Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites
Identifieur interne : 002121 ( Pmc/Checkpoint ); précédent : 002120; suivant : 002122Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites
Auteurs : Elizabeth G. Kane ; Andrew W. Taylor-Robinson [Royaume-Uni]Source :
- Malaria Research and Treatment [ 2090-8075 ] ; 2011.
Abstract
Pregnancy-associated malaria, a manifestation of severe malaria, is the cause of up to 200,000 infant deaths a year, through the effects of placental insufficiency leading to growth restriction and preterm delivery. Development of a vaccine is one strategy for control.
Url:
DOI: 10.4061/2011/764845
PubMed: 22363896
PubMed Central: 3272661
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3272661Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to <italic>Plasmodium falciparum</italic>
VAR2CSA-Expressing Parasites</title>
<author><name sortKey="Kane, Elizabeth G" sort="Kane, Elizabeth G" uniqKey="Kane E" first="Elizabeth G." last="Kane">Elizabeth G. Kane</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taylor Robinson, Andrew W" sort="Taylor Robinson, Andrew W" uniqKey="Taylor Robinson A" first="Andrew W." last="Taylor-Robinson">Andrew W. Taylor-Robinson</name>
<affiliation wicri:level="4"><nlm:aff id="I1">Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT</wicri:regionArea>
<orgName type="university">Université de Leeds</orgName>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22363896</idno>
<idno type="pmc">3272661</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272661</idno>
<idno type="RBID">PMC:3272661</idno>
<idno type="doi">10.4061/2011/764845</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">002F03</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002F03</idno>
<idno type="wicri:Area/Pmc/Curation">002F02</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002F02</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002121</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002121</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to <italic>Plasmodium falciparum</italic>
VAR2CSA-Expressing Parasites</title>
<author><name sortKey="Kane, Elizabeth G" sort="Kane, Elizabeth G" uniqKey="Kane E" first="Elizabeth G." last="Kane">Elizabeth G. Kane</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taylor Robinson, Andrew W" sort="Taylor Robinson, Andrew W" uniqKey="Taylor Robinson A" first="Andrew W." last="Taylor-Robinson">Andrew W. Taylor-Robinson</name>
<affiliation wicri:level="4"><nlm:aff id="I1">Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT</wicri:regionArea>
<orgName type="university">Université de Leeds</orgName>
<placeName><settlement type="city">Leeds</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Yorkshire-et-Humber</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Malaria Research and Treatment</title>
<idno type="ISSN">2090-8075</idno>
<idno type="eISSN">2044-4362</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Pregnancy-associated malaria, a manifestation of severe malaria, is the cause of up to 200,000 infant deaths a year, through the effects of placental insufficiency leading to growth restriction and preterm delivery. Development of a vaccine is one strategy for control. <italic>Plasmodium falciparum</italic>
-infected red blood cells accumulate in the placenta through specific binding of pregnancy-associated parasite variants that express the VAR2CSA antigen to chondroitin sulphate A on the surface of syncytiotrophoblast cells. Parasite accumulation, accompanied by an inflammatory infiltrate, disrupts the cytokine balance of pregnancy with the potential to cause placental damage and compromise foetal growth. Multigravid women develop immunity towards VAR2CSA-expressing parasites in a gravidity-dependent manner which prevents unfavourable pregnancy outcomes. Although current vaccine design, targeting VAR2CSA antigens, has succeeded in inducing antibodies artificially, this candidate may not provide protection during the first trimester and may only protect those women living in areas endemic for malaria. It is concluded that while insufficient information about placental-parasite interactions is presently available to produce an effective vaccine, incremental progress is being made towards achieving this goal.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Steketee, Rw" uniqKey="Steketee R">RW Steketee</name>
</author>
<author><name sortKey="Wirima, Jj" uniqKey="Wirima J">JJ Wirima</name>
</author>
<author><name sortKey="Bloland, Pb" uniqKey="Bloland P">PB Bloland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steketee, Rw" uniqKey="Steketee R">RW Steketee</name>
</author>
<author><name sortKey="Nahlen, Bl" uniqKey="Nahlen B">BL Nahlen</name>
</author>
<author><name sortKey="Parise, Me" uniqKey="Parise M">ME Parise</name>
</author>
<author><name sortKey="Menendez, C" uniqKey="Menendez C">C Menendez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilles, Hm" uniqKey="Gilles H">HM Gilles</name>
</author>
<author><name sortKey="Lawson, Jb" uniqKey="Lawson J">JB Lawson</name>
</author>
<author><name sortKey="Sibelas, M" uniqKey="Sibelas M">M Sibelas</name>
</author>
<author><name sortKey="Voller, A" uniqKey="Voller A">A Voller</name>
</author>
<author><name sortKey="Allan, N" uniqKey="Allan N">N Allan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shulman, Ce" uniqKey="Shulman C">CE Shulman</name>
</author>
<author><name sortKey="Graham, Wj" uniqKey="Graham W">WJ Graham</name>
</author>
<author><name sortKey="Jilo, H" uniqKey="Jilo H">H Jilo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cot, M" uniqKey="Cot M">M Cot</name>
</author>
<author><name sortKey="Le Hesran, Jy" uniqKey="Le Hesran J">JY Le Hesran</name>
</author>
<author><name sortKey="Miailhes, P" uniqKey="Miailhes P">P Miailhes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcgregor, Ia" uniqKey="Mcgregor I">IA McGregor</name>
</author>
<author><name sortKey="Wilson, Me" uniqKey="Wilson M">ME Wilson</name>
</author>
<author><name sortKey="Billewicz, Wz" uniqKey="Billewicz W">WZ Billewicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcgregor, Ia" uniqKey="Mcgregor I">IA McGregor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, B" uniqKey="Brabin B">B Brabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Ter Kuile, F" uniqKey="Ter Kuile F">F ter Kuile</name>
</author>
<author><name sortKey="Maelankirri, L" uniqKey="Maelankirri L">L Maelankirri</name>
</author>
<author><name sortKey="Decludt, B" uniqKey="Decludt B">B Decludt</name>
</author>
<author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steketee, Rw" uniqKey="Steketee R">RW Steketee</name>
</author>
<author><name sortKey="Wirima, Jj" uniqKey="Wirima J">JJ Wirima</name>
</author>
<author><name sortKey="Hightower, Aw" uniqKey="Hightower A">AW Hightower</name>
</author>
<author><name sortKey="Slutsker, L" uniqKey="Slutsker L">L Slutsker</name>
</author>
<author><name sortKey="Heymann, Dl" uniqKey="Heymann D">DL Heymann</name>
</author>
<author><name sortKey="Breman, Jg" uniqKey="Breman J">JG Breman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sullivan, Ad" uniqKey="Sullivan A">AD Sullivan</name>
</author>
<author><name sortKey="Nyirenda, T" uniqKey="Nyirenda T">T Nyirenda</name>
</author>
<author><name sortKey="Cullinan, T" uniqKey="Cullinan T">T Cullinan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Taylor Robinson, A" uniqKey="Taylor Robinson A">A Taylor-Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doolan, Dl" uniqKey="Doolan D">DL Doolan</name>
</author>
<author><name sortKey="Doba O, C" uniqKey="Doba O C">C Dobaño</name>
</author>
<author><name sortKey="Baird, Jk" uniqKey="Baird J">JK Baird</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abrams, Et" uniqKey="Abrams E">ET Abrams</name>
</author>
<author><name sortKey="Brown, H" uniqKey="Brown H">H Brown</name>
</author>
<author><name sortKey="Chensue, Sw" uniqKey="Chensue S">SW Chensue</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ansell, J" uniqKey="Ansell J">J Ansell</name>
</author>
<author><name sortKey="Hamilton, Ka" uniqKey="Hamilton K">KA Hamilton</name>
</author>
<author><name sortKey="Pinder, M" uniqKey="Pinder M">M Pinder</name>
</author>
<author><name sortKey="Walraven, Gel" uniqKey="Walraven G">GEL Walraven</name>
</author>
<author><name sortKey="Lindsay, Sw" uniqKey="Lindsay S">SW Lindsay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name>
</author>
<author><name sortKey="Mutabingwa, Tk" uniqKey="Mutabingwa T">TK Mutabingwa</name>
</author>
<author><name sortKey="Brabin, B" uniqKey="Brabin B">B Brabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
<author><name sortKey="Desowitz, Rs" uniqKey="Desowitz R">RS Desowitz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Looareesuwan, S" uniqKey="Looareesuwan S">S Looareesuwan</name>
</author>
<author><name sortKey="Phillips, Re" uniqKey="Phillips R">RE Phillips</name>
</author>
<author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name>
</author>
<author><name sortKey="Mutabingwa, T" uniqKey="Mutabingwa T">T Mutabingwa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Recker, M" uniqKey="Recker M">M Recker</name>
</author>
<author><name sortKey="Bouma, Mj" uniqKey="Bouma M">MJ Bouma</name>
</author>
<author><name sortKey="Bamford, P" uniqKey="Bamford P">P Bamford</name>
</author>
<author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name>
</author>
<author><name sortKey="Dobson, Ap" uniqKey="Dobson A">AP Dobson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, B" uniqKey="Brabin B">B Brabin</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Megnekou, R" uniqKey="Megnekou R">R Megnekou</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Taylor, Dw" uniqKey="Taylor D">DW Taylor</name>
</author>
<author><name sortKey="Leke, R" uniqKey="Leke R">R Leke</name>
</author>
<author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baird, Jk" uniqKey="Baird J">JK Baird</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Mwapasa, V" uniqKey="Mwapasa V">V Mwapasa</name>
</author>
<author><name sortKey="Meshnick, Sr" uniqKey="Meshnick S">SR Meshnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chico, Rm" uniqKey="Chico R">RM Chico</name>
</author>
<author><name sortKey="Chandramohan, D" uniqKey="Chandramohan D">D Chandramohan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maiga, Om" uniqKey="Maiga O">OM Maiga</name>
</author>
<author><name sortKey="Kayentao, K" uniqKey="Kayentao K">K Kayentao</name>
</author>
<author><name sortKey="Traore, Bt" uniqKey="Traore B">BT Traoré</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sevene, E" uniqKey="Sevene E">E Sevene</name>
</author>
<author><name sortKey="Gonzalez, R" uniqKey="Gonzalez R">R González</name>
</author>
<author><name sortKey="Menendez, C" uniqKey="Menendez C">C Menéndez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ismail, Mr" uniqKey="Ismail M">MR Ismail</name>
</author>
<author><name sortKey="Ordi, J" uniqKey="Ordi J">J Ordi</name>
</author>
<author><name sortKey="Menendez, C" uniqKey="Menendez C">C Menendez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muehlenbachs, A" uniqKey="Muehlenbachs A">A Muehlenbachs</name>
</author>
<author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
<author><name sortKey="Romagosa, C" uniqKey="Romagosa C">C Romagosa</name>
</author>
<author><name sortKey="Abdelgalil, S" uniqKey="Abdelgalil S">S Abdelgalil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leke, Rfg" uniqKey="Leke R">RFG Leke</name>
</author>
<author><name sortKey="Bioga, Jd" uniqKey="Bioga J">JD Bioga</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name>
</author>
<author><name sortKey="Davison, Bb" uniqKey="Davison B">BB Davison</name>
</author>
<author><name sortKey="Stepniewska, K" uniqKey="Stepniewska K">K Stepniewska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khong, Ty" uniqKey="Khong T">TY Khong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamilton, Wj" uniqKey="Hamilton W">WJ Hamilton</name>
</author>
<author><name sortKey="Boyd, Jd" uniqKey="Boyd J">JD Boyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirano, H" uniqKey="Hirano H">H Hirano</name>
</author>
<author><name sortKey="Imai, Y" uniqKey="Imai Y">Y Imai</name>
</author>
<author><name sortKey="Ito, H" uniqKey="Ito H">H Ito</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalilani, L" uniqKey="Kalilani L">L Kalilani</name>
</author>
<author><name sortKey="Mofolo, I" uniqKey="Mofolo I">I Mofolo</name>
</author>
<author><name sortKey="Chaponda, M" uniqKey="Chaponda M">M Chaponda</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Meshnick, Sr" uniqKey="Meshnick S">SR Meshnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desai, M" uniqKey="Desai M">M Desai</name>
</author>
<author><name sortKey="Ter Kuile, Fo" uniqKey="Ter Kuile F">FO ter Kuile</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cottrell, G" uniqKey="Cottrell G">G Cottrell</name>
</author>
<author><name sortKey="Mary, Jy" uniqKey="Mary J">JY Mary</name>
</author>
<author><name sortKey="Barro, D" uniqKey="Barro D">D Barro</name>
</author>
<author><name sortKey="Cot, M" uniqKey="Cot M">M Cot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rijken, Mj" uniqKey="Rijken M">MJ Rijken</name>
</author>
<author><name sortKey="Rijken, Ja" uniqKey="Rijken J">JA Rijken</name>
</author>
<author><name sortKey="Papageorghiou, At" uniqKey="Papageorghiou A">AT Papageorghiou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Landis, Sh" uniqKey="Landis S">SH Landis</name>
</author>
<author><name sortKey="Lokomba, V" uniqKey="Lokomba V">V Lokomba</name>
</author>
<author><name sortKey="Ananth, Cv" uniqKey="Ananth C">CV Ananth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bottero, J" uniqKey="Bottero J">J Bottero</name>
</author>
<author><name sortKey="Briand, V" uniqKey="Briand V">V Briand</name>
</author>
<author><name sortKey="Agbowai, C" uniqKey="Agbowai C">C Agbowai</name>
</author>
<author><name sortKey="Doritchamou, J" uniqKey="Doritchamou J">J Doritchamou</name>
</author>
<author><name sortKey="Massougbodji, A" uniqKey="Massougbodji A">A Massougbodji</name>
</author>
<author><name sortKey="Cot, M" uniqKey="Cot M">M Cot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muthusamy, A" uniqKey="Muthusamy A">A Muthusamy</name>
</author>
<author><name sortKey="Achur, Rn" uniqKey="Achur R">RN Achur</name>
</author>
<author><name sortKey="Valiyaveettil, M" uniqKey="Valiyaveettil M">M Valiyaveettil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Cooke, Bm" uniqKey="Cooke B">BM Cooke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flick, K" uniqKey="Flick K">K Flick</name>
</author>
<author><name sortKey="Scholander, C" uniqKey="Scholander C">C Scholander</name>
</author>
<author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rasti, N" uniqKey="Rasti N">N Rasti</name>
</author>
<author><name sortKey="Namusoke, F" uniqKey="Namusoke F">F Namusoke</name>
</author>
<author><name sortKey="Chene, A" uniqKey="Chene A">A Chêne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khunrae, P" uniqKey="Khunrae P">P Khunrae</name>
</author>
<author><name sortKey="Higgins, Mk" uniqKey="Higgins M">MK Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
<author><name sortKey="Molyneux, Me" uniqKey="Molyneux M">ME Molyneux</name>
</author>
<author><name sortKey="Mhango, C" uniqKey="Mhango C">C Mhango</name>
</author>
<author><name sortKey="Dzinjalamala, F" uniqKey="Dzinjalamala F">F Dzinjalamala</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Chaiyaroj, Sc" uniqKey="Chaiyaroj S">SC Chaiyaroj</name>
</author>
<author><name sortKey="Ng, K" uniqKey="Ng K">K Ng</name>
</author>
<author><name sortKey="Reeder, Jc" uniqKey="Reeder J">JC Reeder</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noviyanti, R" uniqKey="Noviyanti R">R Noviyanti</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
<author><name sortKey="Wickham, Me" uniqKey="Wickham M">ME Wickham</name>
</author>
<author><name sortKey="Duffy, Mf" uniqKey="Duffy M">MF Duffy</name>
</author>
<author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
<author><name sortKey="Reeder, Jc" uniqKey="Reeder J">JC Reeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joergensen, L" uniqKey="Joergensen L">L Joergensen</name>
</author>
<author><name sortKey="Bengtsson, Dc" uniqKey="Bengtsson D">DC Bengtsson</name>
</author>
<author><name sortKey="Bengtsson, A" uniqKey="Bengtsson A">A Bengtsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Lavstsen, T" uniqKey="Lavstsen T">T Lavstsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="Lavstsen, T" uniqKey="Lavstsen T">T Lavstsen</name>
</author>
<author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schieck, E" uniqKey="Schieck E">E Schieck</name>
</author>
<author><name sortKey="Pfahler, Jm" uniqKey="Pfahler J">JM Pfahler</name>
</author>
<author><name sortKey="Sanchez, Cp" uniqKey="Sanchez C">CP Sanchez</name>
</author>
<author><name sortKey="Lanzer, M" uniqKey="Lanzer M">M Lanzer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Udomsangpetch, R" uniqKey="Udomsangpetch R">R Udomsangpetch</name>
</author>
<author><name sortKey="Wahlin, B" uniqKey="Wahlin B">B Wahlin</name>
</author>
<author><name sortKey="Carlson, J" uniqKey="Carlson J">J Carlson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Brockman, A" uniqKey="Brockman A">A Brockman</name>
</author>
<author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Mann, Ej" uniqKey="Mann E">EJ Mann</name>
</author>
<author><name sortKey="Elliott, Sr" uniqKey="Elliott S">SR Elliott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maubert, B" uniqKey="Maubert B">B Maubert</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Tami, G" uniqKey="Tami G">G Tami</name>
</author>
<author><name sortKey="Cot, M" uniqKey="Cot M">M Cot</name>
</author>
<author><name sortKey="Boudin, C" uniqKey="Boudin C">C Boudin</name>
</author>
<author><name sortKey="Deloron, P" uniqKey="Deloron P">P Deloron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salem, Hh" uniqKey="Salem H">HH Salem</name>
</author>
<author><name sortKey="Maruyama, I" uniqKey="Maruyama I">I Maruyama</name>
</author>
<author><name sortKey="Ishii, H" uniqKey="Ishii H">H Ishii</name>
</author>
<author><name sortKey="Majerus, Pw" uniqKey="Majerus P">PW Majerus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaefer, L" uniqKey="Schaefer L">L Schaefer</name>
</author>
<author><name sortKey="Schaefer, Rm" uniqKey="Schaefer R">RM Schaefer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lucchi, Nw" uniqKey="Lucchi N">NW Lucchi</name>
</author>
<author><name sortKey="Koopman, R" uniqKey="Koopman R">R Koopman</name>
</author>
<author><name sortKey="Peterson, Ds" uniqKey="Peterson D">DS Peterson</name>
</author>
<author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lucchi, Nw" uniqKey="Lucchi N">NW Lucchi</name>
</author>
<author><name sortKey="Peterson, Ds" uniqKey="Peterson D">DS Peterson</name>
</author>
<author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="Nielsen, Ma" uniqKey="Nielsen M">MA Nielsen</name>
</author>
<author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matejevic, D" uniqKey="Matejevic D">D Matejevic</name>
</author>
<author><name sortKey="Neudeck, H" uniqKey="Neudeck H">H Neudeck</name>
</author>
<author><name sortKey="Graf, R" uniqKey="Graf R">R Graf</name>
</author>
<author><name sortKey="Muller, T" uniqKey="Muller T">T Müller</name>
</author>
<author><name sortKey="Dietl, J" uniqKey="Dietl J">J Dietl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hommel, M" uniqKey="Hommel M">M Hommel</name>
</author>
<author><name sortKey="Elliott, Sr" uniqKey="Elliott S">SR Elliott</name>
</author>
<author><name sortKey="Soma, V" uniqKey="Soma V">V Soma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Mf" uniqKey="Duffy M">MF Duffy</name>
</author>
<author><name sortKey="Byrne, Tj" uniqKey="Byrne T">TJ Byrne</name>
</author>
<author><name sortKey="Elliott, Sr" uniqKey="Elliott S">SR Elliott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baruch, Di" uniqKey="Baruch D">DI Baruch</name>
</author>
<author><name sortKey="Gormley, Ja" uniqKey="Gormley J">JA Gormley</name>
</author>
<author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name>
</author>
<author><name sortKey="Howard, Rj" uniqKey="Howard R">RJ Howard</name>
</author>
<author><name sortKey="Pasloske, Bl" uniqKey="Pasloske B">BL Pasloske</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kraemer, Sm" uniqKey="Kraemer S">SM Kraemer</name>
</author>
<author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
<author><name sortKey="Kyes, S" uniqKey="Kyes S">S Kyes</name>
</author>
<author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
<author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
<author><name sortKey="Kriek, N" uniqKey="Kriek N">N Kriek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
<author><name sortKey="Leke, Rf" uniqKey="Leke R">RF Leke</name>
</author>
<author><name sortKey="Taylor, Dw" uniqKey="Taylor D">DW Taylor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, N" uniqKey="Singh N">N Singh</name>
</author>
<author><name sortKey="Shukla, Mm" uniqKey="Shukla M">MM Shukla</name>
</author>
<author><name sortKey="Srivastava, R" uniqKey="Srivastava R">R Srivastava</name>
</author>
<author><name sortKey="Sharma, Vp" uniqKey="Sharma V">VP Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Mcgready, R" uniqKey="Mcgready R">R McGready</name>
</author>
<author><name sortKey="Simpson, Ja" uniqKey="Simpson J">JA Simpson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diagne, N" uniqKey="Diagne N">N Diagne</name>
</author>
<author><name sortKey="Rogier, C" uniqKey="Rogier C">C Rogier</name>
</author>
<author><name sortKey="Cisse, B" uniqKey="Cisse B">B Cisse</name>
</author>
<author><name sortKey="Trape, Jf" uniqKey="Trape J">JF Trape</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
<author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luxemburger, C" uniqKey="Luxemburger C">C Luxemburger</name>
</author>
<author><name sortKey="Ricci, F" uniqKey="Ricci F">F Ricci</name>
</author>
<author><name sortKey="Nosten, F" uniqKey="Nosten F">F Nosten</name>
</author>
<author><name sortKey="Raimond, D" uniqKey="Raimond D">D Raimond</name>
</author>
<author><name sortKey="Bathet, S" uniqKey="Bathet S">S Bathet</name>
</author>
<author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diagne, N" uniqKey="Diagne N">N Diagne</name>
</author>
<author><name sortKey="Rogier, C" uniqKey="Rogier C">C Rogier</name>
</author>
<author><name sortKey="Sokhna, Cs" uniqKey="Sokhna C">CS Sokhna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tuikue Ndam, Ng" uniqKey="Tuikue Ndam N">NG Tuikue Ndam</name>
</author>
<author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
<author><name sortKey="Bertin, G" uniqKey="Bertin G">G Bertin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kraemer, Sm" uniqKey="Kraemer S">SM Kraemer</name>
</author>
<author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Viebig, Nk" uniqKey="Viebig N">NK Viebig</name>
</author>
<author><name sortKey="Gamain, B" uniqKey="Gamain B">B Gamain</name>
</author>
<author><name sortKey="Scheidig, C" uniqKey="Scheidig C">C Scheidig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Mf" uniqKey="Duffy M">MF Duffy</name>
</author>
<author><name sortKey="Maier, Ag" uniqKey="Maier A">AG Maier</name>
</author>
<author><name sortKey="Byrne, Tj" uniqKey="Byrne T">TJ Byrne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
<author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="Turner, L" uniqKey="Turner L">L Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gamain, B" uniqKey="Gamain B">B Gamain</name>
</author>
<author><name sortKey="Trimnell, Ar" uniqKey="Trimnell A">AR Trimnell</name>
</author>
<author><name sortKey="Scheidig, C" uniqKey="Scheidig C">C Scheidig</name>
</author>
<author><name sortKey="Schert, A" uniqKey="Schert A">A Schert</name>
</author>
<author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
<author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Viebig, Nk" uniqKey="Viebig N">NK Viebig</name>
</author>
<author><name sortKey="Nunes, Mc" uniqKey="Nunes M">MC Nunes</name>
</author>
<author><name sortKey="Scherf, A" uniqKey="Scherf A">A Scherf</name>
</author>
<author><name sortKey="Gamain, B" uniqKey="Gamain B">B Gamain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cox, Se" uniqKey="Cox S">SE Cox</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Arthur, P" uniqKey="Arthur P">P Arthur</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barfod, L" uniqKey="Barfod L">L Barfod</name>
</author>
<author><name sortKey="Nielsen, Ma" uniqKey="Nielsen M">MA Nielsen</name>
</author>
<author><name sortKey="Turner, L" uniqKey="Turner L">L Turner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Shulman, Ce" uniqKey="Shulman C">CE Shulman</name>
</author>
<author><name sortKey="Bulmer, Jn" uniqKey="Bulmer J">JN Bulmer</name>
</author>
<author><name sortKey="Kawuondo, K" uniqKey="Kawuondo K">K Kawuondo</name>
</author>
<author><name sortKey="Marsh, K" uniqKey="Marsh K">K Marsh</name>
</author>
<author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Megnekou, R" uniqKey="Megnekou R">R Megnekou</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievét</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ricke, Ch" uniqKey="Ricke C">CH Ricke</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Koram, K" uniqKey="Koram K">K Koram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Recker, M" uniqKey="Recker M">M Recker</name>
</author>
<author><name sortKey="Buckee, Co" uniqKey="Buckee C">CO Buckee</name>
</author>
<author><name sortKey="Serazin, A" uniqKey="Serazin A">A Serazin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aitken, Eh" uniqKey="Aitken E">EH Aitken</name>
</author>
<author><name sortKey="Mbewe, B" uniqKey="Mbewe B">B Mbewe</name>
</author>
<author><name sortKey="Luntamo, M" uniqKey="Luntamo M">M Luntamo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="O Eil Dunne, I" uniqKey="O Eil Dunne I">I O’Neil-Dunne</name>
</author>
<author><name sortKey="Achur, Rn" uniqKey="Achur R">RN Achur</name>
</author>
<author><name sortKey="Agbor Enoh, St" uniqKey="Agbor Enoh S">ST Agbor-Enoh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Achtman, Ah" uniqKey="Achtman A">AH Achtman</name>
</author>
<author><name sortKey="Bull, Pc" uniqKey="Bull P">PC Bull</name>
</author>
<author><name sortKey="Stephens, R" uniqKey="Stephens R">R Stephens</name>
</author>
<author><name sortKey="Langhorne, J" uniqKey="Langhorne J">J Langhorne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Elliott, Sr" uniqKey="Elliott S">SR Elliott</name>
</author>
<author><name sortKey="Brennan, Ak" uniqKey="Brennan A">AK Brennan</name>
</author>
<author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guitard, J" uniqKey="Guitard J">J Guitard</name>
</author>
<author><name sortKey="Andersen, P" uniqKey="Andersen P">P Andersen</name>
</author>
<author><name sortKey="Ermont, C" uniqKey="Ermont C">C Ermont</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salanti, A" uniqKey="Salanti A">A Salanti</name>
</author>
<author><name sortKey="Resende, M" uniqKey="Resende M">M Resende</name>
</author>
<author><name sortKey="Ditlev, Sb" uniqKey="Ditlev S">SB Ditlev</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khunrae, P" uniqKey="Khunrae P">P Khunrae</name>
</author>
<author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="Nielsen, Ma" uniqKey="Nielsen M">MA Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
<author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, G" uniqKey="Feng G">G Feng</name>
</author>
<author><name sortKey="Aitken, E" uniqKey="Aitken E">E Aitken</name>
</author>
<author><name sortKey="Yosaatmadja, F" uniqKey="Yosaatmadja F">F Yosaatmadja</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcelroy, Pd" uniqKey="Mcelroy P">PD McElroy</name>
</author>
<author><name sortKey="Ter Kuile, Fo" uniqKey="Ter Kuile F">FO ter Kuile</name>
</author>
<author><name sortKey="Hightower, Aw" uniqKey="Hightower A">AW Hightower</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marinho, Crf" uniqKey="Marinho C">CRF Marinho</name>
</author>
<author><name sortKey="Neres, R" uniqKey="Neres R">R Neres</name>
</author>
<author><name sortKey="Epiphanio, S" uniqKey="Epiphanio S">S Epiphanio</name>
</author>
<author><name sortKey="Goncalves, La" uniqKey="Goncalves L">LA Gonçalves</name>
</author>
<author><name sortKey="Catarino, Mb" uniqKey="Catarino M">MB Catarino</name>
</author>
<author><name sortKey="Penha Goncalves, C" uniqKey="Penha Goncalves C">C Penha-Gonçalves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalanda, Bf" uniqKey="Kalanda B">BF Kalanda</name>
</author>
<author><name sortKey="Verhoeff, Fh" uniqKey="Verhoeff F">FH Verhoeff</name>
</author>
<author><name sortKey="Chimsuku, L" uniqKey="Chimsuku L">L Chimsuku</name>
</author>
<author><name sortKey="Harper, G" uniqKey="Harper G">G Harper</name>
</author>
<author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walker Abbey, A" uniqKey="Walker Abbey A">A Walker-Abbey</name>
</author>
<author><name sortKey="Djokam, Rrt" uniqKey="Djokam R">RRT Djokam</name>
</author>
<author><name sortKey="Eno, A" uniqKey="Eno A">A Eno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schleiermacher, D" uniqKey="Schleiermacher D">D Schleiermacher</name>
</author>
<author><name sortKey="Rogier, C" uniqKey="Rogier C">C Rogier</name>
</author>
<author><name sortKey="Spiegel, A" uniqKey="Spiegel A">A Spiegel</name>
</author>
<author><name sortKey="Tall, A" uniqKey="Tall A">A Tall</name>
</author>
<author><name sortKey="Trape, Jf" uniqKey="Trape J">JF Trape</name>
</author>
<author><name sortKey="Mercereau Puijalon, O" uniqKey="Mercereau Puijalon O">O Mercereau-Puijalon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hay, Si" uniqKey="Hay S">SI Hay</name>
</author>
<author><name sortKey="Guerra, Ca" uniqKey="Guerra C">CA Guerra</name>
</author>
<author><name sortKey="Gething, Pw" uniqKey="Gething P">PW Gething</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mwangi, Tw" uniqKey="Mwangi T">TW Mwangi</name>
</author>
<author><name sortKey="Ross, A" uniqKey="Ross A">A Ross</name>
</author>
<author><name sortKey="Snow, Rw" uniqKey="Snow R">RW Snow</name>
</author>
<author><name sortKey="Marsh, K" uniqKey="Marsh K">K Marsh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giobbia, M" uniqKey="Giobbia M">M Giobbia</name>
</author>
<author><name sortKey="Tonon, E" uniqKey="Tonon E">E Tonon</name>
</author>
<author><name sortKey="Zanatta, A" uniqKey="Zanatta A">A Zanatta</name>
</author>
<author><name sortKey="Cesaris, L" uniqKey="Cesaris L">L Cesaris</name>
</author>
<author><name sortKey="Bisoffi, Z" uniqKey="Bisoffi Z">Z Bisoffi</name>
</author>
<author><name sortKey="Vaglia, A" uniqKey="Vaglia A">A Vaglia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Marinho, Crf" uniqKey="Marinho C">CRF Marinho</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Penha Goncalves, C" uniqKey="Penha Goncalves C">C Penha-Gonçalves</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
<author><name sortKey="Shulman, Ce" uniqKey="Shulman C">CE Shulman</name>
</author>
<author><name sortKey="Dorman, Ek" uniqKey="Dorman E">EK Dorman</name>
</author>
<author><name sortKey="Kawuondo, K" uniqKey="Kawuondo K">K Kawuondo</name>
</author>
<author><name sortKey="Marsh, K" uniqKey="Marsh K">K Marsh</name>
</author>
<author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Wijesinghe, Rs" uniqKey="Wijesinghe R">RS Wijesinghe</name>
</author>
<author><name sortKey="Meshnick, Sr" uniqKey="Meshnick S">SR Meshnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Mann, Ej" uniqKey="Mann E">EJ Mann</name>
</author>
<author><name sortKey="Byrne, Tj" uniqKey="Byrne T">TJ Byrne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="Rask, Ts" uniqKey="Rask T">TS Rask</name>
</author>
<author><name sortKey="Andersen, Ph" uniqKey="Andersen P">PH Andersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barfod, L" uniqKey="Barfod L">L Barfod</name>
</author>
<author><name sortKey="Bernasconi, Nl" uniqKey="Bernasconi N">NL Bernasconi</name>
</author>
<author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piccinni, M P" uniqKey="Piccinni M">M-P Piccinni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ashkar, Aa" uniqKey="Ashkar A">AA Ashkar</name>
</author>
<author><name sortKey="Black, Gp" uniqKey="Black G">GP Black</name>
</author>
<author><name sortKey="Wei, Q" uniqKey="Wei Q">Q Wei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Argi S, Jm" uniqKey="Argi S J">JM Argiĺs</name>
</author>
<author><name sortKey="Carbo, N" uniqKey="Carbo N">N Carbo</name>
</author>
<author><name sortKey="Lpez Soriano, Fj" uniqKey="Lpez Soriano F">FJ Lpez-Soriano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, H" uniqKey="Lin H">H Lin</name>
</author>
<author><name sortKey="Mosmann, Tr" uniqKey="Mosmann T">TR Mosmann</name>
</author>
<author><name sortKey="Guilbert, L" uniqKey="Guilbert L">L Guilbert</name>
</author>
<author><name sortKey="Tuntipopipat, S" uniqKey="Tuntipopipat S">S Tuntipopipat</name>
</author>
<author><name sortKey="Wegmann, Tg" uniqKey="Wegmann T">TG Wegmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piccinni, Mp" uniqKey="Piccinni M">MP Piccinni</name>
</author>
<author><name sortKey="Scaletti, C" uniqKey="Scaletti C">C Scaletti</name>
</author>
<author><name sortKey="Maggi, E" uniqKey="Maggi E">E Maggi</name>
</author>
<author><name sortKey="Romagnani, S" uniqKey="Romagnani S">S Romagnani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lea, Rg" uniqKey="Lea R">RG Lea</name>
</author>
<author><name sortKey="Flanders, Kc" uniqKey="Flanders K">KC Flanders</name>
</author>
<author><name sortKey="Harley, Cb" uniqKey="Harley C">CB Harley</name>
</author>
<author><name sortKey="Manuel, J" uniqKey="Manuel J">J Manuel</name>
</author>
<author><name sortKey="Banwatt, D" uniqKey="Banwatt D">D Banwatt</name>
</author>
<author><name sortKey="Clark, Da" uniqKey="Clark D">DA Clark</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wegmann, Tg" uniqKey="Wegmann T">TG Wegmann</name>
</author>
<author><name sortKey="Lin, H" uniqKey="Lin H">H Lin</name>
</author>
<author><name sortKey="Guilbert, L" uniqKey="Guilbert L">L Guilbert</name>
</author>
<author><name sortKey="Mosmann, Tr" uniqKey="Mosmann T">TR Mosmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thellin, O" uniqKey="Thellin O">O Thellin</name>
</author>
<author><name sortKey="Coumans, B" uniqKey="Coumans B">B Coumans</name>
</author>
<author><name sortKey="Zorzi, W" uniqKey="Zorzi W">W Zorzi</name>
</author>
<author><name sortKey="Igout, A" uniqKey="Igout A">A Igout</name>
</author>
<author><name sortKey="Heinen, E" uniqKey="Heinen E">E Heinen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrier, Bf" uniqKey="Barrier B">BF Barrier</name>
</author>
<author><name sortKey="Gargiulo, Ar" uniqKey="Gargiulo A">AR Gargiulo</name>
</author>
<author><name sortKey="Schust, Dj" uniqKey="Schust D">DJ Schust</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taylor Robinson, Aw" uniqKey="Taylor Robinson A">AW Taylor-Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Osier, Fha" uniqKey="Osier F">FHA Osier</name>
</author>
<author><name sortKey="Engwerda, Cr" uniqKey="Engwerda C">CR Engwerda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suguitan, Al" uniqKey="Suguitan A">AL Suguitan</name>
</author>
<author><name sortKey="Leke, Rgf" uniqKey="Leke R">RGF Leke</name>
</author>
<author><name sortKey="Fouda, G" uniqKey="Fouda G">G Fouda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Moussa, M" uniqKey="Moussa M">M Moussa</name>
</author>
<author><name sortKey="Tami, G" uniqKey="Tami G">G Tami</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Pollina, E" uniqKey="Pollina E">E Pollina</name>
</author>
<author><name sortKey="Getachew, A" uniqKey="Getachew A">A Getachew</name>
</author>
<author><name sortKey="Tadesse, E" uniqKey="Tadesse E">E Tadesse</name>
</author>
<author><name sortKey="Lema, Vm" uniqKey="Lema V">VM Lema</name>
</author>
<author><name sortKey="Molyneux, Me" uniqKey="Molyneux M">ME Molyneux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Taylor Robinson, Aw" uniqKey="Taylor Robinson A">AW Taylor-Robinson</name>
</author>
<author><name sortKey="Smith, Ec" uniqKey="Smith E">EC Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piccinni, Mp" uniqKey="Piccinni M">MP Piccinni</name>
</author>
<author><name sortKey="Beloni, L" uniqKey="Beloni L">L Beloni</name>
</author>
<author><name sortKey="Livi, C" uniqKey="Livi C">C Livi</name>
</author>
<author><name sortKey="Maggi, E" uniqKey="Maggi E">E Maggi</name>
</author>
<author><name sortKey="Scarselli, G" uniqKey="Scarselli G">G Scarselli</name>
</author>
<author><name sortKey="Romagnani, S" uniqKey="Romagnani S">S Romagnani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kwak Kim, Jyh" uniqKey="Kwak Kim J">JYH Kwak-Kim</name>
</author>
<author><name sortKey="Gilman Sachs, A" uniqKey="Gilman Sachs A">A Gilman-Sachs</name>
</author>
<author><name sortKey="Kim, Ce" uniqKey="Kim C">CE Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Muga, Ro" uniqKey="Muga R">RO Muga</name>
</author>
<author><name sortKey="Misore, Ao" uniqKey="Misore A">AO Misore</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moormann, Am" uniqKey="Moormann A">AM Moormann</name>
</author>
<author><name sortKey="Sullivan, Ad" uniqKey="Sullivan A">AD Sullivan</name>
</author>
<author><name sortKey="Rochford, Ra" uniqKey="Rochford R">RA Rochford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maubert, B" uniqKey="Maubert B">B Maubert</name>
</author>
<author><name sortKey="Guilbert, Lj" uniqKey="Guilbert L">LJ Guilbert</name>
</author>
<author><name sortKey="Deloron, P" uniqKey="Deloron P">P Deloron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Renaud, Sj" uniqKey="Renaud S">SJ Renaud</name>
</author>
<author><name sortKey="Sullivan, R" uniqKey="Sullivan R">R Sullivan</name>
</author>
<author><name sortKey="Graham, Ch" uniqKey="Graham C">CH Graham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monz N Bordonaba, F" uniqKey="Monz N Bordonaba F">F Monzón-Bordonaba</name>
</author>
<author><name sortKey="Vadillo Ortega, F" uniqKey="Vadillo Ortega F">F Vadillo-Ortega</name>
</author>
<author><name sortKey="Feinberg, Rf" uniqKey="Feinberg R">RF Feinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arechavaleta Velasco, F" uniqKey="Arechavaleta Velasco F">F Arechavaleta-Velasco</name>
</author>
<author><name sortKey="Mayon Gonzalez, J" uniqKey="Mayon Gonzalez J">J Mayon-Gonzalez</name>
</author>
<author><name sortKey="Gonzalez Jimenez, M" uniqKey="Gonzalez Jimenez M">M Gonzalez-Jimenez</name>
</author>
<author><name sortKey="Hernandez Guerrero, C" uniqKey="Hernandez Guerrero C">C Hernandez-Guerrero</name>
</author>
<author><name sortKey="Vadillo Ortega, F" uniqKey="Vadillo Ortega F">F Vadillo-Ortega</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Brown, Hc" uniqKey="Brown H">HC Brown</name>
</author>
<author><name sortKey="Pollina, E" uniqKey="Pollina E">E Pollina</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name>
</author>
<author><name sortKey="Nahlen, Bl" uniqKey="Nahlen B">BL Nahlen</name>
</author>
<author><name sortKey="Misore, A" uniqKey="Misore A">A Misore</name>
</author>
<author><name sortKey="Lal, Aa" uniqKey="Lal A">AA Lal</name>
</author>
<author><name sortKey="Udhayakumar, V" uniqKey="Udhayakumar V">V Udhayakumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kabyemela, Er" uniqKey="Kabyemela E">ER Kabyemela</name>
</author>
<author><name sortKey="Muehlenbachs, A" uniqKey="Muehlenbachs A">A Muehlenbachs</name>
</author>
<author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Kurtis, Jd" uniqKey="Kurtis J">JD Kurtis</name>
</author>
<author><name sortKey="Mutabingwa, Tk" uniqKey="Mutabingwa T">TK Mutabingwa</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davison, Bb" uniqKey="Davison B">BB Davison</name>
</author>
<author><name sortKey="Kaack, Mb" uniqKey="Kaack M">MB Kaack</name>
</author>
<author><name sortKey="Rogers, Lb" uniqKey="Rogers L">LB Rogers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nmorsi, Opg" uniqKey="Nmorsi O">OPG Nmorsi</name>
</author>
<author><name sortKey="Isaac, C" uniqKey="Isaac C">C Isaac</name>
</author>
<author><name sortKey="Ohaneme, Ba" uniqKey="Ohaneme B">BA Ohaneme</name>
</author>
<author><name sortKey="Obiazi, Hak" uniqKey="Obiazi H">HAK Obiazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaisavaneeyakorn, S" uniqKey="Chaisavaneeyakorn S">S Chaisavaneeyakorn</name>
</author>
<author><name sortKey="Lucchi, N" uniqKey="Lucchi N">N Lucchi</name>
</author>
<author><name sortKey="Abramowsky, C" uniqKey="Abramowsky C">C Abramowsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaisavaneeyakorn, S" uniqKey="Chaisavaneeyakorn S">S Chaisavaneeyakorn</name>
</author>
<author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name>
</author>
<author><name sortKey="Othoro, C" uniqKey="Othoro C">C Othoro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chaiyaroj, Sc" uniqKey="Chaiyaroj S">SC Chaiyaroj</name>
</author>
<author><name sortKey="Rutta, Asm" uniqKey="Rutta A">ASM Rutta</name>
</author>
<author><name sortKey="Muenthaisong, K" uniqKey="Muenthaisong K">K Muenthaisong</name>
</author>
<author><name sortKey="Watkins, P" uniqKey="Watkins P">P Watkins</name>
</author>
<author><name sortKey="Na Ubol, M" uniqKey="Na Ubol M">M Na Ubol</name>
</author>
<author><name sortKey="Looareesuwan, S" uniqKey="Looareesuwan S">S Looareesuwan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diouf, I" uniqKey="Diouf I">I Diouf</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Doucoure, S" uniqKey="Doucoure S">S Doucouré</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ismaili, J" uniqKey="Ismaili J">J Ismaili</name>
</author>
<author><name sortKey="Van Der Sande, M" uniqKey="Van Der Sande M">M van der Sande</name>
</author>
<author><name sortKey="Holland, Mj" uniqKey="Holland M">MJ Holland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fiorentino, Df" uniqKey="Fiorentino D">DF Fiorentino</name>
</author>
<author><name sortKey="Zlotnik, A" uniqKey="Zlotnik A">A Zlotnik</name>
</author>
<author><name sortKey="Mosmann, Tr" uniqKey="Mosmann T">TR Mosmann</name>
</author>
<author><name sortKey="Howard, M" uniqKey="Howard M">M Howard</name>
</author>
<author><name sortKey="O Arra, A" uniqKey="O Arra A">A O’Garra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Achidi, Ea" uniqKey="Achidi E">EA Achidi</name>
</author>
<author><name sortKey="Apinjoh, To" uniqKey="Apinjoh T">TO Apinjoh</name>
</author>
<author><name sortKey="Titanji, Vpk" uniqKey="Titanji V">VPK Titanji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Theander, Tg" uniqKey="Theander T">TG Theander</name>
</author>
<author><name sortKey="Abdulhadi, Nh" uniqKey="Abdulhadi N">NH Abdulhadi</name>
</author>
<author><name sortKey="Abu Zeid, Ya" uniqKey="Abu Zeid Y">YA Abu-Zeid</name>
</author>
<author><name sortKey="Bayoumi, Ra" uniqKey="Bayoumi R">RA Bayoumi</name>
</author>
<author><name sortKey="Jensen, Jb" uniqKey="Jensen J">JB Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Megnekou, R" uniqKey="Megnekou R">R Megnekou</name>
</author>
<author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carter, Am" uniqKey="Carter A">AM Carter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raghupathy, R" uniqKey="Raghupathy R">R Raghupathy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name>
</author>
<author><name sortKey="Schneider, G" uniqKey="Schneider G">G Schneider</name>
</author>
<author><name sortKey="Sambou, I" uniqKey="Sambou I">I Sambou</name>
</author>
<author><name sortKey="Greenwood, Bm" uniqKey="Greenwood B">BM Greenwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Tami, G" uniqKey="Tami G">G Tami</name>
</author>
<author><name sortKey="Maubert, B" uniqKey="Maubert B">B Maubert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frevert, U" uniqKey="Frevert U">U Frevert</name>
</author>
<author><name sortKey="Nardin, E" uniqKey="Nardin E">E Nardin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandele, A" uniqKey="Chandele A">A Chandele</name>
</author>
<author><name sortKey="Mukerjee, P" uniqKey="Mukerjee P">P Mukerjee</name>
</author>
<author><name sortKey="Das, G" uniqKey="Das G">G Das</name>
</author>
<author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name>
</author>
<author><name sortKey="Chauhan, Vs" uniqKey="Chauhan V">VS Chauhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vinetz, Jm" uniqKey="Vinetz J">JM Vinetz</name>
</author>
<author><name sortKey="Kumar, S" uniqKey="Kumar S">S Kumar</name>
</author>
<author><name sortKey="Good, Mf" uniqKey="Good M">MF Good</name>
</author>
<author><name sortKey="Fowlkes, Bj" uniqKey="Fowlkes B">BJ Fowlkes</name>
</author>
<author><name sortKey="Berzofsky, Ja" uniqKey="Berzofsky J">JA Berzofsky</name>
</author>
<author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lurie, S" uniqKey="Lurie S">S Lurie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Othoro, C" uniqKey="Othoro C">C Othoro</name>
</author>
<author><name sortKey="Moore, Jm" uniqKey="Moore J">JM Moore</name>
</author>
<author><name sortKey="Wannemuehler, Ka" uniqKey="Wannemuehler K">KA Wannemuehler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parham, P" uniqKey="Parham P">P Parham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kremsner, Pg" uniqKey="Kremsner P">PG Kremsner</name>
</author>
<author><name sortKey="Winkler, S" uniqKey="Winkler S">S Winkler</name>
</author>
<author><name sortKey="Wildling, E" uniqKey="Wildling E">E Wildling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Artavanis Tsakonas, K" uniqKey="Artavanis Tsakonas K">K Artavanis-Tsakonas</name>
</author>
<author><name sortKey="Eleme, K" uniqKey="Eleme K">K Eleme</name>
</author>
<author><name sortKey="Mcqueen, Kl" uniqKey="Mcqueen K">KL McQueen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Artavanis Tsakonas, K" uniqKey="Artavanis Tsakonas K">K Artavanis-Tsakonas</name>
</author>
<author><name sortKey="Tongren, Je" uniqKey="Tongren J">JE Tongren</name>
</author>
<author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mavoungou, E" uniqKey="Mavoungou E">E Mavoungou</name>
</author>
<author><name sortKey="Luty, Ajf" uniqKey="Luty A">AJF Luty</name>
</author>
<author><name sortKey="Kremsner, Pg" uniqKey="Kremsner P">PG Kremsner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mavoungou, E" uniqKey="Mavoungou E">E Mavoungou</name>
</author>
<author><name sortKey="Poaty Mavoungou, V" uniqKey="Poaty Mavoungou V">V Poaty-Mavoungou</name>
</author>
<author><name sortKey="Toure, Fs" uniqKey="Toure F">FS Touré</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sartelet, H" uniqKey="Sartelet H">H Sartelet</name>
</author>
<author><name sortKey="Schleiermacher, D" uniqKey="Schleiermacher D">D Schleiermacher</name>
</author>
<author><name sortKey="Le Hesran, Jy" uniqKey="Le Hesran J">JY Le-Hesran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouyou Akotet, Mk" uniqKey="Bouyou Akotet M">MK Bouyou-Akotet</name>
</author>
<author><name sortKey="Issifou, S" uniqKey="Issifou S">S Issifou</name>
</author>
<author><name sortKey="Meye, Jf" uniqKey="Meye J">JF Meye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouyou Akotet, Mk" uniqKey="Bouyou Akotet M">MK Bouyou-Akotet</name>
</author>
<author><name sortKey="Mavoungou, E" uniqKey="Mavoungou E">E Mavoungou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diouf, I" uniqKey="Diouf I">I Diouf</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Doucoure, S" uniqKey="Doucoure S">S Doucouré</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turrini, F" uniqKey="Turrini F">F Turrini</name>
</author>
<author><name sortKey="Ginsburg, H" uniqKey="Ginsburg H">H Ginsburg</name>
</author>
<author><name sortKey="Bussolino, F" uniqKey="Bussolino F">F Bussolino</name>
</author>
<author><name sortKey="Pescarmona, Gp" uniqKey="Pescarmona G">GP Pescarmona</name>
</author>
<author><name sortKey="Serra, Mv" uniqKey="Serra M">MV Serra</name>
</author>
<author><name sortKey="Arese, P" uniqKey="Arese P">P Arese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, Ch" uniqKey="Holmes C">CH Holmes</name>
</author>
<author><name sortKey="Simpson, Kl" uniqKey="Simpson K">KL Simpson</name>
</author>
<author><name sortKey="Okada, H" uniqKey="Okada H">H Okada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conroy, A" uniqKey="Conroy A">A Conroy</name>
</author>
<author><name sortKey="Serghides, L" uniqKey="Serghides L">L Serghides</name>
</author>
<author><name sortKey="Finney, C" uniqKey="Finney C">C Finney</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Girardi, G" uniqKey="Girardi G">G Girardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silver, Kl" uniqKey="Silver K">KL Silver</name>
</author>
<author><name sortKey="Higgins, Sj" uniqKey="Higgins S">SJ Higgins</name>
</author>
<author><name sortKey="Mcdonald, Cr" uniqKey="Mcdonald C">CR McDonald</name>
</author>
<author><name sortKey="Kain, Kc" uniqKey="Kain K">KC Kain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albrecht, Ea" uniqKey="Albrecht E">EA Albrecht</name>
</author>
<author><name sortKey="Chinnaiyan, Am" uniqKey="Chinnaiyan A">AM Chinnaiyan</name>
</author>
<author><name sortKey="Varambally, S" uniqKey="Varambally S">S Varambally</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imamura, T" uniqKey="Imamura T">T Imamura</name>
</author>
<author><name sortKey="Sugiyama, T" uniqKey="Sugiyama T">T Sugiyama</name>
</author>
<author><name sortKey="Cuevas, Le" uniqKey="Cuevas L">LE Cuevas</name>
</author>
<author><name sortKey="Makunde, R" uniqKey="Makunde R">R Makunde</name>
</author>
<author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouyou Akotet, Mk" uniqKey="Bouyou Akotet M">MK Bouyou-Akotet</name>
</author>
<author><name sortKey="Adegnika, Aa" uniqKey="Adegnika A">AA Adegnika</name>
</author>
<author><name sortKey="Agnandji, St" uniqKey="Agnandji S">ST Agnandji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mavoungou, E" uniqKey="Mavoungou E">E Mavoungou</name>
</author>
<author><name sortKey="Bouyou Akotet, Mk" uniqKey="Bouyou Akotet M">MK Bouyou-Akotet</name>
</author>
<author><name sortKey="Kremsner, Pg" uniqKey="Kremsner P">PG Kremsner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moffett King, A" uniqKey="Moffett King A">A Moffett-King</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bayoumi, Nk" uniqKey="Bayoumi N">NK Bayoumi</name>
</author>
<author><name sortKey="Elhassan, Em" uniqKey="Elhassan E">EM Elhassan</name>
</author>
<author><name sortKey="Elbashir, Mi" uniqKey="Elbashir M">MI Elbashir</name>
</author>
<author><name sortKey="Adam, I" uniqKey="Adam I">I Adam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ter Kuile, Fo" uniqKey="Ter Kuile F">FO ter Kuile</name>
</author>
<author><name sortKey="Parise, Me" uniqKey="Parise M">ME Parise</name>
</author>
<author><name sortKey="Verhoeff, Fh" uniqKey="Verhoeff F">FH Verhoeff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mwapasa, V" uniqKey="Mwapasa V">V Mwapasa</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Molyneux, Me" uniqKey="Molyneux M">ME Molyneux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mount, Am" uniqKey="Mount A">AM Mount</name>
</author>
<author><name sortKey="Mwapasa, V" uniqKey="Mwapasa V">V Mwapasa</name>
</author>
<author><name sortKey="Elliott, Sr" uniqKey="Elliott S">SR Elliott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Eijk, Am" uniqKey="Van Eijk A">AM van Eijk</name>
</author>
<author><name sortKey="Ayisi, Jg" uniqKey="Ayisi J">JG Ayisi</name>
</author>
<author><name sortKey="Ter Kuile, Fo" uniqKey="Ter Kuile F">FO ter Kuile</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Keen, J" uniqKey="Keen J">J Keen</name>
</author>
<author><name sortKey="Serghides, L" uniqKey="Serghides L">L Serghides</name>
</author>
<author><name sortKey="Ayi, K" uniqKey="Ayi K">K Ayi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mens, Pf" uniqKey="Mens P">PF Mens</name>
</author>
<author><name sortKey="Bojtor, Ec" uniqKey="Bojtor E">EC Bojtor</name>
</author>
<author><name sortKey="Schallig, Hdfh" uniqKey="Schallig H">HDFH Schallig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pallotto, Ek" uniqKey="Pallotto E">EK Pallotto</name>
</author>
<author><name sortKey="Kilbride, Hw" uniqKey="Kilbride H">HW Kilbride</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okoko, Bj" uniqKey="Okoko B">BJ Okoko</name>
</author>
<author><name sortKey="Enwere, G" uniqKey="Enwere G">G Enwere</name>
</author>
<author><name sortKey="Ota, Moc" uniqKey="Ota M">MOC Ota</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Umbers, Aj" uniqKey="Umbers A">AJ Umbers</name>
</author>
<author><name sortKey="Boeuf, P" uniqKey="Boeuf P">P Boeuf</name>
</author>
<author><name sortKey="Clapham, C" uniqKey="Clapham C">C Clapham</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silver, Kl" uniqKey="Silver K">KL Silver</name>
</author>
<author><name sortKey="Zhong, K" uniqKey="Zhong K">K Zhong</name>
</author>
<author><name sortKey="Leke, Rgf" uniqKey="Leke R">RGF Leke</name>
</author>
<author><name sortKey="Taylor, Dw" uniqKey="Taylor D">DW Taylor</name>
</author>
<author><name sortKey="Kain, Kc" uniqKey="Kain K">KC Kain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Etard, Jf" uniqKey="Etard J">JF Etard</name>
</author>
<author><name sortKey="Kodio, B" uniqKey="Kodio B">B Kodio</name>
</author>
<author><name sortKey="Ronsmans, C" uniqKey="Ronsmans C">C Ronsmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, Bj" uniqKey="Brabin B">BJ Brabin</name>
</author>
<author><name sortKey="Johnson, Pm" uniqKey="Johnson P">PM Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muehlenbachs, A" uniqKey="Muehlenbachs A">A Muehlenbachs</name>
</author>
<author><name sortKey="Mutabingwa, Tk" uniqKey="Mutabingwa T">TK Mutabingwa</name>
</author>
<author><name sortKey="Edmonds, S" uniqKey="Edmonds S">S Edmonds</name>
</author>
<author><name sortKey="Fried, M" uniqKey="Fried M">M Fried</name>
</author>
<author><name sortKey="Duffy, Pe" uniqKey="Duffy P">PE Duffy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwarz, Ng" uniqKey="Schwarz N">NG Schwarz</name>
</author>
<author><name sortKey="Adegnika, Aa" uniqKey="Adegnika A">AA Adegnika</name>
</author>
<author><name sortKey="Breitling, Lp" uniqKey="Breitling L">LP Breitling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouyou Akotet, Mk" uniqKey="Bouyou Akotet M">MK Bouyou-Akotet</name>
</author>
<author><name sortKey="Kombila, M" uniqKey="Kombila M">M Kombila</name>
</author>
<author><name sortKey="Kremsner, Pg" uniqKey="Kremsner P">PG Kremsner</name>
</author>
<author><name sortKey="Mavoungou, E" uniqKey="Mavoungou E">E Mavoungou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hartman, Tk" uniqKey="Hartman T">TK Hartman</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
<author><name sortKey="Fischer, Pr" uniqKey="Fischer P">PR Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hviid, L" uniqKey="Hviid L">L Hviid</name>
</author>
<author><name sortKey="Staalsoe, T" uniqKey="Staalsoe T">T Staalsoe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brabin, B" uniqKey="Brabin B">B Brabin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name>
</author>
<author><name sortKey="Wagner, Ge" uniqKey="Wagner G">GE Wagner</name>
</author>
<author><name sortKey="Akanmori, Bd" uniqKey="Akanmori B">BD Akanmori</name>
</author>
<author><name sortKey="Koram, Ka" uniqKey="Koram K">KA Koram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bockhorst, J" uniqKey="Bockhorst J">J Bockhorst</name>
</author>
<author><name sortKey="Lu, F" uniqKey="Lu F">F Lu</name>
</author>
<author><name sortKey="Janes, Jh" uniqKey="Janes J">JH Janes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oehler, L" uniqKey="Oehler L">L Oehler</name>
</author>
<author><name sortKey="Kollars, M" uniqKey="Kollars M">M Kollars</name>
</author>
<author><name sortKey="Bohle, B" uniqKey="Bohle B">B Bohle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name>
</author>
<author><name sortKey="Ulmer, H" uniqKey="Ulmer H">H Ulmer</name>
</author>
<author><name sortKey="Kaser, A" uniqKey="Kaser A">A Kaser</name>
</author>
<author><name sortKey="Weiss, G" uniqKey="Weiss G">G Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ludwiczek, S" uniqKey="Ludwiczek S">S Ludwiczek</name>
</author>
<author><name sortKey="Aigner, E" uniqKey="Aigner E">E Aigner</name>
</author>
<author><name sortKey="Theurl, I" uniqKey="Theurl I">I Theurl</name>
</author>
<author><name sortKey="Weiss, G" uniqKey="Weiss G">G Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clark, Ia" uniqKey="Clark I">IA Clark</name>
</author>
<author><name sortKey="Chaudhri, G" uniqKey="Chaudhri G">G Chaudhri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leopardi, O" uniqKey="Leopardi O">O Leopardi</name>
</author>
<author><name sortKey="Naughten, W" uniqKey="Naughten W">W Naughten</name>
</author>
<author><name sortKey="Salvia, L" uniqKey="Salvia L">L Salvia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guidotti, Rj" uniqKey="Guidotti R">RJ Guidotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Den Broek, Nr" uniqKey="Van Den Broek N">NR van den Broek</name>
</author>
<author><name sortKey="Letsky, Ea" uniqKey="Letsky E">EA Letsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ndao, Ct" uniqKey="Ndao C">CT Ndao</name>
</author>
<author><name sortKey="Dumont, A" uniqKey="Dumont A">A Dumont</name>
</author>
<author><name sortKey="Fievet, N" uniqKey="Fievet N">N Fievet</name>
</author>
<author><name sortKey="Doucoure, S" uniqKey="Doucoure S">S Doucoure</name>
</author>
<author><name sortKey="Gaye, A" uniqKey="Gaye A">A Gaye</name>
</author>
<author><name sortKey="Lehesran, Jy" uniqKey="Lehesran J">JY Lehesran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calleja Agius, J" uniqKey="Calleja Agius J">J Calleja-Agius</name>
</author>
<author><name sortKey="Brincat, Mp" uniqKey="Brincat M">MP Brincat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Higgins, Mk" uniqKey="Higgins M">MK Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singh, K" uniqKey="Singh K">K Singh</name>
</author>
<author><name sortKey="Gittis, Ag" uniqKey="Gittis A">AG Gittis</name>
</author>
<author><name sortKey="Nguyen, P" uniqKey="Nguyen P">P Nguyen</name>
</author>
<author><name sortKey="Gowda, Dc" uniqKey="Gowda D">DC Gowda</name>
</author>
<author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
<author><name sortKey="Garboczi, Dn" uniqKey="Garboczi D">DN Garboczi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez, P" uniqKey="Fernandez P">P Fernandez</name>
</author>
<author><name sortKey="Petres, S" uniqKey="Petres S">S Petres</name>
</author>
<author><name sortKey="Mecheri, S" uniqKey="Mecheri S">S Mécheri</name>
</author>
<author><name sortKey="Gysin, J" uniqKey="Gysin J">J Gysin</name>
</author>
<author><name sortKey="Scherf, A" uniqKey="Scherf A">A Scherf</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nielsen, Ma" uniqKey="Nielsen M">MA Nielsen</name>
</author>
<author><name sortKey="Pinto, Vv" uniqKey="Pinto V">VV Pinto</name>
</author>
<author><name sortKey="Resende, M" uniqKey="Resende M">M Resende</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avril, M" uniqKey="Avril M">M Avril</name>
</author>
<author><name sortKey="Cartwright, Mm" uniqKey="Cartwright M">MM Cartwright</name>
</author>
<author><name sortKey="Hathaway, Mj" uniqKey="Hathaway M">MJ Hathaway</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fernandez, P" uniqKey="Fernandez P">P Fernandez</name>
</author>
<author><name sortKey="Kviebig, N" uniqKey="Kviebig N">N KViebig</name>
</author>
<author><name sortKey="Dechavanne, S" uniqKey="Dechavanne S">S Dechavanne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yosaatmadja, F" uniqKey="Yosaatmadja F">F Yosaatmadja</name>
</author>
<author><name sortKey="Andrews, Kt" uniqKey="Andrews K">KT Andrews</name>
</author>
<author><name sortKey="Duffy, Mf" uniqKey="Duffy M">MF Duffy</name>
</author>
<author><name sortKey="Brown, Gv" uniqKey="Brown G">GV Brown</name>
</author>
<author><name sortKey="Beeson, Jg" uniqKey="Beeson J">JG Beeson</name>
</author>
<author><name sortKey="Rogerson, Sj" uniqKey="Rogerson S">SJ Rogerson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Magistrado, Pa" uniqKey="Magistrado P">PA Magistrado</name>
</author>
<author><name sortKey="Minja, D" uniqKey="Minja D">D Minja</name>
</author>
<author><name sortKey="Doritchamou, J" uniqKey="Doritchamou J">J Doritchamou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avril, M" uniqKey="Avril M">M Avril</name>
</author>
<author><name sortKey="Cartwright, Mm" uniqKey="Cartwright M">MM Cartwright</name>
</author>
<author><name sortKey="Hathaway, Mj" uniqKey="Hathaway M">MJ Hathaway</name>
</author>
<author><name sortKey="Smith, Jd" uniqKey="Smith J">JD Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avril, M" uniqKey="Avril M">M Avril</name>
</author>
<author><name sortKey="Hathaway, Mj" uniqKey="Hathaway M">MJ Hathaway</name>
</author>
<author><name sortKey="Srivastava, A" uniqKey="Srivastava A">A Srivastava</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dahlb Ck, M" uniqKey="Dahlb Ck M">M Dahlbäck</name>
</author>
<author><name sortKey="J Rgensen, Lm" uniqKey="J Rgensen L">LM Jørgensen</name>
</author>
<author><name sortKey="Nielsen, Ma" uniqKey="Nielsen M">MA Nielsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinto, Vv" uniqKey="Pinto V">VV Pinto</name>
</author>
<author><name sortKey="Ditlev, Sb" uniqKey="Ditlev S">SB Ditlev</name>
</author>
<author><name sortKey="Jensen, Ke" uniqKey="Jensen K">KE Jensen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crompton, Pd" uniqKey="Crompton P">PD Crompton</name>
</author>
<author><name sortKey="Pierce, Sk" uniqKey="Pierce S">SK Pierce</name>
</author>
<author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Casares, S" uniqKey="Casares S">S Casares</name>
</author>
<author><name sortKey="Brumeanu, Td" uniqKey="Brumeanu T">TD Brumeanu</name>
</author>
<author><name sortKey="Richie, Tl" uniqKey="Richie T">TL Richie</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Butler, D" uniqKey="Butler D">D Butler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parakh, A" uniqKey="Parakh A">A Parakh</name>
</author>
<author><name sortKey="Agarwal, N" uniqKey="Agarwal N">N Agarwal</name>
</author>
<author><name sortKey="Aggarwal, A" uniqKey="Aggarwal A">A Aggarwal</name>
</author>
<author><name sortKey="Aneja, A" uniqKey="Aneja A">A Aneja</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Malar Res Treat</journal-id>
<journal-id journal-id-type="publisher-id">MRT</journal-id>
<journal-title-group><journal-title>Malaria Research and Treatment</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-8075</issn>
<issn pub-type="epub">2044-4362</issn>
<publisher><publisher-name>SAGE-Hindawi Access to Research</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22363896</article-id>
<article-id pub-id-type="pmc">3272661</article-id>
<article-id pub-id-type="doi">10.4061/2011/764845</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to <italic>Plasmodium falciparum</italic>
VAR2CSA-Expressing Parasites</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kane</surname>
<given-names>Elizabeth G.</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1, 2</sup>
</xref>
<xref ref-type="aff" rid="I2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Taylor-Robinson</surname>
<given-names>Andrew W.</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK</aff>
<aff id="I2"><sup>2</sup>
Faculty of Medicine, University of Liverpool, Liverpool L69 3GA, UK</aff>
<author-notes><corresp id="cor1">*Andrew W. Taylor-Robinson: <email>a.w.taylor-robinson@leeds.ac.uk</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Mats Wahlgren</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>1</month>
<year>2012</year>
</pub-date>
<volume>2011</volume>
<elocation-id>764845</elocation-id>
<history><date date-type="received"><day>12</day>
<month>5</month>
<year>2011</year>
</date>
<date date-type="rev-recd"><day>28</day>
<month>11</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>30</day>
<month>11</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2011 E. G. Kane and A. W. Taylor-Robinson.</copyright-statement>
<copyright-year>2011</copyright-year>
<license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Pregnancy-associated malaria, a manifestation of severe malaria, is the cause of up to 200,000 infant deaths a year, through the effects of placental insufficiency leading to growth restriction and preterm delivery. Development of a vaccine is one strategy for control. <italic>Plasmodium falciparum</italic>
-infected red blood cells accumulate in the placenta through specific binding of pregnancy-associated parasite variants that express the VAR2CSA antigen to chondroitin sulphate A on the surface of syncytiotrophoblast cells. Parasite accumulation, accompanied by an inflammatory infiltrate, disrupts the cytokine balance of pregnancy with the potential to cause placental damage and compromise foetal growth. Multigravid women develop immunity towards VAR2CSA-expressing parasites in a gravidity-dependent manner which prevents unfavourable pregnancy outcomes. Although current vaccine design, targeting VAR2CSA antigens, has succeeded in inducing antibodies artificially, this candidate may not provide protection during the first trimester and may only protect those women living in areas endemic for malaria. It is concluded that while insufficient information about placental-parasite interactions is presently available to produce an effective vaccine, incremental progress is being made towards achieving this goal.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" position="float"><label>Figure 1</label>
<caption><p>Interactions between immune cells and chemokines in placental malaria. References are found within the text. I-309 = CC/<italic>β</italic>
chemokine, MCP-1: monocyte chemoattractant protein 1, MIP-1<italic>α</italic>
/<italic>β</italic>
: macrophage-inflammatory protein 1<italic>α</italic>
/<italic>β</italic>
, IL-8: interleukin 8—member of the CXC/<italic>α</italic>
chemokine group.</p>
</caption>
<graphic xlink:href="MRT2011-764845.001"></graphic>
</fig>
<fig id="fig2" position="float"><label>Figure 2</label>
<caption><p>Summary of immune interactions and outcomes in placental malaria. The box shows the interactions that are thought to be protective in multigravid women.</p>
</caption>
<graphic xlink:href="MRT2011-764845.002"></graphic>
</fig>
<fig id="fig3" position="float"><label>Figure 3</label>
<caption><p>The duffy binding-like domains of the VAR2CSA molecule. Between each DBL region is an interdomain region that appears to be important for both binding properties and antibody induction. Each region has a differing degree of affinity for the CSA molecule on the placenta and individually the domains do not appear to display as strong binding ability as the whole VAR2CSA molecule. Recent evidence suggests that the first four domains are the most important for forming a quaternary structure that forms a complex binding site [<xref ref-type="bibr" rid="B228">228</xref>
].</p>
</caption>
<graphic xlink:href="MRT2011-764845.003"></graphic>
</fig>
<table-wrap id="tab1" position="float"><label>Table 1</label>
<caption><p>Evidence providing support for the integral role of VAR2CSA in placental malaria.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Evidence</th>
<th align="center" rowspan="1" colspan="1">Reference</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">Placental parasites selectively transcribe the <italic>var2csa</italic>
gene</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B58">58</xref>
, <xref ref-type="bibr" rid="B72">72</xref>
, <xref ref-type="bibr" rid="B78">84</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">The <italic>var2csa</italic>
gene is relatively conserved between PAM variants</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B58">58</xref>
, <xref ref-type="bibr" rid="B79">85</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">The <italic>var2csa</italic>
gene is required for pRBC to adhere to CSA</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B80">86</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">If the <italic>var2csa</italic>
gene is knocked out or deleted, adhesion to CSA no longer occurs</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B78">84</xref>
, <xref ref-type="bibr" rid="B81">87</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">VAR2CSA is selectively expressed on the surface of pRBC that are identified in PM</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B82">88</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">VAR2CSA binds specifically to CSA expressed on the placenta</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B83">89</xref>
, <xref ref-type="bibr" rid="B84">90</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Men and non-pregnant women do not produce VAR2CSA-specific IgG</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B62">62</xref>
, <xref ref-type="bibr" rid="B82">88</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Levels of VAR2CSA-specific IgG correlate with parity</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B82">88</xref>
, <xref ref-type="bibr" rid="B85">91</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">High levels of VAR2CSA-specific IgG protect from adverse outcomes</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B82">88</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">VAR2CSA is a target of naturally acquired IgG reactive with the surface of placental pRBC</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B86">92</xref>
]</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tab2" position="float"><label>Table 2</label>
<caption><p>Maternal and foetal outcomes of pregnancy-associated malaria.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"> </th>
<th align="left" rowspan="1" colspan="1">Effect</th>
<th align="left" rowspan="1" colspan="1">Possible pathogenesis</th>
<th align="center" rowspan="1" colspan="1">Transmission</th>
<th align="center" rowspan="1" colspan="1">Likely protection</th>
<th align="center" rowspan="1" colspan="1">References</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">MOTHER</td>
<td align="left" rowspan="1" colspan="1">Anaemia</td>
<td align="left" rowspan="1" colspan="1">Severe malaria: erythrocyte destruction</td>
<td align="center" rowspan="1" colspan="1">BOTH</td>
<td align="center" rowspan="1" colspan="1">Maternal IgG</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B133">133</xref>
, <xref ref-type="bibr" rid="B135">135</xref>
, <xref ref-type="bibr" rid="B162">162</xref>
]</td>
</tr>
<tr><td align="left" rowspan="5" colspan="1"></td>
<td align="left" rowspan="4" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">IL-10: immunosuppression, affects RBC progenitor cells, reduces available iron concentrations in plasma</td>
<td align="center" rowspan="1" colspan="1"></td>
<td align="center" rowspan="1" colspan="1"></td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B208">209</xref>
–<xref ref-type="bibr" rid="B210">211</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">TNF-<italic>α</italic>
: inflicts oxidative stress on RBC membranes, suppresses erythropoiesis secondary to local inflammation</td>
<td align="center" rowspan="1" colspan="1">BOTH </td>
<td align="center" rowspan="1" colspan="1"> Maternal IgG?</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B211">212</xref>
, <xref ref-type="bibr" rid="B212">213</xref>
]</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">Non-PAM causes of anaemia: iron deficiency, nutrient deficiency, HIV infection, hookworm infestation</td>
<td align="center" rowspan="2" colspan="1"></td>
<td align="center" rowspan="2" colspan="1"></td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B192">192</xref>
, <xref ref-type="bibr" rid="B213">214</xref>
, <xref ref-type="bibr" rid="B214">215</xref>
]</td>
</tr>
<tr><td rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Gestational hypertension</td>
<td align="left" rowspan="1" colspan="1">Impaired trophoblast invasion, cytokine release</td>
<td align="center" rowspan="1" colspan="1">BOTH?</td>
<td align="center" rowspan="1" colspan="1"></td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B215">216</xref>
]</td>
</tr>
<tr><td align="center" colspan="6" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">FOETUS </td>
<td align="left" rowspan="1" colspan="1">Preterm delivery </td>
<td align="left" rowspan="1" colspan="1">Maternal anaemia</td>
<td align="center" rowspan="1" colspan="1">LOW</td>
<td align="center" rowspan="1" colspan="1">T cell memory? </td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B133">133</xref>
, <xref ref-type="bibr" rid="B211">212</xref>
]</td>
</tr>
<tr><td align="left" rowspan="7" colspan="1"> </td>
<td align="left" rowspan="3" colspan="1"></td>
<td align="left" rowspan="1" colspan="1">Acute parasitaemia</td>
<td align="center" rowspan="3" colspan="1"></td>
<td align="center" rowspan="3" colspan="1"></td>
<td align="center" rowspan="3" colspan="1"></td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">TNF-<italic>α</italic>
: associated with acutely high parasitaemia</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">IL-10: contributes to anaemia</td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">Spontaneous abortion</td>
<td align="left" rowspan="1" colspan="1">TNF-<italic>α</italic>
: necrosis of implanted foetus</td>
<td align="center" rowspan="1" colspan="1">LOW</td>
<td align="center" rowspan="1" colspan="1"></td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B138">138</xref>
, <xref ref-type="bibr" rid="B196">196</xref>
, <xref ref-type="bibr" rid="B216">217</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">IFN-<italic>γ</italic>
increases risk of uterine contraction, activates NK cells that induce abortion</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td align="left" rowspan="2" colspan="1">Low birth weight, IUGR</td>
<td align="left" rowspan="1" colspan="1">TNF-<italic>α</italic>
: chronic parasitaemia, damages local placental tissue leading to impaired maternal-foetal exchange</td>
<td align="center" rowspan="1" colspan="1">HIGH</td>
<td align="center" rowspan="1" colspan="1">Maternal IgG</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B133">133</xref>
–<xref ref-type="bibr" rid="B135">135</xref>
, <xref ref-type="bibr" rid="B140">140</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Second trimester infection</td>
<td align="center" rowspan="1" colspan="1"></td>
<td align="center" rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td align="center" colspan="6" rowspan="1"><hr></hr>
</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">INFANT</td>
<td align="left" rowspan="1" colspan="1">Congenital malaria</td>
<td align="left" rowspan="1" colspan="1">Passage of parasites</td>
<td align="center" rowspan="1" colspan="1">?</td>
<td align="center" rowspan="1" colspan="1">Maternal IgG</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B205">205</xref>
]</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1">↓ ability to clear parasites</td>
<td align="left" rowspan="1" colspan="1">T cell priming: CD4<sup>+</sup>
CD25<sup>+</sup>
regulatory T cells induced, secrete IL-10, suppresses IFN-<italic>γ</italic>
</td>
<td align="center" rowspan="1" colspan="1">?</td>
<td align="center" rowspan="1" colspan="1">Maternal IgG</td>
<td align="center" rowspan="1" colspan="1">[<xref ref-type="bibr" rid="B205">205</xref>
]</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Yorkshire-et-Humber</li>
</region>
<settlement><li>Leeds</li>
</settlement>
<orgName><li>Université de Leeds</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Kane, Elizabeth G" sort="Kane, Elizabeth G" uniqKey="Kane E" first="Elizabeth G." last="Kane">Elizabeth G. Kane</name>
</noCountry>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Taylor Robinson, Andrew W" sort="Taylor Robinson, Andrew W" uniqKey="Taylor Robinson A" first="Andrew W." last="Taylor-Robinson">Andrew W. Taylor-Robinson</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002121 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 002121 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:3272661 |texte= Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:22363896" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |