Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
Identifieur interne : 000565 ( Main/Merge ); précédent : 000564; suivant : 000566Low incidence of the immune reconstitution inflammatory syndrome among HIV-infected patients starting antiretroviral therapy in Gabon: a prospective cohort study.
Auteurs : S. Janssen [Pays-Bas] ; K. Osbak [Pays-Bas] ; R. Holman [Pays-Bas] ; S. Hermans [Pays-Bas] ; A. Moekotte [Pays-Bas] ; M. Knap [Pays-Bas] ; E. Rossatanga [Gabon] ; M. Massinga-Loembe [Gabon] ; A. Alabi [Gabon] ; A. Adegnika [Gabon] ; C. Meenken [Pays-Bas] ; M. Van Vugt [Pays-Bas] ; P G Kremsner [Gabon] ; G. Meintjes [Afrique du Sud] ; T. Van Der Poll [Pays-Bas] ; M P Grobusch [Pays-Bas]Source :
- Infection [ 1439-0973 ] ; 2017.
Abstract
There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.
DOI: 10.1007/s15010-017-1000-9
PubMed: 28349491
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<author><name sortKey="Massinga Loembe, M" sort="Massinga Loembe, M" uniqKey="Massinga Loembe M" first="M" last="Massinga-Loembe">M. Massinga-Loembe</name>
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<author><name sortKey="Adegnika, A" sort="Adegnika, A" uniqKey="Adegnika A" first="A" last="Adegnika">A. Adegnika</name>
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<author><name sortKey="Van Vugt, M" sort="Van Vugt, M" uniqKey="Van Vugt M" first="M" last="Van Vugt">M. Van Vugt</name>
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<author><name sortKey="Kremsner, P G" sort="Kremsner, P G" uniqKey="Kremsner P" first="P G" last="Kremsner">P G Kremsner</name>
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<author><name sortKey="Meintjes, G" sort="Meintjes, G" uniqKey="Meintjes G" first="G" last="Meintjes">G. Meintjes</name>
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<author><name sortKey="Van Der Poll, T" sort="Van Der Poll, T" uniqKey="Van Der Poll T" first="T" last="Van Der Poll">T. Van Der Poll</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
<author><name sortKey="Grobusch, M P" sort="Grobusch, M P" uniqKey="Grobusch M" first="M P" last="Grobusch">M P Grobusch</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands.</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Division of Internal Medicine, Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
<settlement type="city">Amsterdam</settlement>
</placeName>
<orgName type="university">Université d'Amsterdam</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection</title>
<idno type="eISSN">1439-0973</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">There is a paucity of data on the immune reconstitution inflammatory syndrome (IRIS) in the Central African region. We followed ART-naive HIV-infected patients initiating antiretroviral therapy in an HIV clinic in Gabon, for 6 months. Among 101 patients, IRIS was diagnosed in five. All IRIS cases were mucocutaneous manifestations. There were no cases of tuberculosis (TB) IRIS, but active TB (n = 20) was associated with developing other forms of IRIS (p = 0.02). Six patients died. The incidence of IRIS is low in Gabon, with mild, mucocutaneous manifestations.</div>
</front>
</TEI>
</record>
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