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Benzodiazepine Use as an Independent Risk Factor for HIV Infection in a Canadian Setting

Identifieur interne : 001836 ( Main/Exploration ); précédent : 001835; suivant : 001837

Benzodiazepine Use as an Independent Risk Factor for HIV Infection in a Canadian Setting

Auteurs : Sarah Ickowicz ; Kanna Hayashi ; Huiru Dong ; Mj Milloy ; Thomas Kerr ; Julio S. G. Montaner ; Evan Wood

Source :

Drug and alcohol dependence [ 0376-8716 ] ; 2015.

RBID : PMC:4581956

Abstract

Background

Although the harms of prescription drug diversion are of growing international concern, the potential impact of prescription drug use on HIV infection has not been well assessed. We evaluated whether benzodiazepine use was associated with HIV seroconversion among a cohort of persons who inject drugs (PWID) in a Canadian setting.

Methods

Between May, 1996 and November, 2013, data were derived through a prospective cohort study of PWID in Vancouver, Canada. A total of 1,682 baseline HIV negative participants were followed for a median of 79.5 months (interquartile range: 32.1 – 119.1), among whom 501 (29.8%) reported benzodiazepine use at baseline, and 176 seroconverted during follow-up, equal to an incidence density of 1.5 (95% Confidence Interval [CI]: 1.3 – 1.7) cases per 100 person-years. Poisson regression with time-dependent variables was used to assess whether benzodiazepine use was associated with the time to HIV seroconversion.

Results

After adjustment for potential confounders, benzodiazepine use (Adjusted Rate Ratio: 1.50; 95% CI: 1.01 – 2.24) was independently associated with a higher rate of HIV seroconversion.

Conclusions

Benzodiazepine use was an independent risk factor for HIV seroconversion among PWID in this setting. Greater recognition of the safety concerns related to benzodiazepine medications including d iversion are needed.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581956

DOI: 10.1016/j.drugalcdep.2015.07.017
PubMed: 26243506
PubMed Central: 4581956

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Although the harms of prescription drug diversion are of growing international concern, the potential impact of prescription drug use on HIV infection has not been well assessed. We evaluated whether benzodiazepine use was associated with HIV seroconversion among a cohort of persons who inject drugs (PWID) in a Canadian setting.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Between May, 1996 and November, 2013, data were derived through a prospective cohort study of PWID in Vancouver, Canada. A total of 1,682 baseline HIV negative participants were followed for a median of 79.5 months (interquartile range: 32.1 – 119.1), among whom 501 (29.8%) reported benzodiazepine use at baseline, and 176 seroconverted during follow-up, equal to an incidence density of 1.5 (95% Confidence Interval [CI]: 1.3 – 1.7) cases per 100 person-years. Poisson regression with time-dependent variables was used to assess whether benzodiazepine use was associated with the time to HIV seroconversion.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">After adjustment for potential confounders, benzodiazepine use (Adjusted Rate Ratio: 1.50; 95% CI: 1.01 – 2.24) was independently associated with a higher rate of HIV seroconversion.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Benzodiazepine use was an independent risk factor for HIV seroconversion among PWID in this setting. Greater recognition of the safety concerns related to benzodiazepine medications including d iversion are needed.</p>
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Benzodiazepine Use as an Independent Risk Factor for HIV Infection in a Canadian Setting

Benzodiazepine Use as an Independent Risk Factor for HIV Infection in a Canadian Setting

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