Diabetes mellitus among HIV-infected individuals in follow-up care at University of Gondar Hospital, Northwest Ethiopia
Identifieur interne : 001111 ( Main/Merge ); précédent : 001110; suivant : 001112Diabetes mellitus among HIV-infected individuals in follow-up care at University of Gondar Hospital, Northwest Ethiopia
Auteurs : Solomon Mekonnen Abebe [Éthiopie] ; Assefa Getachew [Éthiopie] ; Solomon Fasika [Éthiopie] ; Mulugeta Bayisa [Éthiopie] ; Abayneh Girma Demisse [Éthiopie] ; Nebiyu Mesfin [Éthiopie]Source :
- BMJ Open [ 2044-6055 ] ; 2016.
Abstract
To assess the prevalence of diabetes mellitus (DM) and associated factors among HIV-infected adults in northwest Ethiopia.
Hospital-based cross-sectional study.
HIV clinic of the University of Gondar Hospital, Ethiopia.
All HIV-infected adults who visited the HIV clinic from December 2013 to the end of February 2014 were the source population.
A structured and pretested questionnaire incorporating the WHO STEPwise approach was used. A multivariate logistic regression analysis was applied to assess factors associated with DM.
The overall prevalence of type 2 DM was 8% (95% CI 5.5% to 10.5%). The prevalence of DM was higher (13.2%; 95% CI 8.0% to 18.3%) among subjects receiving pre-antiretroviral treatment (pre-ART) than among those taking ART (5.1%; 95% CI 2.6% to 7.6%). Thirteen (35.1%) of the DM cases were newly identified during the study. Obesity (adjusted OR (AOR) 6.55; 1.20 to 35.8), hypertension (AOR 3.45; 1.50 to 7.90), being in the pre-ART group (AOR 4.47; 1.80 to 11.08), hypertriglyceridaemia (AOR 2.24; 1.02 to 49.5) and tertiary-level education (AOR 11.8; 2.28 to 61.4) were associated with DM.
Overall DM prevalence was high, particularly among subjects in the pre-ART group. More educated, hypertensive and obese HIV-infected adults were more likely to have DM as a comorbidity. Health policy and the clinical management of HIV-infected individuals should take into account the rising DM.
Url:
DOI: 10.1136/bmjopen-2016-011175
PubMed: 27540099
PubMed Central: 5013550
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Assefa" uniqKey="Getachew A" first="Assefa" last="Getachew">Assefa Getachew</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Medicine, College of Medicine and Health Science, University of Gondar</institution>,<addr-line>Gondar</addr-line>,<country>Ethiopia</country></nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasika, Solomon" sort="Fasika, Solomon" uniqKey="Fasika S" first="Solomon" last="Fasika">Solomon Fasika</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Medicine, College of Medicine and Health Science, University of Gondar</institution>,<addr-line>Gondar</addr-line>,<country>Ethiopia</country></nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bayisa, Mulugeta" sort="Bayisa, Mulugeta" uniqKey="Bayisa M" first="Mulugeta" last="Bayisa">Mulugeta Bayisa</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Medicine, College of Medicine and Health Science, University of Gondar</institution>,<addr-line>Gondar</addr-line>,<country>Ethiopia</country></nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Girma Demisse, Abayneh" sort="Girma Demisse, Abayneh" uniqKey="Girma Demisse A" first="Abayneh" last="Girma Demisse">Abayneh Girma Demisse</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Medicine, College of Medicine and Health Science, University of Gondar</institution>,<addr-line>Gondar</addr-line>,<country>Ethiopia</country></nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mesfin, Nebiyu" sort="Mesfin, Nebiyu" uniqKey="Mesfin N" first="Nebiyu" last="Mesfin">Nebiyu Mesfin</name><affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Medicine, College of Medicine and Health Science, University of Gondar</institution>,<addr-line>Gondar</addr-line>,<country>Ethiopia</country></nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMJ Open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To assess the prevalence of diabetes mellitus (DM) and associated factors among HIV-infected adults in northwest Ethiopia.</p></sec><sec><title>Design</title><p>Hospital-based cross-sectional study.</p></sec><sec><title>Setting</title><p>HIV clinic of the University of Gondar Hospital, Ethiopia.</p></sec><sec><title>Participants</title><p>All HIV-infected adults who visited the HIV clinic from December 2013 to the end of February 2014 were the source population.</p></sec><sec><title>Measures</title><p>A structured and pretested questionnaire incorporating the WHO STEPwise approach was used. A multivariate logistic regression analysis was applied to assess factors associated with DM.</p></sec><sec><title>Results</title><p>The overall prevalence of type 2 DM was 8% (95% CI 5.5% to 10.5%). The prevalence of DM was higher (13.2%; 95% CI 8.0% to 18.3%) among subjects receiving pre-antiretroviral treatment (pre-ART) than among those taking ART (5.1%; 95% CI 2.6% to 7.6%). Thirteen (35.1%) of the DM cases were newly identified during the study. Obesity (adjusted OR (AOR) 6.55; 1.20 to 35.8), hypertension (AOR 3.45; 1.50 to 7.90), being in the pre-ART group (AOR 4.47; 1.80 to 11.08), hypertriglyceridaemia (AOR 2.24; 1.02 to 49.5) and tertiary-level education (AOR 11.8; 2.28 to 61.4) were associated with DM.</p></sec><sec><title>Conclusions</title><p>Overall DM prevalence was high, particularly among subjects in the pre-ART group. More educated, hypertensive and obese HIV-infected adults were more likely to have DM as a comorbidity. Health policy and the clinical management of HIV-infected individuals should take into account the rising DM.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kalra, S" uniqKey="Kalra S">S Kalra</name></author><author><name sortKey="Agrawal, N" uniqKey="Agrawal N">N Agrawal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paula, Aa" uniqKey="Paula A">AA Paula</name></author><author><name sortKey="Schechter, M" uniqKey="Schechter M">M Schechter</name></author><author><name sortKey="Tuboi, Sh" uniqKey="Tuboi S">SH Tuboi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohammed, Ae" uniqKey="Mohammed A">AE Mohammed</name></author><author><name sortKey="Shenkute, Ty" uniqKey="Shenkute T">TY Shenkute</name></author><author><name sortKey="Gebisa, Wc" uniqKey="Gebisa W">WC 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