Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges
Identifieur interne : 000D77 ( Main/Curation ); précédent : 000D76; suivant : 000D78Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges
Auteurs : Rebecca M. Zash [États-Unis] ; Paige L. Williams [États-Unis] ; Jeanne Sibiude ; Hermione Lyall [Royaume-Uni] ; Fatima Kakkar [Canada]Source :
- Expert opinion on drug safety [ 1474-0338 ] ; 2016.
Abstract
The use of antiretroviral therapy (ART) in pregnancy to prevent vertical HIV transmission has been one of the most successful public health programs in the last decade. As a result, an unprecedented number of women are taking ART at conception and during pregnancy. Given few randomized studies evaluating safety of different ART regimens in pregnancy, ongoing drug safety surveillance is critical.
This review aims to provide a rationale for ART drug safety surveillance, describe changing patterns of ART use and summarize current surveillance efforts in both low-resource and high-resource settings. Additionally, biostatistical approaches to and challenges in analysis of observational surveillance data are discussed.
The global landscape of ART use in pregnancy is rapidly increasing and evolving. Any increase in adverse effects of in-utero exposure to ART has the potential to reduce the impact of improvements in infant morbidity and mortality gained from decreased vertical HIV transmission. ART drug safety surveillance should therefore be a critical piece of programs to prevent mother to child transmission in both high- and low-resource settings. Current surveillance efforts could be strengthened with long-term follow-up of exposed children, pooling of data across cohorts and standardized approaches to analysis.
Url:
DOI: 10.1080/14740338.2016.1226281
PubMed: 27552003
PubMed Central: 5071158
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001999
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :001998
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000461
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003968
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003968
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003968
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000D77
Links to Exploration step
PMC:5071158Curation
No country items
Rebecca M. Zash<affiliation><nlm:aff id="A3">Botswana Harvard AIDS Institute Partnership, Gaborone</nlm:aff>
<wicri:noCountry code="subfield">Gaborone</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A4">Groupe hospitalier Cochin Port Royal, Paris, France; INSERM CESP 1018, Le Kremlin Bicêtre France</nlm:aff>
<wicri:noCountry code="subfield">Le Kremlin Bicêtre France</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges</title>
<author><name sortKey="Zash, Rebecca M" sort="Zash, Rebecca M" uniqKey="Zash R" first="Rebecca M." last="Zash">Rebecca M. Zash</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Harvard T. H. Chan School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard T. H. Chan School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="A3">Botswana Harvard AIDS Institute Partnership, Gaborone</nlm:aff>
<wicri:noCountry code="subfield">Gaborone</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Williams, Paige L" sort="Williams, Paige L" uniqKey="Williams P" first="Paige L." last="Williams">Paige L. Williams</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Harvard T. H. Chan School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard T. H. Chan School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sibiude, Jeanne" sort="Sibiude, Jeanne" uniqKey="Sibiude J" first="Jeanne" last="Sibiude">Jeanne Sibiude</name>
<affiliation><nlm:aff id="A4">Groupe hospitalier Cochin Port Royal, Paris, France; INSERM CESP 1018, Le Kremlin Bicêtre France</nlm:aff>
<wicri:noCountry code="subfield">Le Kremlin Bicêtre France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lyall, Hermione" sort="Lyall, Hermione" uniqKey="Lyall H" first="Hermione" last="Lyall">Hermione Lyall</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College Healthcare NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kakkar, Fatima" sort="Kakkar, Fatima" uniqKey="Kakkar F" first="Fatima" last="Kakkar">Fatima Kakkar</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Centre Hospitalier Universitaire, Sainte-Justine, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire, Sainte-Justine</wicri:regionArea>
<wicri:noRegion>Sainte-Justine</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27552003</idno>
<idno type="pmc">5071158</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071158</idno>
<idno type="RBID">PMC:5071158</idno>
<idno type="doi">10.1080/14740338.2016.1226281</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">001999</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001999</idno>
<idno type="wicri:Area/Pmc/Curation">001998</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001998</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000461</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000461</idno>
<idno type="wicri:Area/Ncbi/Merge">003968</idno>
<idno type="wicri:Area/Ncbi/Curation">003968</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003968</idno>
<idno type="wicri:doubleKey">1474-0338:2016:Zash R:surveillance:monitoring:for</idno>
<idno type="wicri:Area/Main/Merge">000D77</idno>
<idno type="wicri:Area/Main/Curation">000D77</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges</title>
<author><name sortKey="Zash, Rebecca M" sort="Zash, Rebecca M" uniqKey="Zash R" first="Rebecca M." last="Zash">Rebecca M. Zash</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Beth Israel Deaconess Medical Center, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Harvard T. H. Chan School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard T. H. Chan School of Public Health, Boston</wicri:cityArea>
</affiliation>
<affiliation><nlm:aff id="A3">Botswana Harvard AIDS Institute Partnership, Gaborone</nlm:aff>
<wicri:noCountry code="subfield">Gaborone</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Williams, Paige L" sort="Williams, Paige L" uniqKey="Williams P" first="Paige L." last="Williams">Paige L. Williams</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Harvard T. H. Chan School of Public Health, Boston, MA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>Harvard T. H. Chan School of Public Health, Boston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sibiude, Jeanne" sort="Sibiude, Jeanne" uniqKey="Sibiude J" first="Jeanne" last="Sibiude">Jeanne Sibiude</name>
<affiliation><nlm:aff id="A4">Groupe hospitalier Cochin Port Royal, Paris, France; INSERM CESP 1018, Le Kremlin Bicêtre France</nlm:aff>
<wicri:noCountry code="subfield">Le Kremlin Bicêtre France</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lyall, Hermione" sort="Lyall, Hermione" uniqKey="Lyall H" first="Hermione" last="Lyall">Hermione Lyall</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Imperial College Healthcare NHS Trust, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College Healthcare NHS Trust, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kakkar, Fatima" sort="Kakkar, Fatima" uniqKey="Kakkar F" first="Fatima" last="Kakkar">Fatima Kakkar</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Centre Hospitalier Universitaire, Sainte-Justine, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Centre Hospitalier Universitaire, Sainte-Justine</wicri:regionArea>
<wicri:noRegion>Sainte-Justine</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Expert opinion on drug safety</title>
<idno type="ISSN">1474-0338</idno>
<idno type="eISSN">1744-764X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">The use of antiretroviral therapy (ART) in pregnancy to prevent vertical HIV transmission has been one of the most successful public health programs in the last decade. As a result, an unprecedented number of women are taking ART at conception and during pregnancy. Given few randomized studies evaluating safety of different ART regimens in pregnancy, ongoing drug safety surveillance is critical.</p>
</sec>
<sec id="S2"><title>Areas Covered</title>
<p id="P2">This review aims to provide a rationale for ART drug safety surveillance, describe changing patterns of ART use and summarize current surveillance efforts in both low-resource and high-resource settings. Additionally, biostatistical approaches to and challenges in analysis of observational surveillance data are discussed.</p>
</sec>
<sec id="S3"><title>Expert Opinion</title>
<p id="P3">The global landscape of ART use in pregnancy is rapidly increasing and evolving. Any increase in adverse effects of in-utero exposure to ART has the potential to reduce the impact of improvements in infant morbidity and mortality gained from decreased vertical HIV transmission. ART drug safety surveillance should therefore be a critical piece of programs to prevent mother to child transmission in both high- and low-resource settings. Current surveillance efforts could be strengthened with long-term follow-up of exposed children, pooling of data across cohorts and standardized approaches to analysis.</p>
</sec>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaSubSaharaV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D77 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000D77 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaSubSaharaV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:5071158 |texte= Surveillance monitoring for safety of in utero antiretroviral therapy exposures: current strategies and challenges }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:27552003" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a SidaSubSaharaV1
![]() | This area was generated with Dilib version V0.6.32. | ![]() |