SidaSubSaharaV1, Main, Merge, bibRecord, 006429

Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia

Identifieur interne : 006429 ( Main/Merge ); précédent : 006428; suivant : 006430

Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia

Auteurs : Matthew P. Fox [États-Unis] ; Daniel Brooks [États-Unis] ; Louise Kuhn [États-Unis] ; Grace Aldrovandi [États-Unis] ; Moses Sinkala [Zambie] ; Chipepo Kankasa [Zambie] ; Mwiya Mwiya [Zambie] ; Robert Horsburgh [États-Unis] ; Donald M. Thea [États-Unis]

Source :

Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2008.

RBID : Pascal:08-0263793

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Allaitement, Enfant, Zambie, Nourrisson, Transmission verticale, Microbiologie, Virologie, SIDA.
Wicri :
- geographic : Zambie.
- topic : Enfant.

English descriptors

KwdEn :
- AIDS, Breast feeding, Child, Human immunodeficiency virus, Infant, Microbiology, Vertical transmission, Virology, Zambia.

Abstract

Objectives: In developing countries, where mother-to-child transmission of HIV through breast-feeding is common, little is known about the impact of postpartum transmission on child survival. This study assessed whether children infected postpartum have longer survival from time of infection versus those infected during gestation or delivery. Design: We used a prospective cohort study to analyze data from 213 HIV-infected children enrolled in a breast-feeding intervention trial in Lusaka, Zambia (2001 to 2004). Methods: We compared mortality 1 year after HIV infection in children stratified by age of infection: 0 to 3 days (intrauterine [IU] group), 4 to 40 days (intrapartum/early postpartum [IP/EPP] group), and >40 days (postpartum [PP] group). Results: A total of 61, 71, and 81 children were infected in the IU, IP/EPP, and PP groups, respectively. Children with intrauterine or intrapartum/early postpartum transmission had higher mortality over the first 12 months after infection than children with postpartum transmission (P = 0.001 and P = 0.006, respectively); no differences were detected between children with intrauterine and intrapartum/ early postpartum transmission. Nearly 20% of the IU and IP/EPP groups died by 100 days after infection, whereas nearly 10% of the PP group had died by this time. After adjusting for birth weight, maternal CD4 cell count, breast-feeding, and maternal death, children infected postpartum had one quarter the mortality rate (hazard ratio [HR] = 0.27, 95% confidence interval [CI]: 0.15 to 0.50) of those infected in utero. Stopping breast-feeding increased mortality in infected children (HR = 3.1, 95% CI: 1.8 to 5.3). Conclusions: This study demonstrates a survival benefit among children infected postpartum versus children infected during pregnancy or delivery and a benefit to increased breast-feeding duration among infected children. Testing children for HIV early may provide a means to allow for earlier intervention.

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000543
to stream PascalFrancis, to step Curation: 000428
to stream PascalFrancis, to step Checkpoint: 000434

Links to Exploration step

Pascal:08-0263793

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia</title>
<author><name sortKey="Fox, Matthew P" sort="Fox, Matthew P" uniqKey="Fox M" first="Matthew P." last="Fox">Matthew P. Fox</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for International Health and Development, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brooks, Daniel" sort="Brooks, Daniel" uniqKey="Brooks D" first="Daniel" last="Brooks">Daniel Brooks</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Aldrovandi, Grace" sort="Aldrovandi, Grace" uniqKey="Aldrovandi G" first="Grace" last="Aldrovandi">Grace Aldrovandi</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Childrens Hospital of Los Angeles</s1>
<s2>Los Angeles, CA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Lusaka District Health Management Team</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka District Health Management Team</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Teaching Hospital, University of Zambia</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mwiya, Mwiya" sort="Mwiya, Mwiya" uniqKey="Mwiya M" first="Mwiya" last="Mwiya">Mwiya Mwiya</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Teaching Hospital, University of Zambia</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Horsburgh, Robert" sort="Horsburgh, Robert" uniqKey="Horsburgh R" first="Robert" last="Horsburgh">Robert Horsburgh</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M." last="Thea">Donald M. Thea</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for International Health and Development, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">08-0263793</idno>
<date when="2008">2008</date>
<idno type="stanalyst">PASCAL 08-0263793 INIST</idno>
<idno type="RBID">Pascal:08-0263793</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000543</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000428</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000434</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000434</idno>
<idno type="wicri:doubleKey">1525-4135:2008:Fox M:reduced:mortality:associated</idno>
<idno type="wicri:Area/Main/Merge">006429</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia</title>
<author><name sortKey="Fox, Matthew P" sort="Fox, Matthew P" uniqKey="Fox M" first="Matthew P." last="Fox">Matthew P. Fox</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for International Health and Development, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brooks, Daniel" sort="Brooks, Daniel" uniqKey="Brooks D" first="Daniel" last="Brooks">Daniel Brooks</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name>
<affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Sergievsky Center and Department of Epidemiology, Mailman School of Public Health, Columbia University</s1>
<s2>New York, NY</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Aldrovandi, Grace" sort="Aldrovandi, Grace" uniqKey="Aldrovandi G" first="Grace" last="Aldrovandi">Grace Aldrovandi</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Childrens Hospital of Los Angeles</s1>
<s2>Los Angeles, CA</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Lusaka District Health Management Team</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka District Health Management Team</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Teaching Hospital, University of Zambia</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mwiya, Mwiya" sort="Mwiya, Mwiya" uniqKey="Mwiya M" first="Mwiya" last="Mwiya">Mwiya Mwiya</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University Teaching Hospital, University of Zambia</s1>
<s2>Lusaka</s2>
<s3>ZMB</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Zambie</country>
<wicri:noRegion>Lusaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Horsburgh, Robert" sort="Horsburgh, Robert" uniqKey="Horsburgh R" first="Robert" last="Horsburgh">Robert Horsburgh</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Epidemiology, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M." last="Thea">Donald M. Thea</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Center for International Health and Development, Boston University</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
<title level="j" type="abbreviated">J. acquir. immune defic. syndr. : (1999)</title>
<idno type="ISSN">1525-4135</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Breast feeding</term>
<term>Child</term>
<term>Human immunodeficiency virus</term>
<term>Infant</term>
<term>Microbiology</term>
<term>Vertical transmission</term>
<term>Virology</term>
<term>Zambia</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Virus immunodéficience humaine</term>
<term>Allaitement</term>
<term>Enfant</term>
<term>Zambie</term>
<term>Nourrisson</term>
<term>Transmission verticale</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>SIDA</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Zambie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objectives: In developing countries, where mother-to-child transmission of HIV through breast-feeding is common, little is known about the impact of postpartum transmission on child survival. This study assessed whether children infected postpartum have longer survival from time of infection versus those infected during gestation or delivery. Design: We used a prospective cohort study to analyze data from 213 HIV-infected children enrolled in a breast-feeding intervention trial in Lusaka, Zambia (2001 to 2004). Methods: We compared mortality 1 year after HIV infection in children stratified by age of infection: 0 to 3 days (intrauterine [IU] group), 4 to 40 days (intrapartum/early postpartum [IP/EPP] group), and >40 days (postpartum [PP] group). Results: A total of 61, 71, and 81 children were infected in the IU, IP/EPP, and PP groups, respectively. Children with intrauterine or intrapartum/early postpartum transmission had higher mortality over the first 12 months after infection than children with postpartum transmission (P = 0.001 and P = 0.006, respectively); no differences were detected between children with intrauterine and intrapartum/ early postpartum transmission. Nearly 20% of the IU and IP/EPP groups died by 100 days after infection, whereas nearly 10% of the PP group had died by this time. After adjusting for birth weight, maternal CD4 cell count, breast-feeding, and maternal death, children infected postpartum had one quarter the mortality rate (hazard ratio [HR] = 0.27, 95% confidence interval [CI]: 0.15 to 0.50) of those infected in utero. Stopping breast-feeding increased mortality in infected children (HR = 3.1, 95% CI: 1.8 to 5.3). Conclusions: This study demonstrates a survival benefit among children infected postpartum versus children infected during pregnancy or delivery and a benefit to increased breast-feeding duration among infected children. Testing children for HIV early may provide a means to allow for earlier intervention.</div>
</front>
</TEI>
<affiliations><list><country><li>Zambie</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Massachusetts</li>
<li>État de New York</li>
</region>
<settlement><li>New York</li>
</settlement>
<orgName><li>Université Columbia</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Fox, Matthew P" sort="Fox, Matthew P" uniqKey="Fox M" first="Matthew P." last="Fox">Matthew P. Fox</name>
</region>
<name sortKey="Aldrovandi, Grace" sort="Aldrovandi, Grace" uniqKey="Aldrovandi G" first="Grace" last="Aldrovandi">Grace Aldrovandi</name>
<name sortKey="Brooks, Daniel" sort="Brooks, Daniel" uniqKey="Brooks D" first="Daniel" last="Brooks">Daniel Brooks</name>
<name sortKey="Horsburgh, Robert" sort="Horsburgh, Robert" uniqKey="Horsburgh R" first="Robert" last="Horsburgh">Robert Horsburgh</name>
<name sortKey="Kuhn, Louise" sort="Kuhn, Louise" uniqKey="Kuhn L" first="Louise" last="Kuhn">Louise Kuhn</name>
<name sortKey="Thea, Donald M" sort="Thea, Donald M" uniqKey="Thea D" first="Donald M." last="Thea">Donald M. Thea</name>
</country>
<country name="Zambie"><noRegion><name sortKey="Sinkala, Moses" sort="Sinkala, Moses" uniqKey="Sinkala M" first="Moses" last="Sinkala">Moses Sinkala</name>
</noRegion>
<name sortKey="Kankasa, Chipepo" sort="Kankasa, Chipepo" uniqKey="Kankasa C" first="Chipepo" last="Kankasa">Chipepo Kankasa</name>
<name sortKey="Mwiya, Mwiya" sort="Mwiya, Mwiya" uniqKey="Mwiya M" first="Mwiya" last="Mwiya">Mwiya Mwiya</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006429 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 006429 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    SidaSubSaharaV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:08-0263793
   |texte=   Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia
}}

This area was generated with Dilib version V0.6.32.
Data generation: Mon Nov 13 19:31:10 2017. Site generation: Wed Mar 6 19:14:32 2024

	Le SIDA en Afrique subsaharienne (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Le SIDA en Afrique subsaharienne (serveur d'exploration)

Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia

Reduced Mortality Associated With Breast-Feeding-Acquired HIV Infection and Breast-Feeding Among HIV-Infected Children in Zambia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri