SidaSubSaharaV1, Main, Exploration, bibRecord, 005338

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provide insights into risks for potential new cross-species transmissions

Identifieur interne : 005338 ( Main/Exploration ); précédent : 005337; suivant : 005339

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provide insights into risks for potential new cross-species transmissions

Auteurs : Avelin F. Aghokeng [France] ; Ahidjo Ayouba [France] ; Eitel Mpoudi-Ngole [Cameroun] ; Severin Loul [Cameroun] ; Florian Liegeois [France] ; Eric Delaporte [France] ; Martine Peeters [France]

Source :

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [ 1567-1348 ] ; 2009.

RBID : PMC:2844463

Abstract

To evaluate the risk of cross-species transmissions of SIVs from non-human primates to humans at the primate/hunter interface, a total of 2586 samples, derived from primate bushmeat representing 11 different primate species, were collected at 6 distinct remote forest sites in southeastern Cameroon and in Yaoundé, the capital city. SIV prevalences were estimated with an updated SIV lineage specific gp41 peptide Elisa covering the major part of the SIV diversity. SIV positive samples were confirmed by PCR and sequence analysis of partial pol fragments. The updated SIV Elisa showed good performance with overall sensitivity and specificity of 96% and 97.5% respectively. The overall SIV seroprevalence was low, 2.93% (76/2586) and ranged between 0.0% and 5.7% at forest sites, and reached up to 10.3% in Yaoundé. SIV infection was documented in 8 of the 11 species with significantly different prevalence rates per species: 9/859 (1.0%) in Cercopithecus nictitans, 9/864 (1.0%) Cercopithecus cephus, 10/60 (16.7%) Miopithecus ogouensis, 14/78 (17.9%) Colobus guereza, 15/37 (40.5%) Cercopithecus neglectus, 10/27 (33.3%) Mandrillus sphinx, 6/12 (50%) Cercocebus torquatus, and 3/6 (50%) Chlorocebus tantalus. No SIV infection was identified in Cercopithecus pogonias (n=293), Lophocebus albigena (n=168) and Cercocebus agilis (n=182). The SIV prevalences seem to vary also within species according to the sampling site, but most importantly, the highest SIV prevalences are observed in the primate species which represent only 8.5% of the overall primate bushmeat. The phylogenetic tree of partial pol sequences illustrates the high genetic diversity of SIVs between and within different primate species. The tree showed also some interesting features within the SIVdeb lineage suggesting phylogeographic clusters. Overall, the risk for additional cross-species transmissions is not equal throughout southern Cameroon and depends on the hunted species and SIV prevalences in each species. However, humans are still exposed to a high diversity of SIVs as illustrated by the high inter and intra SIV lineage genetic diversity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844463

DOI: 10.1016/j.meegid.2009.04.014
PubMed: 19393772
PubMed Central: 2844463

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P2">To evaluate the risk of cross-species transmissions of SIVs from non-human primates to humans at the primate/hunter interface, a total of 2586 samples, derived from primate bushmeat representing 11 different primate species, were collected at 6 distinct remote forest sites in southeastern Cameroon and in Yaoundé, the capital city. SIV prevalences were estimated with an updated SIV lineage specific gp41 peptide Elisa covering the major part of the SIV diversity. SIV positive samples were confirmed by PCR and sequence analysis of partial <italic>pol</italic>
 fragments. The updated SIV Elisa showed good performance with overall sensitivity and specificity of 96% and 97.5% respectively. The overall SIV seroprevalence was low, 2.93% (76/2586) and ranged between 0.0% and 5.7% at forest sites, and reached up to 10.3% in Yaoundé. SIV infection was documented in 8 of the 11 species with significantly different prevalence rates per species: 9/859 (1.0%) in <italic>Cercopithecus nictitans</italic>
, 9/864 (1.0%) <italic>Cercopithecus cephus</italic>
, 10/60 (16.7%) <italic>Miopithecus ogouensis</italic>
, 14/78 (17.9%) <italic>Colobus guereza</italic>
, 15/37 (40.5%) <italic>Cercopithecus neglectus</italic>
, 10/27 (33.3%) <italic>Mandrillus sphinx</italic>
, 6/12 (50%) <italic>Cercocebus torquatus</italic>
, and 3/6 (50%) <italic>Chlorocebus tantalus</italic>
. No SIV infection was identified in <italic>Cercopithecus pogonias</italic>
 (n=293), <italic>Lophocebus albigena</italic>
 (n=168) and <italic>Cercocebus agilis</italic>
 (n=182). The SIV prevalences seem to vary also within species according to the sampling site, but most importantly, the highest SIV prevalences are observed in the primate species which represent only 8.5% of the overall primate bushmeat. The phylogenetic tree of partial <italic>pol</italic>
 sequences illustrates the high genetic diversity of SIVs between and within different primate species. The tree showed also some interesting features within the SIVdeb lineage suggesting phylogeographic clusters. Overall, the risk for additional cross-species transmissions is not equal throughout southern Cameroon and depends on the hunted species and SIV prevalences in each species. However, humans are still exposed to a high diversity of SIVs as illustrated by the high inter and intra SIV lineage genetic diversity.</p>
</div>
</front>
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provide insights into risks for potential new cross-species transmissions

Extensive survey on the prevalence and genetic diversity of SIVs in primate bushmeat provide insights into risks for potential new cross-species transmissions

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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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