Determinants of non-adherence to antiretroviral therapy in adult hospitalized patients, Northwest Ethiopia
Identifieur interne : 001771 ( Main/Exploration ); précédent : 001770; suivant : 001772Determinants of non-adherence to antiretroviral therapy in adult hospitalized patients, Northwest Ethiopia
Auteurs : Bayew Tsega [Éthiopie] ; Bhagavathula Akshaya Srikanth [Éthiopie] ; Zewdneh Shewamene [Éthiopie]Source :
- Patient preference and adherence [ 1177-889X ] ; 2015.
Abstract
The aim of this study was to assess the rate of antiretroviral therapy (ART) adherence and to identify any determinants among adult patients.
A cross-sectional study was conducted on 351 ART patients in the ART clinic of the University of Gondar referral hospital. Data were collected by a pretested interviewer-administered structured questionnaire from May to June 2014. Multivariate logistic regression was used to determine factors significantly associated with adherence.
Of 351 study subjects, women were more predominant than men (64.4% versus 35.6%). Three hundred and forty (96.9%) patients agreed and strongly agreed that the use of ART is essential in their life, and approximately 327 (93.2%) disclosed their sero-status to family. Seventy-nine (22.5%) participants were active substance users. The level of adherence was 284 (80.9%). Three hundred forty-one (97.2%) respondents had good or fair adherence. Among the reasons for missing doses were forgetfulness (29 [43.3%]), missing appointments (14 [20.9%]), running out of medicine (9 [13.4%]), depression, anger, or hopelessness (4 [6.0%]), side effects of the medicine used (2 [3.0%]), and nonbelief in the ART (2 [3.0%]). The variables found significantly associated with non-adherence were age (
From this study, it was determined that forgetfulness (43.3%) was the most common reason for missing doses. Also, employment and acceptance in using ART in the presence of others are significant issues observed for non-adherence. Hence, the ART counselor needs to place more emphasis on the provision and use of memory aids.
Url:
DOI: 10.2147/PPA.S75876
PubMed: 25784793
PubMed Central: 4356699
Affiliations:
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type="main">Determinants of non-adherence to antiretroviral therapy in adult hospitalized patients, Northwest Ethiopia</title><author><name sortKey="Tsega, Bayew" sort="Tsega, Bayew" uniqKey="Tsega B" first="Bayew" last="Tsega">Bayew Tsega</name><affiliation wicri:level="1"><nlm:aff id="af1-ppa-9-373">Department of Clinical Pharmacy, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Clinical Pharmacy, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Srikanth, Bhagavathula Akshaya" sort="Srikanth, Bhagavathula Akshaya" uniqKey="Srikanth B" first="Bhagavathula Akshaya" last="Srikanth">Bhagavathula Akshaya Srikanth</name><affiliation wicri:level="1"><nlm:aff id="af1-ppa-9-373">Department of Clinical Pharmacy, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Clinical Pharmacy, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author><author><name sortKey="Shewamene, Zewdneh" sort="Shewamene, Zewdneh" uniqKey="Shewamene Z" first="Zewdneh" last="Shewamene">Zewdneh Shewamene</name><affiliation wicri:level="1"><nlm:aff id="af2-ppa-9-373">Department of Pharmacology, School of Pharmacy – College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Pharmacology, School of Pharmacy – College of Medicine and Health Sciences, University of Gondar, Gondar</wicri:regionArea><wicri:noRegion>Gondar</wicri:noRegion></affiliation></author></analytic><series><title level="j">Patient preference and adherence</title><idno type="eISSN">1177-889X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>The aim of this study was to assess the rate of antiretroviral therapy (ART) adherence and to identify any determinants among adult patients.</p></sec><sec><title>Methods</title><p>A cross-sectional study was conducted on 351 ART patients in the ART clinic of the University of Gondar referral hospital. Data were collected by a pretested interviewer-administered structured questionnaire from May to June 2014. Multivariate logistic regression was used to determine factors significantly associated with adherence.</p></sec><sec><title>Results</title><p>Of 351 study subjects, women were more predominant than men (64.4% versus 35.6%). Three hundred and forty (96.9%) patients agreed and strongly agreed that the use of ART is essential in their life, and approximately 327 (93.2%) disclosed their sero-status to family. Seventy-nine (22.5%) participants were active substance users. The level of adherence was 284 (80.9%). Three hundred forty-one (97.2%) respondents had good or fair adherence. Among the reasons for missing doses were forgetfulness (29 [43.3%]), missing appointments (14 [20.9%]), running out of medicine (9 [13.4%]), depression, anger, or hopelessness (4 [6.0%]), side effects of the medicine used (2 [3.0%]), and nonbelief in the ART (2 [3.0%]). The variables found significantly associated with non-adherence were age (<italic>P</italic>-value 0.017), employment (<italic>P</italic>-value 0.02), HIV disclosure (<italic>P</italic>-value 0.04), and comfortability to take ART in the presence of others (<italic>P</italic>-value 0.02).</p></sec><sec><title>Conclusion</title><p>From this study, it was determined that forgetfulness (43.3%) was the most common reason for missing doses. Also, employment and acceptance in using ART in the presence of others are significant issues observed for non-adherence. Hence, the ART counselor needs to place more emphasis on the provision and use of memory aids.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Erah, Po" uniqKey="Erah P">PO Erah</name></author><author><name sortKey="Arute, Je" uniqKey="Arute J">JE Arute</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Apisarnthanarak, A" uniqKey="Apisarnthanarak A">A Apisarnthanarak</name></author><author><name sortKey="Mundy, Lm" uniqKey="Mundy L">LM Mundy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chesney, Ma" uniqKey="Chesney M">MA Chesney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mills, Ej" uniqKey="Mills E">EJ Mills</name></author><author><name sortKey="Nachega, Jb" uniqKey="Nachega J">JB 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