SidaSubSaharaV1, Main, Exploration, bibRecord, 000F00

Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda

Identifieur interne : 000F00 ( Main/Exploration ); précédent : 000E99; suivant : 000F01

Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda

Auteurs : Ruise Or-Escudero Horacio ; Familiar-Lopez Itziar ; Sikorskii Alla ; Jambulingam Nikita ; Nakasujja Noelline ; Opoka Robert ; Bass Judith ; Boivin Michael

Source :

Journal of acquired immune deficiency syndromes (1999) [ 1525-4135 ] ; 2016.

RBID : PMC:4788522

Abstract

Objective

To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda.

Design

This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children ages 1–6 years participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda.

Methods

Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z-scores (WAZ), antiretroviral therapy (ART) status and immunological biomarkers.

Results

111 children were included in the final analysis. Lower levels of CD4⁺ CD38⁺ T-cells (p=0.04) were associated to higher Immediate and Total Recall scores (p=0.04). Higher levels of CD8⁺ HLA-DR⁺ T-cells were associated with higher Total Recall score (p=0.04) of the COAT. Higher CD4⁺ CD38⁺ HLA-DR⁺ T-cells levels were associated with higher Gross Motor scores of the MSEL (p=0.02). WAZ was positively correlated to Visual Reception, Fine Motor, Expressive Language and composite score of the MSEL.

Conclusions

Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4⁺ CD38⁺ T-cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788522

DOI: 10.1097/QAI.0000000000000905
PubMed: 26605506
PubMed Central: 4788522

Affiliations:

Le document en format XML

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<author><name sortKey="Horacio, Ruise Or Escudero" sort="Horacio, Ruise Or Escudero" uniqKey="Horacio R" first="Ruise Or-Escudero" last="Horacio">Ruise Or-Escudero Horacio</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>
,<email>huiseore@msu.edu</email>
,<email>Michael.Boivin@hc.msu.edu</email>
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<author><name sortKey="Nikita, Jambulingam" sort="Nikita, Jambulingam" uniqKey="Nikita J" first="Jambulingam" last="Nikita">Jambulingam Nikita</name>
<affiliation><nlm:aff id="A3">University of Michigan Medical School. 500 Catherine St, Apartment 2, Ann Arbor, MI 48104,<email>nikitaj@med.umich.edu</email>
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<author><name sortKey="Noelline, Nakasujja" sort="Noelline, Nakasujja" uniqKey="Noelline N" first="Nakasujja" last="Noelline">Nakasujja Noelline</name>
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<author><name sortKey="Robert, Opoka" sort="Robert, Opoka" uniqKey="Robert O" first="Opoka" last="Robert">Opoka Robert</name>
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<author><name sortKey="Judith, Bass" sort="Judith, Bass" uniqKey="Judith B" first="Bass" last="Judith">Bass Judith</name>
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<author><name sortKey="Michael, Boivin" sort="Michael, Boivin" uniqKey="Michael B" first="Boivin" last="Michael">Boivin Michael</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda</title>
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<affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>
,<email>huiseore@msu.edu</email>
,<email>Michael.Boivin@hc.msu.edu</email>
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,<email>huiseore@msu.edu</email>
,<email>Michael.Boivin@hc.msu.edu</email>
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<affiliation><nlm:aff id="A2">Department of Statistics and Probability, Michigan State University, 619 Red Cedar Road., C423, East Lansing, MI 48824,<email>sikorska@stt.msu.edu</email>
</nlm:aff>
</affiliation>
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<author><name sortKey="Nikita, Jambulingam" sort="Nikita, Jambulingam" uniqKey="Nikita J" first="Jambulingam" last="Nikita">Jambulingam Nikita</name>
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<author><name sortKey="Noelline, Nakasujja" sort="Noelline, Nakasujja" uniqKey="Noelline N" first="Nakasujja" last="Noelline">Nakasujja Noelline</name>
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<author><name sortKey="Robert, Opoka" sort="Robert, Opoka" uniqKey="Robert O" first="Opoka" last="Robert">Opoka Robert</name>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Judith, Bass" sort="Judith, Bass" uniqKey="Judith B" first="Bass" last="Judith">Bass Judith</name>
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</nlm:aff>
</affiliation>
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<author><name sortKey="Michael, Boivin" sort="Michael, Boivin" uniqKey="Michael B" first="Boivin" last="Michael">Boivin Michael</name>
<affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>
,<email>huiseore@msu.edu</email>
,<email>Michael.Boivin@hc.msu.edu</email>
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<series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title>
<idno type="ISSN">1525-4135</idno>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title>
<p id="P1">To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children ages 1–6 years participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda.</p>
</sec>
<sec id="S3"><title>Methods</title>
<p id="P3">Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z-scores (WAZ), antiretroviral therapy (ART) status and immunological biomarkers.</p>
</sec>
<sec id="S4"><title>Results</title>
<p id="P4">111 children were included in the final analysis. Lower levels of CD4<sup>+</sup>
 CD38<sup>+</sup>
 T-cells (p=0.04) were associated to higher Immediate and Total Recall scores (p=0.04). Higher levels of CD8<sup>+</sup>
 HLA-DR<sup>+</sup>
 T-cells were associated with higher Total Recall score (p=0.04) of the COAT. Higher CD4<sup>+</sup>
 CD38<sup>+</sup>
 HLA-DR<sup>+</sup>
 T-cells levels were associated with higher Gross Motor scores of the MSEL (p=0.02). WAZ was positively correlated to Visual Reception, Fine Motor, Expressive Language and composite score of the MSEL.</p>
</sec>
<sec id="S5"><title>Conclusions</title>
<p id="P5">Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4<sup>+</sup>
 CD38<sup>+</sup>
 T-cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Alla, Sikorskii" sort="Alla, Sikorskii" uniqKey="Alla S" first="Sikorskii" last="Alla">Sikorskii Alla</name>
<name sortKey="Horacio, Ruise Or Escudero" sort="Horacio, Ruise Or Escudero" uniqKey="Horacio R" first="Ruise Or-Escudero" last="Horacio">Ruise Or-Escudero Horacio</name>
<name sortKey="Itziar, Familiar Lopez" sort="Itziar, Familiar Lopez" uniqKey="Itziar F" first="Familiar-Lopez" last="Itziar">Familiar-Lopez Itziar</name>
<name sortKey="Judith, Bass" sort="Judith, Bass" uniqKey="Judith B" first="Bass" last="Judith">Bass Judith</name>
<name sortKey="Michael, Boivin" sort="Michael, Boivin" uniqKey="Michael B" first="Boivin" last="Michael">Boivin Michael</name>
<name sortKey="Nikita, Jambulingam" sort="Nikita, Jambulingam" uniqKey="Nikita J" first="Jambulingam" last="Nikita">Jambulingam Nikita</name>
<name sortKey="Noelline, Nakasujja" sort="Noelline, Nakasujja" uniqKey="Noelline N" first="Nakasujja" last="Noelline">Nakasujja Noelline</name>
<name sortKey="Robert, Opoka" sort="Robert, Opoka" uniqKey="Robert O" first="Opoka" last="Robert">Opoka Robert</name>
</noCountry>
</tree>
</affiliations>
</record>

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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda

Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda

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