Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo
Identifieur interne : 005C10 ( Main/Curation ); précédent : 005C09; suivant : 005C11Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo
Auteurs : Annelies Van Rie [États-Unis] ; Aimee Mupuala ; Anna Dow [États-Unis]Source :
- Pediatrics [ 0031-4005 ] ; 2008.
Abstract
Pediatric HIV infection is a growing problem in most regions of the world. Data on the effects of HIV on the neurodevelopment of children in resource-poor settings are scarce but necessary to guide interventions. The purpose of this study was to compare the neurodevelopment of preschool-aged HIV-infected, HIV-affected (HIV-uninfected AIDS orphans and HIV-uninfected children whose mother had symptomatic AIDS), and healthy control children in Kinshasa, Democratic Republic of Congo.
Thirty-five HIV-infected, 35 HIV-affected, and 90 control children aged 18 to 72 months were assessed by using the Bayley Scales of Infant Development II, Peabody Developmental Motor Scales, Snijders-Oomen Nonverbal Intelligence Test, and Rossetti Infant-Toddler Language Scale, as appropriate for age.
Overall, 60% of HIV-infected children had severe delay in cognitive function, 29% had severe delay in motor skills, 85% had delays in language expression, and 77% had delays in language comprehension, all significantly higher rates as compared with control children. Young HIV-infected children (aged 18–29 months) performed worse, with 91% and 82% demonstrating severe mental and motor delay, respectively, compared with 46% and 4% in older HIV-infected children (aged 30–72 months). HIV-affected children had significantly more motor and language expression delay than control children.
The impact of the HIV pandemic on children’s neurodevelopment extends beyond the direct effect of the HIV virus on the central nervous system. AIDS orphans and HIV-negative children whose mothers had AIDS demonstrated significant delays in their neurodevelopment, although to a lesser degree and in fewer developmental domains than HIV-infected children. Young HIV-infected children were the most severely afflicted group, indicating the need for early interventions. Older children performed better as a result of a “survival effect,” with only those children with less aggressive disease surviving.
Url:
DOI: 10.1542/peds.2007-2558
PubMed: 18595957
PubMed Central: 2900927
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000F74
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000F73
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002982
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000575
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000575
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000575
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005C99
Links to Exploration step
PMC:2900927Curation
No country items
Aimee Mupuala<affiliation><nlm:aff id="A2">Department of Pediatrics, University of Kinshasa, Kinshasa, Democratic Republic of Congo</nlm:aff>
<wicri:noCountry code="subfield">Democratic Republic of Congo</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo</title>
<author><name sortKey="Van Rie, Annelies" sort="Van Rie, Annelies" uniqKey="Van Rie A" first="Annelies" last="Van Rie">Annelies Van Rie</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of North Carolina, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mupuala, Aimee" sort="Mupuala, Aimee" uniqKey="Mupuala A" first="Aimee" last="Mupuala">Aimee Mupuala</name>
<affiliation><nlm:aff id="A2">Department of Pediatrics, University of Kinshasa, Kinshasa, Democratic Republic of Congo</nlm:aff>
<wicri:noCountry code="subfield">Democratic Republic of Congo</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dow, Anna" sort="Dow, Anna" uniqKey="Dow A" first="Anna" last="Dow">Anna Dow</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of North Carolina, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18595957</idno>
<idno type="pmc">2900927</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900927</idno>
<idno type="RBID">PMC:2900927</idno>
<idno type="doi">10.1542/peds.2007-2558</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000F74</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F74</idno>
<idno type="wicri:Area/Pmc/Curation">000F73</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F73</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002982</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002982</idno>
<idno type="wicri:Area/Ncbi/Merge">000575</idno>
<idno type="wicri:Area/Ncbi/Curation">000575</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000575</idno>
<idno type="wicri:doubleKey">0031-4005:2008:Van Rie A:impact:of:the</idno>
<idno type="wicri:Area/Main/Merge">005C99</idno>
<idno type="wicri:Area/Main/Curation">005C10</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo</title>
<author><name sortKey="Van Rie, Annelies" sort="Van Rie, Annelies" uniqKey="Van Rie A" first="Annelies" last="Van Rie">Annelies Van Rie</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of North Carolina, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Mupuala, Aimee" sort="Mupuala, Aimee" uniqKey="Mupuala A" first="Aimee" last="Mupuala">Aimee Mupuala</name>
<affiliation><nlm:aff id="A2">Department of Pediatrics, University of Kinshasa, Kinshasa, Democratic Republic of Congo</nlm:aff>
<wicri:noCountry code="subfield">Democratic Republic of Congo</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Dow, Anna" sort="Dow, Anna" uniqKey="Dow A" first="Anna" last="Dow">Anna Dow</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of North Carolina, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Pediatrics</title>
<idno type="ISSN">0031-4005</idno>
<idno type="eISSN">1098-4275</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVES</title>
<p id="P1">Pediatric HIV infection is a growing problem in most regions of the world. Data on the effects of HIV on the neurodevelopment of children in resource-poor settings are scarce but necessary to guide interventions. The purpose of this study was to compare the neurodevelopment of preschool-aged HIV-infected, HIV-affected (HIV-uninfected AIDS orphans and HIV-uninfected children whose mother had symptomatic AIDS), and healthy control children in Kinshasa, Democratic Republic of Congo.</p>
</sec>
<sec sec-type="methods" id="S2"><title>METHODS</title>
<p id="P2">Thirty-five HIV-infected, 35 HIV-affected, and 90 control children aged 18 to 72 months were assessed by using the Bayley Scales of Infant Development II, Peabody Developmental Motor Scales, Snijders-Oomen Nonverbal Intelligence Test, and Rossetti Infant-Toddler Language Scale, as appropriate for age.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">Overall, 60% of HIV-infected children had severe delay in cognitive function, 29% had severe delay in motor skills, 85% had delays in language expression, and 77% had delays in language comprehension, all significantly higher rates as compared with control children. Young HIV-infected children (aged 18–29 months) performed worse, with 91% and 82% demonstrating severe mental and motor delay, respectively, compared with 46% and 4% in older HIV-infected children (aged 30–72 months). HIV-affected children had significantly more motor and language expression delay than control children.</p>
</sec>
<sec id="S4"><title>CONCLUSIONS</title>
<p id="P4">The impact of the HIV pandemic on children’s neurodevelopment extends beyond the direct effect of the HIV virus on the central nervous system. AIDS orphans and HIV-negative children whose mothers had AIDS demonstrated significant delays in their neurodevelopment, although to a lesser degree and in fewer developmental domains than HIV-infected children. Young HIV-infected children were the most severely afflicted group, indicating the need for early interventions. Older children performed better as a result of a “survival effect,” with only those children with less aggressive disease surviving.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005C10 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005C10 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:2900927 |texte= Impact of the HIV/AIDS Epidemic on the Neurodevelopment of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:18595957" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
This area was generated with Dilib version V0.6.32. |