbean region</article-title><trans-title-group xml:lang="es"><trans-title>Caracterización del fracaso terapéutico en pacientes VIH positivos en la región del Caribe Colombiano</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>De La Hoz</surname><given-names>Juan Manuel</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bolaño</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cárdenas</surname><given-names>Oriana</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>González</surname><given-names>Robertulio</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sabbag</surname><given-names>José</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Palacio</surname><given-names>Lucy</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alonso</surname><given-names>Luz Marina</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>San-Juan-Vergara</surname><given-names>Homero</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Cervantes-Acosta</surname><given-names>Guillermo</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label>Departamento de Medicina, Universidad del Norte, Barranquilla,<country>Colombia</country>.</aff><aff id="aff2"><label>2</label> IPS QUIMIOSALUD. Barranquilla,<country>Colombia</country></aff><aff id="aff3"><label>3</label> Departamento de Salud Pública, Universidad del Norte, Barranquilla,<country>Colombia</country></aff><author-notes><corresp id="c01"> Guillermo Cervantes-Acosta. Departamento de Medicina. Universidad del Norte. Kilómetro 5, Vía Puerto Colombia. Barranquilla, Colombia. Phone: +57 5 3509285. E-mail: <email>guicerva@uninorte.edu.co</email></corresp><fn id="fn01" fn-type="conflict"><p><bold>Conflict of interest:
</bold>No conflicts of interest exist </p></fn></author-notes><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2014-12-30"><day>30</day><month>12</month><year>2014</year></pub-date><pub-date date-type="collection" publication-format="electronic"><season>Oct-Dec</season><year>2014</year></pub-date><volume>45</volume><issue>4</issue><fpage>162</fpage><lpage>167</lpage><history><date date-type="received"><day>30</day><month>4</month><year>2014</year></date><date date-type="rev-recd"><day>10</day><month>11</month><year>2014</year></date><date date-type="accepted"><day>19</day><month>12</month><year>2014</year></date></history><permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p> © 2014 Universidad del Valle. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited </license-p></license></permissions><abstract><sec><title>Background:</title><p>Treatment failure (TF) in patients receiving antiretroviral therapy against human immunodeficiency virus (HIV) is always a concern. </p></sec><sec><title>Objective:</title><p>To examine the correlates associated with TF in patients living in the Colombian Caribbean city of Barranquilla, an aspect that was poorly studied in this region.</p></sec><sec><title>Methods:</title><p>Treatment failure was evaluated in a cross-sectional study from virological, immunological and clinical standpoints.</p></sec><sec><title>Results:</title><p> It was established that 29.5% of patients under highly active antiretroviral therapy (ART) could be considered in TF. Among those, virological failure was most frequent (20.9%), followed by immunological- (14.0%) and clinical failure (4.7%). In patients showing lack of adherence to the treatment, the likelihood of suffering from TF and virogical failure were respectively increased by 6.67-fold and 12.19-fold, compared with patients showing good adherence. Although there was no statistically significant association, TF tended to be more frequent in young adults, in patients with low income and, low level of education. When ART regimens were compared, there was no apparent difference in TF between regimens based on non-nucleoside reverse transcriptase inhibitors and those based on protease inhibitors. This is very important in the context of recent ART strategies, such as early-initiated ART, aimed at achieving long-term infection control. </p></sec><sec><title>Conclusions:</title><p> Is confirmed the importance of treatment adherence to avoid TF and further highlights the importance of educating HIV-infected patients in all parts of the world, especially those individuals with a lower socio-economic status. </p></sec></abstract><trans-abstract xml:lang="es"><sec><title>Objetivos:</title><p>El fracaso terapéutico (FT) en pacientes que están recibiendo terapia antirretroviral contra el Virus de la Inmunodeficiencia Humana (VIH) ha sido siempre preocupante. </p></sec><sec><title>Objetivo:</title><p> Examinar las variables asociadas con el fracaso terapéutico, un problema que ha sido pobremente estudiado en la región, en pacientes que habitan en Barranquilla, ciudad del Caribe colombiano.</p></sec><sec><title>Métodos:</title><p>El fracaso terapéutico fue evaluado en un estudio transversal desde los puntos de vista virológico, inmunológico y clínico.</p></sec><sec><title>Resultados:</title><p> Se determinó que el 29.5% de los pacientes bajo terapia antirretroviral (TAR) de gran actividad podría considerase en fracaso terapéutico. El fracaso virológico fue el más frecuente (20.9%), seguido por el inmunológico (14.0%) y el clínico (4.7%). En pacientes que mostraron falta de adherencia al tratamiento, las posibilidades de presentar un fracaso terapéutico y virológico fue mayor, 6.67 y 12.19 veces, respectivamente, comparados con pacientes que mostraron buena adherencia. Aun cuando no hubo una asociación estadística significativa, el fracaso terapéutico tendió a ser más frecuente en adultos jóvenes, en pacientes con bajos ingresos y bajo nivel de educación. Cuando se compararon diferentes regímenes de TAR no hubo una diferencia aparente entre el fracaso terapéutico en los regímenes basados en inhibidores no nucleósidos de la transcriptasa inversa y en aquellos basados en inhibidores de la proteasa. Esto es muy importante en el contexto de recientes estrategias de TAR, como es el caso de las iniciadas en forma temprana con el fin de lograr el control de la infección a largo plazo.</p></sec><sec><title>Conclusiones:</title><p> Se confirma la importancia de la adherencia al tratamiento para evitar el fracaso terapéutico y la importancia de educar a los pacientes infectados con el VIH, especialmente aquellos individuos con un nivel socioeconómico bajo.</p></sec></trans-abstract><kwd-group><kwd>HIV</kwd><kwd>virological failure</kwd><kwd>immunological failure</kwd><kwd>clinical failure</kwd><kwd>adherence</kwd><kwd>antiretroviral therapy</kwd></kwd-group><counts><table-count count="4"></table-count><ref-count count="23"></ref-count><page-count count="6"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Colombie</li></country></list><tree><country name="Colombie"><noRegion><name sortKey="De La Hoz, Juan Manuel" sort="De La Hoz, Juan Manuel" uniqKey="De La Hoz J" first="Juan Manuel" last="De La Hoz">Juan Manuel De La Hoz</name></noRegion><name sortKey="Alonso, Luz Marina" sort="Alonso, Luz Marina" uniqKey="Alonso L" first="Luz Marina" last="Alonso">Luz Marina Alonso</name><name sortKey="Bola O, Laura" sort="Bola O, Laura" uniqKey="Bola O L" first="Laura" last="Bola O">Laura Bola O</name><name sortKey="Cardenas, Oriana" sort="Cardenas, Oriana" uniqKey="Cardenas O" first="Oriana" last="Cárdenas">Oriana Cárdenas</name><name sortKey="Cervantes Acosta, Guillermo" sort="Cervantes Acosta, Guillermo" uniqKey="Cervantes Acosta G" first="Guillermo" last="Cervantes-Acosta">Guillermo Cervantes-Acosta</name><name sortKey="Gonzalez, Robertulio" sort="Gonzalez, Robertulio" uniqKey="Gonzalez R" first="Robertulio" last="González">Robertulio González</name><name sortKey="Palacio, Lucy" sort="Palacio, Lucy" uniqKey="Palacio L" first="Lucy" last="Palacio">Lucy Palacio</name><name sortKey="Sabbag, Jose" sort="Sabbag, Jose" uniqKey="Sabbag J" first="José" last="Sabbag">José Sabbag</name><name sortKey="San Juan Vergara, Homero" sort="San Juan Vergara, Homero" uniqKey="San Juan Vergara H" first="Homero" last="San-Juan-Vergara">Homero San-Juan-Vergara</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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