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The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Identifieur interne : 001661 ( Pmc/Checkpoint ); précédent : 001660; suivant : 001662

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

Auteurs : Koosha Paydary [Iran] ; Parisa Khaghani [Iran] ; Sahra Emamzadeh-Fard [Iran] ; Seyed Ahmad Seyed Alinaghi [Iran] ; Kazem Baesi [Iran]

Source :

Asian Pacific Journal of Tropical Biomedicine [ 2221-1691 ] ; 2013.

RBID : PMC:3695575

Abstract

After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world; however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695575

DOI: 10.1016/S2221-1691(13)60106-9
PubMed: 23835806
PubMed Central: 3695575

Affiliations:

Iran

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PMC:3695575

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world; however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.</p>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Asian Pac J Trop Biomed</journal-id>
<journal-id journal-id-type="publisher-id">APJTB</journal-id>
<journal-title-group><journal-title>Asian Pacific Journal of Tropical Biomedicine</journal-title>
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<issn pub-type="ppub">2221-1691</issn>
<publisher><publisher-name>Asian Pacific Tropical Medicine Press</publisher-name>
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<article-meta><article-id pub-id-type="pmid">23835806</article-id>
<article-id pub-id-type="pmc">3695575</article-id>
<article-id pub-id-type="publisher-id">apjtb-03-07-515</article-id>
<article-id pub-id-type="doi">10.1016/S2221-1691(13)60106-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>The emergence of drug resistant HIV variants and novel anti-retroviral therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Paydary</surname>
<given-names>Koosha</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khaghani</surname>
<given-names>Parisa</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Emamzadeh-Fard</surname>
<given-names>Sahra</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alinaghi</surname>
<given-names>Seyed Ahmad Seyed</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baesi</surname>
<given-names>Kazem</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences, Tehran, Iran</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran</addr-line>
</aff>
<contrib-group><contrib contrib-type="reviewer"><name><surname>Zandie</surname>
<given-names>Saeed</given-names>
<prefix>Dr.</prefix>
</name>
</contrib>
</contrib-group>
<aff id="aff3"><addr-line>Cancer institute, Tehran University of Medical Sciences, Tehran, Iran.</addr-line>
 Tel:<phone>+98(21)88427840</phone>
 Fax:<fax>+98(21)88427840</fax>
 E-mail:<email>saeedzandieh@yahoo.com</email>
</aff>
<author-notes><corresp id="cor1">*Corresponding author: Dr. Sahra Emamzadeh-Fard, Iranian Research Center for HIV/AIDS (IRCHA), Imam Khomeini Hospital, Keshavarz Blvd, Tehran, Iran. Tel: <phone>982166947984</phone>
 Fax: <fax>982166947984</fax>
 E-mail: <email>sahra_emamzadeh@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>7</month>
<year>2013</year>
</pub-date>
<volume>3</volume>
<issue>7</issue>
<fpage>515</fpage>
<lpage>522</lpage>
<history><date date-type="received"><day>9</day>
<month>5</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>21</day>
<month>7</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© 2013 by the Asian Pacific Journal of Tropical Biomedicine. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><p>After its identification in 1980s, HIV has infected more than 30 million people worldwide. In the era of highly active anti-retroviral therapy, anti-retroviral drug resistance results from insufficient anti-retroviral pressure, which may lead to treatment failure. Preliminary studies support the idea that anti-retroviral drug resistance has evolved largely as a result of low-adherence of patients to therapy and extensive use of anti-retroviral drugs in the developed world; however, a highly heterogeneous horde of viral quasi-species are currently circulating in developing nations. Thus, the prioritizing of strategies adopted in such two worlds should be quite different considering the varying anti-retroviral drug resistance prevalence. In this article, we explore differences in anti-retroviral drug resistance patterns between developed and developing countries, as they represent two distinct ecological niches of HIV from an evolutionary standpoint.</p>
</abstract>
<kwd-group><kwd>HIV infection</kwd>
<kwd>Evolution</kwd>
<kwd>Drug resistance</kwd>
<kwd>Developed world</kwd>
<kwd>Developing world</kwd>
</kwd-group>
</article-meta>
</front>
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<name sortKey="Alinaghi, Seyed Ahmad Seyed" sort="Alinaghi, Seyed Ahmad Seyed" uniqKey="Alinaghi S" first="Seyed Ahmad Seyed" last="Alinaghi">Seyed Ahmad Seyed Alinaghi</name>
<name sortKey="Baesi, Kazem" sort="Baesi, Kazem" uniqKey="Baesi K" first="Kazem" last="Baesi">Kazem Baesi</name>
<name sortKey="Emamzadeh Fard, Sahra" sort="Emamzadeh Fard, Sahra" uniqKey="Emamzadeh Fard S" first="Sahra" last="Emamzadeh-Fard">Sahra Emamzadeh-Fard</name>
<name sortKey="Emamzadeh Fard, Sahra" sort="Emamzadeh Fard, Sahra" uniqKey="Emamzadeh Fard S" first="Sahra" last="Emamzadeh-Fard">Sahra Emamzadeh-Fard</name>
<name sortKey="Khaghani, Parisa" sort="Khaghani, Parisa" uniqKey="Khaghani P" first="Parisa" last="Khaghani">Parisa Khaghani</name>
<name sortKey="Khaghani, Parisa" sort="Khaghani, Parisa" uniqKey="Khaghani P" first="Parisa" last="Khaghani">Parisa Khaghani</name>
<name sortKey="Paydary, Koosha" sort="Paydary, Koosha" uniqKey="Paydary K" first="Koosha" last="Paydary">Koosha Paydary</name>
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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

The emergence of drug resistant HIV variants and novel anti-retroviral therapy

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Abstract

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