A Description of Congenital Anomalies Among Infants in Entebbe, Uganda
Identifieur interne : 002387 ( Pmc/Checkpoint ); précédent : 002386; suivant : 002388A Description of Congenital Anomalies Among Infants in Entebbe, Uganda
Auteurs : Juliet Ndibazza [Ouganda] ; Swaib Lule [Ouganda] ; Margaret Nampijja [Ouganda] ; Harriet Mpairwe [Ouganda] ; Gloria Oduru [Ouganda] ; Molly Kiggundu [Ouganda] ; Miriam Akello [Ouganda] ; Lawrence Muhangi [Ouganda] ; Alison M. Elliott [Ouganda, Royaume-Uni]Source :
- Birth Defects Research. Part A, Clinical and Molecular Teratology [ 1542-0752 ] ; 2011.
Abstract
Url:
DOI: 10.1002/bdra.20838
PubMed: 21770020
PubMed Central: 3272344
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Description of Congenital Anomalies Among Infants in Entebbe, Uganda</title><author><name sortKey="Ndibazza, Juliet" sort="Ndibazza, Juliet" uniqKey="Ndibazza J" first="Juliet" last="Ndibazza">Juliet Ndibazza</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Lule, Swaib" sort="Lule, Swaib" uniqKey="Lule S" first="Swaib" last="Lule">Swaib Lule</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Nampijja, Margaret" sort="Nampijja, Margaret" uniqKey="Nampijja M" first="Margaret" last="Nampijja">Margaret Nampijja</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Mpairwe, Harriet" sort="Mpairwe, Harriet" uniqKey="Mpairwe H" first="Harriet" last="Mpairwe">Harriet Mpairwe</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Oduru, Gloria" sort="Oduru, Gloria" uniqKey="Oduru G" first="Gloria" last="Oduru">Gloria Oduru</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Kiggundu, Molly" sort="Kiggundu, Molly" uniqKey="Kiggundu M" first="Molly" last="Kiggundu">Molly Kiggundu</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Akello, Miriam" sort="Akello, Miriam" uniqKey="Akello M" first="Miriam" last="Akello">Miriam Akello</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Muhangi, Lawrence" sort="Muhangi, Lawrence" uniqKey="Muhangi L" first="Lawrence" last="Muhangi">Lawrence Muhangi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M" last="Elliott">Alison M. Elliott</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>London School of Hygiene and Tropical Medicine</institution><addr-line>Keppel Street, London WC1E 7HT, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21770020</idno><idno type="pmc">3272344</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272344</idno><idno type="RBID">PMC:3272344</idno><idno type="doi">10.1002/bdra.20838</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002304</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002304</idno><idno type="wicri:Area/Pmc/Curation">002303</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002303</idno><idno type="wicri:Area/Pmc/Checkpoint">002387</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002387</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Description of Congenital Anomalies Among Infants in Entebbe, Uganda</title><author><name sortKey="Ndibazza, Juliet" sort="Ndibazza, Juliet" uniqKey="Ndibazza J" first="Juliet" last="Ndibazza">Juliet Ndibazza</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Lule, Swaib" sort="Lule, Swaib" uniqKey="Lule S" first="Swaib" last="Lule">Swaib Lule</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Nampijja, Margaret" sort="Nampijja, Margaret" uniqKey="Nampijja M" first="Margaret" last="Nampijja">Margaret Nampijja</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Mpairwe, Harriet" sort="Mpairwe, Harriet" uniqKey="Mpairwe H" first="Harriet" last="Mpairwe">Harriet Mpairwe</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Oduru, Gloria" sort="Oduru, Gloria" uniqKey="Oduru G" first="Gloria" last="Oduru">Gloria Oduru</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Kiggundu, Molly" sort="Kiggundu, Molly" uniqKey="Kiggundu M" first="Molly" last="Kiggundu">Molly Kiggundu</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Akello, Miriam" sort="Akello, Miriam" uniqKey="Akello M" first="Miriam" last="Akello">Miriam Akello</name><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P.O. Box 29, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Muhangi, Lawrence" sort="Muhangi, Lawrence" uniqKey="Muhangi L" first="Lawrence" last="Muhangi">Lawrence Muhangi</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M" last="Elliott">Alison M. Elliott</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>P. O. Box 49, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="au2"><institution>London School of Hygiene and Tropical Medicine</institution><addr-line>Keppel Street, London WC1E 7HT, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Keppel Street, London WC1E 7HT</wicri:regionArea><wicri:noRegion>London WC1E 7HT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Birth Defects Research. Part A, Clinical and Molecular Teratology</title><idno type="ISSN">1542-0752</idno><idno type="eISSN">1542-0760</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>BACKGROUND:</bold> Data on congenital anomalies from developing countries of the sub-Saharan region are scarce. However, it is important to have comprehensive and reliable data on the description and prevalence of congenital anomalies to allow surveillance and the implementation of appropriate public health strategies for prevention and management. In this study, we describe the profile of congenital anomalies seen in a birth cohort in Entebbe, Uganda. <bold>METHODS:</bold> Congenital anomalies were defined as any structural defect present at birth. Pregnant women were recruited to the cohort between 2003 and 2005. Defects present at birth were recorded by the midwife at delivery and by physicians at the routine six-week postnatal visit and at illness-related visits until 1 year of life. The anomalies were classified by organ system according to the 10th version of the World Health Organization International Classification of Diseases (ICD-10). <bold>RESULTS:</bold> There were 180 infants with a congenital anomaly among 2365 births. The most commonly affected systems were the musculoskeletal (42.7 per 1000 births) and skin (16.1 per 1000 births). The prevalence of major anomalies was 20.3 per 1000 births; 1.7 per 1000 births for cardiac anomalies and 1.3 per 1000 births for neural system anomalies. Forty (22%) of the congenital anomalies were identified at birth, 131 (73%) at the 6-week postnatal visit, and nine (5%) at illness-related visits. <bold>CONCLUSION:</bold> Congenital anomalies are common in developing countries. Establishment of comprehensive databases for surveillance would be helpful for surveillance of effects of new exposures, for prevention, management, and health care planning. Birth Defects Research (Part A) 2011. © 2011 Wiley-Liss, Inc.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anthony, S" uniqKey="Anthony S">S Anthony</name></author><author><name sortKey="Kateman, H" uniqKey="Kateman H">H Kateman</name></author><author><name sortKey="Brand, R" uniqKey="Brand R">R Brand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakare, Ti" uniqKey="Bakare T">TI Bakare</name></author><author><name sortKey="Sowande, Oa" uniqKey="Sowande O">OA Sowande</name></author><author><name sortKey="Adejuyigbe, Oo" uniqKey="Adejuyigbe O">OO Adejuyigbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmona, Rh" uniqKey="Carmona R">RH Carmona</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Christianson, Re" uniqKey="Christianson R">RE Christianson</name></author><author><name sortKey="Van Den Berg, Bj" uniqKey="Van Den Berg B">BJ van den Berg</name></author><author><name sortKey="Milkovich, L" uniqKey="Milkovich L">L Milkovich</name></author><author><name sortKey="Oechsli, Fw" uniqKey="Oechsli F">FW Oechsli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elliott, Am" uniqKey="Elliott A">AM Elliott</name></author><author><name sortKey="Kizza, M" uniqKey="Kizza M">M Kizza</name></author><author><name sortKey="Quigley, Ma" uniqKey="Quigley M">MA Quigley</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kromberg, Jg" uniqKey="Kromberg J">JG Kromberg</name></author><author><name sortKey="Jenkins, T" uniqKey="Jenkins T">T Jenkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lary, Jm" uniqKey="Lary J">JM Lary</name></author><author><name sortKey="Paulozzi, Lj" uniqKey="Paulozzi L">LJ Paulozzi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ndibazza, J" uniqKey="Ndibazza J">J Ndibazza</name></author><author><name sortKey="Muhangi, L" uniqKey="Muhangi L">L Muhangi</name></author><author><name sortKey="Akishule, D" uniqKey="Akishule D">D Akishule</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riley, M" uniqKey="Riley M">M Riley</name></author><author><name sortKey="Halliday, J" uniqKey="Halliday J">J Halliday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpkiss, M" uniqKey="Simpkiss M">M Simpkiss</name></author><author><name sortKey="Lowe, A" uniqKey="Lowe A">A Lowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tann, C" uniqKey="Tann C">C Tann</name></author><author><name sortKey="Kiggundu, M" uniqKey="Kiggundu M">M Kiggundu</name></author><author><name sortKey="Ayiko, B" uniqKey="Ayiko B">B Ayiko</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Watts, Dh" uniqKey="Watts D">DH Watts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, El" uniqKey="Webb E">EL Webb</name></author><author><name sortKey="Mawa, Pa" uniqKey="Mawa P">PA Mawa</name></author><author><name sortKey="Ndibazza, J" uniqKey="Ndibazza J">J Ndibazza</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Williamson, A" uniqKey="Williamson A">A Williamson</name></author><author><name sortKey="Mullet, J" uniqKey="Mullet J">J Mullet</name></author><author><name sortKey="Bunting, M" uniqKey="Bunting M">M Bunting</name></author><author><name sortKey="Eason, J" uniqKey="Eason J">J Eason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woodburn, Pw" uniqKey="Woodburn P">PW Woodburn</name></author><author><name sortKey="Muhangi, L" uniqKey="Muhangi L">L Muhangi</name></author><author><name sortKey="Hillier, S" uniqKey="Hillier S">S Hillier</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Birth Defects Res A Clin Mol Teratol</journal-id><journal-id journal-id-type="publisher-id">bdra</journal-id><journal-title-group><journal-title>Birth Defects Research. Part A, Clinical and Molecular Teratology</journal-title></journal-title-group><issn pub-type="ppub">1542-0752</issn><issn pub-type="epub">1542-0760</issn><publisher><publisher-name>Wiley Subscription Services, Inc., A Wiley Company</publisher-name><publisher-loc>Hoboken</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21770020</article-id><article-id pub-id-type="pmc">3272344</article-id><article-id pub-id-type="doi">10.1002/bdra.20838</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Reports</subject></subj-group></article-categories><title-group><article-title>A Description of Congenital Anomalies Among Infants in Entebbe, Uganda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ndibazza</surname><given-names>Juliet</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lule</surname><given-names>Swaib</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nampijja</surname><given-names>Margaret</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mpairwe</surname><given-names>Harriet</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Oduru</surname><given-names>Gloria</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kiggundu</surname><given-names>Molly</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Akello</surname><given-names>Miriam</given-names></name><xref ref-type="aff" rid="au3">3</xref></contrib><contrib contrib-type="author"><name><surname>Muhangi</surname><given-names>Lawrence</given-names></name><xref ref-type="aff" rid="au1">1</xref></contrib><contrib contrib-type="author"><name><surname>Elliott</surname><given-names>Alison M</given-names></name><xref ref-type="aff" rid="au1">1</xref><xref ref-type="aff" rid="au2">2</xref></contrib><aff id="au1"><label>1</label><institution>MRC/UVRI Uganda Research Unit on AIDS, Uganda Virus Research Institute</institution><addr-line>P. O. Box 49, Entebbe, Uganda</addr-line></aff><aff id="au2"><label>2</label><institution>London School of Hygiene and Tropical Medicine</institution><addr-line>Keppel Street, London WC1E 7HT, United Kingdom</addr-line></aff><aff id="au3"><label>3</label><institution>Entebbe Hospital</institution><addr-line>P.O. Box 29, Entebbe, Uganda</addr-line></aff></contrib-group><author-notes><corresp id="cor1">*Correspondence to: Juliet Ndibazza, MRC/UVRI Uganda Research Unit on AIDS, P. O. Box 49 Entebbe, Uganda. E-mail: <email>Juliet.Ndibazza@mrcuganda.org</email></corresp><fn><p>The study was funded by a Wellcome Trust Senior Fellowship held by Alison M. Elliott; grant number 064693.</p></fn></author-notes><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>18</day><month>7</month><year>2011</year></pub-date><volume>91</volume><issue>9</issue><fpage>857</fpage><lpage>861</lpage><history><date date-type="received"><day>05</day><month>1</month><year>2011</year></date><date date-type="rev-recd"><day>15</day><month>4</month><year>2011</year></date><date date-type="accepted"><day>19</day><month>4</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011 Wiley-Liss, Inc.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.</license-p></license></permissions><abstract><p><bold>BACKGROUND:</bold> Data on congenital anomalies from developing countries of the sub-Saharan region are scarce. However, it is important to have comprehensive and reliable data on the description and prevalence of congenital anomalies to allow surveillance and the implementation of appropriate public health strategies for prevention and management. In this study, we describe the profile of congenital anomalies seen in a birth cohort in Entebbe, Uganda. <bold>METHODS:</bold> Congenital anomalies were defined as any structural defect present at birth. Pregnant women were recruited to the cohort between 2003 and 2005. Defects present at birth were recorded by the midwife at delivery and by physicians at the routine six-week postnatal visit and at illness-related visits until 1 year of life. The anomalies were classified by organ system according to the 10th version of the World Health Organization International Classification of Diseases (ICD-10). <bold>RESULTS:</bold> There were 180 infants with a congenital anomaly among 2365 births. The most commonly affected systems were the musculoskeletal (42.7 per 1000 births) and skin (16.1 per 1000 births). The prevalence of major anomalies was 20.3 per 1000 births; 1.7 per 1000 births for cardiac anomalies and 1.3 per 1000 births for neural system anomalies. Forty (22%) of the congenital anomalies were identified at birth, 131 (73%) at the 6-week postnatal visit, and nine (5%) at illness-related visits. <bold>CONCLUSION:</bold> Congenital anomalies are common in developing countries. Establishment of comprehensive databases for surveillance would be helpful for surveillance of effects of new exposures, for prevention, management, and health care planning. Birth Defects Research (Part A) 2011. © 2011 Wiley-Liss, Inc.</p></abstract><kwd-group><kwd>congenital anomalies</kwd><kwd>infants</kwd><kwd>epidemiology</kwd><kwd>Uganda</kwd><kwd>Africa</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Ouganda</li><li>Royaume-Uni</li></country></list><tree><country name="Ouganda"><noRegion><name sortKey="Ndibazza, Juliet" sort="Ndibazza, Juliet" uniqKey="Ndibazza J" first="Juliet" last="Ndibazza">Juliet Ndibazza</name></noRegion><name sortKey="Akello, Miriam" sort="Akello, Miriam" uniqKey="Akello M" first="Miriam" last="Akello">Miriam Akello</name><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M" last="Elliott">Alison M. Elliott</name><name sortKey="Kiggundu, Molly" sort="Kiggundu, Molly" uniqKey="Kiggundu M" first="Molly" last="Kiggundu">Molly Kiggundu</name><name sortKey="Lule, Swaib" sort="Lule, Swaib" uniqKey="Lule S" first="Swaib" last="Lule">Swaib Lule</name><name sortKey="Mpairwe, Harriet" sort="Mpairwe, Harriet" uniqKey="Mpairwe H" first="Harriet" last="Mpairwe">Harriet Mpairwe</name><name sortKey="Muhangi, Lawrence" sort="Muhangi, Lawrence" uniqKey="Muhangi L" first="Lawrence" last="Muhangi">Lawrence Muhangi</name><name sortKey="Nampijja, Margaret" sort="Nampijja, Margaret" uniqKey="Nampijja M" first="Margaret" last="Nampijja">Margaret Nampijja</name><name sortKey="Oduru, Gloria" sort="Oduru, Gloria" uniqKey="Oduru G" first="Gloria" last="Oduru">Gloria Oduru</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Elliott, Alison M" sort="Elliott, Alison M" uniqKey="Elliott A" first="Alison M" last="Elliott">Alison M. Elliott</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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