Efficacy and immunogenicity of influenza vaccine in HIV-infected children: a randomized, double-blind, placebo controlled trial.
Identifieur interne : 002877 ( Main/Exploration ); précédent : 002876; suivant : 002878Efficacy and immunogenicity of influenza vaccine in HIV-infected children: a randomized, double-blind, placebo controlled trial.
Auteurs : Shabir A. Madhi [Afrique du Sud] ; Sylvia Dittmer ; Locadiah Kuwanda ; Marietjie Venter ; Haseena Cassim ; Erica Lazarus ; Teena Thomas ; Afaaf Liberty ; Florette Treurnich ; Clare L. Cutland ; Adriana Weinberg ; Avy ViolariSource :
- AIDS (London, England) [ 1473-5571 ] ; 2013.
Descripteurs français
- KwdFr :
- Anticorps antiviraux (immunologie), Enfant d'âge préscolaire, Excrétion virale, Femelle, Grippe humaine (immunologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Hospitalisation, Humains, Mâle, Méthode en double aveugle, Nourrisson, Numération des lymphocytes CD4, Phylogénie, Pneumopathie infectieuse (immunologie), Pneumopathie infectieuse (virologie), Pneumopathie infectieuse (épidémiologie), République d'Afrique du Sud (épidémiologie), Résultat thérapeutique, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H3N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (isolement et purification), Séropositivité VIH (immunologie), Séropositivité VIH (épidémiologie), Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (immunologie), Virus de la grippe A (isolement et purification), Virus influenza B (immunologie), Virus influenza B (isolement et purification), Études de suivi.
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Anticorps antiviraux, Grippe humaine, Pneumopathie infectieuse, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Séropositivité VIH, Vaccins antigrippaux, Virus de la grippe A, Virus influenza B.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Virus de la grippe A, Virus influenza B.
- virologie : Grippe humaine, Pneumopathie infectieuse.
- épidémiologie : Grippe humaine, Pneumopathie infectieuse, République d'Afrique du Sud, Séropositivité VIH.
- Enfant d'âge préscolaire, Excrétion virale, Femelle, Hospitalisation, Humains, Mâle, Méthode en double aveugle, Nourrisson, Numération des lymphocytes CD4, Phylogénie, Résultat thérapeutique, Tests d'inhibition de l'hémagglutination, Études de suivi.
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- Antibodies, Viral (immunology), CD4 Lymphocyte Count, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, HIV Seropositivity (epidemiology), HIV Seropositivity (immunology), Hemagglutination Inhibition Tests, Hospitalization, Humans, Infant, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H3N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza A virus (immunology), Influenza A virus (isolation & purification), Influenza B virus (immunology), Influenza B virus (isolation & purification), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Male, Phylogeny, Pneumonia (epidemiology), Pneumonia (immunology), Pneumonia (virology), South Africa (epidemiology), Treatment Outcome, Virus Shedding.
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Antibodies, Viral, Influenza Vaccines.
- geographic , epidemiology : South Africa.
- epidemiology : HIV Seropositivity, Influenza, Human, Pneumonia.
- immunology : HIV Seropositivity, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Influenza B virus, Influenza, Human, Pneumonia.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Influenza B virus.
- virology : Influenza, Human, Pneumonia.
- CD4 Lymphocyte Count, Child, Preschool, Double-Blind Method, Female, Follow-Up Studies, Hemagglutination Inhibition Tests, Hospitalization, Humans, Infant, Male, Phylogeny, Treatment Outcome, Virus Shedding.
Abstract
HIV-infected children are at heightened risk for severe influenza illness; however, there is no study on the efficacy or effectiveness of influenza vaccine in these children. We evaluated the safety, immunogenicity, and efficacy of nonadjuvanted, trivalent inactivated influenza vaccine (TIV) against confirmed seasonal influenza virus illness in HIV-infected children.
DOI: 10.1097/QAD.0b013e32835ab5b2
PubMed: 23032417
Affiliations:
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Le document en format XML
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<term>CD4 Lymphocyte Count</term>
<term>Child, Preschool</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>HIV Seropositivity (epidemiology)</term>
<term>HIV Seropositivity (immunology)</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Infant</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (isolation & purification)</term>
<term>Influenza B virus (immunology)</term>
<term>Influenza B virus (isolation & purification)</term>
<term>Influenza Vaccines (administration & dosage)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Phylogeny</term>
<term>Pneumonia (epidemiology)</term>
<term>Pneumonia (immunology)</term>
<term>Pneumonia (virology)</term>
<term>South Africa (epidemiology)</term>
<term>Treatment Outcome</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (immunologie)</term>
<term>Enfant d'âge préscolaire</term>
<term>Excrétion virale</term>
<term>Femelle</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Nourrisson</term>
<term>Numération des lymphocytes CD4</term>
<term>Phylogénie</term>
<term>Pneumopathie infectieuse (immunologie)</term>
<term>Pneumopathie infectieuse (virologie)</term>
<term>Pneumopathie infectieuse (épidémiologie)</term>
<term>République d'Afrique du Sud (épidémiologie)</term>
<term>Résultat thérapeutique</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term>
<term>Séropositivité VIH (immunologie)</term>
<term>Séropositivité VIH (épidémiologie)</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Vaccins antigrippaux (administration et posologie)</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
<term>Virus de la grippe A (isolement et purification)</term>
<term>Virus influenza B (immunologie)</term>
<term>Virus influenza B (isolement et purification)</term>
<term>Études de suivi</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term>
<term>Influenza Vaccines</term>
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<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Seropositivity</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Grippe humaine</term>
<term>Pneumopathie infectieuse</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Séropositivité VIH</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
<term>Virus influenza B</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Seropositivity</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A virus</term>
<term>Influenza B virus</term>
<term>Influenza, Human</term>
<term>Pneumonia</term>
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<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A virus</term>
<term>Influenza B virus</term>
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<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Virus de la grippe A</term>
<term>Virus influenza B</term>
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<term>Pneumonia</term>
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<term>Pneumopathie infectieuse</term>
<term>République d'Afrique du Sud</term>
<term>Séropositivité VIH</term>
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<term>Child, Preschool</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Hospitalization</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Phylogeny</term>
<term>Treatment Outcome</term>
<term>Virus Shedding</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Enfant d'âge préscolaire</term>
<term>Excrétion virale</term>
<term>Femelle</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Nourrisson</term>
<term>Numération des lymphocytes CD4</term>
<term>Phylogénie</term>
<term>Résultat thérapeutique</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">HIV-infected children are at heightened risk for severe influenza illness; however, there is no study on the efficacy or effectiveness of influenza vaccine in these children. We evaluated the safety, immunogenicity, and efficacy of nonadjuvanted, trivalent inactivated influenza vaccine (TIV) against confirmed seasonal influenza virus illness in HIV-infected children.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
</country>
</list>
<tree><noCountry><name sortKey="Cassim, Haseena" sort="Cassim, Haseena" uniqKey="Cassim H" first="Haseena" last="Cassim">Haseena Cassim</name>
<name sortKey="Cutland, Clare L" sort="Cutland, Clare L" uniqKey="Cutland C" first="Clare L" last="Cutland">Clare L. Cutland</name>
<name sortKey="Dittmer, Sylvia" sort="Dittmer, Sylvia" uniqKey="Dittmer S" first="Sylvia" last="Dittmer">Sylvia Dittmer</name>
<name sortKey="Kuwanda, Locadiah" sort="Kuwanda, Locadiah" uniqKey="Kuwanda L" first="Locadiah" last="Kuwanda">Locadiah Kuwanda</name>
<name sortKey="Lazarus, Erica" sort="Lazarus, Erica" uniqKey="Lazarus E" first="Erica" last="Lazarus">Erica Lazarus</name>
<name sortKey="Liberty, Afaaf" sort="Liberty, Afaaf" uniqKey="Liberty A" first="Afaaf" last="Liberty">Afaaf Liberty</name>
<name sortKey="Thomas, Teena" sort="Thomas, Teena" uniqKey="Thomas T" first="Teena" last="Thomas">Teena Thomas</name>
<name sortKey="Treurnich, Florette" sort="Treurnich, Florette" uniqKey="Treurnich F" first="Florette" last="Treurnich">Florette Treurnich</name>
<name sortKey="Venter, Marietjie" sort="Venter, Marietjie" uniqKey="Venter M" first="Marietjie" last="Venter">Marietjie Venter</name>
<name sortKey="Violari, Avy" sort="Violari, Avy" uniqKey="Violari A" first="Avy" last="Violari">Avy Violari</name>
<name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name>
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<country name="Afrique du Sud"><noRegion><name sortKey="Madhi, Shabir A" sort="Madhi, Shabir A" uniqKey="Madhi S" first="Shabir A" last="Madhi">Shabir A. Madhi</name>
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