Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants.
Identifieur interne : 000355 ( Main/Exploration ); précédent : 000354; suivant : 000356Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants.
Auteurs : Helen Mcilleron [Afrique du Sud] ; Paolo Denti [Afrique du Sud] ; Silvia Cohn [États-Unis] ; Fildah Mashabela [Afrique du Sud] ; Jennifer D. Hoffmann [États-Unis] ; Saba Shembe [Afrique du Sud] ; Regina Msandiwa [Afrique du Sud] ; Lubbe Wiesner [Afrique du Sud] ; Sithembiso Velaphi [Afrique du Sud] ; Sanjay G. Lala [Afrique du Sud] ; Richard E. Chaisson [États-Unis] ; Neil Martinson [Afrique du Sud] ; Kelly E. Dooley [États-Unis]Source :
- The Journal of antimicrobial chemotherapy [ 1460-2091 ] ; 2017.
Abstract
Newborns of HIV-infected mothers are given daily doses of nevirapine to prevent HIV-1 acquisition. Infants born to mothers with TB should also receive TB preventive therapy. TB preventive regimens include isoniazid for 6 months or rifampicin plus isoniazid for 3 months (RH preventive therapy). The effect of concomitant RH preventive therapy on nevirapine concentrations in infants is unknown.
DOI: 10.1093/jac/dkx112
PubMed: 28419277
Affiliations:
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Hoffmann</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Shembe, Saba" sort="Shembe, Saba" uniqKey="Shembe S" first="Saba" last="Shembe">Saba Shembe</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand</wicri:regionArea><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Msandiwa, Regina" sort="Msandiwa, Regina" uniqKey="Msandiwa R" first="Regina" last="Msandiwa">Regina Msandiwa</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand</wicri:regionArea><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Wiesner, Lubbe" sort="Wiesner, Lubbe" uniqKey="Wiesner L" first="Lubbe" last="Wiesner">Lubbe Wiesner</name><affiliation wicri:level="1"><nlm:affiliation>Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town</wicri:regionArea><wicri:noRegion>Cape Town</wicri:noRegion></affiliation></author><author><name sortKey="Velaphi, Sithembiso" sort="Velaphi, Sithembiso" uniqKey="Velaphi S" first="Sithembiso" last="Velaphi">Sithembiso Velaphi</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand</wicri:regionArea><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Lala, Sanjay G" sort="Lala, Sanjay G" uniqKey="Lala S" first="Sanjay G" last="Lala">Sanjay G. Lala</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand</wicri:regionArea><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Chaisson, Richard E" sort="Chaisson, Richard E" uniqKey="Chaisson R" first="Richard E" last="Chaisson">Richard E. Chaisson</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Martinson, Neil" sort="Martinson, Neil" uniqKey="Martinson N" first="Neil" last="Martinson">Neil Martinson</name><affiliation wicri:level="4"><nlm:affiliation>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV/AIDS and TB, University of the Witwatersrand</wicri:regionArea><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Dooley, Kelly E" sort="Dooley, Kelly E" uniqKey="Dooley K" first="Kelly E" last="Dooley">Kelly E. Dooley</name><affiliation wicri:level="2"><nlm:affiliation>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of antimicrobial chemotherapy</title><idno type="eISSN">1460-2091</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Newborns of HIV-infected mothers are given daily doses of nevirapine to prevent HIV-1 acquisition. Infants born to mothers with TB should also receive TB preventive therapy. TB preventive regimens include isoniazid for 6 months or rifampicin plus isoniazid for 3 months (RH preventive therapy). The effect of concomitant RH preventive therapy on nevirapine concentrations in infants is unknown.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>États-Unis</li></country><region><li>Gauteng</li><li>Maryland</li></region><settlement><li>Johannesbourg</li></settlement><orgName><li>Université du Witwatersrand</li></orgName></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Mcilleron, Helen" sort="Mcilleron, Helen" uniqKey="Mcilleron H" first="Helen" last="Mcilleron">Helen Mcilleron</name></noRegion><name sortKey="Denti, Paolo" sort="Denti, Paolo" uniqKey="Denti P" first="Paolo" last="Denti">Paolo Denti</name><name sortKey="Lala, Sanjay G" sort="Lala, Sanjay G" uniqKey="Lala S" first="Sanjay G" last="Lala">Sanjay G. Lala</name><name sortKey="Martinson, Neil" sort="Martinson, Neil" uniqKey="Martinson N" first="Neil" last="Martinson">Neil Martinson</name><name sortKey="Mashabela, Fildah" sort="Mashabela, Fildah" uniqKey="Mashabela F" first="Fildah" last="Mashabela">Fildah Mashabela</name><name sortKey="Msandiwa, Regina" sort="Msandiwa, Regina" uniqKey="Msandiwa R" first="Regina" last="Msandiwa">Regina Msandiwa</name><name sortKey="Shembe, Saba" sort="Shembe, Saba" uniqKey="Shembe S" first="Saba" last="Shembe">Saba Shembe</name><name sortKey="Velaphi, Sithembiso" sort="Velaphi, Sithembiso" uniqKey="Velaphi S" first="Sithembiso" last="Velaphi">Sithembiso Velaphi</name><name sortKey="Wiesner, Lubbe" sort="Wiesner, Lubbe" uniqKey="Wiesner L" first="Lubbe" last="Wiesner">Lubbe Wiesner</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Cohn, Silvia" sort="Cohn, Silvia" uniqKey="Cohn S" first="Silvia" last="Cohn">Silvia Cohn</name></region><name sortKey="Chaisson, Richard E" sort="Chaisson, Richard E" uniqKey="Chaisson R" first="Richard E" last="Chaisson">Richard E. Chaisson</name><name sortKey="Dooley, Kelly E" sort="Dooley, Kelly E" uniqKey="Dooley K" first="Kelly E" last="Dooley">Kelly E. Dooley</name><name sortKey="Hoffmann, Jennifer D" sort="Hoffmann, Jennifer D" uniqKey="Hoffmann J" first="Jennifer D" last="Hoffmann">Jennifer D. Hoffmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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