Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.
Identifieur interne : 000639 ( Main/Exploration ); précédent : 000638; suivant : 000640Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.
Auteurs : G. Abongomera [Ouganda] ; A. Cook [Royaume-Uni] ; V. Musiime [Ouganda] ; C. Chabala [Zambie] ; M. Lamorde [Ouganda] ; J. Abach [Ouganda] ; M. Thomason [Royaume-Uni] ; V. Mulenga [Zambie] ; A. Kekitiinwa [Ouganda] ; R. Colebunders [Belgique] ; C. Kityo [Ouganda] ; A S Walker [Royaume-Uni] ; D M Gibb [Royaume-Uni]Source :
- AIDS and behavior [ 1573-3254 ] ; 2017.
Abstract
A high level of adherence to antiretroviral treatment is essential for optimal clinical outcomes in HIV infection, but measuring adherence is difficult. We investigated whether responses to a questionnaire eliciting caregiver beliefs in medicines were associated with adherence of their child (median age 2.8 years), and whether this in turn was associated with viral suppression. We used the validated beliefs in medicine questionnaire (BMQ) to measure caregiver beliefs, and medication event monitoring system caps to measure adherence. We found significant associations between BMQ scores and adherence, and between adherence and viral suppression. Among children initiating Antiretroviral therapy (ART), we also found significant associations between BMQ 'necessity' scores, and BMQ 'necessity-concerns' scores, and later viral suppression. This suggests that the BMQ may be a valuable tool when used alongside other adherence measures, and that it remains important to keep caregivers well informed about the long-term necessity of their child's ART.
DOI: 10.1007/s10461-016-1582-8
PubMed: 27761679
Affiliations:
- Belgique, Ouganda, Royaume-Uni, Zambie
- Angleterre, Grand Londres, Province d'Anvers, Région flamande
- Anvers, Londres
- University College de Londres, Université d'Anvers
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000772
- to stream PubMed, to step Curation: 000772
- to stream PubMed, to step Checkpoint: 000772
- to stream Ncbi, to step Merge: 003A86
- to stream Ncbi, to step Curation: 003A86
- to stream Ncbi, to step Checkpoint: 003A86
- to stream Main, to step Merge: 000639
- to stream Main, to step Curation: 000639
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.</title><author><name sortKey="Abongomera, G" sort="Abongomera, G" uniqKey="Abongomera G" first="G" last="Abongomera">G. Abongomera</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Gulu, Uganda. gabongomera@jcrc.org.ug.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Gulu</wicri:regionArea><wicri:noRegion>Gulu</wicri:noRegion></affiliation></author><author><name sortKey="Cook, A" sort="Cook, A" uniqKey="Cook A" first="A" last="Cook">A. Cook</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Musiime, V" sort="Musiime, V" uniqKey="Musiime V" first="V" last="Musiime">V. Musiime</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Chabala, C" sort="Chabala, C" uniqKey="Chabala C" first="C" last="Chabala">C. Chabala</name><affiliation wicri:level="1"><nlm:affiliation>University Teaching Hospital, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>University Teaching Hospital, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Lamorde, M" sort="Lamorde, M" uniqKey="Lamorde M" first="M" last="Lamorde">M. Lamorde</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Institute, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Infectious Diseases Institute, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Abach, J" sort="Abach, J" uniqKey="Abach J" first="J" last="Abach">J. Abach</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Gulu, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Gulu</wicri:regionArea><wicri:noRegion>Gulu</wicri:noRegion></affiliation></author><author><name sortKey="Thomason, M" sort="Thomason, M" uniqKey="Thomason M" first="M" last="Thomason">M. Thomason</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mulenga, V" sort="Mulenga, V" uniqKey="Mulenga V" first="V" last="Mulenga">V. Mulenga</name><affiliation wicri:level="1"><nlm:affiliation>University Teaching Hospital, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>University Teaching Hospital, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Kekitiinwa, A" sort="Kekitiinwa, A" uniqKey="Kekitiinwa A" first="A" last="Kekitiinwa">A. Kekitiinwa</name><affiliation wicri:level="1"><nlm:affiliation>Baylor-Uganda, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Baylor-Uganda, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R" last="Colebunders">R. Colebunders</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Antwerp, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Faculty of Medicine, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Kityo, C" sort="Kityo, C" uniqKey="Kityo C" first="C" last="Kityo">C. Kityo</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Walker, A S" sort="Walker, A S" uniqKey="Walker A" first="A S" last="Walker">A S Walker</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Gibb, D M" sort="Gibb, D M" uniqKey="Gibb D" first="D M" last="Gibb">D M Gibb</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27761679</idno><idno type="pmid">27761679</idno><idno type="doi">10.1007/s10461-016-1582-8</idno><idno type="wicri:Area/PubMed/Corpus">000772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000772</idno><idno type="wicri:Area/PubMed/Curation">000772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000772</idno><idno type="wicri:Area/PubMed/Checkpoint">000772</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000772</idno><idno type="wicri:Area/Ncbi/Merge">003A86</idno><idno type="wicri:Area/Ncbi/Curation">003A86</idno><idno type="wicri:Area/Ncbi/Checkpoint">003A86</idno><idno type="wicri:Area/Main/Merge">000639</idno><idno type="wicri:Area/Main/Curation">000639</idno><idno type="wicri:Area/Main/Exploration">000639</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.</title><author><name sortKey="Abongomera, G" sort="Abongomera, G" uniqKey="Abongomera G" first="G" last="Abongomera">G. Abongomera</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Gulu, Uganda. gabongomera@jcrc.org.ug.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Gulu</wicri:regionArea><wicri:noRegion>Gulu</wicri:noRegion></affiliation></author><author><name sortKey="Cook, A" sort="Cook, A" uniqKey="Cook A" first="A" last="Cook">A. Cook</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Musiime, V" sort="Musiime, V" uniqKey="Musiime V" first="V" last="Musiime">V. Musiime</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Chabala, C" sort="Chabala, C" uniqKey="Chabala C" first="C" last="Chabala">C. Chabala</name><affiliation wicri:level="1"><nlm:affiliation>University Teaching Hospital, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>University Teaching Hospital, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Lamorde, M" sort="Lamorde, M" uniqKey="Lamorde M" first="M" last="Lamorde">M. Lamorde</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Institute, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Infectious Diseases Institute, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Abach, J" sort="Abach, J" uniqKey="Abach J" first="J" last="Abach">J. Abach</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Gulu, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Gulu</wicri:regionArea><wicri:noRegion>Gulu</wicri:noRegion></affiliation></author><author><name sortKey="Thomason, M" sort="Thomason, M" uniqKey="Thomason M" first="M" last="Thomason">M. Thomason</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Mulenga, V" sort="Mulenga, V" uniqKey="Mulenga V" first="V" last="Mulenga">V. Mulenga</name><affiliation wicri:level="1"><nlm:affiliation>University Teaching Hospital, Lusaka, Zambia.</nlm:affiliation><country xml:lang="fr">Zambie</country><wicri:regionArea>University Teaching Hospital, Lusaka</wicri:regionArea><wicri:noRegion>Lusaka</wicri:noRegion></affiliation></author><author><name sortKey="Kekitiinwa, A" sort="Kekitiinwa, A" uniqKey="Kekitiinwa A" first="A" last="Kekitiinwa">A. Kekitiinwa</name><affiliation wicri:level="1"><nlm:affiliation>Baylor-Uganda, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Baylor-Uganda, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R" last="Colebunders">R. Colebunders</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Antwerp, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Faculty of Medicine, University of Antwerp, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Kityo, C" sort="Kityo, C" uniqKey="Kityo C" first="C" last="Kityo">C. Kityo</name><affiliation wicri:level="1"><nlm:affiliation>Joint Clinical Research Centre, Kampala, Uganda.</nlm:affiliation><country xml:lang="fr">Ouganda</country><wicri:regionArea>Joint Clinical Research Centre, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation></author><author><name sortKey="Walker, A S" sort="Walker, A S" uniqKey="Walker A" first="A S" last="Walker">A S Walker</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Gibb, D M" sort="Gibb, D M" uniqKey="Gibb D" first="D M" last="Gibb">D M Gibb</name><affiliation wicri:level="4"><nlm:affiliation>Medical Research Council Clinical Trials Unit at University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Research Council Clinical Trials Unit at University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">University College de Londres</orgName></affiliation></author></analytic><series><title level="j">AIDS and behavior</title><idno type="eISSN">1573-3254</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A high level of adherence to antiretroviral treatment is essential for optimal clinical outcomes in HIV infection, but measuring adherence is difficult. We investigated whether responses to a questionnaire eliciting caregiver beliefs in medicines were associated with adherence of their child (median age 2.8 years), and whether this in turn was associated with viral suppression. We used the validated beliefs in medicine questionnaire (BMQ) to measure caregiver beliefs, and medication event monitoring system caps to measure adherence. We found significant associations between BMQ scores and adherence, and between adherence and viral suppression. Among children initiating Antiretroviral therapy (ART), we also found significant associations between BMQ 'necessity' scores, and BMQ 'necessity-concerns' scores, and later viral suppression. This suggests that the BMQ may be a valuable tool when used alongside other adherence measures, and that it remains important to keep caregivers well informed about the long-term necessity of their child's ART.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Ouganda</li><li>Royaume-Uni</li><li>Zambie</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université d'Anvers</li></orgName></list><tree><country name="Ouganda"><noRegion><name sortKey="Abongomera, G" sort="Abongomera, G" uniqKey="Abongomera G" first="G" last="Abongomera">G. Abongomera</name></noRegion><name sortKey="Abach, J" sort="Abach, J" uniqKey="Abach J" first="J" last="Abach">J. Abach</name><name sortKey="Kekitiinwa, A" sort="Kekitiinwa, A" uniqKey="Kekitiinwa A" first="A" last="Kekitiinwa">A. Kekitiinwa</name><name sortKey="Kityo, C" sort="Kityo, C" uniqKey="Kityo C" first="C" last="Kityo">C. Kityo</name><name sortKey="Lamorde, M" sort="Lamorde, M" uniqKey="Lamorde M" first="M" last="Lamorde">M. Lamorde</name><name sortKey="Musiime, V" sort="Musiime, V" uniqKey="Musiime V" first="V" last="Musiime">V. Musiime</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Cook, A" sort="Cook, A" uniqKey="Cook A" first="A" last="Cook">A. Cook</name></region><name sortKey="Gibb, D M" sort="Gibb, D M" uniqKey="Gibb D" first="D M" last="Gibb">D M Gibb</name><name sortKey="Thomason, M" sort="Thomason, M" uniqKey="Thomason M" first="M" last="Thomason">M. Thomason</name><name sortKey="Walker, A S" sort="Walker, A S" uniqKey="Walker A" first="A S" last="Walker">A S Walker</name></country><country name="Zambie"><noRegion><name sortKey="Chabala, C" sort="Chabala, C" uniqKey="Chabala C" first="C" last="Chabala">C. Chabala</name></noRegion><name sortKey="Mulenga, V" sort="Mulenga, V" uniqKey="Mulenga V" first="V" last="Mulenga">V. Mulenga</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Colebunders, R" sort="Colebunders, R" uniqKey="Colebunders R" first="R" last="Colebunders">R. Colebunders</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000639 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000639 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaSubSaharaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27761679
|texte= Improved Adherence to Antiretroviral Therapy Observed Among HIV-Infected Children Whose Caregivers had Positive Beliefs in Medicine in Sub-Saharan Africa.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27761679" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SidaSubSaharaV1
| This area was generated with Dilib version V0.6.32. |  |