HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam
Identifieur interne : 003B64 ( Ncbi/Merge ); précédent : 003B63; suivant : 003B65HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam
Auteurs : Vu Van Tam [Suède] ; Do Duy Cuong [Suède] ; Tobias Alfven [Suède] ; Ho Dang Phuc [Viêt Nam] ; Nguyen Thi Kim Chuc [Viêt Nam] ; Nguyen Phuong Hoa [Viêt Nam] ; Vinod Diwan [Suède] ; Mattias Larsson [Suède, Viêt Nam]Source :
- AIDS Research and Therapy [ 1742-6405 ] ; 2016.
Abstract
In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to female partners over time.
All adult married patients initiating antiretroviral treatment at four out-patient clinics in Quang Ninh province in north-eastern Vietnam between 2007 and 2009 were asked to participate in the study. Clinical information was extracted from patients’ records, and a structured questionnaire was used to collect social, demographic and economic data.
Two hundred eighty-eight married patients for whom information on the HIV status of their spouse was available were included in the study. Overall, the sero-discordance rate was 58%. The sero-discordance rate was significantly higher among married males, 71% had spouses not infected, than married females, of whom 18% had spouses not infected. Other factors associated with a high rate of sero-discordance were injection drug use (IDU) history, tuberculosis (TB) history and the availability of voluntary counselling and testing (VCT) in residential locations. High sero-concordance was associated with college/university education.
The sero-discordance was significantly higher among married males than married females. Other factors also related to high sero-discordance were history of IDU, history of TB and the availability of VCT in residential locations. In contrast, college/university education and female sex were significantly related to low sero-discordance. To contain the increasing HIV prevalence among women, measures should be taken to prevent transmission among sero-discordant couples.
Url:
DOI: 10.1186/s12981-016-0124-9
PubMed: 27891160
PubMed Central: 5109648
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to female partners over time.</p>
</sec>
<sec><title>Methods</title>
<p>All adult married patients initiating antiretroviral treatment at four out-patient clinics in Quang Ninh province in north-eastern Vietnam between 2007 and 2009 were asked to participate in the study. Clinical information was extracted from patients’ records, and a structured questionnaire was used to collect social, demographic and economic data.</p>
</sec>
<sec><title>Results</title>
<p>Two hundred eighty-eight married patients for whom information on the HIV status of their spouse was available were included in the study. Overall, the sero-discordance rate was 58%. The sero-discordance rate was significantly higher among married males, 71% had spouses not infected, than married females, of whom 18% had spouses not infected. Other factors associated with a high rate of sero-discordance were injection drug use (IDU) history, tuberculosis (TB) history and the availability of voluntary counselling and testing (VCT) in residential locations. High sero-concordance was associated with college/university education.</p>
</sec>
<sec><title>Conclusion</title>
<p>The sero-discordance was significantly higher among married males than married females. Other factors also related to high sero-discordance were history of IDU, history of TB and the availability of VCT in residential locations. In contrast, college/university education and female sex were significantly related to low sero-discordance. To contain the increasing HIV prevalence among women, measures should be taken to prevent transmission among sero-discordant couples.</p>
<p><italic>Trial registration</italic>
NCT01433601</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS Res Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">AIDS Res Ther</journal-id>
<journal-title-group><journal-title>AIDS Research and Therapy</journal-title>
</journal-title-group>
<issn pub-type="epub">1742-6405</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27891160</article-id>
<article-id pub-id-type="pmc">5109648</article-id>
<article-id pub-id-type="publisher-id">124</article-id>
<article-id pub-id-type="doi">10.1186/s12981-016-0124-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>HIV sero-discordance among married HIV patients initiating anti-retroviral therapy in northern Vietnam</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Van Tam</surname>
<given-names>Vu</given-names>
</name>
<address><email>tamvanvu@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cuong</surname>
<given-names>Do Duy</given-names>
</name>
<address><email>doduy.cuong@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Alfven</surname>
<given-names>Tobias</given-names>
</name>
<address><email>tobias.alfven@ki.se</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Phuc</surname>
<given-names>Ho Dang</given-names>
</name>
<address><email>hodang54@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chuc</surname>
<given-names>Nguyen Thi Kim</given-names>
</name>
<address><email>chuc.ntk@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hoa</surname>
<given-names>Nguyen Phuong</given-names>
</name>
<address><email>hoatuber@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diwan</surname>
<given-names>Vinod</given-names>
</name>
<address><email>vinod.diwan@ki.se</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0514-7445</contrib-id>
<name><surname>Larsson</surname>
<given-names>Mattias</given-names>
</name>
<address><email>mattias.larsson@ki.se</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Division of Global Health, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden</aff>
<aff id="Aff2"><label>2</label>
Health System Research Project, Ha Noi Medical University, Ha Noi, Vietnam</aff>
<aff id="Aff3"><label>3</label>
Oxford University Clinical Research Unit, Ha Noi, Vietnam</aff>
<aff id="Aff4"><label>4</label>
Department of Probability and Mathematical Statistics, Institute of Mathematics, Ha Noi, Vietnam</aff>
</contrib-group>
<pub-date pub-type="epub"><day>15</day>
<month>11</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>11</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>13</volume>
<elocation-id>39</elocation-id>
<history><date date-type="received"><day>7</day>
<month>6</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>1</day>
<month>11</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2016</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>In many countries in Asia, the HIV epidemic is in a concentrated phase, with high prevalence in certain risk groups, such as men who inject drugs. There is also a rapid increase of HIV among women. The latter might be due to high levels of sero-discordant couples and increasing transmission from male to female partners over time.</p>
</sec>
<sec><title>Methods</title>
<p>All adult married patients initiating antiretroviral treatment at four out-patient clinics in Quang Ninh province in north-eastern Vietnam between 2007 and 2009 were asked to participate in the study. Clinical information was extracted from patients’ records, and a structured questionnaire was used to collect social, demographic and economic data.</p>
</sec>
<sec><title>Results</title>
<p>Two hundred eighty-eight married patients for whom information on the HIV status of their spouse was available were included in the study. Overall, the sero-discordance rate was 58%. The sero-discordance rate was significantly higher among married males, 71% had spouses not infected, than married females, of whom 18% had spouses not infected. Other factors associated with a high rate of sero-discordance were injection drug use (IDU) history, tuberculosis (TB) history and the availability of voluntary counselling and testing (VCT) in residential locations. High sero-concordance was associated with college/university education.</p>
</sec>
<sec><title>Conclusion</title>
<p>The sero-discordance was significantly higher among married males than married females. Other factors also related to high sero-discordance were history of IDU, history of TB and the availability of VCT in residential locations. In contrast, college/university education and female sex were significantly related to low sero-discordance. To contain the increasing HIV prevalence among women, measures should be taken to prevent transmission among sero-discordant couples.</p>
<p><italic>Trial registration</italic>
NCT01433601</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>HIV</kwd>
<kwd>ART</kwd>
<kwd>Gender</kwd>
<kwd>Late presentation</kwd>
<kwd>Sero-discordance</kwd>
<kwd>Vietnam</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution>the Swedish International Development Cooperation Agency (Sida)</institution>
</funding-source>
<award-id>SWE2007404</award-id>
<principal-award-recipient><name><surname>Larsson</surname>
<given-names>Mattias</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Suède</li>
<li>Viêt Nam</li>
</country>
<region><li>Svealand</li>
</region>
<settlement><li>Stockholm</li>
</settlement>
</list>
<tree><country name="Suède"><region name="Svealand"><name sortKey="Van Tam, Vu" sort="Van Tam, Vu" uniqKey="Van Tam V" first="Vu" last="Van Tam">Vu Van Tam</name>
</region>
<name sortKey="Alfven, Tobias" sort="Alfven, Tobias" uniqKey="Alfven T" first="Tobias" last="Alfven">Tobias Alfven</name>
<name sortKey="Cuong, Do Duy" sort="Cuong, Do Duy" uniqKey="Cuong D" first="Do Duy" last="Cuong">Do Duy Cuong</name>
<name sortKey="Diwan, Vinod" sort="Diwan, Vinod" uniqKey="Diwan V" first="Vinod" last="Diwan">Vinod Diwan</name>
<name sortKey="Larsson, Mattias" sort="Larsson, Mattias" uniqKey="Larsson M" first="Mattias" last="Larsson">Mattias Larsson</name>
</country>
<country name="Viêt Nam"><noRegion><name sortKey="Phuc, Ho Dang" sort="Phuc, Ho Dang" uniqKey="Phuc H" first="Ho Dang" last="Phuc">Ho Dang Phuc</name>
</noRegion>
<name sortKey="Chuc, Nguyen Thi Kim" sort="Chuc, Nguyen Thi Kim" uniqKey="Chuc N" first="Nguyen Thi Kim" last="Chuc">Nguyen Thi Kim Chuc</name>
<name sortKey="Hoa, Nguyen Phuong" sort="Hoa, Nguyen Phuong" uniqKey="Hoa N" first="Nguyen Phuong" last="Hoa">Nguyen Phuong Hoa</name>
<name sortKey="Larsson, Mattias" sort="Larsson, Mattias" uniqKey="Larsson M" first="Mattias" last="Larsson">Mattias Larsson</name>
</country>
</tree>
</affiliations>
</record>
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