Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol
Identifieur interne : 002451 ( Ncbi/Merge ); précédent : 002450; suivant : 002452Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol
Auteurs : Woldesellassie M. Bezabhe [Australie, Éthiopie] ; Gregory M. Peterson [Australie] ; Luke Bereznicki [Australie] ; Leanne Chalmers [Australie] ; Peter Gee [Australie]Source :
- BMJ Open [ 2044-6055 ] ; 2013.
Abstract
Achievement of optimal medication adherence and management of antiretroviral toxicity pose great challenges among Ethiopian patients with HIV/AIDS. There is currently a lack of long-term follow-up studies that identify the barriers to, and facilitators of, adherence to antiretroviral therapy (ART) in the Ethiopian setting. Therefore, we aim to investigate the level of adherence to ART and a wide range of potential influencing factors, including adverse drug reactions occurring with ART.
We are conducting a 1-year prospective cohort study involving adult patients with HIV/AIDS starting on ART between December 2012 and March 2013. Data are being collected on patients’ appointment dates in the ART clinics. Adherence to ART is being measured using pill count, medication possession ratio and patient's self-report. The primary outcome of the study will be the proportion of patients who are adherent to their ART regimen at 3, 6 and 12 months using pill count. Taking 95% or more of the dispensed ART regimen using pill count at given points of time will be considered the optimal level of adherence in this study. Data will be analysed using descriptive and inferential statistical procedures.
Ethics approval was obtained from the Tasmania Health and Medical Human Research Ethics Committee and Bahir-Dar University's Ethics Committee. The results of the study will be reported in peer-reviewed scientific journals, conferences and seminar presentations.
Url:
DOI: 10.1136/bmjopen-2013-003559
PubMed: 24176794
PubMed Central: 3816234
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Achievement of optimal medication adherence and management of antiretroviral toxicity pose great challenges among Ethiopian patients with HIV/AIDS. There is currently a lack of long-term follow-up studies that identify the barriers to, and facilitators of, adherence to antiretroviral therapy (ART) in the Ethiopian setting. Therefore, we aim to investigate the level of adherence to ART and a wide range of potential influencing factors, including adverse drug reactions occurring with ART.</p>
</sec>
<sec><title>Methods and analysis</title>
<p>We are conducting a 1-year prospective cohort study involving adult patients with HIV/AIDS starting on ART between December 2012 and March 2013. Data are being collected on patients’ appointment dates in the ART clinics. Adherence to ART is being measured using pill count, medication possession ratio and patient's self-report. The primary outcome of the study will be the proportion of patients who are adherent to their ART regimen at 3, 6 and 12 months using pill count. Taking 95% or more of the dispensed ART regimen using pill count at given points of time will be considered the optimal level of adherence in this study. Data will be analysed using descriptive and inferential statistical procedures.</p>
</sec>
<sec><title>Ethics and dissemination</title>
<p>Ethics approval was obtained from the Tasmania Health and Medical Human Research Ethics Committee and Bahir-Dar University's Ethics Committee. The results of the study will be reported in peer-reviewed scientific journals, conferences and seminar presentations.</p>
</sec>
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<biblStruct><analytic><author><name sortKey="Berg, Km" uniqKey="Berg K">KM Berg</name>
</author>
<author><name sortKey="Arnsten, Jh" uniqKey="Arnsten J">JH Arnsten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haberer, Je" uniqKey="Haberer J">JE Haberer</name>
</author>
<author><name sortKey="Kiwanuka, J" uniqKey="Kiwanuka J">J Kiwanuka</name>
</author>
<author><name sortKey="Nansera, D" uniqKey="Nansera D">D Nansera</name>
</author>
</analytic>
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</TEI>
<pmc article-type="protocol"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMJ Open</journal-id>
<journal-id journal-id-type="iso-abbrev">BMJ Open</journal-id>
<journal-id journal-id-type="hwp">bmjopen</journal-id>
<journal-id journal-id-type="publisher-id">bmjopen</journal-id>
<journal-title-group><journal-title>BMJ Open</journal-title>
</journal-title-group>
<issn pub-type="epub">2044-6055</issn>
<publisher><publisher-name>BMJ Publishing Group</publisher-name>
<publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24176794</article-id>
<article-id pub-id-type="pmc">3816234</article-id>
<article-id pub-id-type="publisher-id">bmjopen-2013-003559</article-id>
<article-id pub-id-type="doi">10.1136/bmjopen-2013-003559</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>HIV/AIDS</subject>
<subj-group><subject>Protocol</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject>
<subject>1842</subject>
<subject>1706</subject>
<subject>1723</subject>
<subject>1704</subject>
</subj-group>
</article-categories>
<title-group><article-title>Adherence to antiretroviral drug therapy in adult patients who are HIV-positive in Northwest Ethiopia: a study protocol</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bezabhe</surname>
<given-names>Woldesellassie M</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterson</surname>
<given-names>Gregory M</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bereznicki</surname>
<given-names>Luke</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chalmers</surname>
<given-names>Leanne</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gee</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<institution>School of Pharmacy, University of Tasmania (UTAS), Sandy Bay Campus</institution>
,<addr-line>Tasmania</addr-line>
,<country>Australia</country>
</aff>
<aff id="af2"><label>2</label>
<institution>College of Medicine and Health Science</institution>
,<institution>Bahir-Dar University</institution>
,<addr-line>Bahir-Dar, Gojjam</addr-line>
,<country>Ethiopia</country>
</aff>
<author-notes><corresp><label>Correspondence to</label>
Woldesellassie M Bezabhe; <email>mwoldesellassie@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>31</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>3</volume>
<issue>10</issue>
<elocation-id>e003559</elocation-id>
<history><date date-type="received"><day>7</day>
<month>7</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>19</day>
<month>9</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>3</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="open-access"><license-p>This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
</license-p>
</license>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="bmjopen-2013-003559.pdf"></self-uri>
<self-uri content-type="draft-revisions-pdf" xlink:type="simple" xlink:href="bmjopen-2013-003559.draft_revisions.pdf"></self-uri>
<self-uri content-type="reviewers-comments-pdf" xlink:type="simple" xlink:href="bmjopen-2013-003559.reviewer_comments.pdf"></self-uri>
<abstract><sec><title>Introduction</title>
<p>Achievement of optimal medication adherence and management of antiretroviral toxicity pose great challenges among Ethiopian patients with HIV/AIDS. There is currently a lack of long-term follow-up studies that identify the barriers to, and facilitators of, adherence to antiretroviral therapy (ART) in the Ethiopian setting. Therefore, we aim to investigate the level of adherence to ART and a wide range of potential influencing factors, including adverse drug reactions occurring with ART.</p>
</sec>
<sec><title>Methods and analysis</title>
<p>We are conducting a 1-year prospective cohort study involving adult patients with HIV/AIDS starting on ART between December 2012 and March 2013. Data are being collected on patients’ appointment dates in the ART clinics. Adherence to ART is being measured using pill count, medication possession ratio and patient's self-report. The primary outcome of the study will be the proportion of patients who are adherent to their ART regimen at 3, 6 and 12 months using pill count. Taking 95% or more of the dispensed ART regimen using pill count at given points of time will be considered the optimal level of adherence in this study. Data will be analysed using descriptive and inferential statistical procedures.</p>
</sec>
<sec><title>Ethics and dissemination</title>
<p>Ethics approval was obtained from the Tasmania Health and Medical Human Research Ethics Committee and Bahir-Dar University's Ethics Committee. The results of the study will be reported in peer-reviewed scientific journals, conferences and seminar presentations.</p>
</sec>
</abstract>
<kwd-group><kwd>Clinical Pharmacology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>Éthiopie</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Bezabhe, Woldesellassie M" sort="Bezabhe, Woldesellassie M" uniqKey="Bezabhe W" first="Woldesellassie M" last="Bezabhe">Woldesellassie M. Bezabhe</name>
</noRegion>
<name sortKey="Bereznicki, Luke" sort="Bereznicki, Luke" uniqKey="Bereznicki L" first="Luke" last="Bereznicki">Luke Bereznicki</name>
<name sortKey="Chalmers, Leanne" sort="Chalmers, Leanne" uniqKey="Chalmers L" first="Leanne" last="Chalmers">Leanne Chalmers</name>
<name sortKey="Gee, Peter" sort="Gee, Peter" uniqKey="Gee P" first="Peter" last="Gee">Peter Gee</name>
<name sortKey="Peterson, Gregory M" sort="Peterson, Gregory M" uniqKey="Peterson G" first="Gregory M" last="Peterson">Gregory M. Peterson</name>
</country>
<country name="Éthiopie"><noRegion><name sortKey="Bezabhe, Woldesellassie M" sort="Bezabhe, Woldesellassie M" uniqKey="Bezabhe W" first="Woldesellassie M" last="Bezabhe">Woldesellassie M. Bezabhe</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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