Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
Identifieur interne : 002369 ( Ncbi/Merge ); précédent : 002368; suivant : 002370Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
Auteurs : K. Kawai [États-Unis] ; S. N. Meydani [États-Unis] ; W. Urassa [Tanzanie] ; D. Wu [États-Unis] ; F. M. Mugusi [Tanzanie] ; E. Saathoff [Allemagne] ; R. J. Bosch [États-Unis] ; E. Villamor [États-Unis] ; D. Spiegelman [États-Unis] ; W. W. Fawzi [États-Unis]Source :
- Epidemiology and infection [ 0950-2688 ] ; 2013.
Abstract
Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis (TB) treatment may improve cell-mediated immune response. We examined the effect of micronutrient supplementation on lymphocyte proliferation response to mycobacteria or T-cell mitogens in a randomized trial conducted on 423 patients with pulmonary TB. Eligible participants were randomly assigned to receive a daily dose of micronutrients (vitamins A, B-complex, C, E, and selenium) or placebo at the time of initiation of TB treatment. We found no overall effect of micronutrient supplements on lymphocyte proliferative responses to phytohaemagglutinin or purified protein derivatives in HIV-negative and HIV-positive TB patients. Of HIV-negative TB patients, the micronutrient group tended to show higher proliferative responses to concanavalin A than the placebo group, although the clinical relevance of this finding is not readily notable. The role of nutritional intervention in this vulnerable population remains an important area of future research.
Url:
DOI: 10.1017/S0950268813002495
PubMed: 24093552
PubMed Central: 5639693
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001D26
- to stream Pmc, to step Curation: 001D25
- to stream Pmc, to step Checkpoint: 001828
Links to Exploration step
PMC:5639693Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania</title><author><name sortKey="Kawai, K" sort="Kawai, K" uniqKey="Kawai K" first="K." last="Kawai">K. Kawai</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Meydani, S N" sort="Meydani, S N" uniqKey="Meydani S" first="S. N." last="Meydani">S. N. Meydani</name><affiliation wicri:level="2"><nlm:aff id="A6">Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Urassa, W" sort="Urassa, W" uniqKey="Urassa W" first="W." last="Urassa">W. Urassa</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name><affiliation wicri:level="2"><nlm:aff id="A6">Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mugusi, F M" sort="Mugusi, F M" uniqKey="Mugusi F" first="F. M." last="Mugusi">F. M. Mugusi</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Saathoff, E" sort="Saathoff, E" uniqKey="Saathoff E" first="E." last="Saathoff">E. Saathoff</name><affiliation wicri:level="4"><nlm:aff id="A9">Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Germany & German Centre for Infection Research, LMU Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Germany & German Centre for Infection Research, LMU Munich</wicri:regionArea><wicri:noRegion>LMU Munich</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Bosch, R J" sort="Bosch, R J" uniqKey="Bosch R" first="R. J." last="Bosch">R. J. Bosch</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Villamor, E" sort="Villamor, E" uniqKey="Villamor E" first="E." last="Villamor">E. Villamor</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A10">Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Spiegelman, D" sort="Spiegelman, D" uniqKey="Spiegelman D" first="D." last="Spiegelman">D. Spiegelman</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fawzi, W W" sort="Fawzi, W W" uniqKey="Fawzi W" first="W. W." last="Fawzi">W. W. Fawzi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health and Population, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24093552</idno><idno type="pmc">5639693</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639693</idno><idno type="RBID">PMC:5639693</idno><idno type="doi">10.1017/S0950268813002495</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">001D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D26</idno><idno type="wicri:Area/Pmc/Curation">001D25</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001D25</idno><idno type="wicri:Area/Pmc/Checkpoint">001828</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001828</idno><idno type="wicri:Area/Ncbi/Merge">002369</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania</title><author><name sortKey="Kawai, K" sort="Kawai, K" uniqKey="Kawai K" first="K." last="Kawai">K. Kawai</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Meydani, S N" sort="Meydani, S N" uniqKey="Meydani S" first="S. N." last="Meydani">S. N. Meydani</name><affiliation wicri:level="2"><nlm:aff id="A6">Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Urassa, W" sort="Urassa, W" uniqKey="Urassa W" first="W." last="Urassa">W. Urassa</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name><affiliation wicri:level="2"><nlm:aff id="A6">Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Mugusi, F M" sort="Mugusi, F M" uniqKey="Mugusi F" first="F. M." last="Mugusi">F. M. Mugusi</name><affiliation wicri:level="1"><nlm:aff id="A8">Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</nlm:aff><country xml:lang="fr">Tanzanie</country><wicri:regionArea>Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam</wicri:regionArea><wicri:noRegion>Dar es Salaam</wicri:noRegion></affiliation></author><author><name sortKey="Saathoff, E" sort="Saathoff, E" uniqKey="Saathoff E" first="E." last="Saathoff">E. Saathoff</name><affiliation wicri:level="4"><nlm:aff id="A9">Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Germany & German Centre for Infection Research, LMU Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Germany & German Centre for Infection Research, LMU Munich</wicri:regionArea><wicri:noRegion>LMU Munich</wicri:noRegion><orgName type="university">Université Louis-et-Maximilien de Munich</orgName><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName></affiliation></author><author><name sortKey="Bosch, R J" sort="Bosch, R J" uniqKey="Bosch R" first="R. J." last="Bosch">R. J. Bosch</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Villamor, E" sort="Villamor, E" uniqKey="Villamor E" first="E." last="Villamor">E. Villamor</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A10">Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Spiegelman, D" sort="Spiegelman, D" uniqKey="Spiegelman D" first="D." last="Spiegelman">D. Spiegelman</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fawzi, W W" sort="Fawzi, W W" uniqKey="Fawzi W" first="W. W." last="Fawzi">W. W. Fawzi</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A4">Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Global Health and Population, Harvard School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><series><title level="j">Epidemiology and infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p id="P2">Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis (TB) treatment may improve cell-mediated immune response. We examined the effect of micronutrient supplementation on lymphocyte proliferation response to mycobacteria or T-cell mitogens in a randomized trial conducted on 423 patients with pulmonary TB. Eligible participants were randomly assigned to receive a daily dose of micronutrients (vitamins A, B-complex, C, E, and selenium) or placebo at the time of initiation of TB treatment. We found no overall effect of micronutrient supplements on lymphocyte proliferative responses to phytohaemagglutinin or purified protein derivatives in HIV-negative and HIV-positive TB patients. Of HIV-negative TB patients, the micronutrient group tended to show higher proliferative responses to concanavalin A than the placebo group, although the clinical relevance of this finding is not readily notable. The role of nutritional intervention in this vulnerable population remains an important area of future research.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8703737</journal-id><journal-id journal-id-type="pubmed-jr-id">3646</journal-id><journal-id journal-id-type="nlm-ta">Epidemiol Infect</journal-id><journal-id journal-id-type="iso-abbrev">Epidemiol. Infect.</journal-id><journal-title-group><journal-title>Epidemiology and infection</journal-title></journal-title-group><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn></journal-meta><article-meta><article-id pub-id-type="pmid">24093552</article-id><article-id pub-id-type="pmc">5639693</article-id><article-id pub-id-type="doi">10.1017/S0950268813002495</article-id><article-id pub-id-type="manuscript">NIHMS906028</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>KAWAI</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>MEYDANI</surname><given-names>S. N.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>URASSA</surname><given-names>W.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>WU</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>MUGUSI</surname><given-names>F. M.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>SAATHOFF</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>BOSCH</surname><given-names>R. J.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>VILLAMOR</surname><given-names>E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>SPIEGELMAN</surname><given-names>D.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>FAWZI</surname><given-names>W. W.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A4">4</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A2"><label>2</label>Department of Nutrition, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A3"><label>3</label>Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A4"><label>4</label>Department of Global Health and Population, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A5"><label>5</label>Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, USA</aff><aff id="A6"><label>6</label>Nutritional Immunology Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging, Department of Pathology at the Sackler Graduate School of Biochemical Sciences, and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA USA</aff><aff id="A7"><label>7</label>Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</aff><aff id="A8"><label>8</label>Department of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania</aff><aff id="A9"><label>9</label>Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich, Germany & German Centre for Infection Research, LMU Munich, Germany</aff><aff id="A10"><label>10</label>Departments of Environmental Health Sciences and Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA</aff><author-notes><corresp id="FN1"><label>*</label>Author for correspondence: Dr K. Kawai, c/o Professor W. Fawzi, Department of Global Health and Population, Harvard School of Public Health, 677 Huntington Avenue, Boston MA 02115, USA. <email>kkawai@post.harvard.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>7</day><month>10</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>10</month><year>2017</year></pub-date><volume>142</volume><issue>7</issue><fpage>1505</fpage><lpage>1509</lpage><pmc-comment>elocation-id from pubmed: 10.1017/S0950268813002495</pmc-comment>
<abstract><title>SUMMARY</title><p id="P2">Limited studies exist regarding whether incorporating micronutrient supplements during tuberculosis (TB) treatment may improve cell-mediated immune response. We examined the effect of micronutrient supplementation on lymphocyte proliferation response to mycobacteria or T-cell mitogens in a randomized trial conducted on 423 patients with pulmonary TB. Eligible participants were randomly assigned to receive a daily dose of micronutrients (vitamins A, B-complex, C, E, and selenium) or placebo at the time of initiation of TB treatment. We found no overall effect of micronutrient supplements on lymphocyte proliferative responses to phytohaemagglutinin or purified protein derivatives in HIV-negative and HIV-positive TB patients. Of HIV-negative TB patients, the micronutrient group tended to show higher proliferative responses to concanavalin A than the placebo group, although the clinical relevance of this finding is not readily notable. The role of nutritional intervention in this vulnerable population remains an important area of future research.</p></abstract><kwd-group><kwd>HIV/AIDS</kwd><kwd>tuberculosis (TB)</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Tanzanie</li><li>États-Unis</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Massachusetts</li><li>Michigan</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Kawai, K" sort="Kawai, K" uniqKey="Kawai K" first="K." last="Kawai">K. Kawai</name></region><name sortKey="Bosch, R J" sort="Bosch, R J" uniqKey="Bosch R" first="R. J." last="Bosch">R. J. Bosch</name><name sortKey="Bosch, R J" sort="Bosch, R J" uniqKey="Bosch R" first="R. J." last="Bosch">R. J. Bosch</name><name sortKey="Fawzi, W W" sort="Fawzi, W W" uniqKey="Fawzi W" first="W. W." last="Fawzi">W. W. Fawzi</name><name sortKey="Fawzi, W W" sort="Fawzi, W W" uniqKey="Fawzi W" first="W. W." last="Fawzi">W. W. Fawzi</name><name sortKey="Fawzi, W W" sort="Fawzi, W W" uniqKey="Fawzi W" first="W. W." last="Fawzi">W. W. Fawzi</name><name sortKey="Meydani, S N" sort="Meydani, S N" uniqKey="Meydani S" first="S. N." last="Meydani">S. N. Meydani</name><name sortKey="Spiegelman, D" sort="Spiegelman, D" uniqKey="Spiegelman D" first="D." last="Spiegelman">D. Spiegelman</name><name sortKey="Spiegelman, D" sort="Spiegelman, D" uniqKey="Spiegelman D" first="D." last="Spiegelman">D. Spiegelman</name><name sortKey="Villamor, E" sort="Villamor, E" uniqKey="Villamor E" first="E." last="Villamor">E. Villamor</name><name sortKey="Villamor, E" sort="Villamor, E" uniqKey="Villamor E" first="E." last="Villamor">E. Villamor</name><name sortKey="Villamor, E" sort="Villamor, E" uniqKey="Villamor E" first="E." last="Villamor">E. Villamor</name><name sortKey="Wu, D" sort="Wu, D" uniqKey="Wu D" first="D." last="Wu">D. Wu</name></country><country name="Tanzanie"><noRegion><name sortKey="Urassa, W" sort="Urassa, W" uniqKey="Urassa W" first="W." last="Urassa">W. Urassa</name></noRegion><name sortKey="Mugusi, F M" sort="Mugusi, F M" uniqKey="Mugusi F" first="F. M." last="Mugusi">F. M. Mugusi</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Saathoff, E" sort="Saathoff, E" uniqKey="Saathoff E" first="E." last="Saathoff">E. Saathoff</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002369 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 002369 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5639693
|texte= Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:24093552" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |