Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy
Identifieur interne : 001231 ( Main/Merge ); précédent : 001230; suivant : 001232Plasmodium falciparum Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy
Auteurs : M Nica Guerra [Portugal] ; Rita Neres [Portugal] ; Patrícia Salgueiro [Portugal] ; Cristina Mendes [Portugal] ; Nicolas Ndong-Mabale [Guinée équatoriale] ; Pedro Berzosa [Espagne] ; Bruno De Sousa [Portugal] ; Ana Paula Arez [Portugal]Source :
- Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2016.
Abstract
Efforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling
Url:
DOI: 10.1128/AAC.02556-15
PubMed: 27795385
PubMed Central: 5192141
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PMC:5192141Le document en format XML
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Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy</title>
<author><name sortKey="Guerra, M Nica" sort="Guerra, M Nica" uniqKey="Guerra M" first="M Nica" last="Guerra">M Nica Guerra</name>
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Genetic Diversity in Continental Equatorial Guinea before and after Introduction of Artemisinin-Based Combination Therapy</title>
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<author><name sortKey="Ndong Mabale, Nicolas" sort="Ndong Mabale, Nicolas" uniqKey="Ndong Mabale N" first="Nicolas" last="Ndong-Mabale">Nicolas Ndong-Mabale</name>
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<country xml:lang="fr">Espagne</country>
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<placeName><settlement type="city">Madrid</settlement>
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</placeName>
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<author><name sortKey="De Sousa, Bruno" sort="De Sousa, Bruno" uniqKey="De Sousa B" first="Bruno" last="De Sousa">Bruno De Sousa</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Faculdade de Psicologia e de Ciências da Educação, Universidade de Coimbra, Coimbra, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
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<author><name sortKey="Arez, Ana Paula" sort="Arez, Ana Paula" uniqKey="Arez A" first="Ana Paula" last="Arez">Ana Paula Arez</name>
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<country xml:lang="fr">Portugal</country>
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<series><title level="j">Antimicrobial Agents and Chemotherapy</title>
<idno type="ISSN">0066-4804</idno>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Efforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling <named-content content-type="genus-species">Plasmodium falciparum</named-content>
malaria, and thus the study of the origin and spread of associated mutations may provide some insights into the prevention of its emergence. This study reports an analysis of <named-content content-type="genus-species">P. falciparum</named-content>
genetic diversity, focusing on antimalarial resistance-associated molecular markers in two socioeconomically different villages in mainland Equatorial Guinea. The present study took place 8 years after a previous one, allowing the analysis of results before and after the introduction of an artemisinin-based combination therapy (ACT), i.e., artesunate plus amodiaquine. Genetic diversity was assessed by analysis of the <italic>Pfmsp2</italic>
gene and neutral microsatellite loci. <italic>Pfdhps</italic>
and <italic>Pfdhfr</italic>
alleles associated with sulfadoxine-pyrimethamine (SP) resistance and flanking microsatellite loci were investigated, and the prevalences of drug resistance-associated point mutations of the <italic>Pfcrt</italic>
, <italic>Pfmdr1</italic>
, <italic>Pfdhfr</italic>
, and <italic>Pfdhps</italic>
genes were estimated. Further, to monitor the use of ACT, we provide the baseline prevalences of K13 propeller mutations and <italic>Pfmdr1</italic>
copy numbers. After 8 years, noticeable differences occurred in the distribution of genotypes conferring resistance to chloroquine and SP, and the spread of mutated genotypes differed according to the setting. Regarding artemisinin resistance, although mutations reported as being linked to artemisinin resistance were not present at the time, several single nucleotide polymorphisms (SNPs) were observed in the K13 gene, suggesting that closer monitoring should be maintained to prevent the possible spread of artemisinin resistance in Africa.</p>
</div>
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