Sero-epidemiology of rubella in the urban population of Addis Ababa, Ethiopia
Identifieur interne : 004255 ( Istex/Corpus ); précédent : 004254; suivant : 004256Sero-epidemiology of rubella in the urban population of Addis Ababa, Ethiopia
Auteurs : F. T. Cutts ; A. Abebe ; T. Messele ; A. Dejene ; F. Enquselassie ; W. Nigatu ; D. J. NokesSource :
- Epidemiology and Infection [ 0950-2688 ] ; 2000-06.
Abstract
We conducted a community-based cluster sample survey of rubella sero-epidemiology in Addis Ababa, Ethiopia in 1994. Among 4666 individuals for whom complete data were available, rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for 1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated average age at infection was 5·2 years. The highest age-specific force of infection was estimated to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness. Unless very high coverage of rubella vaccine could be guaranteed, the introduction of childhood vaccination could increase the incidence of CRS in Addis Ababa.
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Nokes</name><affiliation><mods:affiliation>Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Epidemiology and Infection</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><publisher>Cambridge University Press</publisher><date type="published" when="2000-06">2000-06</date><biblScope unit="volume">124</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="467">467</biblScope><biblScope unit="page" to="479">479</biblScope></imprint><idno type="ISSN">0950-2688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">We conducted a community-based cluster sample survey of rubella sero-epidemiology in Addis Ababa, Ethiopia in 1994. Among 4666 individuals for whom complete data were available, rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for 1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated average age at infection was 5·2 years. The highest age-specific force of infection was estimated to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness. 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Among 4666 individuals for whom complete data were available, rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for 1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated average age at infection was 5·2 years. The highest age-specific force of infection was estimated to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness. Unless very high coverage of rubella vaccine could be guaranteed, the introduction of childhood vaccination could increase the incidence of CRS in Addis Ababa.</p></abstract></profileDesc><revisionDesc><change when="2000-06-01">Created</change><change when="2000-06">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-09-5">References added</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version='1.0' encoding='UTF-8'</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.0 20120330//EN" URI="JATS-journalpublishing1.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="1.0" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title-group><journal-title>Epidemiology and Infection</journal-title><abbrev-journal-title>Epidemiol. 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T.</given-names></name><aff>Department of Infectious and Tropical Diseases, <institution>London School of Hygiene and Tropical Medicine</institution>, Keppel St, London WC1E 7HT, <country>UK</country></aff></contrib><contrib><name><surname>ABEBE</surname><given-names>A.</given-names></name><aff><institution>Ethiopian Health and Nutrition Research Institute</institution>, PO Box 1242, Addis Ababa, <country>Ethiopia</country></aff></contrib><contrib><name><surname>MESSELE</surname><given-names>T.</given-names></name><aff><institution>Ethiopian Health and Nutrition Research Institute</institution>, PO Box 1242, Addis Ababa, <country>Ethiopia</country></aff></contrib><contrib><name><surname>DEJENE</surname><given-names>A.</given-names></name><aff><institution>Ethiopian Health and Nutrition Research Institute</institution>, PO Box 1242, Addis Ababa, <country>Ethiopia</country></aff></contrib><contrib><name><surname>ENQUSELASSIE</surname><given-names>F.</given-names></name><aff>Department of Community Health, <institution>Faculty of Medicine, University of Addis Ababa</institution>, PO Box 1176, Addis Ababa, <country>Ethiopia</country></aff><aff><institution>Ecology and Epidemiology Group</institution>, Department of Biological Sciences, <institution>University of Warwick</institution>, Coventry, CV4 7AL, <country>UK</country></aff></contrib><contrib><name><surname>NIGATU</surname><given-names>W.</given-names></name><aff><institution>Ethiopian Health and Nutrition Research Institute</institution>, PO Box 1242, Addis Ababa, <country>Ethiopia</country></aff></contrib><contrib><name><surname>NOKES</surname><given-names>D. J.</given-names></name><aff><institution>Ecology and Epidemiology Group</institution>, Department of Biological Sciences, <institution>University of Warwick</institution>, Coventry, CV4 7AL, <country>UK</country></aff></contrib></contrib-group><pub-date pub-type="epub"><day>1</day><month>6</month><year>2000</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2000</year></pub-date><volume>124</volume><issue>3</issue><fpage>467</fpage><lpage>479</lpage><history><date date-type="accepted"><day>20</day><month>11</month><year>1999</year></date></history><permissions><copyright-statement>© 2000 Cambridge University Press</copyright-statement></permissions><abstract><p>We conducted a community-based cluster sample survey of rubella sero-epidemiology in Addis
Ababa, Ethiopia in 1994. Among 4666 individuals for whom complete data were available,
rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable
analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for
1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated
average age at infection was 5·2 years. The highest age-specific force of infection was estimated
to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated
incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine
cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via
vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness.
Unless very high coverage of rubella vaccine could be guaranteed, the introduction of
childhood vaccination could increase the incidence of CRS in Addis Ababa.</p></abstract><counts><page-count count="13"></page-count></counts><custom-meta-group><custom-meta><meta-name>pdf</meta-name><meta-value>S0950268899003532a.pdf</meta-value></custom-meta></custom-meta-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Sero-epidemiology of rubella in the urban population of Addis Ababa, Ethiopia</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Sero-epidemiology of rubella in the urban population of Addis Ababa, Ethiopia</title></titleInfo><name type="personal"><namePart type="given">F. T.</namePart><namePart type="family">CUTTS</namePart><affiliation>Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">ABEBE</namePart><affiliation>Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">MESSELE</namePart><affiliation>Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">DEJENE</namePart><affiliation>Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">ENQUSELASSIE</namePart><affiliation>Department of Community Health, Faculty of Medicine, University of Addis Ababa, PO Box 1176, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">NIGATU</namePart><affiliation>Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. J.</namePart><namePart type="family">NOKES</namePart><affiliation>Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Cambridge University Press</publisher><dateIssued encoding="w3cdtf">2000-06</dateIssued><dateCreated encoding="w3cdtf">2000-06-01</dateCreated><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>We conducted a community-based cluster sample survey of rubella sero-epidemiology in Addis Ababa, Ethiopia in 1994. Among 4666 individuals for whom complete data were available, rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for 1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated average age at infection was 5·2 years. The highest age-specific force of infection was estimated to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness. Unless very high coverage of rubella vaccine could be guaranteed, the introduction of childhood vaccination could increase the incidence of CRS in Addis Ababa.</abstract><relatedItem type="host"><titleInfo><title>Epidemiology and Infection</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0950-2688</identifier><identifier type="eISSN">1469-4409</identifier><identifier type="PublisherID">HYG</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>124</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>467</start><end>479</end><total>13</total></extent></part></relatedItem><identifier type="istex">CC4AD51B2F07698656DE3078CED333DF23D28E03</identifier><identifier type="ark">ark:/67375/6GQ-GD1R9KZB-H</identifier><identifier type="PII">S0950268899003532</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2000 Cambridge University Press</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>© 2000 Cambridge University Press</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/CC4AD51B2F07698656DE3078CED333DF23D28E03/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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