Le SIDA en Afrique subsaharienne (serveur d'exploration)

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Modelling HIV incidence and survival from age-specific seroprevalence after antiretroviral treatment scale-up in rural South Africa.

Identifieur interne : 002105 ( Ncbi/Merge ); précédent : 002104; suivant : 002106

Modelling HIV incidence and survival from age-specific seroprevalence after antiretroviral treatment scale-up in rural South Africa.

Auteurs : Joël Mossong [Royaume-Uni] ; Erofili Grapsa ; Frank Tanser ; Till B Rnighausen ; Marie-Louise Newell

Source :

RBID : pubmed:23842131

Descripteurs français

English descriptors

Abstract

Our study uses sex-specific and age-specific HIV prevalence data from an ongoing population-based demographic and HIV survey to infer HIV incidence and survival in rural KwaZulu-Natal between 2003 and 2011, a period when antiretroviral treatment (ART) was rolled out on a large scale.

DOI: 10.1097/01.aids.0000432475.14992.da
PubMed: 23842131

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pubmed:23842131

Le document en format XML

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<div type="abstract" xml:lang="en">Our study uses sex-specific and age-specific HIV prevalence data from an ongoing population-based demographic and HIV survey to infer HIV incidence and survival in rural KwaZulu-Natal between 2003 and 2011, a period when antiretroviral treatment (ART) was rolled out on a large scale.</div>
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<AbstractText Label="DESIGN" NlmCategory="METHODS">Catalytic mathematical model for estimating HIV incidence and differential survival in HIV-infected persons on multiple rounds of HIV seroprevalence.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We evaluate trends of HIV incidence and survival by estimating parameters separately for women and men aged 15-49 years during three calendar periods (2003-2005, 2006-2008, 2009-2011) reflecting increasing ART coverage. We compare model-based estimates of HIV incidence with observed cohort-based estimates from the longitudinal HIV surveillance.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Median survival after HIV infection increased significantly between 2003-2005 and 2009-2011 from 10.0 [95% confidence interval (CI) 8.8-11.2] to 14.2 (95% CI 12.6-15.8) years in women (P < 0.001) and from 10.0 (95% CI 9.2-10.8) to 14.0 (95% CI 10.6-17.4) years in men (P = 0.02). Our model suggests no statistically significant reduction of HIV incidence in the age-group 15-49 years in 2009-2011 compared with 2003-2005. Age-specific and sex-specific model-based HIV incidence estimates were in good agreement with observed cohort-based estimates from the ongoing HIV surveillance.</AbstractText>
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