Circumcision as a strategy to minimize HIV transmission.
Identifieur interne : 002A41 ( Main/Merge ); précédent : 002A40; suivant : 002A42Circumcision as a strategy to minimize HIV transmission.
Auteurs : Imani Jackson Rosario [États-Unis] ; Khushabu Kasabwala ; Hossein Sadeghi-NejadSource :
- Current urology reports [ 1534-6285 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- geographic : Africa South of the Sahara.
- prevention & control : Disease Transmission, Infectious, HIV Infections.
- transmission : HIV Infections.
- Circumcision, Male, Female, Humans, Male, Patient Acceptance of Health Care, Sexual Partners.
Abstract
The newest data related to the Human Immunodeficiency Virus (HIV) / Acquired Immune Disease Syndrome (AIDS) epidemic is primarily positive, but many areas of the world, especially Sub-Saharan Africa, remain disproportionately affected. Between 2005 and 2007, three large randomized trials evaluating circumcision for prevention of HIV acquisition in heterosexual African males showed a reduction in the rate of acquisition of HIV by up to 66 % over 24 months. Since the results of these studies were published, global health organizations have ramped up efforts to help target countries to provide male circumcision delivery services in sub-Saharan Africa. Male circumcision (MC) is cost-effective and efficacious, especially when used in combination with other prevention strategies. Available data shows good acceptability amongst target populations. Neonatal circumcision is well tolerated and more cost effective than adult male circumcision and should be included as part of MC initiatives in the future. Behavioral disinhibition and risk compensation are important factors that may mitigate the rate of risk reduction conferred by male circumcision and should be further investigated. As delivery of male circumcision services is expanded, the issues affecting the female sexual partners of the target population must be outlined and addressed. Whether or not the results of the African trials can be extrapolated to warrant expansion of MC programs to other populations is a critical area for further study.
DOI: 10.1007/s11934-013-0343-8
PubMed: 23775468
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pubmed:23775468Le document en format XML
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<author><name sortKey="Kasabwala, Khushabu" sort="Kasabwala, Khushabu" uniqKey="Kasabwala K" first="Khushabu" last="Kasabwala">Khushabu Kasabwala</name>
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<author><name sortKey="Sadeghi Nejad, Hossein" sort="Sadeghi Nejad, Hossein" uniqKey="Sadeghi Nejad H" first="Hossein" last="Sadeghi-Nejad">Hossein Sadeghi-Nejad</name>
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<term>Circumcision, Male</term>
<term>Disease Transmission, Infectious (prevention & control)</term>
<term>Female</term>
<term>HIV Infections (prevention & control)</term>
<term>HIV Infections (transmission)</term>
<term>Humans</term>
<term>Male</term>
<term>Patient Acceptance of Health Care</term>
<term>Sexual Partners</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acceptation des soins par le patient</term>
<term>Afrique subsaharienne</term>
<term>Circoncision masculine</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH ()</term>
<term>Infections à VIH (transmission)</term>
<term>Mâle</term>
<term>Partenaire sexuel</term>
<term>Transmission de maladie infectieuse ()</term>
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<term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>HIV Infections</term>
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<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Patient Acceptance of Health Care</term>
<term>Sexual Partners</term>
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<term>Afrique subsaharienne</term>
<term>Circoncision masculine</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à VIH</term>
<term>Mâle</term>
<term>Partenaire sexuel</term>
<term>Transmission de maladie infectieuse</term>
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<front><div type="abstract" xml:lang="en">The newest data related to the Human Immunodeficiency Virus (HIV) / Acquired Immune Disease Syndrome (AIDS) epidemic is primarily positive, but many areas of the world, especially Sub-Saharan Africa, remain disproportionately affected. Between 2005 and 2007, three large randomized trials evaluating circumcision for prevention of HIV acquisition in heterosexual African males showed a reduction in the rate of acquisition of HIV by up to 66 % over 24 months. Since the results of these studies were published, global health organizations have ramped up efforts to help target countries to provide male circumcision delivery services in sub-Saharan Africa. Male circumcision (MC) is cost-effective and efficacious, especially when used in combination with other prevention strategies. Available data shows good acceptability amongst target populations. Neonatal circumcision is well tolerated and more cost effective than adult male circumcision and should be included as part of MC initiatives in the future. Behavioral disinhibition and risk compensation are important factors that may mitigate the rate of risk reduction conferred by male circumcision and should be further investigated. As delivery of male circumcision services is expanded, the issues affecting the female sexual partners of the target population must be outlined and addressed. Whether or not the results of the African trials can be extrapolated to warrant expansion of MC programs to other populations is a critical area for further study.</div>
</front>
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