SidaSubSaharaV1, Main, Exploration, bibRecord, 003A24

Longer Term Clinical and Virological Outcome of Sub-Saharan African Participants on Antiretroviral Treatment in the Swiss HIV Cohort Study

Identifieur interne : 003A24 ( Main/Exploration ); précédent : 003A23; suivant : 003A25

Longer Term Clinical and Virological Outcome of Sub-Saharan African Participants on Antiretroviral Treatment in the Swiss HIV Cohort Study

Auteurs : Cornelia Staehelin [Suisse] ; Olivia Keiser [Suisse] ; Alexandra Calmy [Suisse] ; Rainer Weber [Suisse] ; Luigia Elzi [Suisse] ; Matthias Cavassini [Suisse] ; Patrick Schmid [Suisse] ; Enos Bernasconi [Suisse] ; Hansjakob Furrer [Suisse]

Source :

Journal of acquired immune deficiency syndromes : (1999) [ 1525-4135 ] ; 2012.

RBID : Pascal:12-0094172

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Pronostic, Antiviral, Antirétroviral, Traitement, Etude cohorte, Adhérence, Afrique subsaharienne, Echec, SIDA.

English descriptors

KwdEn :
- AIDS, Adhesion, Antiretroviral agent, Antiviral, Cohort study, Failure, Human immunodeficiency virus, Prognosis, Sub-Saharan Africa, Treatment.

Abstract

Objectives: Persons from sub-Saharan Africa (SSA) are increasingly enrolled in the Swiss HIV Cohort Study (SHCS). Cohorts from other European countries showed higher rates of viral failure among their SSA participants. We analyzed long-term outcomes of SSA versus North Western European participants. Design: We analyzed data of the SHCS, a nation-wide prospective cohort study of HIV-infected adults at 7 sites in Switzerland. Methods: SSA and North Western European participants were included if their first treatment combination consisted of at least 3 antiretroviral drugs (cART), if they had at least 1 follow-up visit, did not report active injecting drug use, and did not start cART with CD4 counts >200 cells per microliter during pregnancy. Early viral response, CD4 cell recovery, viral failure, adherence, discontinuation from SHCS, new AIDS-defining events, and survival were analyzed using linear regression and Cox proportional hazard models. Results: The proportion of participants from SSA within the SHCS increased from 2.6% (<1995) to 20.8% (2005-2009). Of 4656 included participants, 808 (17.4%) were from SSA. Early viral response (6 months) and rate of viral failure in an intent-to-stay-on-cART approach were similar. However, SSA participants had a higher risk of viral failure on cART (adjusted hazard ratio: 2.03, 95% confidence interval: 1.50 to 2.75). Self-reported adherence was inferior for SSA. There was no increase of AIDS-defining events or mortality in SSA participants. Conclusions: Increased attention must be given to factors negatively influencing adherence to cART in participants from SSA to guarantee equal longer-term results on cART.

Affiliations:

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Le document en format XML

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<series><title level="j" type="main">Journal of acquired immune deficiency syndromes : (1999)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term>
<term>Adhesion</term>
<term>Antiretroviral agent</term>
<term>Antiviral</term>
<term>Cohort study</term>
<term>Failure</term>
<term>Human immunodeficiency virus</term>
<term>Prognosis</term>
<term>Sub-Saharan Africa</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus immunodéficience humaine</term>
<term>Pronostic</term>
<term>Antiviral</term>
<term>Antirétroviral</term>
<term>Traitement</term>
<term>Etude cohorte</term>
<term>Adhérence</term>
<term>Afrique subsaharienne</term>
<term>Echec</term>
<term>SIDA</term>
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<front><div type="abstract" xml:lang="en">Objectives: Persons from sub-Saharan Africa (SSA) are increasingly enrolled in the Swiss HIV Cohort Study (SHCS). Cohorts from other European countries showed higher rates of viral failure among their SSA participants. We analyzed long-term outcomes of SSA versus North Western European participants. Design: We analyzed data of the SHCS, a nation-wide prospective cohort study of HIV-infected adults at 7 sites in Switzerland. Methods: SSA and North Western European participants were included if their first treatment combination consisted of at least 3 antiretroviral drugs (cART), if they had at least 1 follow-up visit, did not report active injecting drug use, and did not start cART with CD4 counts >200 cells per microliter during pregnancy. Early viral response, CD4 cell recovery, viral failure, adherence, discontinuation from SHCS, new AIDS-defining events, and survival were analyzed using linear regression and Cox proportional hazard models. Results: The proportion of participants from SSA within the SHCS increased from 2.6% (<1995) to 20.8% (2005-2009). Of 4656 included participants, 808 (17.4%) were from SSA. Early viral response (6 months) and rate of viral failure in an intent-to-stay-on-cART approach were similar. However, SSA participants had a higher risk of viral failure on cART (adjusted hazard ratio: 2.03, 95% confidence interval: 1.50 to 2.75). Self-reported adherence was inferior for SSA. There was no increase of AIDS-defining events or mortality in SSA participants. Conclusions: Increased attention must be given to factors negatively influencing adherence to cART in participants from SSA to guarantee equal longer-term results on cART.</div>
</front>
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<tree><country name="Suisse"><region name="Canton de Berne"><name sortKey="Staehelin, Cornelia" sort="Staehelin, Cornelia" uniqKey="Staehelin C" first="Cornelia" last="Staehelin">Cornelia Staehelin</name>
</region>
<name sortKey="Bernasconi, Enos" sort="Bernasconi, Enos" uniqKey="Bernasconi E" first="Enos" last="Bernasconi">Enos Bernasconi</name>
<name sortKey="Bernasconi, Enos" sort="Bernasconi, Enos" uniqKey="Bernasconi E" first="Enos" last="Bernasconi">Enos Bernasconi</name>
<name sortKey="Calmy, Alexandra" sort="Calmy, Alexandra" uniqKey="Calmy A" first="Alexandra" last="Calmy">Alexandra Calmy</name>
<name sortKey="Cavassini, Matthias" sort="Cavassini, Matthias" uniqKey="Cavassini M" first="Matthias" last="Cavassini">Matthias Cavassini</name>
<name sortKey="Elzi, Luigia" sort="Elzi, Luigia" uniqKey="Elzi L" first="Luigia" last="Elzi">Luigia Elzi</name>
<name sortKey="Furrer, Hansjakob" sort="Furrer, Hansjakob" uniqKey="Furrer H" first="Hansjakob" last="Furrer">Hansjakob Furrer</name>
<name sortKey="Keiser, Olivia" sort="Keiser, Olivia" uniqKey="Keiser O" first="Olivia" last="Keiser">Olivia Keiser</name>
<name sortKey="Schmid, Patrick" sort="Schmid, Patrick" uniqKey="Schmid P" first="Patrick" last="Schmid">Patrick Schmid</name>
<name sortKey="Weber, Rainer" sort="Weber, Rainer" uniqKey="Weber R" first="Rainer" last="Weber">Rainer Weber</name>
</country>
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Longer Term Clinical and Virological Outcome of Sub-Saharan African Participants on Antiretroviral Treatment in the Swiss HIV Cohort Study

Longer Term Clinical and Virological Outcome of Sub-Saharan African Participants on Antiretroviral Treatment in the Swiss HIV Cohort Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri