This study uses the baseline (wave 1) data from a 4-year (2008-2012) longitudinal study called the Suubi-Maka family economic empowerment intervention for AIDS-orphaned children in Uganda funded by the National Institute of Mental Health (Grant # RMH081763A). Specifically, using baseline data from the Suubi-Maka study, this paper provides a contextualized understanding of depression levels among caregivers for AIDS-orphaned children in two rural communities heavily affected by AIDS in Uganda: Rakai and Masaka districts. Using baseline data collected from caregivers of children orphaned by AIDS (N=297) the study examines the factors that influence reported depression levels of caregivers of AIDS-orphaned children in rural communities of Uganda. We specifically use OLS regression methods. In the analysis we control for several demographic factors, including age, gender, assets, social support, and caregiving status. We find that caregivers’ reported economic status and social support system are highly correlated with caregivers’ reported depression scores. Specifically, caregivers with cash savings and a strong family support system reported better depression scores. These findings have implications for community development practice and programming. Specifically, the study highlights a need for family economic empowerment programs and, strengthened family support among caregivers for AIDS-orphaned children, especially those caregivers with reported poor mental health functioning.