Determinants of death among tuberculosis patients in a semi urban diagnostic and treatment centre of Bafoussam, West Cameroon: a retrospective case-control study
Identifieur interne : 000E17 ( Pmc/Checkpoint ); précédent : 000E16; suivant : 000E18Determinants of death among tuberculosis patients in a semi urban diagnostic and treatment centre of Bafoussam, West Cameroon: a retrospective case-control study
Auteurs : Fabrice Nembot Djouma [Cameroun] ; Michel Noubom [Cameroun] ; Armelle Viviane Ngomba [Cameroun] ; Hubert Donfack [Cameroun] ; Patrick Stéphane Mfin Kouomboua [Cameroun] ; Michael Amede Fopa Saah [Cameroun]Source :
- The Pan African Medical Journal [ 1937-8688 ] ; 2015.
Abstract
Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. Despite the progress recorded in fighting against this disease in the recent years, Africa is still not on the track to achieve the objective to reduce by half the death rate due to this disease by 2015.
A case-control study was conducted on data of patients admitted for tuberculosis between 1996 and 2011 in the Diagnostic and Treatment Center of Baleng. Cases were patients who died from any cause during anti tuberculosis treatment. Logistic regression model was used to identify factors associated to death.
In 4201 patients treated during the study period, 3245 (77.24%) were included in the study. The mean age was 35.9 (SD 14.2) and male represent 62.2% (CI 60.6- 63.9) of them. At the end of the follow up, 2883 patients were successfully treated, 362 died during treatment and 132 (36.5%) deaths occurred during the first two months of TB treatment. HIV positive status, Extra-pulmonary TB, sputum smear-negative pulmonary TB and male sex were significant independent risk factors of death with adjusted odds ratio of 4.8 (CI 3.2- 7.4); 3.0 (CI 1.6- 5.4); 2.7 (CI 1.7- 4.4) and 1.5 (CI 1.0- 2.3) respectively.
The mortality rate of TB patients undergoing TB treatment remains high. Studies are needed to identify and test efficient interventions of mortality reduction among TB patients in resource limiting settings.
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DOI: 10.11604/pamj.2015.22.253.6576
PubMed: 26958116
PubMed Central: 4764316
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Dschang, Diagnostic and Treatment Centre of Baleng, Bafoussam, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Dschang, Diagnostic and Treatment Centre of Baleng, Bafoussam</wicri:regionArea><wicri:noRegion>Bafoussam</wicri:noRegion></affiliation></author><author><name sortKey="Ngomba, Armelle Viviane" sort="Ngomba, Armelle Viviane" uniqKey="Ngomba A" first="Armelle Viviane" last="Ngomba">Armelle Viviane Ngomba</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Central Technical Group Expanded Program on Immunization, Ministry of Public Health, Yaounde, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Central Technical Group Expanded Program on Immunization, Ministry of Public Health, Yaounde</wicri:regionArea><wicri:noRegion>Yaounde</wicri:noRegion></affiliation></author><author><name sortKey="Donfack, Hubert" sort="Donfack, Hubert" uniqKey="Donfack H" first="Hubert" last="Donfack">Hubert Donfack</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author><author><name sortKey="Kouomboua, Patrick Stephane Mfin" sort="Kouomboua, Patrick Stephane Mfin" uniqKey="Kouomboua P" first="Patrick Stéphane Mfin" last="Kouomboua">Patrick Stéphane Mfin Kouomboua</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author><author><name sortKey="Saah, Michael Amede Fopa" sort="Saah, Michael Amede Fopa" uniqKey="Saah M" first="Michael Amede Fopa" last="Saah">Michael Amede Fopa Saah</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26958116</idno><idno type="pmc">4764316</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764316</idno><idno type="RBID">PMC:4764316</idno><idno type="doi">10.11604/pamj.2015.22.253.6576</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000431</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000431</idno><idno 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Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author><author><name sortKey="Noubom, Michel" sort="Noubom, Michel" uniqKey="Noubom M" first="Michel" last="Noubom">Michel Noubom</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Biomedical Sciences, University of Dschang, Dschang, Diagnostic and Treatment Centre of Baleng, Bafoussam, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Dschang, Diagnostic and Treatment Centre of Baleng, Bafoussam</wicri:regionArea><wicri:noRegion>Bafoussam</wicri:noRegion></affiliation></author><author><name sortKey="Ngomba, Armelle Viviane" sort="Ngomba, Armelle Viviane" uniqKey="Ngomba A" first="Armelle Viviane" last="Ngomba">Armelle Viviane Ngomba</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Central Technical Group Expanded Program on Immunization, Ministry of Public Health, Yaounde, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Central Technical Group Expanded Program on Immunization, Ministry of Public Health, Yaounde</wicri:regionArea><wicri:noRegion>Yaounde</wicri:noRegion></affiliation></author><author><name sortKey="Donfack, Hubert" sort="Donfack, Hubert" uniqKey="Donfack H" first="Hubert" last="Donfack">Hubert Donfack</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author><author><name sortKey="Kouomboua, Patrick Stephane Mfin" sort="Kouomboua, Patrick Stephane Mfin" uniqKey="Kouomboua P" first="Patrick Stéphane Mfin" last="Kouomboua">Patrick Stéphane Mfin Kouomboua</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author><author><name sortKey="Saah, Michael Amede Fopa" sort="Saah, Michael Amede Fopa" uniqKey="Saah M" first="Michael Amede Fopa" last="Saah">Michael Amede Fopa Saah</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang</wicri:regionArea><wicri:noRegion>Dschang</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Introduction</title><p>Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. Despite the progress recorded in fighting against this disease in the recent years, Africa is still not on the track to achieve the objective to reduce by half the death rate due to this disease by 2015.</p></sec><sec id="st2"><title>Methods</title><p>A case-control study was conducted on data of patients admitted for tuberculosis between 1996 and 2011 in the Diagnostic and Treatment Center of Baleng. Cases were patients who died from any cause during anti tuberculosis treatment. Logistic regression model was used to identify factors associated to death.</p></sec><sec id="st3"><title>Results</title><p>In 4201 patients treated during the study period, 3245 (77.24%) were included in the study. The mean age was 35.9 (SD 14.2) and male represent 62.2% (CI 60.6- 63.9) of them. At the end of the follow up, 2883 patients were successfully treated, 362 died during treatment and 132 (36.5%) deaths occurred during the first two months of TB treatment. HIV positive status, Extra-pulmonary TB, sputum smear-negative pulmonary TB and male sex were significant independent risk factors of death with adjusted odds ratio of 4.8 (CI 3.2- 7.4); 3.0 (CI 1.6- 5.4); 2.7 (CI 1.7- 4.4) and 1.5 (CI 1.0- 2.3) respectively.</p></sec><sec id="st4"><title>Conclusion</title><p>The mortality rate of TB patients undergoing TB treatment remains high. Studies are needed to identify and test efficient interventions of mortality reduction among TB patients in resource limiting settings.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raviglione, M" uniqKey="Raviglione M">M Raviglione</name></author><author><name sortKey="Uplekar, M" uniqKey="Uplekar M">M Uplekar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glaziou, Philippe" uniqKey="Glaziou P">Philippe Glaziou</name></author><author><name sortKey="Floyd, Katherine" uniqKey="Floyd K">Katherine Floyd</name></author><author><name sortKey="Korenromp, Eline" uniqKey="Korenromp E">Eline Korenromp</name></author><author><name sortKey="Sismanidis, Charalambos" uniqKey="Sismanidis C">Charalambos Sismanidis</name></author><author><name sortKey="Bierrenbach, Ana" uniqKey="Bierrenbach A">Ana Bierrenbach</name></author><author><name sortKey="Williams, Brian" uniqKey="Williams B">Brian Williams</name></author><author><name sortKey="Atun, Rifat" uniqKey="Atun R">Rifat Atun</name></author><author><name sortKey="Raviglione, Mario" uniqKey="Raviglione M">Mario Raviglione</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waitt, Cj" uniqKey="Waitt C">CJ Waitt</name></author><author><name sortKey="Squire, Sb" uniqKey="Squire S">SB Squire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuaban, C" uniqKey="Kuaban C">C Kuaban</name></author><author><name sortKey="Koulla Shiro, S" uniqKey="Koulla Shiro S">S Koulla-Shiro</name></author><author><name sortKey="Hagbe, P" uniqKey="Hagbe P">P Hagbe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lawn, Sd" uniqKey="Lawn S">SD Lawn</name></author><author><name sortKey="Acheampong, Jw" uniqKey="Acheampong J">JW Acheampong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horne, David" uniqKey="Horne D">David Horne</name></author><author><name sortKey="Hubbard, Rebecca" uniqKey="Hubbard R">Rebecca Hubbard</name></author><author><name sortKey="Narita, Masahiro" uniqKey="Narita M">Masahiro Narita</name></author><author><name sortKey="Exarchos, Alexia" uniqKey="Exarchos A">Alexia Exarchos</name></author><author><name sortKey="Park, David" uniqKey="Park D">David Park</name></author><author><name sortKey="Goss, Christopher" uniqKey="Goss C">Christopher Goss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Juan Pablo" uniqKey="Millet J">Juan-Pablo Millet</name></author><author><name sortKey="Orcau, Angels" uniqKey="Orcau A">Angels Orcau</name></author><author><name sortKey="Rius, Cristina" uniqKey="Rius C">Cristina Rius</name></author><author><name sortKey="Casals, Marti" uniqKey="Casals M">Marti Casals</name></author><author><name sortKey="Olalla Patricia, Garcia" uniqKey="Olalla Patricia G">Garcia Olalla Patricia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pawlowski, Andrzej" uniqKey="Pawlowski A">Andrzej Pawlowski</name></author><author><name sortKey="Jansson, Marianne" uniqKey="Jansson M">Marianne Jansson</name></author><author><name sortKey="Skoild, Markus" uniqKey="Skoild M">Markus Skoïld</name></author><author><name sortKey="Rottenberg, Martin" uniqKey="Rottenberg M">Martin Rottenberg</name></author><author><name sortKey="Kaillenius, Gunilla" uniqKey="Kaillenius G">Gunilla Kaïllenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmaltz Carolina, Arana Stanis" uniqKey="Schmaltz Carolina A">Arana Stanis Schmaltz Carolina</name></author><author><name sortKey="Santoro Lopes, Guilherme" uniqKey="Santoro Lopes G">Guilherme Santoro-Lopes</name></author><author><name sortKey="Lourenco Maria, Cristina" uniqKey="Lourenco Maria C">Cristina Lourenço Maria</name></author><author><name sortKey="Morgado Mariza, Goncalves" uniqKey="Morgado Mariza G">GonÇalves Morgado Mariza</name></author><author><name sortKey="Velasque Luciane De, Souza" uniqKey="Velasque Luciane De S">Souza Velasque Luciane de</name></author><author><name sortKey="Rolla Valeria, Cavalcanti" uniqKey="Rolla Valeria C">Cavalcanti Rolla Valéria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karim Salim, Abdool" uniqKey="Karim Salim A">Abdool Karim Salim</name></author><author><name sortKey="Naidoo, Kogieleum" uniqKey="Naidoo K">Kogieleum Naidoo</name></author><author><name sortKey="Grobler, Anneke" uniqKey="Grobler A">Anneke Grobler</name></author><author><name sortKey="Padayatchi, Nesri" uniqKey="Padayatchi N">Nesri Padayatchi</name></author><author><name sortKey="Baxter, Cheryl" uniqKey="Baxter C">Cheryl Baxter</name></author><author><name sortKey="Gray, Andrew" uniqKey="Gray A">Andrew Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manosuthi, Weerawat" uniqKey="Manosuthi W">Weerawat Manosuthi</name></author><author><name sortKey="Chottanapand, Suthat" uniqKey="Chottanapand S">Suthat Chottanapand</name></author><author><name sortKey="Thongyen, Supeda" uniqKey="Thongyen S">Supeda Thongyen</name></author><author><name sortKey="Chaovavanich, Achara" uniqKey="Chaovavanich A">Achara Chaovavanich</name></author><author><name sortKey="Sungkanuparph, Somnuek" uniqKey="Sungkanuparph S">Somnuek Sungkanuparph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, K" uniqKey="Cohen K">K Cohen</name></author><author><name sortKey="Meintjes, G" uniqKey="Meintjes G">G Meintjes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefebvre, N" uniqKey="Lefebvre N">N Lefebvre</name></author><author><name sortKey="Falzon, D" uniqKey="Falzon D">D Falzon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kingkaew, N" uniqKey="Kingkaew N">N Kingkaew</name></author><author><name sortKey="Sangtong, B" uniqKey="Sangtong B">B Sangtong</name></author><author><name sortKey="Amnuaiphon, W" uniqKey="Amnuaiphon W">W Amnuaiphon</name></author><author><name sortKey="Jongpaibulpatana, J" uniqKey="Jongpaibulpatana J">J Jongpaibulpatana</name></author><author><name sortKey="Mankatittham, W" uniqKey="Mankatittham W">W Mankatittham</name></author><author><name sortKey="Akksilp, S" uniqKey="Akksilp S">S Akksilp</name></author><author><name sortKey="Sirinak, C" uniqKey="Sirinak C">C Sirinak</name></author><author><name sortKey="Nateniyom, S" uniqKey="Nateniyom S">S Nateniyom</name></author><author><name sortKey="Burapat, C" uniqKey="Burapat C">C Burapat</name></author><author><name sortKey="Kittikraisak, W" uniqKey="Kittikraisak W">W Kittikraisak</name></author><author><name sortKey="Monkongdee, P" uniqKey="Monkongdee P">P Monkongdee</name></author><author><name sortKey="Varma, Jk" uniqKey="Varma J">JK Varma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vasankari, Tuula" uniqKey="Vasankari T">Tuula Vasankari</name></author><author><name sortKey="Holmstrom, Pekka" uniqKey="Holmstrom P">Pekka Holmström</name></author><author><name sortKey="Ollgren, Jukka" uniqKey="Ollgren J">Jukka Ollgren</name></author><author><name sortKey="Liippo, Kari" uniqKey="Liippo K">Kari Liippo</name></author><author><name sortKey="Kokki, Maarit" uniqKey="Kokki M">Maarit Kokki</name></author><author><name sortKey="Ruutu, Petri" uniqKey="Ruutu P">Petri Ruutu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Connolly, M" uniqKey="Connolly M">M Connolly</name></author><author><name sortKey="Nunn, P" uniqKey="Nunn P">P Nunn</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Pan Afr Med J</journal-id><journal-id journal-id-type="iso-abbrev">Pan Afr Med J</journal-id><journal-id journal-id-type="publisher-id">PAMJ</journal-id><journal-title-group><journal-title>The Pan African Medical Journal</journal-title></journal-title-group><issn pub-type="epub">1937-8688</issn><publisher><publisher-name>The African Field Epidemiology Network</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26958116</article-id><article-id pub-id-type="pmc">4764316</article-id><article-id pub-id-type="publisher-id">PAMJ-22-253</article-id><article-id pub-id-type="doi">10.11604/pamj.2015.22.253.6576</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Determinants of death among tuberculosis patients in a semi urban diagnostic and treatment centre of Bafoussam, West Cameroon: a retrospective case-control study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Djouma</surname><given-names>Fabrice Nembot</given-names></name><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="corresp" rid="cor1">&</xref></contrib><contrib contrib-type="author"><name><surname>Noubom</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Ngomba</surname><given-names>Armelle Viviane</given-names></name><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Donfack</surname><given-names>Hubert</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Kouomboua</surname><given-names>Patrick Stéphane Mfin</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Saah</surname><given-names>Michael Amede Fopa</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Department of Biomedical Sciences, University of Dschang, Cameroon, Dschang, Cameroon</aff><aff id="AF0002"><label>2</label>Department of Biomedical Sciences, University of Dschang, Dschang, Diagnostic and Treatment Centre of Baleng, Bafoussam, Cameroon</aff><aff id="AF0003"><label>3</label>Central Technical Group Expanded Program on Immunization, Ministry of Public Health, Yaounde, Cameroon</aff><author-notes><corresp id="cor1"><label>&</label>Corresponding author: Fabrice Nembot Djouma, Department of Biomedical Sciences, University of Dschang, Cameroon</corresp></author-notes><pub-date pub-type="epub"><day>18</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>22</volume><elocation-id>253</elocation-id><history><date date-type="received"><day>16</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>04</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>© Fabrice Nembot Djouma et al.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Introduction</title><p>Tuberculosis (TB) remains a worldwide public health problem with 8.6 millions of new cases and 1.3 millions of death annually. Despite the progress recorded in fighting against this disease in the recent years, Africa is still not on the track to achieve the objective to reduce by half the death rate due to this disease by 2015.</p></sec><sec id="st2"><title>Methods</title><p>A case-control study was conducted on data of patients admitted for tuberculosis between 1996 and 2011 in the Diagnostic and Treatment Center of Baleng. Cases were patients who died from any cause during anti tuberculosis treatment. Logistic regression model was used to identify factors associated to death.</p></sec><sec id="st3"><title>Results</title><p>In 4201 patients treated during the study period, 3245 (77.24%) were included in the study. The mean age was 35.9 (SD 14.2) and male represent 62.2% (CI 60.6- 63.9) of them. At the end of the follow up, 2883 patients were successfully treated, 362 died during treatment and 132 (36.5%) deaths occurred during the first two months of TB treatment. HIV positive status, Extra-pulmonary TB, sputum smear-negative pulmonary TB and male sex were significant independent risk factors of death with adjusted odds ratio of 4.8 (CI 3.2- 7.4); 3.0 (CI 1.6- 5.4); 2.7 (CI 1.7- 4.4) and 1.5 (CI 1.0- 2.3) respectively.</p></sec><sec id="st4"><title>Conclusion</title><p>The mortality rate of TB patients undergoing TB treatment remains high. Studies are needed to identify and test efficient interventions of mortality reduction among TB patients in resource limiting settings.</p></sec></abstract><kwd-group><kwd>Tuberculosis</kwd><kwd>death</kwd><kwd>factors</kwd><kwd>Cameroon</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Cameroun</li></country></list><tree><country name="Cameroun"><noRegion><name sortKey="Djouma, Fabrice Nembot" sort="Djouma, Fabrice Nembot" uniqKey="Djouma F" first="Fabrice Nembot" last="Djouma">Fabrice Nembot Djouma</name></noRegion><name sortKey="Donfack, Hubert" sort="Donfack, Hubert" uniqKey="Donfack H" first="Hubert" last="Donfack">Hubert Donfack</name><name sortKey="Kouomboua, Patrick Stephane Mfin" sort="Kouomboua, Patrick Stephane Mfin" uniqKey="Kouomboua P" first="Patrick Stéphane Mfin" last="Kouomboua">Patrick Stéphane Mfin Kouomboua</name><name sortKey="Ngomba, Armelle Viviane" sort="Ngomba, Armelle Viviane" uniqKey="Ngomba A" first="Armelle Viviane" last="Ngomba">Armelle Viviane Ngomba</name><name sortKey="Noubom, Michel" sort="Noubom, Michel" uniqKey="Noubom M" first="Michel" last="Noubom">Michel Noubom</name><name sortKey="Saah, Michael Amede Fopa" sort="Saah, Michael Amede Fopa" uniqKey="Saah M" first="Michael Amede Fopa" last="Saah">Michael Amede Fopa Saah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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