Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment
Identifieur interne : 002729 ( Ncbi/Curation ); précédent : 002728; suivant : 002730Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment
Auteurs : Saurabh Gupta [États-Unis] ; Jennifer E. Iudicello [États-Unis] ; Chuan Shi [République populaire de Chine] ; Scott Letendre [États-Unis] ; Adam Knight [États-Unis] ; Jianhua Li [République populaire de Chine] ; Patricia K. Riggs [États-Unis] ; Donald R. Franklin [États-Unis] ; Nichole Duarte [États-Unis] ; Hua Jin [États-Unis] ; J. Hampton Atkinson [États-Unis] ; Xin Yu [République populaire de Chine] ; Zunyou Wu [République populaire de Chine] ; Igor Grant [États-Unis] ; Robert K. Heaton [États-Unis]Source :
- Drug and alcohol dependence [ 0376-8716 ] ; 2014.
Abstract
Prior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination. This issue is particularly important in China, which is addressing its highly HCV-comorbid IDU epidemic with widespread government sponsored MMT, especially in light of recent evidence suggesting that methadone may be neuroprotective in some circumstances.
We administered a comprehensive NP test battery to 195 Chinese heroin IDU individuals taking MMT (IDU+ group), the majority of whom were also HCV+ (87%;
The IDU+ group did not have an increased rate of global NP impairment, or perform significantly worse on any individual NP test measure. Within the IDU+ group, liver disease characteristics and reported details of heroin use were not significantly associated with NP performance.
Failure to detect NP impairment in IDU+ subjects with or without HCV infection was surprising, particularly considering the previously demonstrated sensitivity of our NP battery to neurocognitive disorders associated with HIV infection in China. One possible explanation, which should be explored in future research, is the potential neuroprotective effect of methadone in the context of HCV infection and/or heroin withdrawal.
Url:
DOI: 10.1016/j.drugalcdep.2013.12.021
PubMed: 24508003
PubMed Central: 3961522
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<author><name sortKey="Letendre, Scott" sort="Letendre, Scott" uniqKey="Letendre S" first="Scott" last="Letendre">Scott Letendre</name>
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<author><name sortKey="Knight, Adam" sort="Knight, Adam" uniqKey="Knight A" first="Adam" last="Knight">Adam Knight</name>
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<author><name sortKey="Li, Jianhua" sort="Li, Jianhua" uniqKey="Li J" first="Jianhua" last="Li">Jianhua Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>China Yunnan Institute of Drug Abuse, Kunming</wicri:regionArea>
<wicri:noRegion>Kunming</wicri:noRegion>
</affiliation>
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<author><name sortKey="Riggs, Patricia K" sort="Riggs, Patricia K" uniqKey="Riggs P" first="Patricia K." last="Riggs">Patricia K. Riggs</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Franklin, Donald R" sort="Franklin, Donald R" uniqKey="Franklin D" first="Donald R." last="Franklin">Donald R. Franklin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duarte, Nichole" sort="Duarte, Nichole" uniqKey="Duarte N" first="Nichole" last="Duarte">Nichole Duarte</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5">Gupta Psychology & Assessment Services, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gupta Psychology & Assessment Services</wicri:regionArea>
</affiliation>
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<author><name sortKey="Jin, Hua" sort="Jin, Hua" uniqKey="Jin H" first="Hua" last="Jin">Hua Jin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="A2">VA San Diego Healthcare System, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Atkinson, J Hampton" sort="Atkinson, J Hampton" uniqKey="Atkinson J" first="J. Hampton" last="Atkinson">J. Hampton Atkinson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">VA San Diego Healthcare System, San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>VA San Diego Healthcare System, San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Xin" sort="Yu, Xin" uniqKey="Yu X" first="Xin" last="Yu">Xin Yu</name>
<affiliation wicri:level="3"><nlm:aff id="A3">The Institute of Mental Health at Peking University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>The Institute of Mental Health at Peking University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Zunyou" sort="Wu, Zunyou" uniqKey="Wu Z" first="Zunyou" last="Wu">Zunyou Wu</name>
<affiliation wicri:level="3"><nlm:aff id="A4">China Centers for Disease Control (China CDC), Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>China Centers for Disease Control (China CDC), Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grant, Igor" sort="Grant, Igor" uniqKey="Grant I" first="Igor" last="Grant">Igor Grant</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heaton, Robert K" sort="Heaton, Robert K" uniqKey="Heaton R" first="Robert K." last="Heaton">Robert K. Heaton</name>
<affiliation wicri:level="2"><nlm:aff id="A1">HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Drug and alcohol dependence</title>
<idno type="ISSN">0376-8716</idno>
<idno type="eISSN">1879-0046</idno>
<imprint><date when="2014">2014</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Prior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination. This issue is particularly important in China, which is addressing its highly HCV-comorbid IDU epidemic with widespread government sponsored MMT, especially in light of recent evidence suggesting that methadone may be neuroprotective in some circumstances.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">We administered a comprehensive NP test battery to 195 Chinese heroin IDU individuals taking MMT (IDU+ group), the majority of whom were also HCV+ (87%; <italic>n</italic>
= 169), and compared their NP performance to that of 198 demographically comparable, non-IDU Chinese controls (IDU− group). All participants in both groups tested negative for HIV infection, which is also a common comorbidity in the Chinese IDU population.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The IDU+ group did not have an increased rate of global NP impairment, or perform significantly worse on any individual NP test measure. Within the IDU+ group, liver disease characteristics and reported details of heroin use were not significantly associated with NP performance.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">Failure to detect NP impairment in IDU+ subjects with or without HCV infection was surprising, particularly considering the previously demonstrated sensitivity of our NP battery to neurocognitive disorders associated with HIV infection in China. One possible explanation, which should be explored in future research, is the potential neuroprotective effect of methadone in the context of HCV infection and/or heroin withdrawal.</p>
</sec>
</div>
</front>
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