Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study
Identifieur interne : 001139 ( Main/Exploration ); précédent : 001138; suivant : 001140Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study
Auteurs : Nader Kim El-Mallawany [États-Unis] ; William Kamiyango [Malawi] ; Jeremy S. Slone [États-Unis] ; Jimmy Villiera [Malawi] ; Carrie L. Kovarik [États-Unis] ; Carrie M. Cox [États-Unis] ; Dirk P. Dittmer [États-Unis] ; Saeed Ahmed [Malawi, États-Unis] ; Gordon E. Schutze [États-Unis] ; Michael E. Scheurer [États-Unis] ; Peter N. Kazembe [Malawi] ; Parth S. Mehta [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Kaposi sarcoma (KS) is the most common HIV-associated malignancy in children and adolescents in Africa. Pediatric KS is distinct from adult disease. We evaluated the clinical characteristics associated with long-term outcomes. We performed a retrospective observational analysis of 70 HIV-infected children and adolescents with KS less than 18 years of age diagnosed between 8/2010 and 6/2013 in Lilongwe, Malawi. Local first-line treatment included bleomycin and vincristine plus nevirapine-based highly active anti-retroviral therapy (HAART). Median age was 8.6 years (range 1.7–17.9); there were 35 females (50%). Most common sites of presentation were: lymph node (74%), skin (59%), subcutaneous nodules (33%), oral (27%), woody edema (24%), and visceral (16%). Eighteen (26%) presented with lymphadenopathy only. Severe CD4 suppression occurred in 28%. At time of KS diagnosis, 49% were already on HAART. Overall, 28% presented with a platelet count < 100 x 109/L and 37% with hemoglobin < 8 g/dL. The 2-year event-free (EFS) and overall survival (OS) were 46% and 58% respectively (median follow-up 29 months, range 15–50). Multivariable analysis of risk of death and failure to achieve EFS demonstrated that visceral disease (odds ratios [OR] 19.08 and 11.61, 95% CI 2.22–163.90 and 1.60–83.95 respectively) and presenting with more than 20 skin/oral lesions (OR 9.57 and 22.90, 95% CI 1.01–90.99 and 1.00–524.13 respectively) were independent risk factors for both. Woody edema was associated with failure to achieve EFS (OR 7.80, 95% CI 1.84–33.08) but not death. Univariable analysis revealed that lymph node involvement was favorable for EFS (OR 0.28, 95% CI 0.08–0.99), while T1 TIS staging criteria, presence of cytopenias, and severe immune suppression were not associated with increased mortality. Long-term complete remission is achievable in pediatric KS, however outcomes vary according to clinical presentation. Based on clinical heterogeneity, treatment according to risk-stratification is necessary to improve overall outcomes.
Url:
DOI: 10.1371/journal.pone.0153335
PubMed: 27082863
PubMed Central: 4833299
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000417
- to stream Pmc, to step Curation: 000417
- to stream Pmc, to step Checkpoint: 000807
- to stream Ncbi, to step Merge: 003729
- to stream Ncbi, to step Curation: 003729
- to stream Ncbi, to step Checkpoint: 003729
- to stream Main, to step Merge: 001140
- to stream Main, to step Curation: 001139
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study</title>
<author><name sortKey="El Mallawany, Nader Kim" sort="El Mallawany, Nader Kim" uniqKey="El Mallawany N" first="Nader Kim" last="El-Mallawany">Nader Kim El-Mallawany</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Pediatrics, Division of Hematology, Oncology, and Hematopoietic Stem Cell Transplantation, New York Medical College, Valhalla, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Division of Hematology, Oncology, and Hematopoietic Stem Cell Transplantation, New York Medical College, Valhalla, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kamiyango, William" sort="Kamiyango, William" uniqKey="Kamiyango W" first="William" last="Kamiyango">William Kamiyango</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slone, Jeremy S" sort="Slone, Jeremy S" uniqKey="Slone J" first="Jeremy S." last="Slone">Jeremy S. Slone</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villiera, Jimmy" sort="Villiera, Jimmy" uniqKey="Villiera J" first="Jimmy" last="Villiera">Jimmy Villiera</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kovarik, Carrie L" sort="Kovarik, Carrie L" uniqKey="Kovarik C" first="Carrie L." last="Kovarik">Carrie L. Kovarik</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cox, Carrie M" sort="Cox, Carrie M" uniqKey="Cox C" first="Carrie M." last="Cox">Carrie M. Cox</name>
<affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Pediatrics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dittmer, Dirk P" sort="Dittmer, Dirk P" uniqKey="Dittmer D" first="Dirk P." last="Dittmer">Dirk P. Dittmer</name>
<affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahmed, Saeed" sort="Ahmed, Saeed" uniqKey="Ahmed S" first="Saeed" last="Ahmed">Saeed Ahmed</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schutze, Gordon E" sort="Schutze, Gordon E" uniqKey="Schutze G" first="Gordon E." last="Schutze">Gordon E. Schutze</name>
<affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheurer, Michael E" sort="Scheurer, Michael E" uniqKey="Scheurer M" first="Michael E." last="Scheurer">Michael E. Scheurer</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kazembe, Peter N" sort="Kazembe, Peter N" uniqKey="Kazembe P" first="Peter N." last="Kazembe">Peter N. Kazembe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehta, Parth S" sort="Mehta, Parth S" uniqKey="Mehta P" first="Parth S." last="Mehta">Parth S. Mehta</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27082863</idno>
<idno type="pmc">4833299</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833299</idno>
<idno type="RBID">PMC:4833299</idno>
<idno type="doi">10.1371/journal.pone.0153335</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000417</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000417</idno>
<idno type="wicri:Area/Pmc/Curation">000417</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000417</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000807</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000807</idno>
<idno type="wicri:Area/Ncbi/Merge">003729</idno>
<idno type="wicri:Area/Ncbi/Curation">003729</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003729</idno>
<idno type="wicri:Area/Main/Merge">001140</idno>
<idno type="wicri:Area/Main/Curation">001139</idno>
<idno type="wicri:Area/Main/Exploration">001139</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study</title>
<author><name sortKey="El Mallawany, Nader Kim" sort="El Mallawany, Nader Kim" uniqKey="El Mallawany N" first="Nader Kim" last="El-Mallawany">Nader Kim El-Mallawany</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Pediatrics, Division of Hematology, Oncology, and Hematopoietic Stem Cell Transplantation, New York Medical College, Valhalla, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Division of Hematology, Oncology, and Hematopoietic Stem Cell Transplantation, New York Medical College, Valhalla, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kamiyango, William" sort="Kamiyango, William" uniqKey="Kamiyango W" first="William" last="Kamiyango">William Kamiyango</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slone, Jeremy S" sort="Slone, Jeremy S" uniqKey="Slone J" first="Jeremy S." last="Slone">Jeremy S. Slone</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Villiera, Jimmy" sort="Villiera, Jimmy" uniqKey="Villiera J" first="Jimmy" last="Villiera">Jimmy Villiera</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kovarik, Carrie L" sort="Kovarik, Carrie L" uniqKey="Kovarik C" first="Carrie L." last="Kovarik">Carrie L. Kovarik</name>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cox, Carrie M" sort="Cox, Carrie M" uniqKey="Cox C" first="Carrie M." last="Cox">Carrie M. Cox</name>
<affiliation wicri:level="2"><nlm:aff id="aff006"><addr-line>Department of Pediatrics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dittmer, Dirk P" sort="Dittmer, Dirk P" uniqKey="Dittmer D" first="Dirk P." last="Dittmer">Dirk P. Dittmer</name>
<affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahmed, Saeed" sort="Ahmed, Saeed" uniqKey="Ahmed S" first="Saeed" last="Ahmed">Saeed Ahmed</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schutze, Gordon E" sort="Schutze, Gordon E" uniqKey="Schutze G" first="Gordon E." last="Schutze">Gordon E. Schutze</name>
<affiliation wicri:level="2"><nlm:aff id="aff008"><addr-line>Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scheurer, Michael E" sort="Scheurer, Michael E" uniqKey="Scheurer M" first="Michael E." last="Scheurer">Michael E. Scheurer</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kazembe, Peter N" sort="Kazembe, Peter N" uniqKey="Kazembe P" first="Peter N." last="Kazembe">Peter N. Kazembe</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe, Malawi</addr-line>
</nlm:aff>
<country xml:lang="fr">Malawi</country>
<wicri:regionArea>Baylor College of Medicine Children’s Foundation Malawi, Lilongwe</wicri:regionArea>
<wicri:noRegion>Lilongwe</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehta, Parth S" sort="Mehta, Parth S" uniqKey="Mehta P" first="Parth S." last="Mehta">Parth S. Mehta</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Texas Children’s Cancer and Hematology Centers, Houston, Texas, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Texas Children’s Cancer and Hematology Centers, Houston, Texas</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Kaposi sarcoma (KS) is the most common HIV-associated malignancy in children and adolescents in Africa. Pediatric KS is distinct from adult disease. We evaluated the clinical characteristics associated with long-term outcomes. We performed a retrospective observational analysis of 70 HIV-infected children and adolescents with KS less than 18 years of age diagnosed between 8/2010 and 6/2013 in Lilongwe, Malawi. Local first-line treatment included bleomycin and vincristine plus nevirapine-based highly active anti-retroviral therapy (HAART). Median age was 8.6 years (range 1.7–17.9); there were 35 females (50%). Most common sites of presentation were: lymph node (74%), skin (59%), subcutaneous nodules (33%), oral (27%), woody edema (24%), and visceral (16%). Eighteen (26%) presented with lymphadenopathy only. Severe CD4 suppression occurred in 28%. At time of KS diagnosis, 49% were already on HAART. Overall, 28% presented with a platelet count < 100 x 10<sup>9</sup>
/L and 37% with hemoglobin < 8 g/dL. The 2-year event-free (EFS) and overall survival (OS) were 46% and 58% respectively (median follow-up 29 months, range 15–50). Multivariable analysis of risk of death and failure to achieve EFS demonstrated that visceral disease (odds ratios [OR] 19.08 and 11.61, 95% CI 2.22–163.90 and 1.60–83.95 respectively) and presenting with more than 20 skin/oral lesions (OR 9.57 and 22.90, 95% CI 1.01–90.99 and 1.00–524.13 respectively) were independent risk factors for both. Woody edema was associated with failure to achieve EFS (OR 7.80, 95% CI 1.84–33.08) but not death. Univariable analysis revealed that lymph node involvement was favorable for EFS (OR 0.28, 95% CI 0.08–0.99), while T<sub>1</sub>
TIS staging criteria, presence of cytopenias, and severe immune suppression were not associated with increased mortality. Long-term complete remission is achievable in pediatric KS, however outcomes vary according to clinical presentation. Based on clinical heterogeneity, treatment according to risk-stratification is necessary to improve overall outcomes.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Orem, J" uniqKey="Orem J">J Orem</name>
</author>
<author><name sortKey="Otieno, Mw" uniqKey="Otieno M">MW Otieno</name>
</author>
<author><name sortKey="Remick, Sc" uniqKey="Remick S">SC Remick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name>
</author>
<author><name sortKey="Cesarman, E" uniqKey="Cesarman E">E Cesarman</name>
</author>
<author><name sortKey="Pessin, Ms" uniqKey="Pessin M">MS Pessin</name>
</author>
<author><name sortKey="Lee, F" uniqKey="Lee F">F Lee</name>
</author>
<author><name sortKey="Culpepper, J" uniqKey="Culpepper J">J Culpepper</name>
</author>
<author><name sortKey="Knowles, Dm" uniqKey="Knowles D">DM Knowles</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martro, E" uniqKey="Martro E">E Martro</name>
</author>
<author><name sortKey="Bulterys, M" uniqKey="Bulterys M">M Bulterys</name>
</author>
<author><name sortKey="Stewart, Ja" uniqKey="Stewart J">JA Stewart</name>
</author>
<author><name sortKey="Spira, Tj" uniqKey="Spira T">TJ Spira</name>
</author>
<author><name sortKey="Cannon, Mj" uniqKey="Cannon M">MJ Cannon</name>
</author>
<author><name sortKey="Thacher, Td" uniqKey="Thacher T">TD Thacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarmati, L" uniqKey="Sarmati L">L Sarmati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chatlynne, Lg" uniqKey="Chatlynne L">LG Chatlynne</name>
</author>
<author><name sortKey="Ablashi, Dv" uniqKey="Ablashi D">DV Ablashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olsen, Sj" uniqKey="Olsen S">SJ Olsen</name>
</author>
<author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name>
</author>
<author><name sortKey="Moore, Ps" uniqKey="Moore P">PS Moore</name>
</author>
<author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name>
</author>
<author><name sortKey="Melbye, M" uniqKey="Melbye M">M Melbye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rohner, E" uniqKey="Rohner E">E Rohner</name>
</author>
<author><name sortKey="Wyss, N" uniqKey="Wyss N">N Wyss</name>
</author>
<author><name sortKey="Heg, Z" uniqKey="Heg Z">Z Heg</name>
</author>
<author><name sortKey="Faralli, Z" uniqKey="Faralli Z">Z Faralli</name>
</author>
<author><name sortKey="Mbulaiteye, Sm" uniqKey="Mbulaiteye S">SM Mbulaiteye</name>
</author>
<author><name sortKey="Novak, U" uniqKey="Novak U">U Novak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mbulaiteye, Sm" uniqKey="Mbulaiteye S">SM Mbulaiteye</name>
</author>
<author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name>
</author>
<author><name sortKey="Whitby, D" uniqKey="Whitby D">D Whitby</name>
</author>
<author><name sortKey="Brubaker, Gr" uniqKey="Brubaker G">GR Brubaker</name>
</author>
<author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name>
</author>
<author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plancoulaine, S" uniqKey="Plancoulaine S">S Plancoulaine</name>
</author>
<author><name sortKey="Abel, L" uniqKey="Abel L">L Abel</name>
</author>
<author><name sortKey="Van Beveren, M" uniqKey="Van Beveren M">M van Beveren</name>
</author>
<author><name sortKey="Tregouet, Da" uniqKey="Tregouet D">DA Tregouet</name>
</author>
<author><name sortKey="Joubert, M" uniqKey="Joubert M">M Joubert</name>
</author>
<author><name sortKey="Tortevoye, P" uniqKey="Tortevoye P">P Tortevoye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cox, Cm" uniqKey="Cox C">CM Cox</name>
</author>
<author><name sortKey="El Mallawany, Nk" uniqKey="El Mallawany N">NK El-Mallawany</name>
</author>
<author><name sortKey="Kabue, M" uniqKey="Kabue M">M Kabue</name>
</author>
<author><name sortKey="Kovarik, C" uniqKey="Kovarik C">C Kovarik</name>
</author>
<author><name sortKey="Schutze, Ge" uniqKey="Schutze G">GE Schutze</name>
</author>
<author><name sortKey="Kazembe, Pn" uniqKey="Kazembe P">PN Kazembe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gantt, S" uniqKey="Gantt S">S Gantt</name>
</author>
<author><name sortKey="Kakuru, A" uniqKey="Kakuru A">A Kakuru</name>
</author>
<author><name sortKey="Wald, A" uniqKey="Wald A">A Wald</name>
</author>
<author><name sortKey="Walusansa, V" uniqKey="Walusansa V">V Walusansa</name>
</author>
<author><name sortKey="Corey, L" uniqKey="Corey L">L Corey</name>
</author>
<author><name sortKey="Casper, C" uniqKey="Casper C">C Casper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vaz, P" uniqKey="Vaz P">P Vaz</name>
</author>
<author><name sortKey="Macassa, E" uniqKey="Macassa E">E Macassa</name>
</author>
<author><name sortKey="Jani, I" uniqKey="Jani I">I Jani</name>
</author>
<author><name sortKey="Thome, B" uniqKey="Thome B">B Thome</name>
</author>
<author><name sortKey="Mahagaja, E" uniqKey="Mahagaja E">E Mahagaja</name>
</author>
<author><name sortKey="Madede, T" uniqKey="Madede T">T Madede</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chagaluka, G" uniqKey="Chagaluka G">G Chagaluka</name>
</author>
<author><name sortKey="Stanley, C" uniqKey="Stanley C">C Stanley</name>
</author>
<author><name sortKey="Banda, K" uniqKey="Banda K">K Banda</name>
</author>
<author><name sortKey="Depani, S" uniqKey="Depani S">S Depani</name>
</author>
<author><name sortKey="Nijram Madzi, J" uniqKey="Nijram Madzi J">J Nijram'madzi</name>
</author>
<author><name sortKey="Katangwe, T" uniqKey="Katangwe T">T Katangwe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stefan, Dc" uniqKey="Stefan D">DC Stefan</name>
</author>
<author><name sortKey="Stones, Dk" uniqKey="Stones D">DK Stones</name>
</author>
<author><name sortKey="Wainwright, L" uniqKey="Wainwright L">L Wainwright</name>
</author>
<author><name sortKey="Newton, R" uniqKey="Newton R">R Newton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name>
</author>
<author><name sortKey="Frisch, M" uniqKey="Frisch M">M Frisch</name>
</author>
<author><name sortKey="Goedert, Jj" uniqKey="Goedert J">JJ Goedert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pollock, Bh" uniqKey="Pollock B">BH Pollock</name>
</author>
<author><name sortKey="Jenson, Hb" uniqKey="Jenson H">HB Jenson</name>
</author>
<author><name sortKey="Leach, Ct" uniqKey="Leach C">CT Leach</name>
</author>
<author><name sortKey="Mcclain, Kl" uniqKey="Mcclain K">KL McClain</name>
</author>
<author><name sortKey="Hutchison, Re" uniqKey="Hutchison R">RE Hutchison</name>
</author>
<author><name sortKey="Garzarella, L" uniqKey="Garzarella L">L Garzarella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kest, H" uniqKey="Kest H">H Kest</name>
</author>
<author><name sortKey="Brogly, S" uniqKey="Brogly S">S Brogly</name>
</author>
<author><name sortKey="Mcsherry, G" uniqKey="Mcsherry G">G McSherry</name>
</author>
<author><name sortKey="Dashefsky, B" uniqKey="Dashefsky B">B Dashefsky</name>
</author>
<author><name sortKey="Oleske, J" uniqKey="Oleske J">J Oleske</name>
</author>
<author><name sortKey="Seage, Gr" uniqKey="Seage G">GR Seage</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Granovsky, Mo" uniqKey="Granovsky M">MO Granovsky</name>
</author>
<author><name sortKey="Mueller, Bu" uniqKey="Mueller B">BU Mueller</name>
</author>
<author><name sortKey="Nicholson, Hs" uniqKey="Nicholson H">HS Nicholson</name>
</author>
<author><name sortKey="Rosenberg, Ps" uniqKey="Rosenberg P">PS Rosenberg</name>
</author>
<author><name sortKey="Rabkin, Cs" uniqKey="Rabkin C">CS Rabkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Caselli, D" uniqKey="Caselli D">D Caselli</name>
</author>
<author><name sortKey="Klersy, C" uniqKey="Klersy C">C Klersy</name>
</author>
<author><name sortKey="De Martino, M" uniqKey="De Martino M">M de Martino</name>
</author>
<author><name sortKey="Gabiano, C" uniqKey="Gabiano C">C Gabiano</name>
</author>
<author><name sortKey="Galli, L" uniqKey="Galli L">L Galli</name>
</author>
<author><name sortKey="Tovo, Pa" uniqKey="Tovo P">PA Tovo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Evans, Ja" uniqKey="Evans J">JA Evans</name>
</author>
<author><name sortKey="Gibb, Dm" uniqKey="Gibb D">DM Gibb</name>
</author>
<author><name sortKey="Holland, Fj" uniqKey="Holland F">FJ Holland</name>
</author>
<author><name sortKey="Tookey, Pa" uniqKey="Tookey P">PA Tookey</name>
</author>
<author><name sortKey="Pritchard, J" uniqKey="Pritchard J">J Pritchard</name>
</author>
<author><name sortKey="Ades, Ae" uniqKey="Ades A">AE Ades</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Desantis, Sm" uniqKey="Desantis S">SM DeSantis</name>
</author>
<author><name sortKey="Pau, Cp" uniqKey="Pau C">CP Pau</name>
</author>
<author><name sortKey="Archibald, Lk" uniqKey="Archibald L">LK Archibald</name>
</author>
<author><name sortKey="Nwanyanwu, Oc" uniqKey="Nwanyanwu O">OC Nwanyanwu</name>
</author>
<author><name sortKey="Kazembe, Pn" uniqKey="Kazembe P">PN Kazembe</name>
</author>
<author><name sortKey="Dobbie, H" uniqKey="Dobbie H">H Dobbie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasolo, Fc" uniqKey="Kasolo F">FC Kasolo</name>
</author>
<author><name sortKey="Spinks, J" uniqKey="Spinks J">J Spinks</name>
</author>
<author><name sortKey="Bima, H" uniqKey="Bima H">H Bima</name>
</author>
<author><name sortKey="Bates, M" uniqKey="Bates M">M Bates</name>
</author>
<author><name sortKey="Gompels, Ua" uniqKey="Gompels U">UA Gompels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfeiffer, Rm" uniqKey="Pfeiffer R">RM Pfeiffer</name>
</author>
<author><name sortKey="Wheeler, Wa" uniqKey="Wheeler W">WA Wheeler</name>
</author>
<author><name sortKey="Mbisa, G" uniqKey="Mbisa G">G Mbisa</name>
</author>
<author><name sortKey="Whitby, D" uniqKey="Whitby D">D Whitby</name>
</author>
<author><name sortKey="Goedert, Jj" uniqKey="Goedert J">JJ Goedert</name>
</author>
<author><name sortKey="De The, G" uniqKey="De The G">G de The</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dollard, Sc" uniqKey="Dollard S">SC Dollard</name>
</author>
<author><name sortKey="Butler, Lm" uniqKey="Butler L">LM Butler</name>
</author>
<author><name sortKey="Jones, Am" uniqKey="Jones A">AM Jones</name>
</author>
<author><name sortKey="Mermin, Jh" uniqKey="Mermin J">JH Mermin</name>
</author>
<author><name sortKey="Chidzonga, M" uniqKey="Chidzonga M">M Chidzonga</name>
</author>
<author><name sortKey="Chipato, T" uniqKey="Chipato T">T Chipato</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andreoni, M" uniqKey="Andreoni M">M Andreoni</name>
</author>
<author><name sortKey="Sarmati, L" uniqKey="Sarmati L">L Sarmati</name>
</author>
<author><name sortKey="Nicastri, E" uniqKey="Nicastri E">E Nicastri</name>
</author>
<author><name sortKey="El Sawaf, G" uniqKey="El Sawaf G">G El Sawaf</name>
</author>
<author><name sortKey="El Zalabani, M" uniqKey="El Zalabani M">M El Zalabani</name>
</author>
<author><name sortKey="Uccella, I" uniqKey="Uccella I">I Uccella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourboulia, D" uniqKey="Bourboulia D">D Bourboulia</name>
</author>
<author><name sortKey="Whitby, D" uniqKey="Whitby D">D Whitby</name>
</author>
<author><name sortKey="Boshoff, C" uniqKey="Boshoff C">C Boshoff</name>
</author>
<author><name sortKey="Newton, R" uniqKey="Newton R">R Newton</name>
</author>
<author><name sortKey="Beral, V" uniqKey="Beral V">V Beral</name>
</author>
<author><name sortKey="Carrara, H" uniqKey="Carrara H">H Carrara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mayama, S" uniqKey="Mayama S">S Mayama</name>
</author>
<author><name sortKey="Cuevas, Le" uniqKey="Cuevas L">LE Cuevas</name>
</author>
<author><name sortKey="Sheldon, J" uniqKey="Sheldon J">J Sheldon</name>
</author>
<author><name sortKey="Omar, Oh" uniqKey="Omar O">OH Omar</name>
</author>
<author><name sortKey="Smith, Dh" uniqKey="Smith D">DH Smith</name>
</author>
<author><name sortKey="Okong, P" uniqKey="Okong P">P Okong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dow, De" uniqKey="Dow D">DE Dow</name>
</author>
<author><name sortKey="Cunningham, Ck" uniqKey="Cunningham C">CK Cunningham</name>
</author>
<author><name sortKey="Buchanan, Am" uniqKey="Buchanan A">AM Buchanan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anglemyer, A" uniqKey="Anglemyer A">A Anglemyer</name>
</author>
<author><name sortKey="Agrawal, Ak" uniqKey="Agrawal A">AK Agrawal</name>
</author>
<author><name sortKey="Rutherford, Gw" uniqKey="Rutherford G">GW Rutherford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gopal, S" uniqKey="Gopal S">S Gopal</name>
</author>
<author><name sortKey="Krysiak, R" uniqKey="Krysiak R">R Krysiak</name>
</author>
<author><name sortKey="Liomba, Ng" uniqKey="Liomba N">NG Liomba</name>
</author>
<author><name sortKey="Horner, Mj" uniqKey="Horner M">MJ Horner</name>
</author>
<author><name sortKey="Shores, Cg" uniqKey="Shores C">CG Shores</name>
</author>
<author><name sortKey="Alide, N" uniqKey="Alide N">N Alide</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tweya, H" uniqKey="Tweya H">H Tweya</name>
</author>
<author><name sortKey="Ben Smith, A" uniqKey="Ben Smith A">A Ben-Smith</name>
</author>
<author><name sortKey="Kalulu, M" uniqKey="Kalulu M">M Kalulu</name>
</author>
<author><name sortKey="Jahn, A" uniqKey="Jahn A">A Jahn</name>
</author>
<author><name sortKey="Ng Ambi, W" uniqKey="Ng Ambi W">W Ng'ambi</name>
</author>
<author><name sortKey="Mkandawire, E" uniqKey="Mkandawire E">E Mkandawire</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reddy Holdcraft, S" uniqKey="Reddy Holdcraft S">S Reddy-Holdcraft</name>
</author>
<author><name sortKey="Mehta, Ps" uniqKey="Mehta P">PS Mehta</name>
</author>
<author><name sortKey="Agrawal, Ak" uniqKey="Agrawal A">AK Agrawal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krown, Se" uniqKey="Krown S">SE Krown</name>
</author>
<author><name sortKey="Testa, Ma" uniqKey="Testa M">MA Testa</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krown, Se" uniqKey="Krown S">SE Krown</name>
</author>
<author><name sortKey="Metroka, C" uniqKey="Metroka C">C Metroka</name>
</author>
<author><name sortKey="Wernz, Jc" uniqKey="Wernz J">JC Wernz</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Firth, D" uniqKey="Firth D">D Firth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arkin, Lm" uniqKey="Arkin L">LM Arkin</name>
</author>
<author><name sortKey="Cox, Cm" uniqKey="Cox C">CM Cox</name>
</author>
<author><name sortKey="Kovarik, Cl" uniqKey="Kovarik C">CL Kovarik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tobin, Nh" uniqKey="Tobin N">NH Tobin</name>
</author>
<author><name sortKey="Aldrovandi, Gm" uniqKey="Aldrovandi G">GM Aldrovandi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hosseinipour, Mc" uniqKey="Hosseinipour M">MC Hosseinipour</name>
</author>
<author><name sortKey="Sweet, Km" uniqKey="Sweet K">KM Sweet</name>
</author>
<author><name sortKey="Xiong, J" uniqKey="Xiong J">J Xiong</name>
</author>
<author><name sortKey="Namarika, D" uniqKey="Namarika D">D Namarika</name>
</author>
<author><name sortKey="Mwafongo, A" uniqKey="Mwafongo A">A Mwafongo</name>
</author>
<author><name sortKey="Nyirenda, M" uniqKey="Nyirenda M">M Nyirenda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herce, Me" uniqKey="Herce M">ME Herce</name>
</author>
<author><name sortKey="Kalanga, N" uniqKey="Kalanga N">N Kalanga</name>
</author>
<author><name sortKey="Wroe, Eb" uniqKey="Wroe E">EB Wroe</name>
</author>
<author><name sortKey="Keck, Jw" uniqKey="Keck J">JW Keck</name>
</author>
<author><name sortKey="Chingoli, F" uniqKey="Chingoli F">F Chingoli</name>
</author>
<author><name sortKey="Tengatenga, L" uniqKey="Tengatenga L">L Tengatenga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polizzotto, Mn" uniqKey="Polizzotto M">MN Polizzotto</name>
</author>
<author><name sortKey="Uldrick, Ts" uniqKey="Uldrick T">TS Uldrick</name>
</author>
<author><name sortKey="Wang, V" uniqKey="Wang V">V Wang</name>
</author>
<author><name sortKey="Aleman, K" uniqKey="Aleman K">K Aleman</name>
</author>
<author><name sortKey="Wyvill, Km" uniqKey="Wyvill K">KM Wyvill</name>
</author>
<author><name sortKey="Marshall, V" uniqKey="Marshall V">V Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Polizzotto, Mn" uniqKey="Polizzotto M">MN Polizzotto</name>
</author>
<author><name sortKey="Uldrick, Ts" uniqKey="Uldrick T">TS Uldrick</name>
</author>
<author><name sortKey="Hu, D" uniqKey="Hu D">D Hu</name>
</author>
<author><name sortKey="Yarchoan, R" uniqKey="Yarchoan R">R Yarchoan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uldrick, Ts" uniqKey="Uldrick T">TS Uldrick</name>
</author>
<author><name sortKey="Wang, V" uniqKey="Wang V">V Wang</name>
</author>
<author><name sortKey="O Mahony, D" uniqKey="O Mahony D">D O'Mahony</name>
</author>
<author><name sortKey="Aleman, K" uniqKey="Aleman K">K Aleman</name>
</author>
<author><name sortKey="Wyvill, Km" uniqKey="Wyvill K">KM Wyvill</name>
</author>
<author><name sortKey="Marshall, V" uniqKey="Marshall V">V Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Venkataraman, G" uniqKey="Venkataraman G">G Venkataraman</name>
</author>
<author><name sortKey="Uldrick, Ts" uniqKey="Uldrick T">TS Uldrick</name>
</author>
<author><name sortKey="Aleman, K" uniqKey="Aleman K">K Aleman</name>
</author>
<author><name sortKey="O Mahony, D" uniqKey="O Mahony D">D O'Mahony</name>
</author>
<author><name sortKey="Karcher, Ds" uniqKey="Karcher D">DS Karcher</name>
</author>
<author><name sortKey="Steinberg, Sm" uniqKey="Steinberg S">SM Steinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slavin, G" uniqKey="Slavin G">G Slavin</name>
</author>
<author><name sortKey="Cameron, Hm" uniqKey="Cameron H">HM Cameron</name>
</author>
<author><name sortKey="Forbes, C" uniqKey="Forbes C">C Forbes</name>
</author>
<author><name sortKey="Mitchell, Rm" uniqKey="Mitchell R">RM Mitchell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olweny, Cl" uniqKey="Olweny C">CL Olweny</name>
</author>
<author><name sortKey="Kaddumukasa, A" uniqKey="Kaddumukasa A">A Kaddumukasa</name>
</author>
<author><name sortKey="Atine, I" uniqKey="Atine I">I Atine</name>
</author>
<author><name sortKey="Owor, R" uniqKey="Owor R">R Owor</name>
</author>
<author><name sortKey="Magrath, I" uniqKey="Magrath I">I Magrath</name>
</author>
<author><name sortKey="Ziegler, Jl" uniqKey="Ziegler J">JL Ziegler</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Malawi</li>
<li>États-Unis</li>
</country>
<region><li>Caroline du Nord</li>
<li>Illinois</li>
<li>Pennsylvanie</li>
<li>Texas</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="El Mallawany, Nader Kim" sort="El Mallawany, Nader Kim" uniqKey="El Mallawany N" first="Nader Kim" last="El-Mallawany">Nader Kim El-Mallawany</name>
</region>
<name sortKey="Ahmed, Saeed" sort="Ahmed, Saeed" uniqKey="Ahmed S" first="Saeed" last="Ahmed">Saeed Ahmed</name>
<name sortKey="Cox, Carrie M" sort="Cox, Carrie M" uniqKey="Cox C" first="Carrie M." last="Cox">Carrie M. Cox</name>
<name sortKey="Dittmer, Dirk P" sort="Dittmer, Dirk P" uniqKey="Dittmer D" first="Dirk P." last="Dittmer">Dirk P. Dittmer</name>
<name sortKey="El Mallawany, Nader Kim" sort="El Mallawany, Nader Kim" uniqKey="El Mallawany N" first="Nader Kim" last="El-Mallawany">Nader Kim El-Mallawany</name>
<name sortKey="Kovarik, Carrie L" sort="Kovarik, Carrie L" uniqKey="Kovarik C" first="Carrie L." last="Kovarik">Carrie L. Kovarik</name>
<name sortKey="Mehta, Parth S" sort="Mehta, Parth S" uniqKey="Mehta P" first="Parth S." last="Mehta">Parth S. Mehta</name>
<name sortKey="Mehta, Parth S" sort="Mehta, Parth S" uniqKey="Mehta P" first="Parth S." last="Mehta">Parth S. Mehta</name>
<name sortKey="Scheurer, Michael E" sort="Scheurer, Michael E" uniqKey="Scheurer M" first="Michael E." last="Scheurer">Michael E. Scheurer</name>
<name sortKey="Scheurer, Michael E" sort="Scheurer, Michael E" uniqKey="Scheurer M" first="Michael E." last="Scheurer">Michael E. Scheurer</name>
<name sortKey="Schutze, Gordon E" sort="Schutze, Gordon E" uniqKey="Schutze G" first="Gordon E." last="Schutze">Gordon E. Schutze</name>
<name sortKey="Slone, Jeremy S" sort="Slone, Jeremy S" uniqKey="Slone J" first="Jeremy S." last="Slone">Jeremy S. Slone</name>
<name sortKey="Slone, Jeremy S" sort="Slone, Jeremy S" uniqKey="Slone J" first="Jeremy S." last="Slone">Jeremy S. Slone</name>
</country>
<country name="Malawi"><noRegion><name sortKey="Kamiyango, William" sort="Kamiyango, William" uniqKey="Kamiyango W" first="William" last="Kamiyango">William Kamiyango</name>
</noRegion>
<name sortKey="Ahmed, Saeed" sort="Ahmed, Saeed" uniqKey="Ahmed S" first="Saeed" last="Ahmed">Saeed Ahmed</name>
<name sortKey="Kazembe, Peter N" sort="Kazembe, Peter N" uniqKey="Kazembe P" first="Peter N." last="Kazembe">Peter N. Kazembe</name>
<name sortKey="Villiera, Jimmy" sort="Villiera, Jimmy" uniqKey="Villiera J" first="Jimmy" last="Villiera">Jimmy Villiera</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001139 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001139 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4833299 |texte= Clinical Factors Associated with Long-Term Complete Remission versus Poor Response to Chemotherapy in HIV-Infected Children and Adolescents with Kaposi Sarcoma Receiving Bleomycin and Vincristine: A Retrospective Observational Study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27082863" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |