SidaSubSaharaV1, Istex, Corpus, bibRecord, 003A85

Predominant human herpesvirus 6 variant A infant infections in an HIV‐1 endemic region of Sub‐Saharan Africa

Identifieur interne : 003A85 ( Istex/Corpus ); précédent : 003A84; suivant : 003A86

Predominant human herpesvirus 6 variant A infant infections in an HIV‐1 endemic region of Sub‐Saharan Africa

Auteurs : Matthew Bates ; Mwaka Monze ; Humphrey Bima ; Mirriam Kapambwe ; David Clark ; Francis C. Kasolo ; Ursula A. Gompels

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2009-05.

RBID : ISTEX:B3F338CD35829D4C80EDACB57363B16F6526863D

English descriptors

Abstract

Human herpesvirus 6, HHV‐6, commonly infects children, causing febrile illness and can cause more severe pathology, especially in an immune compromised setting. There are virulence distinctions between variants HHV‐6A and B, with evidence for increased severity and neurotropism for HHV‐6A. While HHV‐6B is the predominant infant infection in USA, Europe and Japan, HHV‐6A appears rare. Here HHV‐6 prevalence, loads and variant genotypes, in asymptomatic compared to symptomatic infants were investigated from an African region with endemic HIV‐1/AIDS. DNA was extracted from blood or sera from asymptomatic infants at 6 and 18 months age in a population‐based micronutrient study, and from symptomatic infants hospitalised for febrile disease. DNA was screened by qualitative and quantitative real‐time PCR, then genotyped by sequencing at variable loci, U46 (gN) and U47 (gO). HIV‐1 serostatus of infants and mothers were also determined. HHV‐6 DNA prevalence rose from 15% to 22% (80/371) by 18 months. At 6 months, infants born to HIV‐1 positive mothers had lower HHV‐6 prevalence (11%, 6/53), but higher HCMV prevalence (25%, 17/67). HHV‐6 positive febrile hospitalized infants had higher HIV‐1, 57% (4/7), compared to asymptomatic infants, 3% (2/74). HHV‐6A was detected exclusively in 86% (48/56) of asymptomatic HHV‐6 positive samples genotyped. Co‐infections with both strain variants were linked with higher viral loads and found in 13% (7/56) asymptomatic infants and 43% (3/7) HIV‐1 positive febrile infants. Overall, the results show HHV‐6A as the predominant variant significantly associated with viremic infant‐infections in this African population, distinct from other global cohorts, suggesting emergent infections elsewhere. J. Med. Virol. 81:779–789, 2009. © 2009 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/B3F338CD35829D4C80EDACB57363B16F6526863D/fulltext/pdf

DOI: 10.1002/jmv.21455

Links to Exploration step

ISTEX:B3F338CD35829D4C80EDACB57363B16F6526863D

Le document en format XML

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<front><div type="abstract" xml:lang="en">Human herpesvirus 6, HHV‐6, commonly infects children, causing febrile illness and can cause more severe pathology, especially in an immune compromised setting. There are virulence distinctions between variants HHV‐6A and B, with evidence for increased severity and neurotropism for HHV‐6A. While HHV‐6B is the predominant infant infection in USA, Europe and Japan, HHV‐6A appears rare. Here HHV‐6 prevalence, loads and variant genotypes, in asymptomatic compared to symptomatic infants were investigated from an African region with endemic HIV‐1/AIDS. DNA was extracted from blood or sera from asymptomatic infants at 6 and 18 months age in a population‐based micronutrient study, and from symptomatic infants hospitalised for febrile disease. DNA was screened by qualitative and quantitative real‐time PCR, then genotyped by sequencing at variable loci, U46 (gN) and U47 (gO). HIV‐1 serostatus of infants and mothers were also determined. HHV‐6 DNA prevalence rose from 15% to 22% (80/371) by 18 months. At 6 months, infants born to HIV‐1 positive mothers had lower HHV‐6 prevalence (11%, 6/53), but higher HCMV prevalence (25%, 17/67). HHV‐6 positive febrile hospitalized infants had higher HIV‐1, 57% (4/7), compared to asymptomatic infants, 3% (2/74). HHV‐6A was detected exclusively in 86% (48/56) of asymptomatic HHV‐6 positive samples genotyped. Co‐infections with both strain variants were linked with higher viral loads and found in 13% (7/56) asymptomatic infants and 43% (3/7) HIV‐1 positive febrile infants. Overall, the results show HHV‐6A as the predominant variant significantly associated with viremic infant‐infections in this African population, distinct from other global cohorts, suggesting emergent infections elsewhere. J. Med. Virol. 81:779–789, 2009. © 2009 Wiley‐Liss, Inc.</div>
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<affiliation>Correspondence address: Pathogen Molecular Biology Unit, Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, University of London, London WC1E 7HT, UK.===</affiliation>
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<place><placeTerm type="text">Hoboken</placeTerm>
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<dateIssued encoding="w3cdtf">2009-05</dateIssued>
<dateValid encoding="w3cdtf">2009-01-14</dateValid>
<copyrightDate encoding="w3cdtf">2009</copyrightDate>
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<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
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<abstract lang="en">Human herpesvirus 6, HHV‐6, commonly infects children, causing febrile illness and can cause more severe pathology, especially in an immune compromised setting. There are virulence distinctions between variants HHV‐6A and B, with evidence for increased severity and neurotropism for HHV‐6A. While HHV‐6B is the predominant infant infection in USA, Europe and Japan, HHV‐6A appears rare. Here HHV‐6 prevalence, loads and variant genotypes, in asymptomatic compared to symptomatic infants were investigated from an African region with endemic HIV‐1/AIDS. DNA was extracted from blood or sera from asymptomatic infants at 6 and 18 months age in a population‐based micronutrient study, and from symptomatic infants hospitalised for febrile disease. DNA was screened by qualitative and quantitative real‐time PCR, then genotyped by sequencing at variable loci, U46 (gN) and U47 (gO). HIV‐1 serostatus of infants and mothers were also determined. HHV‐6 DNA prevalence rose from 15% to 22% (80/371) by 18 months. At 6 months, infants born to HIV‐1 positive mothers had lower HHV‐6 prevalence (11%, 6/53), but higher HCMV prevalence (25%, 17/67). HHV‐6 positive febrile hospitalized infants had higher HIV‐1, 57% (4/7), compared to asymptomatic infants, 3% (2/74). HHV‐6A was detected exclusively in 86% (48/56) of asymptomatic HHV‐6 positive samples genotyped. Co‐infections with both strain variants were linked with higher viral loads and found in 13% (7/56) asymptomatic infants and 43% (3/7) HIV‐1 positive febrile infants. Overall, the results show HHV‐6A as the predominant variant significantly associated with viremic infant‐infections in this African population, distinct from other global cohorts, suggesting emergent infections elsewhere. J. Med. Virol. 81:779–789, 2009. © 2009 Wiley‐Liss, Inc.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>HHV‐6A</topic>
<topic>HHV‐6B</topic>
<topic>herpesvirus recombination</topic>
<topic>emergent infections</topic>
<topic>exanthema subitum</topic>
<topic>multiple sclerosis</topic>
<topic>virus gene variation</topic>
<topic>HIV/AIDS</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Journal of Medical Virology</title>
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<titleInfo type="abbreviated"><title>J. Med. Virol.</title>
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<topic>Research Article</topic>
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<identifier type="ISSN">0146-6615</identifier>
<identifier type="eISSN">1096-9071</identifier>
<identifier type="DOI">10.1002/(ISSN)1096-9071</identifier>
<identifier type="PublisherID">JMV</identifier>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>81</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>779</start>
<end>789</end>
<total>11</total>
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<identifier type="ark">ark:/67375/WNG-DS9VLKF4-6</identifier>
<identifier type="DOI">10.1002/jmv.21455</identifier>
<identifier type="ArticleID">JMV21455</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Wiley‐Liss, Inc.</accessCondition>
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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Predominant human herpesvirus 6 variant A infant infections in an HIV‐1 endemic region of Sub‐Saharan Africa

Predominant human herpesvirus 6 variant A infant infections in an HIV‐1 endemic region of Sub‐Saharan Africa

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