The Role of Pre-Existing Diabetes Mellitus on Hepatocellular Carcinoma Occurrence and Prognosis: A Meta-Analysis of Prospective Cohort Studies
Identifieur interne : 003B32 ( Main/Exploration ); précédent : 003B31; suivant : 003B33The Role of Pre-Existing Diabetes Mellitus on Hepatocellular Carcinoma Occurrence and Prognosis: A Meta-Analysis of Prospective Cohort Studies
Auteurs : Wan-Shui Yang [République populaire de Chine] ; Puthiery Va [États-Unis] ; Freddie Bray [France] ; Shan Gao [République populaire de Chine] ; Jing Gao [République populaire de Chine] ; Hong-Lan Li [République populaire de Chine] ; Yong-Bing Xiang [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2011.
Abstract
The impact of pre-existing diabetes mellitus (DM) on hepatocellular carcinoma (HCC) occurrence and prognosis is complex and unclear. The aim of this meta-analysis is to evaluate the association between pre-existing diabetes mellitus and hepatocellular carcinoma occurrence and prognosis.
We searched PubMed, Embase and the Cochrane Library from their inception to January, 2011 for prospective epidemiological studies assessing the effect of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence, mortality outcomes, cancer recurrence, and treatment-related complications. Study-specific risk estimates were combined by using fixed effect or random effect models.
The database search generated a total of 28 prospective studies that met the inclusion criteria. Among these studies, 14 reported the risk of HCC incidence and 6 studies reported risk of HCC specific mortality. Six studies provided a total of 8 results for all-cause mortality in HCC patients. Four studies documented HCC recurrence risks and 2 studies reported risks for hepatic decomposition occurrence in HCC patients. Meta-analysis indicated that pre-existing diabetes mellitus (DM) was significantly associated with increased risk of HCC incidence [meta-relative risk (RR) = 1.87, 95% confidence interval (CI): 1.15–2.27] and HCC-specific mortality (meta-RR = 1.88, 95%CI: 1.39–2.55) compared with their non-DM counterparts. HCC patients with pre-existing DM had a 38% increased (95% CI: 1.13–1.48) risk of death from all-causes and 91% increased (95%CI: 1.41–2.57) risk of hepatic decomposition occurrence compared to those without DM. In DM patients, the meta-RR for HCC recurrence-free survival was 1.93(95%CI: 1.12–3.33) compared with non-diabetic patients.
The findings from the current meta-analysis suggest that DM may be both associated with elevated risks of both HCC incidence and mortality. Furthermore, HCC patients with pre-existing diabetes have a poorer prognosis relative to their non-diabetic counterparts.
Url:
DOI: 10.1371/journal.pone.0027326
PubMed: 22205924
PubMed Central: 3244388
Affiliations:
- France, République populaire de Chine, États-Unis
- Auvergne-Rhône-Alpes, Maine (État), Rhône-Alpes
- Lyon
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Studies</title><author><name sortKey="Yang, Wan Shui" sort="Yang, Wan Shui" uniqKey="Yang W" first="Wan-Shui" last="Yang">Wan-Shui Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, School of Public Health, Fudan University, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, School of Public Health, Fudan University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Va, Puthiery" sort="Va, Puthiery" uniqKey="Va P" first="Puthiery" last="Va">Puthiery Va</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>University of New England College of Osteopathic Medicine, Biddeford, Maine, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of New England College of Osteopathic Medicine, Biddeford, Maine</wicri:regionArea><placeName><region type="state">Maine (État)</region></placeName></affiliation></author><author><name sortKey="Bray, Freddie" sort="Bray, Freddie" uniqKey="Bray F" first="Freddie" last="Bray">Freddie Bray</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Section of Cancer Information, International Agency for Research on Cancer, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Section of Cancer Information, International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Gao, Shan" sort="Gao, Shan" uniqKey="Gao S" first="Shan" last="Gao">Shan Gao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Jing" sort="Gao, Jing" uniqKey="Gao J" first="Jing" last="Gao">Jing Gao</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Li, Hong Lan" sort="Li, Hong Lan" uniqKey="Li H" first="Hong-Lan" last="Li">Hong-Lan Li</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The impact of pre-existing diabetes mellitus (DM) on hepatocellular carcinoma (HCC) occurrence and prognosis is complex and unclear. The aim of this meta-analysis is to evaluate the association between pre-existing diabetes mellitus and hepatocellular carcinoma occurrence and prognosis.</p></sec><sec><title>Methods</title><p>We searched PubMed, Embase and the Cochrane Library from their inception to January, 2011 for prospective epidemiological studies assessing the effect of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence, mortality outcomes, cancer recurrence, and treatment-related complications. Study-specific risk estimates were combined by using fixed effect or random effect models.</p></sec><sec><title>Results</title><p>The database search generated a total of 28 prospective studies that met the inclusion criteria. Among these studies, 14 reported the risk of HCC incidence and 6 studies reported risk of HCC specific mortality. Six studies provided a total of 8 results for all-cause mortality in HCC patients. Four studies documented HCC recurrence risks and 2 studies reported risks for hepatic decomposition occurrence in HCC patients. Meta-analysis indicated that pre-existing diabetes mellitus (DM) was significantly associated with increased risk of HCC incidence [meta-relative risk (RR) = 1.87, 95% confidence interval (CI): 1.15–2.27] and HCC-specific mortality (meta-RR = 1.88, 95%CI: 1.39–2.55) compared with their non-DM counterparts. HCC patients with pre-existing DM had a 38% increased (95% CI: 1.13–1.48) risk of death from all-causes and 91% increased (95%CI: 1.41–2.57) risk of hepatic decomposition occurrence compared to those without DM. In DM patients, the meta-RR for HCC recurrence-free survival was 1.93(95%CI: 1.12–3.33) compared with non-diabetic patients.</p></sec><sec><title>Conclusion</title><p>The findings from the current meta-analysis suggest that DM may be both associated with elevated risks of both HCC incidence and mortality. Furthermore, HCC patients with pre-existing diabetes have a poorer prognosis relative to their non-diabetic counterparts.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Pisani, P" uniqKey="Pisani P">P Pisani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Jg" uniqKey="Chen J">JG Chen</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name></author><author><name sortKey="Zhu, Yr" uniqKey="Zhu Y">YR Zhu</name></author><author><name sortKey="Lu, Jh" uniqKey="Lu J">JH Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jin, F" uniqKey="Jin F">F Jin</name></author><author><name sortKey="Devesa, Ss" uniqKey="Devesa S">SS Devesa</name></author><author><name sortKey="Chow, Wh" uniqKey="Chow W">WH Chow</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author><author><name sortKey="Ji, Bt" uniqKey="Ji B">BT Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cl" uniqKey="Lee C">CL Lee</name></author><author><name sortKey="Hsieh, Ks" uniqKey="Hsieh K">KS Hsieh</name></author><author><name sortKey="Ko, Yc" uniqKey="Ko Y">YC Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Altekruse, Sf" uniqKey="Altekruse S">SF Altekruse</name></author><author><name sortKey="Mcglynn, Ka" uniqKey="Mcglynn K">KA McGlynn</name></author><author><name sortKey="Reichman, Me" uniqKey="Reichman M">ME Reichman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hassan, Mm" uniqKey="Hassan M">MM Hassan</name></author><author><name sortKey="Frome, A" uniqKey="Frome A">A Frome</name></author><author><name sortKey="Patt, Yz" uniqKey="Patt Y">YZ Patt</name></author><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davila, Ja" uniqKey="Davila J">JA Davila</name></author><author><name sortKey="Morgan, Ro" uniqKey="Morgan R">RO Morgan</name></author><author><name sortKey="Shaib, Y" uniqKey="Shaib Y">Y Shaib</name></author><author><name sortKey="Mcglynn, Ka" uniqKey="Mcglynn K">KA McGlynn</name></author><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donadon, V" uniqKey="Donadon V">V Donadon</name></author><author><name sortKey="Balbi, M" uniqKey="Balbi M">M Balbi</name></author><author><name sortKey="Zanette, G" uniqKey="Zanette G">G Zanette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowie, Cc" uniqKey="Cowie C">CC Cowie</name></author><author><name sortKey="Rust, Kf" uniqKey="Rust K">KF Rust</name></author><author><name sortKey="Ford, Es" uniqKey="Ford E">ES Ford</name></author><author><name sortKey="Eberhardt, Ms" uniqKey="Eberhardt M">MS Eberhardt</name></author><author><name sortKey="Byrd Holt, Dd" uniqKey="Byrd Holt D">DD Byrd-Holt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rousseau, Mc" uniqKey="Rousseau M">MC Rousseau</name></author><author><name sortKey="Parent, Me" uniqKey="Parent M">ME Parent</name></author><author><name sortKey="Pollak, Mn" uniqKey="Pollak M">MN Pollak</name></author><author><name sortKey="Siemiatycki, J" uniqKey="Siemiatycki J">J Siemiatycki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davila, Ja" uniqKey="Davila J">JA Davila</name></author><author><name sortKey="Morgan, Ro" uniqKey="Morgan R">RO Morgan</name></author><author><name sortKey="Shaib, Y" uniqKey="Shaib Y">Y Shaib</name></author><author><name sortKey="Mcglynn, Ka" uniqKey="Mcglynn K">KA McGlynn</name></author><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hassan, Mm" uniqKey="Hassan M">MM Hassan</name></author><author><name sortKey="Hwang, Ly" uniqKey="Hwang L">LY Hwang</name></author><author><name sortKey="Hatten, Cj" uniqKey="Hatten C">CJ Hatten</name></author><author><name sortKey="Swaim, M" uniqKey="Swaim M">M Swaim</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author><author><name sortKey="Richardson, Pa" uniqKey="Richardson P">PA Richardson</name></author><author><name sortKey="Everhart, Je" uniqKey="Everhart J">JE Everhart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="La Vecchia, C" uniqKey="La Vecchia C">C La Vecchia</name></author><author><name sortKey="Negri, E" uniqKey="Negri E">E Negri</name></author><author><name sortKey="Decarli, A" uniqKey="Decarli A">A Decarli</name></author><author><name sortKey="Franceschi, S" uniqKey="Franceschi S">S Franceschi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, Mc" uniqKey="Yu M">MC Yu</name></author><author><name sortKey="Tong, Mj" uniqKey="Tong M">MJ Tong</name></author><author><name sortKey="Govindarajan, S" uniqKey="Govindarajan S">S Govindarajan</name></author><author><name sortKey="Henderson, Be" uniqKey="Henderson B">BE Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chodick, G" uniqKey="Chodick G">G Chodick</name></author><author><name sortKey="Heymann, Ad" uniqKey="Heymann A">AD Heymann</name></author><author><name sortKey="Rosenmann, L" uniqKey="Rosenmann L">L Rosenmann</name></author><author><name sortKey="Green, Ms" uniqKey="Green M">MS Green</name></author><author><name sortKey="Flash, S" uniqKey="Flash S">S Flash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Cs" uniqKey="Wang C">CS Wang</name></author><author><name sortKey="Yao, Wj" uniqKey="Yao W">WJ Yao</name></author><author><name sortKey="Chang, Tt" uniqKey="Chang T">TT Chang</name></author><author><name sortKey="Wang, St" uniqKey="Wang S">ST Wang</name></author><author><name sortKey="Chou, P" uniqKey="Chou P">P Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogunleye, Aa" uniqKey="Ogunleye A">AA Ogunleye</name></author><author><name sortKey="Ogston, Sa" uniqKey="Ogston S">SA Ogston</name></author><author><name sortKey="Morris, Ad" uniqKey="Morris A">AD Morris</name></author><author><name sortKey="Evans, Jm" uniqKey="Evans J">JM Evans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torisu, Y" uniqKey="Torisu Y">Y Torisu</name></author><author><name sortKey="Ikeda, K" uniqKey="Ikeda K">K Ikeda</name></author><author><name sortKey="Kobayashi, M" uniqKey="Kobayashi M">M Kobayashi</name></author><author><name sortKey="Hosaka, T" uniqKey="Hosaka T">T Hosaka</name></author><author><name sortKey="Sezaki, H" uniqKey="Sezaki H">H Sezaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lai, Ms" uniqKey="Lai M">MS Lai</name></author><author><name sortKey="Hsieh, Ms" uniqKey="Hsieh M">MS Hsieh</name></author><author><name sortKey="Chiu, Yh" uniqKey="Chiu Y">YH Chiu</name></author><author><name sortKey="Chen, Th" uniqKey="Chen T">TH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, M" uniqKey="Khan M">M Khan</name></author><author><name sortKey="Mori, M" uniqKey="Mori M">M Mori</name></author><author><name sortKey="Fujino, Y" uniqKey="Fujino Y">Y Fujino</name></author><author><name sortKey="Shibata, A" uniqKey="Shibata A">A Shibata</name></author><author><name sortKey="Sakauchi, F" uniqKey="Sakauchi F">F Sakauchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inoue, M" uniqKey="Inoue M">M Inoue</name></author><author><name sortKey="Iwasaki, M" uniqKey="Iwasaki M">M Iwasaki</name></author><author><name sortKey="Otani, T" uniqKey="Otani T">T Otani</name></author><author><name sortKey="Sasazuki, S" uniqKey="Sasazuki S">S Sasazuki</name></author><author><name sortKey="Noda, M" uniqKey="Noda M">M Noda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Serag, Hb" uniqKey="El Serag H">HB El-Serag</name></author><author><name sortKey="Tran, T" uniqKey="Tran T">T Tran</name></author><author><name sortKey="Everhart, Je" uniqKey="Everhart J">JE Everhart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tazawa, J" uniqKey="Tazawa J">J Tazawa</name></author><author><name sortKey="Maeda, M" uniqKey="Maeda M">M Maeda</name></author><author><name sortKey="Nakagawa, M" uniqKey="Nakagawa M">M Nakagawa</name></author><author><name sortKey="Ohbayashi, H" uniqKey="Ohbayashi H">H Ohbayashi</name></author><author><name sortKey="Kusano, F" uniqKey="Kusano F">F Kusano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hung, Ch" uniqKey="Hung C">CH Hung</name></author><author><name sortKey="Lee, Cm" uniqKey="Lee C">CM Lee</name></author><author><name sortKey="Wang, Jh" uniqKey="Wang J">JH Wang</name></author><author><name sortKey="Hu, Th" uniqKey="Hu T">TH Hu</name></author><author><name sortKey="Chen, Ch" uniqKey="Chen C">CH Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veldt, Bj" uniqKey="Veldt B">BJ Veldt</name></author><author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name></author><author><name sortKey="Heathcote, Ej" uniqKey="Heathcote E">EJ Heathcote</name></author><author><name sortKey="Wedemeyer, H" uniqKey="Wedemeyer H">H Wedemeyer</name></author><author><name sortKey="Reichen, Jh" uniqKey="Reichen J">JH Reichen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Costanzo, Gg" uniqKey="Di Costanzo G">GG Di Costanzo</name></author><author><name sortKey="De Luca, M" uniqKey="De Luca M">M De Luca</name></author><author><name sortKey="Tritto, G" uniqKey="Tritto G">G Tritto</name></author><author><name sortKey="Lampasi, F" uniqKey="Lampasi F">F Lampasi</name></author><author><name sortKey="Addario, L" uniqKey="Addario L">L Addario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioannou, Gn" uniqKey="Ioannou G">GN Ioannou</name></author><author><name sortKey="Splan, Mf" uniqKey="Splan M">MF Splan</name></author><author><name sortKey="Weiss, Ns" uniqKey="Weiss N">NS Weiss</name></author><author><name sortKey="Mcdonald, Gb" uniqKey="Mcdonald G">GB McDonald</name></author><author><name sortKey="Beretta, L" uniqKey="Beretta L">L Beretta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richardson, Lc" uniqKey="Richardson L">LC Richardson</name></author><author><name sortKey="Pollack, La" uniqKey="Pollack L">LA Pollack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barone, Bb" uniqKey="Barone B">BB Barone</name></author><author><name sortKey="Yeh, Hc" uniqKey="Yeh H">HC Yeh</name></author><author><name sortKey="Snyder, Cf" uniqKey="Snyder C">CF Snyder</name></author><author><name sortKey="Peairs, Ks" uniqKey="Peairs K">KS Peairs</name></author><author><name sortKey="Stein, Kb" uniqKey="Stein K">KB Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giovannucci, E" uniqKey="Giovannucci E">E Giovannucci</name></author><author><name sortKey="Harlan, Dm" uniqKey="Harlan D">DM Harlan</name></author><author><name sortKey="Archer, Mc" uniqKey="Archer M">MC Archer</name></author><author><name sortKey="Bergenstal, Rm" uniqKey="Bergenstal R">RM Bergenstal</name></author><author><name sortKey="Gapstur, Sm" uniqKey="Gapstur S">SM Gapstur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coughlin, Ss" uniqKey="Coughlin S">SS Coughlin</name></author><author><name sortKey="Calle, Ee" uniqKey="Calle E">EE Calle</name></author><author><name sortKey="Teras, Lr" uniqKey="Teras L">LR Teras</name></author><author><name sortKey="Petrelli, J" uniqKey="Petrelli J">J Petrelli</name></author><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lipscombe, Ll" uniqKey="Lipscombe L">LL Lipscombe</name></author><author><name sortKey="Goodwin, Pj" uniqKey="Goodwin P">PJ Goodwin</name></author><author><name sortKey="Zinman, B" uniqKey="Zinman B">B Zinman</name></author><author><name sortKey="Mclaughlin, Jr" uniqKey="Mclaughlin J">JR McLaughlin</name></author><author><name sortKey="Hux, Je" uniqKey="Hux J">JE Hux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rose, Dp" uniqKey="Rose D">DP Rose</name></author><author><name sortKey="Haffner, Sm" uniqKey="Haffner S">SM Haffner</name></author><author><name sortKey="Baillargeon, J" uniqKey="Baillargeon J">J Baillargeon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, Cf" uniqKey="Snyder C">CF Snyder</name></author><author><name sortKey="Stein, Kb" uniqKey="Stein K">KB Stein</name></author><author><name sortKey="Barone, Bb" uniqKey="Barone B">BB Barone</name></author><author><name sortKey="Peairs, Ks" uniqKey="Peairs K">KS Peairs</name></author><author><name sortKey="Yeh, Hc" uniqKey="Yeh H">HC Yeh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giovannucci, E" uniqKey="Giovannucci E">E Giovannucci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyerhardt, Ja" uniqKey="Meyerhardt J">JA Meyerhardt</name></author><author><name sortKey="Catalano, Pj" uniqKey="Catalano P">PJ Catalano</name></author><author><name sortKey="Haller, Dg" uniqKey="Haller D">DG Haller</name></author><author><name sortKey="Mayer, Rj" uniqKey="Mayer R">RJ Mayer</name></author><author><name sortKey="Macdonald, Js" uniqKey="Macdonald J">JS Macdonald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Pardoll, D" uniqKey="Pardoll D">D Pardoll</name></author><author><name sortKey="Jove, R" uniqKey="Jove R">R Jove</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mantovani, A" uniqKey="Mantovani A">A Mantovani</name></author><author><name sortKey="Allavena, P" uniqKey="Allavena P">P Allavena</name></author><author><name sortKey="Sica, A" uniqKey="Sica A">A Sica</name></author><author><name sortKey="Balkwill, F" uniqKey="Balkwill F">F Balkwill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Ej" uniqKey="Park E">EJ Park</name></author><author><name sortKey="Lee, Jh" uniqKey="Lee J">JH Lee</name></author><author><name sortKey="Yu, Gy" uniqKey="Yu G">GY Yu</name></author><author><name sortKey="He, G" uniqKey="He G">G He</name></author><author><name sortKey="Ali, Sr" uniqKey="Ali S">SR Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author><author><name sortKey="Cantley, Lc" uniqKey="Cantley L">LC Cantley</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yun, J" uniqKey="Yun J">J Yun</name></author><author><name sortKey="Rago, C" uniqKey="Rago C">C Rago</name></author><author><name sortKey="Cheong, I" uniqKey="Cheong I">I Cheong</name></author><author><name sortKey="Pagliarini, R" uniqKey="Pagliarini R">R Pagliarini</name></author><author><name sortKey="Angenendt, P" uniqKey="Angenendt P">P Angenendt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morss, As" uniqKey="Morss A">AS Morss</name></author><author><name sortKey="Edelman, Er" uniqKey="Edelman E">ER Edelman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clemmons, Dr" uniqKey="Clemmons D">DR Clemmons</name></author><author><name sortKey="Maile, La" uniqKey="Maile L">LA Maile</name></author><author><name sortKey="Ling, Y" uniqKey="Ling Y">Y Ling</name></author><author><name sortKey="Yarber, J" uniqKey="Yarber J">J Yarber</name></author><author><name sortKey="Busby, Wh" uniqKey="Busby W">WH Busby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radhakrishnan, Y" uniqKey="Radhakrishnan Y">Y Radhakrishnan</name></author><author><name sortKey="Maile, La" uniqKey="Maile L">LA Maile</name></author><author><name sortKey="Ling, Y" uniqKey="Ling Y">Y Ling</name></author><author><name sortKey="Graves, Lm" uniqKey="Graves L">LM Graves</name></author><author><name sortKey="Clemmons, Dr" uniqKey="Clemmons D">DR Clemmons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Renehan, Ag" uniqKey="Renehan A">AG Renehan</name></author><author><name sortKey="Frystyk, J" uniqKey="Frystyk J">J Frystyk</name></author><author><name sortKey="Flyvbjerg, A" uniqKey="Flyvbjerg A">A Flyvbjerg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denley, A" uniqKey="Denley A">A Denley</name></author><author><name sortKey="Carroll, Jm" uniqKey="Carroll J">JM Carroll</name></author><author><name sortKey="Brierley, Gv" uniqKey="Brierley G">GV Brierley</name></author><author><name sortKey="Cosgrove, L" uniqKey="Cosgrove L">L Cosgrove</name></author><author><name sortKey="Wallace, J" uniqKey="Wallace J">J Wallace</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Pelzer, Am" uniqKey="Pelzer A">AM Pelzer</name></author><author><name sortKey="Kiang, Dt" uniqKey="Kiang D">DT Kiang</name></author><author><name sortKey="Yee, D" uniqKey="Yee D">D Yee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollak, M" uniqKey="Pollak M">M Pollak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mardilovich, K" uniqKey="Mardilovich K">K Mardilovich</name></author><author><name sortKey="Pankratz, Sl" uniqKey="Pankratz S">SL Pankratz</name></author><author><name sortKey="Shaw, Lm" uniqKey="Shaw L">LM Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Payne, Je" uniqKey="Payne J">JE Payne</name></author><author><name sortKey="Meyer, Hj" uniqKey="Meyer H">HJ Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Poll Franse, Lv" uniqKey="Van De Poll Franse L">LV Van de Poll-Franse</name></author><author><name sortKey="Houterman, S" uniqKey="Houterman S">S Houterman</name></author><author><name sortKey="Janssen Heijnen, Ml" uniqKey="Janssen Heijnen M">ML Janssen-Heijnen</name></author><author><name sortKey="Dercksen, Mw" uniqKey="Dercksen M">MW Dercksen</name></author><author><name sortKey="Coebergh, Jw" uniqKey="Coebergh J">JW Coebergh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weiser, Ma" uniqKey="Weiser M">MA Weiser</name></author><author><name sortKey="Cabanillas, Me" uniqKey="Cabanillas M">ME Cabanillas</name></author><author><name sortKey="Konopleva, M" uniqKey="Konopleva M">M Konopleva</name></author><author><name sortKey="Pierce, Sa" uniqKey="Pierce S">SA Pierce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huo, Ti" uniqKey="Huo T">TI Huo</name></author><author><name sortKey="Hsu, Cy" uniqKey="Hsu C">CY Hsu</name></author><author><name sortKey="Huang, Yh" uniqKey="Huang Y">YH Huang</name></author><author><name sortKey="Hsia, Cy" uniqKey="Hsia C">CY Hsia</name></author><author><name sortKey="Lin, Hc" uniqKey="Lin H">HC Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, Ek" uniqKey="Lam E">EK Lam</name></author><author><name sortKey="Batty, Gd" uniqKey="Batty G">GD Batty</name></author><author><name sortKey="Huxley, Rr" uniqKey="Huxley R">RR Huxley</name></author><author><name sortKey="Martiniuk, Al" uniqKey="Martiniuk A">AL Martiniuk</name></author><author><name sortKey="Barzi, F" uniqKey="Barzi F">F Barzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kawamura, Y" uniqKey="Kawamura Y">Y Kawamura</name></author><author><name sortKey="Ikeda, K" uniqKey="Ikeda K">K Ikeda</name></author><author><name sortKey="Arase, Y" uniqKey="Arase Y">Y Arase</name></author><author><name sortKey="Yatsuji, H" uniqKey="Yatsuji H">H Yatsuji</name></author><author><name sortKey="Sezaki, H" uniqKey="Sezaki H">H Sezaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oba, S" uniqKey="Oba S">S Oba</name></author><author><name sortKey="Nagata, C" uniqKey="Nagata C">C Nagata</name></author><author><name sortKey="Nakamura, K" uniqKey="Nakamura K">K Nakamura</name></author><author><name sortKey="Takatsuka, N" uniqKey="Takatsuka N">N Takatsuka</name></author><author><name sortKey="Shimizu, H" uniqKey="Shimizu H">H Shimizu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komura, T" uniqKey="Komura T">T Komura</name></author><author><name sortKey="Mizukoshi, E" uniqKey="Mizukoshi E">E Mizukoshi</name></author><author><name sortKey="Kita, Y" uniqKey="Kita Y">Y Kita</name></author><author><name sortKey="Sakurai, M" uniqKey="Sakurai M">M Sakurai</name></author><author><name sortKey="Takata, Y" uniqKey="Takata Y">Y Takata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Sm" uniqKey="Park S">SM Park</name></author><author><name sortKey="Lim, Mk" uniqKey="Lim M">MK Lim</name></author><author><name sortKey="Shin, Sa" uniqKey="Shin S">SA Shin</name></author><author><name sortKey="Yun, Yh" uniqKey="Yun Y">YH Yun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jee, Sh" uniqKey="Jee S">SH Jee</name></author><author><name sortKey="Ohrr, H" uniqKey="Ohrr H">H Ohrr</name></author><author><name sortKey="Sull, Jw" uniqKey="Sull J">JW Sull</name></author><author><name sortKey="Yun, Je" uniqKey="Yun J">JE Yun</name></author><author><name sortKey="Ji, M" uniqKey="Ji M">M Ji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huo, Ti" uniqKey="Huo T">TI Huo</name></author><author><name sortKey="Wu, Jc" uniqKey="Wu J">JC Wu</name></author><author><name sortKey="Lui, Wy" uniqKey="Lui W">WY Lui</name></author><author><name sortKey="Huang, Yh" uniqKey="Huang Y">YH Huang</name></author><author><name sortKey="Lee, Pc" uniqKey="Lee P">PC Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coughlin, Ss" uniqKey="Coughlin S">SS Coughlin</name></author><author><name sortKey="Calle, Ee" uniqKey="Calle E">EE Calle</name></author><author><name sortKey="Teras, Lr" uniqKey="Teras L">LR Teras</name></author><author><name sortKey="Petrelli, J" uniqKey="Petrelli J">J Petrelli</name></author><author><name sortKey="Thun, Mj" uniqKey="Thun M">MJ Thun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Batty, Gd" uniqKey="Batty G">GD Batty</name></author><author><name sortKey="Shipley, Mj" uniqKey="Shipley M">MJ Shipley</name></author><author><name sortKey="Marmot, M" uniqKey="Marmot M">M Marmot</name></author><author><name sortKey="Smith, Gd" uniqKey="Smith G">GD Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huo, Ti" uniqKey="Huo T">TI Huo</name></author><author><name sortKey="Lui, Wy" uniqKey="Lui W">WY Lui</name></author><author><name sortKey="Huang, Yh" uniqKey="Huang Y">YH Huang</name></author><author><name sortKey="Chau, Gy" uniqKey="Chau G">GY Chau</name></author><author><name sortKey="Wu, Jc" uniqKey="Wu J">JC Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huo, Ti" uniqKey="Huo T">TI Huo</name></author><author><name sortKey="Wu, Jc" uniqKey="Wu J">JC Wu</name></author><author><name sortKey="Lui, Wy" uniqKey="Lui W">WY Lui</name></author><author><name sortKey="Lee, Pc" uniqKey="Lee P">PC Lee</name></author><author><name sortKey="Huang, Yh" uniqKey="Huang Y">YH Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poon, Rt" uniqKey="Poon R">RT Poon</name></author><author><name sortKey="Fan, St" uniqKey="Fan S">ST Fan</name></author><author><name sortKey="Wong, J" uniqKey="Wong J">J Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujino, Y" uniqKey="Fujino Y">Y Fujino</name></author><author><name sortKey="Mizoue, T" uniqKey="Mizoue T">T Mizoue</name></author><author><name sortKey="Tokui, N" uniqKey="Tokui N">N Tokui</name></author><author><name sortKey="Yoshimura, T" uniqKey="Yoshimura T">T Yoshimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikeda, Y" uniqKey="Ikeda Y">Y Ikeda</name></author><author><name sortKey="Shimada, M" uniqKey="Shimada M">M Shimada</name></author><author><name sortKey="Hasegawa, H" uniqKey="Hasegawa H">H Hasegawa</name></author><author><name sortKey="Gion, T" uniqKey="Gion T">T Gion</name></author><author><name sortKey="Kajiyama, K" uniqKey="Kajiyama K">K Kajiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Higgins, Jp" uniqKey="Higgins J">JP Higgins</name></author><author><name sortKey="Thompson, Sg" uniqKey="Thompson S">SG Thompson</name></author><author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dersimonian, R" uniqKey="Dersimonian R">R DerSimonian</name></author><author><name sortKey="Laird, N" uniqKey="Laird N">N Laird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egger, M" uniqKey="Egger M">M Egger</name></author><author><name sortKey="Davey, Sg" uniqKey="Davey S">SG Davey</name></author><author><name sortKey="Schneider, M" uniqKey="Schneider M">M Schneider</name></author><author><name sortKey="Minder, C" uniqKey="Minder C">C Minder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Begg, Cb" uniqKey="Begg C">CB Begg</name></author><author><name sortKey="Mazumdar, M" uniqKey="Mazumdar M">M Mazumdar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duval, S" uniqKey="Duval S">S Duval</name></author><author><name sortKey="Tweedie, R" uniqKey="Tweedie R">R Tweedie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Lm" uniqKey="Martin L">LM Martin</name></author><author><name sortKey="Leff, M" uniqKey="Leff M">M Leff</name></author><author><name sortKey="Calonge, N" uniqKey="Calonge N">N Calonge</name></author><author><name sortKey="Garrett, C" uniqKey="Garrett C">C Garrett</name></author><author><name sortKey="Nelson, De" uniqKey="Nelson D">DE Nelson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Sc" uniqKey="Wu S">SC Wu</name></author><author><name sortKey="Li, Cy" uniqKey="Li C">CY Li</name></author><author><name sortKey="Ke, Ds" uniqKey="Ke D">DS Ke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, Jh" uniqKey="Fuller J">JH Fuller</name></author><author><name sortKey="Elford, J" uniqKey="Elford J">J Elford</name></author><author><name sortKey="Goldblatt, P" uniqKey="Goldblatt P">P Goldblatt</name></author><author><name sortKey="Adelstein, Am" uniqKey="Adelstein A">AM Adelstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Landman, Gw" uniqKey="Landman G">GW Landman</name></author><author><name sortKey="Kleefstra, N" uniqKey="Kleefstra N">N Kleefstra</name></author><author><name sortKey="Van Hateren, Kj" uniqKey="Van Hateren K">KJ van Hateren</name></author><author><name sortKey="Groenier, Kh" uniqKey="Groenier K">KH Groenier</name></author><author><name sortKey="Gans, Ro" uniqKey="Gans R">RO Gans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Currie, Cj" uniqKey="Currie C">CJ Currie</name></author><author><name sortKey="Poole, Cd" uniqKey="Poole C">CD Poole</name></author><author><name sortKey="Gale, Ea" uniqKey="Gale E">EA Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monami, M" uniqKey="Monami M">M Monami</name></author><author><name sortKey="Lamanna, C" uniqKey="Lamanna C">C Lamanna</name></author><author><name sortKey="Pala, L" uniqKey="Pala L">L Pala</name></author><author><name sortKey="Bardini, G" uniqKey="Bardini G">G Bardini</name></author><author><name sortKey="Cresci, B" uniqKey="Cresci B">B Cresci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roden, M" uniqKey="Roden M">M Roden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitehead, Jp" uniqKey="Whitehead J">JP Whitehead</name></author><author><name sortKey="Richards, Aa" uniqKey="Richards A">AA Richards</name></author><author><name sortKey="Hickman, Ij" uniqKey="Hickman I">Ij Hickman</name></author><author><name sortKey="Macdonald, Ga" uniqKey="Macdonald G">GA Macdonald</name></author><author><name sortKey="Prins, Jb" uniqKey="Prins J">JB Prins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jonsson, Jr" uniqKey="Jonsson J">JR Jonsson</name></author><author><name sortKey="Moschen, Ar" uniqKey="Moschen A">AR Moschen</name></author><author><name sortKey="Hickman, Ij" uniqKey="Hickman I">IJ Hickman</name></author><author><name sortKey="Richardson, Mm" uniqKey="Richardson M">MM Richardson</name></author><author><name sortKey="Kaser, S" uniqKey="Kaser S">S Kaser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheruvattath, R" uniqKey="Cheruvattath R">R Cheruvattath</name></author><author><name sortKey="Balan, V" uniqKey="Balan V">V Balan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, Ax" uniqKey="Zhu A">AX Zhu</name></author><author><name sortKey="Chabner, Ba" uniqKey="Chabner B">BA Chabner</name></author><author><name sortKey="Tanabe, Kk" uniqKey="Tanabe K">KK Tanabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanyal, Aj" uniqKey="Sanyal A">AJ Sanyal</name></author><author><name sortKey="Yoon, Sk" uniqKey="Yoon S">SK Yoon</name></author><author><name sortKey="Lencioni, R" uniqKey="Lencioni R">R Lencioni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Wy" uniqKey="Lau W">WY Lau</name></author><author><name sortKey="Lai, Ec" uniqKey="Lai E">EC Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoerger, Tj" uniqKey="Hoerger T">TJ Hoerger</name></author><author><name sortKey="Segel, Je" uniqKey="Segel J">JE Segel</name></author><author><name sortKey="Gregg, Ew" uniqKey="Gregg E">EW Gregg</name></author><author><name sortKey="Saaddine, Jb" uniqKey="Saaddine J">JB Saaddine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanz, C" uniqKey="Sanz C">C Sanz</name></author><author><name sortKey="Gautier, Jf" uniqKey="Gautier J">JF Gautier</name></author><author><name sortKey="Hanaire, H" uniqKey="Hanaire H">H Hanaire</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cucchetti, A" uniqKey="Cucchetti A">A Cucchetti</name></author><author><name sortKey="Zanello, M" uniqKey="Zanello M">M Zanello</name></author><author><name sortKey="Cescon, M" uniqKey="Cescon M">M Cescon</name></author><author><name sortKey="Ercolani, G" uniqKey="Ercolani G">G Ercolani</name></author><author><name sortKey="Del, Gm" uniqKey="Del G">GM Del</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name></author><author><name sortKey="Zhang, Cq" uniqKey="Zhang C">CQ Zhang</name></author><author><name sortKey="Zhang, Yq" uniqKey="Zhang Y">YQ Zhang</name></author><author><name sortKey="Liang, Xm" uniqKey="Liang X">XM Liang</name></author><author><name sortKey="Li, Jq" uniqKey="Li J">JQ Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ih" uniqKey="Wong I">IH Wong</name></author><author><name sortKey="Yeo, W" uniqKey="Yeo W">W Yeo</name></author><author><name sortKey="Leung, T" uniqKey="Leung T">T Leung</name></author><author><name sortKey="Lau, Wy" uniqKey="Lau W">WY Lau</name></author><author><name sortKey="Johnson, Pj" uniqKey="Johnson P">PJ Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takiya, L" uniqKey="Takiya L">L Takiya</name></author><author><name sortKey="Chawla, S" uniqKey="Chawla S">S Chawla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Yh" uniqKey="Feng Y">YH Feng</name></author><author><name sortKey="Lin, Cy" uniqKey="Lin C">CY Lin</name></author><author><name sortKey="Huang, Wt" uniqKey="Huang W">WT Huang</name></author><author><name sortKey="Wu, Cl" uniqKey="Wu C">CL Wu</name></author><author><name sortKey="Fang, Jl" uniqKey="Fang J">JL Fang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Maine (État)</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Yang, Wan Shui" sort="Yang, Wan Shui" uniqKey="Yang W" first="Wan-Shui" last="Yang">Wan-Shui Yang</name></noRegion><name sortKey="Gao, Jing" sort="Gao, Jing" uniqKey="Gao J" first="Jing" last="Gao">Jing Gao</name><name sortKey="Gao, Jing" sort="Gao, Jing" uniqKey="Gao J" first="Jing" last="Gao">Jing Gao</name><name sortKey="Gao, Shan" sort="Gao, Shan" uniqKey="Gao S" first="Shan" last="Gao">Shan Gao</name><name sortKey="Gao, Shan" sort="Gao, Shan" uniqKey="Gao S" first="Shan" last="Gao">Shan Gao</name><name sortKey="Li, Hong Lan" sort="Li, Hong Lan" uniqKey="Li H" first="Hong-Lan" last="Li">Hong-Lan Li</name><name sortKey="Li, Hong Lan" sort="Li, Hong Lan" uniqKey="Li H" first="Hong-Lan" last="Li">Hong-Lan Li</name><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><name sortKey="Xiang, Yong Bing" sort="Xiang, Yong Bing" uniqKey="Xiang Y" first="Yong-Bing" last="Xiang">Yong-Bing Xiang</name><name sortKey="Yang, Wan Shui" sort="Yang, Wan Shui" uniqKey="Yang W" first="Wan-Shui" last="Yang">Wan-Shui Yang</name><name sortKey="Yang, Wan Shui" sort="Yang, Wan Shui" uniqKey="Yang W" first="Wan-Shui" last="Yang">Wan-Shui Yang</name></country><country name="États-Unis"><region name="Maine (État)"><name sortKey="Va, Puthiery" sort="Va, Puthiery" uniqKey="Va P" first="Puthiery" last="Va">Puthiery Va</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bray, Freddie" sort="Bray, Freddie" uniqKey="Bray F" first="Freddie" last="Bray">Freddie Bray</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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