Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti
Identifieur interne : 004569 ( Ncbi/Merge ); précédent : 004568; suivant : 004570Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti
Auteurs : Jean Wysler Domercant [Haïti] ; Frantz Jean Louis [Haïti] ; Erin Hulland [États-Unis] ; Mark Griswold [États-Unis] ; Jocelyne Andre-Alboth [Haïti] ; Tun Ye [États-Unis] ; Barbara J. Marston [États-Unis]Source :
- BMC Infectious Diseases [ 1471-2334 ] ; 2017.
Abstract
Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population.
Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies. We evaluated rates of HSV-2 seropositivity and HSV-2/HIV co-infection, associations between HSV-2 and demographic characteristics using multivariable Cox proportional hazards modeling, and HSV-2 test performance in this population.
Serum samples from 1000 pregnant women (all 164 HIV positive and 836 random HIV negative) were selected. The overall weighted prevalence of HSV-2 was 31.4% (95% CI: 27.7–35.4) and the prevalence of HIV-positivity among HSV-2 positive pregnant women was five times higher than the prevalence among HSV-2 negative women (4.8% [95% CI: 3.9–6.0] vs. 0.9% [95% CI: 0.6–1.3], respectively). Factors significantly associated with HSV-2 positivity were HIV-positivity (PR: 2.27 [95% CI: 1.94–2.65]) and older age (PRs: 1.41 [95% CI: 1.05–1.91] for 20–24 years, 1.71 [95% CI:1.13–2.60] for 30–34 years, and 1.55 [95% CI: 1.10–2.19] for 35 years or greater]), while rural residence was negatively associated with HSV-2 positivity (PR 0.83 [95% CI: 0.69–1.00]), after controlling for other covariables. For this study a conservative Focus index cutoff of 3.5 was used, but among samples with a Focus index value ≥2.5, 98.4% had positive Kalon tests.
The prevalence of HSV-2 is relatively high among pregnant women in Haiti. Public health interventions to increase access to HSV-2 screening in antenatal services are warranted.
Url:
DOI: 10.1186/s12879-017-2674-4
PubMed: 28821230
PubMed Central: 5563013
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Prevention, Tabarre</wicri:regionArea><wicri:noRegion>Tabarre</wicri:noRegion></affiliation></author><author><name sortKey="Jean Louis, Frantz" sort="Jean Louis, Frantz" uniqKey="Jean Louis F" first="Frantz" last="Jean Louis">Frantz Jean Louis</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Centers for Disease Control and Prevention, Tabarre, Haiti</nlm:aff><country xml:lang="fr">Haïti</country><wicri:regionArea>Centers for Disease Control and Prevention, Tabarre</wicri:regionArea><wicri:noRegion>Tabarre</wicri:noRegion></affiliation></author><author><name sortKey="Hulland, Erin" sort="Hulland, Erin" uniqKey="Hulland E" first="Erin" last="Hulland">Erin Hulland</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2163 0069</institution-id><institution-id institution-id-type="GRID">grid.416738.f</institution-id><institution></institution><institution>Centers for Disease Control and Prevention,</institution></institution-wrap>1600 Clifton Rd, Atlanta, GA 30329 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>1600 Clifton Rd, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Griswold, Mark" sort="Griswold, Mark" uniqKey="Griswold M" first="Mark" last="Griswold">Mark Griswold</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.422147.6</institution-id><institution></institution><institution>National Alliance of State and Territorial AIDS Directors,</institution></institution-wrap>Washington, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Washington</wicri:regionArea></affiliation></author><author><name sortKey="Andre Alboth, Jocelyne" sort="Andre Alboth, Jocelyne" uniqKey="Andre Alboth J" first="Jocelyne" last="Andre-Alboth">Jocelyne Andre-Alboth</name><affiliation wicri:level="1"><nlm:aff id="Aff4">National Public Health Laboratory/Ministry of Health of Haiti, Delmas, Haiti</nlm:aff><country xml:lang="fr">Haïti</country><wicri:regionArea>National Public Health Laboratory/Ministry of Health of Haiti, Delmas</wicri:regionArea><wicri:noRegion>Delmas</wicri:noRegion></affiliation></author><author><name sortKey="Ye, Tun" sort="Ye, Tun" uniqKey="Ye T" first="Tun" last="Ye">Tun Ye</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2163 0069</institution-id><institution-id institution-id-type="GRID">grid.416738.f</institution-id><institution></institution><institution>Centers for Disease Control and Prevention,</institution></institution-wrap>1600 Clifton Rd, Atlanta, GA 30329 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>1600 Clifton Rd, Atlanta</wicri:cityArea></affiliation></author><author><name sortKey="Marston, Barbara J" sort="Marston, Barbara J" uniqKey="Marston B" first="Barbara J." last="Marston">Barbara J. Marston</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2163 0069</institution-id><institution-id institution-id-type="GRID">grid.416738.f</institution-id><institution></institution><institution>Centers for Disease Control and Prevention,</institution></institution-wrap>1600 Clifton Rd, Atlanta, GA 30329 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>1600 Clifton Rd, Atlanta</wicri:cityArea></affiliation></author></analytic><series><title level="j">BMC Infectious Diseases</title><idno type="eISSN">1471-2334</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population.</p></sec><sec><title>Methods</title><p id="Par2">Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies. We evaluated rates of HSV-2 seropositivity and HSV-2/HIV co-infection, associations between HSV-2 and demographic characteristics using multivariable Cox proportional hazards modeling, and HSV-2 test performance in this population.</p></sec><sec><title>Results</title><p id="Par3">Serum samples from 1000 pregnant women (all 164 HIV positive and 836 random HIV negative) were selected. The overall weighted prevalence of HSV-2 was 31.4% (95% CI: 27.7–35.4) and the prevalence of HIV-positivity among HSV-2 positive pregnant women was five times higher than the prevalence among HSV-2 negative women (4.8% [95% CI: 3.9–6.0] vs. 0.9% [95% CI: 0.6–1.3], respectively). Factors significantly associated with HSV-2 positivity were HIV-positivity (PR: 2.27 [95% CI: 1.94–2.65]) and older age (PRs: 1.41 [95% CI: 1.05–1.91] for 20–24 years, 1.71 [95% CI:1.13–2.60] for 30–34 years, and 1.55 [95% CI: 1.10–2.19] for 35 years or greater]), while rural residence was negatively associated with HSV-2 positivity (PR 0.83 [95% CI: 0.69–1.00]), after controlling for other covariables. For this study a conservative Focus index cutoff of 3.5 was used, but among samples with a Focus index value ≥2.5, 98.4% had positive Kalon tests.</p></sec><sec><title>Conclusion</title><p id="Par4">The prevalence of HSV-2 is relatively high among pregnant women in Haiti. 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article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">BMC Infect. Dis</journal-id><journal-title-group><journal-title>BMC Infectious Diseases</journal-title></journal-title-group><issn pub-type="epub">1471-2334</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28821230</article-id><article-id pub-id-type="pmc">5563013</article-id><article-id pub-id-type="publisher-id">2674</article-id><article-id pub-id-type="doi">10.1186/s12879-017-2674-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Seroprevalence of Herpes Simplex Virus type-2 (HSV-2) among pregnant women who participated in a national HIV surveillance activity in Haiti</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Domercant</surname><given-names>Jean Wysler</given-names></name><address><email>jeanwysler@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Jean Louis</surname><given-names>Frantz</given-names></name><address><email>frantz_jeanlouis@yahoo.fr</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Hulland</surname><given-names>Erin</given-names></name><address><email>ygj3@cdc.gov</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Griswold</surname><given-names>Mark</given-names></name><address><email>mgriswold@nastad.org</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Andre-Alboth</surname><given-names>Jocelyne</given-names></name><address><email>alboth28@yahoo.fr</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Ye</surname><given-names>Tun</given-names></name><address><email>gwr5@cdc.gov</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Marston</surname><given-names>Barbara J.</given-names></name><address><email>bxm5@cdc.gov</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label>Centers for Disease Control and Prevention, Tabarre, Haiti</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2163 0069</institution-id><institution-id institution-id-type="GRID">grid.416738.f</institution-id><institution></institution><institution>Centers for Disease Control and Prevention,</institution></institution-wrap>1600 Clifton Rd, Atlanta, GA 30329 USA</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.422147.6</institution-id><institution></institution><institution>National Alliance of State and Territorial AIDS Directors,</institution></institution-wrap>Washington, USA</aff><aff id="Aff4"><label>4</label>National Public Health Laboratory/Ministry of Health of Haiti, Delmas, Haiti</aff></contrib-group><pub-date pub-type="epub"><day>18</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>17</volume><elocation-id>577</elocation-id><history><date date-type="received"><day>30</day><month>3</month><year>2017</year></date><date date-type="accepted"><day>8</day><month>8</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s). 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p id="Par1">Herpes simplex virus type 2 (HSV-2), one the most common causes of genital ulcers, appears to increase both the risk of HIV acquisition and HIV transmission. HSV-2/HIV co-infection among pregnant women may increase the risk of perinatal transmission of HIV. This study describes rates of HSV-2 among pregnant women in Haiti and HSV-2 test performance in this population.</p></sec><sec><title>Methods</title><p id="Par2">Unlinked residual serum specimens from the 2012 National HIV and Syphilis Sentinel Surveillance Survey among pregnant women in Haiti were tested using two commercial kits (Focus HerpeSelect, Kalon) for HSV-2 antibodies. We evaluated rates of HSV-2 seropositivity and HSV-2/HIV co-infection, associations between HSV-2 and demographic characteristics using multivariable Cox proportional hazards modeling, and HSV-2 test performance in this population.</p></sec><sec><title>Results</title><p id="Par3">Serum samples from 1000 pregnant women (all 164 HIV positive and 836 random HIV negative) were selected. The overall weighted prevalence of HSV-2 was 31.4% (95% CI: 27.7–35.4) and the prevalence of HIV-positivity among HSV-2 positive pregnant women was five times higher than the prevalence among HSV-2 negative women (4.8% [95% CI: 3.9–6.0] vs. 0.9% [95% CI: 0.6–1.3], respectively). Factors significantly associated with HSV-2 positivity were HIV-positivity (PR: 2.27 [95% CI: 1.94–2.65]) and older age (PRs: 1.41 [95% CI: 1.05–1.91] for 20–24 years, 1.71 [95% CI:1.13–2.60] for 30–34 years, and 1.55 [95% CI: 1.10–2.19] for 35 years or greater]), while rural residence was negatively associated with HSV-2 positivity (PR 0.83 [95% CI: 0.69–1.00]), after controlling for other covariables. For this study a conservative Focus index cutoff of 3.5 was used, but among samples with a Focus index value ≥2.5, 98.4% had positive Kalon tests.</p></sec><sec><title>Conclusion</title><p id="Par4">The prevalence of HSV-2 is relatively high among pregnant women in Haiti. Public health interventions to increase access to HSV-2 screening in antenatal services are warranted.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>HSV-2</kwd><kwd>HIV women</kwd><kwd>Pregnant women</kwd><kwd>Prevalence</kwd><kwd>Screening</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Haïti</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li></region></list><tree><country name="Haïti"><noRegion><name sortKey="Domercant, Jean Wysler" sort="Domercant, Jean Wysler" uniqKey="Domercant J" first="Jean Wysler" last="Domercant">Jean Wysler Domercant</name></noRegion><name sortKey="Andre Alboth, Jocelyne" sort="Andre Alboth, Jocelyne" uniqKey="Andre Alboth J" first="Jocelyne" last="Andre-Alboth">Jocelyne Andre-Alboth</name><name sortKey="Jean Louis, Frantz" sort="Jean Louis, Frantz" uniqKey="Jean Louis F" first="Frantz" last="Jean Louis">Frantz Jean Louis</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Hulland, Erin" sort="Hulland, Erin" uniqKey="Hulland E" first="Erin" last="Hulland">Erin Hulland</name></region><name sortKey="Griswold, Mark" sort="Griswold, Mark" uniqKey="Griswold M" first="Mark" last="Griswold">Mark Griswold</name><name sortKey="Marston, Barbara J" sort="Marston, Barbara J" uniqKey="Marston B" first="Barbara J." last="Marston">Barbara J. Marston</name><name sortKey="Ye, Tun" sort="Ye, Tun" uniqKey="Ye T" first="Tun" last="Ye">Tun Ye</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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